{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T21:48:20Z","timestamp":1725486500077},"publisher-location":"Berlin, Heidelberg","reference-count":40,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783540416357"},{"type":"electronic","value":"9783540445777"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001]]},"DOI":"10.1007\/3-540-44577-3_24","type":"book-chapter","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T18:23:39Z","timestamp":1181413419000},"page":"341-355","source":"Crossref","is-referenced-by-count":5,"title":["Computational Biology at the Beginning of the Post-genomic Era"],"prefix":"10.1007","author":[{"given":"Thomas","family":"Lengauer","sequence":"first","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2001,3,29]]},"reference":[{"key":"24_CR1","unstructured":"T. Werner, Analyzing Regulatory Regions in Genomes, in Bioinformatics-From Genomes to Drugs (T. Lengauer, ed.), Wiley-VCH, Heidelberg, to appear."},{"key":"24_CR2","unstructured":"V. Solovyev, Structure, Properties and Computer Identification of Eucaryotic Genes, in Bioinformatics-From Genomes to Drugs (T. Lengauer, ed.), Wiley-VCH, Heidelberg, to appear."},{"key":"24_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1063\/1.475379","volume":"108","author":"S. He","year":"1998","unstructured":"S. He, H. A. Scheraga, Brownian Dynamics Simulations of Protein Folding. J. Chem. Phys. 108 (1998) 287\u2013300.","journal-title":"J. Chem. Phys."},{"key":"24_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/35011000","volume":"405","author":"D. Baker","year":"2000","unstructured":"D. Baker, A Surprising Simplicity to Protein Folding, Nature 405 (2000) 39\u201342.","journal-title":"Nature"},{"key":"24_CR5","doi-asserted-by":"publisher","first-page":"7442","DOI":"10.1021\/j100197a057","volume":"96","author":"J. Kostrowicki","year":"1992","unstructured":"J. Kostrowicki, H. A. Scheraga, Application of the Diffusion Equation Method for Global Optimization of Oligopeptides, J. Phys. Chem. 96 (1992) 7442\u20137449.","journal-title":"J. Phys. Chem."},{"key":"24_CR6","unstructured":"R. L. Dunbrack, Jr., Homology Modeling in Biology and Medicine, in Bioinformatics-From Genomes to Drugs (T. Lengauer, ed.), Wiley-VCH, Heidelberg, to appear."},{"key":"24_CR7","unstructured":"R. M. Zimmer, Protein Structure Prediction and Applications in Structural Genomics, Protein Function Assignment and Drug Target Finding, in Bioinformatics-From Genomes to Drugs (T. Lengauer, ed.), Wiley-VCH, Heidelberg, to appear."},{"key":"24_CR8","series-title":"Lect Notes Comput Sci","first-page":"137","volume-title":"Proceedings of German Conference on Bioinformatics (GCB\u201996)","author":"R. M. Zimmer","year":"1997","unstructured":"R. M. Zimmer, R. Thiele, Fast Protein Fold Recognition and Accurate Sequence-Structure Alignment, Proceedings of German Conference on Bioinformatics (GCB\u201996), R. Hofest\u00e4dt, T. Lengauer, M. L\u00f6ffler, D. Schomburg, eds., Springer Lecture Notes in Computer Science No. 1278 (1997) 137\u2013148."},{"key":"24_CR9","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1006\/jmbi.1999.2893","volume":"290","author":"R. Thiele","year":"1999","unstructured":"R. Thiele, R. M. Zimmer, T. Lengauer, Protein Threading by Recursive Dynamic Programming. J. Mol. Biol. 290, 3 (1999) 757\u2013779","journal-title":"J. Mol. Biol."},{"key":"24_CR10","unstructured":"Proteins: Structure, Function and Genetics, Suppl: Third Meeting on the Critical Assessment of Techniques for Protein Structure Prediction (1999). \n                    http:\/\/PredictionCenter.llnl.gov\/casp3\/Casp3.html"},{"key":"24_CR11","doi-asserted-by":"crossref","unstructured":"T. Lengauer, R. Zimmer, Structure Prediction Methods for Drug Design, Briefings in Bioinformatics 1,3 (2000)","DOI":"10.1093\/bib\/1.3.275"},{"key":"24_CR12","first-page":"11","volume":"61","author":"S. Anderson","year":"1999","unstructured":"S. Anderson, Structural genomics: keystone for a Human Proteome Project. Nat Struct Biol. 6,1 (1999)11\u201312","journal-title":"Nat Struct Biol"},{"issue":"5","key":"24_CR