{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:54:09Z","timestamp":1791024849158,"version":"4.1.0"},"publisher-location":"Berlin\/Heidelberg","reference-count":46,"publisher":"Springer-Verlag","isbn-type":[{"value":"354024011X","type":"print"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1007\/3-540-27485-5_3","type":"book-chapter","created":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T19:30:22Z","timestamp":1124134222000},"page":"45-56","source":"Crossref","is-referenced-by-count":39,"title":["Pathogenesis of Rabies"],"prefix":"10.1007","author":[{"given":"B.","family":"Dietzschold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Koprowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"3_CR1","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1128\/JVI.73.6.4705-4712.1999","volume":"73","author":"L.A. Ball","year":"1999","unstructured":"Ball LA, Pringle CR, Flanagan B, Perepelitsa VP, Wertz GW (1999) Phenotypic consequences of rearranging the P, M, G genes of vesicular stomatitis virus. J Virol 73:4705\u20134712","journal-title":"J Virol"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1073\/pnas.031575198","volume":"98","author":"C.F. Basler","year":"2001","unstructured":"Basler CF, Reid AH, Dybing JK, Janczewski TA, Fanning TG, Zheng H, Salvatore M, Perdue ML, Swayne DE, Garcia-Sastre A, Palese P, Taubenberger JK (2001) Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc Natl Acad Sci U S A 98:2746\u20132751","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1046\/j.1460-9568.2003.02497.x","volume":"17","author":"R. Butowt","year":"2003","unstructured":"Butowt R, von Bartheld CS (2003) Connecting the dots: trafficking of neurotrophins, lectins and diverse pathogens by binding to the neurotrophin receptor p75NTR Eur J Neurosci 17:673\u2013680","journal-title":"Eur J Neurosci"},{"key":"3_CR4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-3-642-78490-3_6","volume-title":"Lyssaviruses","author":"K.M. Charlton","year":"1994","unstructured":"Charlton KM (1994) The pathogenesis of rabies and other lyssaviral infections: recent studies. In: Rupprecht CE, Dietzschold B, Koprowski H (eds) Lyssaviruses. Springer-Verlag, Berlin Heidelberg New York, pp 95\u2013115"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/nm1201-1306","volume":"7","author":"W. Chen","year":"2001","unstructured":"Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O\u2019Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW (2001) A novel influenza A virus mitochondrial protein that induces cell death. Nature Med 7:1306\u20131332","journal-title":"Nature Med"},{"key":"3_CR6","unstructured":"Constatine DG (1967) Rabies transmission by air in bat caverns. CDC, Atlanta, Public Health Service publication 1617"},{"key":"3_CR7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1073\/pnas.80.1.70","volume":"80","author":"B. Dietzschold","year":"1983","unstructured":"Dietzschold B, Wunner WH, Wiktor TJ, Lopes AD, Lafon M, Smith CL, Koprowski H (1983) Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus. Proc Natl Acad Sci U S A 80:70\u201374","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1128\/JVI.56.1.12-18.1985","volume":"56","author":"B. Dietzschold","year":"1985","unstructured":"Dietzschold B, Wiktor TJ, Trojanowski JQ, Macfarlan RI, Wunner WH, Torres-Anjel MJ, Koprowski H (1985) Differences in cell-to-cell spread of pathogenic and apathogenic rabies virus in vivo and in vitro. J Virol 56:12\u201318","journal-title":"J Virol"},{"key":"3_CR9","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1099\/0022-1317-81-9-2147","volume":"81","author":"R. Etessami","year":"2000","unstructured":"Etessami R, Conzelmann K-K, Fadai-Ghotbi B, Natelson B, Tsiang H, Ceccaldi P-E (2000) Spread and pathogenic characteristics of a G-deficient rabies virus recombinant: an in vitro and in vivo study. J Gen Virol 81:2147\u20132153","journal-title":"J Gen Virol"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1128\/JVI.76.7.3374-3381.2002","volume":"76","author":"M. Faber","year":"2002","unstructured":"Faber M, Pulmanausahakul R, Hodawadekar SS, Spitsin S, McGettigan JP, Schnell MJ, Dietzschold B (2002) Overexpression of the rabies virus glycoprotein (G) results in enhancement of apoptosis and anti-viral immune response. J Virol 76:3374\u20133381","journal-title":"J Virol"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"7261","DOI":"10.1128\/JVI.74.16.7261-7269.2000","volume":"74","author":"S. Finke","year":"2000","unstructured":"Finke S, Cox JH, Conzelmann KK (2000) Differential transcription attenuation of rabies virus genes by intergenic regions: generation of recombinant viruses overexpressing the polymerase gene. J Virol 74:7261\u20137269","journal-title":"J Virol"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"7895","DOI":"10.1128\/JVI.74.17.7895-7902.2000","volume":"74","author":"E.B. Flanagan","year":"2000","unstructured":"Flanagan EB, Ball LA, Wertz GW (2000) Moving the glycoprotein gene of vesicular stomatitis virus to promoter-proximal positions accelerates and enhances the protective immune response. J Virol 74:7895\u20137902","journal-title":"J Virol"},{"key":"3_CR13","doi-asserted-by":"crossref","first-page":"6674","DOI":"10.1128\/JVI.67.11.6674-6681.1993","volume":"67","author":"Z.F. Fu","year":"1993","unstructured":"Fu ZF, Weihe E, Zheng YM, Schaefer MK-H, Sheng H, Corisdeo S, Rauscher FJ III, Koprowski H, Dietzschold B (1993) Differential effects of rabies and Borna disease viruses on immediate-early-and late-response gene expression in brain tissue. J Virol 67:6674\u20136681","journal-title":"J Virol"},{"key":"3_CR14","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1099\/0022-1317-77-10-2437","volume":"77","author":"M. Gastka","year":"1996","unstructured":"Gastka M, Horvath J, Lentz TL (1996) Rabies virus binding to the nicotinic acetylcholine receptor \u03b1 subunit demonstrated by the virus overlay protein binding assay. J Gen Virol 77:2437\u20132440","journal-title":"J Gen Virol"},{"key":"3_CR15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-3-642-78490-3_3","volume-title":"Lyssaviruses","author":"G. Gostonyi","year":"1994","unstructured":"Gostonyi G (1994) Reproduction of lyssaviruses: ultrastructural composition of lyssavirus and functional aspects of pathogenesis. In: Rupprecht CE, Dietzschold B, Koprowski H (eds) Lyssaviruses. Springer-Verlag, Berlin Heidelberg New York, pp 43\u201368"},{"key":"3_CR16","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1128\/JVI.67.1.530-542.1993","volume":"67","author":"C.A. Hanham","year":"1993","unstructured":"Hanham CA, Zhao F, Tignor GH (1993) Evidence from the anti-idiotypic network that the acetylcholine receptor is a rabies virus receptor. J Virol 67:530\u2013542","journal-title":"J Virol"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1126\/science.1062882","volume":"293","author":"M. Hatta","year":"2001","unstructured":"Hatta M, Gao P, Halfmann P, Kawaoka Y (2001) Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293:1840\u20131842","journal-title":"Science"},{"key":"3_CR18","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1128\/JVI.71.7.5603-5607.1997","volume":"71","author":"A.C. Jackson","year":"1997","unstructured":"Jackson AC, Rossiter JP (1997) Apoptosis plays an important role in experimental rabies virus infection. J Virol 71:5603\u20135607","journal-title":"J Virol"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"10217","DOI":"10.1128\/JVI.74.21.10217-10222.2000","volume":"74","author":"Y. Jacob","year":"2000","unstructured":"Jacob Y, Badrane H, Ceccaldi P-E, Tordo N (2000) Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein. J Virol 74:10217\u201310222","journal-title":"J Virol"},{"key":"3_CR20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1128\/JVI.55.1.158-162.1985","volume":"55","author":"P. Kucera","year":"1985","unstructured":"Kucera P, Dolovo M, Coulon P, Flamand A (1985) Pathways of the early propagation of virulent and avirulent rabies strains from the eye to the brain. J Virol 55:158\u2013162","journal-title":"J Virol"},{"key":"3_CR21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1126\/science.7053569","volume":"215","author":"T.L. Lentz","year":"1982","unstructured":"Lentz TL, Burrage TG, Smith AL, Crick J, Tignor GH (1982) Is the acetylcholine receptor a rabies virus receptor? Science 215:182\u2013184","journal-title":"Science"},{"key":"3_CR22","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.6494916","volume":"226","author":"T.L. Lentz","year":"1984","unstructured":"Lentz TL, Wilson PT, Speicher DM (1984) Amino acid sequence similarity between rabies virus glycoprotein and snake venom curaremimetic neurotoxin. Science 226:847\u2013848","journal-title":"Science"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"14059","DOI":"10.1074\/jbc.M104701200","volume":"276","author":"K.-H. Lo","year":"2001","unstructured":"Lo KW-H, Naisbitt S, Fan J-S, Sheng M Zhang M(2001) The 8-kDa dynein light chain binds to its targets via a conserved(K\/RXTQT) motif. J Biol Chem 276:14059\u201314066","journal-title":"J Biol Chem"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/S1201-9712(00)90114-0","volume":"4","author":"L. Martinez","year":"2000","unstructured":"Martinez L (2000) Global infectious disease surveillance. Int J Infect Dis 4:222\u2013228","journal-title":"Int J Infect Dis"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/S0092-8674(00)80349-9","volume":"90","author":"T. Mebatsion","year":"1997","unstructured":"Mebatsion T, Finke S, Weiland F, Conzelmann K-K (1997) A CXCR4\/CD4 pseudotype rhabdovirus that selectively infects HIV-1 envelope protein-expressing cells. Cell 90:841\u2013847","journal-title":"Cell"},{"key":"3_CR26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1128\/JVI.73.1.242-250.1999","volume":"73","author":"T. Mebatsion","year":"1999","unstructured":"Mebatsion T, Weiland F, Conzelmann KK (1999) Matrix protein of rabies virus is responsible for the assembly and budding of bullet-shaped particles and interacts with the transmembrane spike glycoprotein G. J Virol 73:242\u2013250","journal-title":"J Virol"},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"11496","DOI":"10.1128\/JVI.75.23.11496-11502.2001","volume":"75","author":"T. Mebatsion","year":"2001","unstructured":"Mebatsion T (2001) Extensive attenuation of rabies virus by simultaneously modifying the dynein light chain binding site in the P protein and replacing Arg333 in the G protein. J Virol 75:11496\u201311502","journal-title":"J Virol"},{"key":"3_CR28","first-page":"1","volume-title":"Lyssaviruses","author":"F.-X. Meslin","year":"1994","unstructured":"Meslin F-X, Fishbein DB, Matter HC (1994) Rationale and prospects for rabies elimination in developing countries, In: Rupprecht CE, Dietzschold B, Koprowski H (eds) Lyssaviruses. Springer-Verlag, Berlin Heidelberg New York, pp 1\u201326"},{"key":"3_CR29","doi-asserted-by":"publisher","first-page":"5653","DOI":"10.1073\/pnas.93.11.5653","volume":"93","author":"K. Morimoto","year":"1996","unstructured":"Morimoto K, Patel M, Corisdeo S, Hooper DC, Fu ZF, Rupprecht CE, Koprowski H, Dietzschold B (1996) Characterization of a unique variant of bat rabies virus responsible for newly emerging human cases in North America. Proc Natl Acad. Sci U S A 93:5653\u20135658","journal-title":"Proc Natl Acad. Sci U S A"},{"key":"3_CR30","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1128\/JVI.73.1.510-518.1999","volume":"73","author":"K. Morimoto","year":"1999","unstructured":"Morimoto K, Hooper DC, Spitsin S, Koprowski H, Dietzschold B (1999) Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J Virol 73:510\u2013518","journal-title":"J Virol"},{"key":"3_CR31","first-page":"373","volume":"6","author":"K. Morimoto","year":"2000","unstructured":"Morimoto K, Foley HD, McGettigan JP, Schnell MJ, Dietzschold B (2000) Reinvestigation of the role of the rabies virus glycoprotein in viral pathogenesis using a reverse genetics approach. J Neuro Virol 6:373\u2013381","journal-title":"J Neuro Virol"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/BF01314774","volume":"54","author":"F.A. Murphy","year":"1977","unstructured":"Murphy FA (1977) Rabies pathogenesis. Arch Virol 54:279\u2013297","journal-title":"Arch Virol"},{"key":"3_CR33","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/JVI.52.2.664-671.1984","volume":"52","author":"S. Pilder","year":"1984","unstructured":"Pilder S, Logan J, Shenk T (1984) Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA. J Virol 52:664\u2013671","journal-title":"J Virol"},{"key":"3_CR34","doi-asserted-by":"publisher","first-page":"10800","DOI":"10.1128\/JVI.75.22.10800-10807.2001","volume":"75","author":"R. Pulmanausahakul","year":"2001","unstructured":"Pulmanausahakul R, Faber M, Morimoto K, Spitsin S, Weihe E, Hooper DC, Schnell MJ, Dietzschold B (2001) Overexpression of cytochrome c by a recombinant rabies virus attenuates pathogenicity and enhances antiviral immunity. J Virol 75:10800\u201310807","journal-title":"J Virol"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"10212","DOI":"10.1128\/JVI.74.21.10212-10216.2000","volume":"74","author":"H. Raux","year":"2000","unstructured":"Raux H, Flamand A, Blondel D (2000) Interaction of the rabies virus P protein with the LC8 dynein light chain. J Virol 74:10212\u201310216","journal-title":"J Virol"},{"key":"3_CR36","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/viro.1996.0644","volume":"226","author":"R.B. Ray","year":"1996","unstructured":"Ray RB, Meyer K, Ray R (1996) Suppression of apoptotic cell death by hepatitis C virus core protein. Virology 226:176\u2013182","journal-title":"Virology"},{"key":"3_CR37","first-page":"1","volume":"187","author":"C.E. Rupprecht","year":"1994","unstructured":"Rupprecht CE, Dietzschold B, Koprowski H (1994) Lyssavirus. In: Current topics in microbiology and immunology. 187:1\u2013339","journal-title":"Current topics in microbiology and immunology"},{"key":"3_CR38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3201\/eid0104.950401","volume":"1","author":"C.E. Rupprecht","year":"1995","unstructured":"Rupprecht CE, Smith JS, Fekadu M, Childs JE (1995) The ascension of wildlife rabies: a cause for public health concern or intervention? Emerg Infect Dis 1:107\u2013114","journal-title":"Emerg Infect Dis"},{"key":"3_CR39","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1002\/j.1460-2075.1994.tb06739.x","volume":"13","author":"M.J. Schnell","year":"1994","unstructured":"Schnell MJ, Mebatsion T, Conzelmann KK (1994) Infectious rabies viruses from cloned cDNA. EMBO J 13:4195\u20134203","journal-title":"EMBO J"},{"key":"3_CR40","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1128\/JVI.53.3.926-934.1985","volume":"53","author":"I. Seif","year":"1985","unstructured":"Seif I, Coulon P, Rollin PE, Flamand A (1985) Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein. J Virol 53:926\u2013934","journal-title":"J Virol"},{"key":"3_CR41","first-page":"27","volume-title":"Handbook of Neurovirology","author":"W.G. Stroop","year":"1995","unstructured":"Stroop WG (1995) Viral pathogenesis. In: McKendall RR, Stroop WG (eds) Handbook of Neurovirology. Marcel Deckker, New York, pp 27\u201354"},{"key":"3_CR42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1099\/0022-1317-61-2-277","volume":"61","author":"H. Tsiang","year":"1982","unstructured":"Tsiang H (1982) Neuronal function impairment in rabies-infected rat brain. J Gen Virol 61:277\u2013281","journal-title":"J Gen Virol"},{"key":"3_CR43","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/0042-6822(89)90122-0","volume":"172","author":"C. Tuffereau","year":"1989","unstructured":"Tuffereau C, Leblois H, Benejean J, Coulon P, Lafay F, Flamand A (1989) Arginine or lysine in position 333 of ERA and CVS glycoprotein is necessary for rabies virulence in adult mice. Virology 172:206\u2013212","journal-title":"Virology"},{"key":"3_CR44","doi-asserted-by":"publisher","first-page":"7250","DOI":"10.1093\/emboj\/17.24.7250","volume":"17","author":"C. Tuffereau","year":"1998","unstructured":"Tuffereau C, Benejean J, Blondel D, Kieffer B, Flamand A (1998) Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus. EMBO J 17:7250\u20137259","journal-title":"EMBO J"},{"key":"3_CR45","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/JVI.72.2.1085-1091.1998","volume":"72","author":"C. Tuffereau","year":"1998","unstructured":"Tuffereau C, Benejean J, Alfonso A-MR, Flamand A, Fishman MC (1998) Neuronal cell surface molecules mediate specific binding to rabies virus glycoprotein expressed by a recombinant baculovirus on the surfaces of lepidopteran cells. J Virol 72:1085\u20131091","journal-title":"J Virol"},{"key":"3_CR46","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1099\/0022-1317-82-12-2861","volume":"82","author":"C. Tuffereau","year":"2001","unstructured":"Tuffereau C, Desmezieres E, Benejean J, Jallet C, Flamand A, Tordo N, Perrin P (2001) Interaction of lyssaviruses with low-affinity nerve-growth factor receptor p75NTR. J Gen Virol 82:2861\u20132867","journal-title":"J Gen Virol"}],"container-title":["Current Topics in Microbiology and Immunology","The World of Rhabdoviruses"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/3-540-27485-5_3.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T21:15:50Z","timestamp":1619558150000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/3-540-27485-5_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[null]]},"ISBN":["354024011X"],"references-count":46,"URL":"https:\/\/doi.org\/10.1007\/3-540-27485-5_3","relation":{},"subject":[]}}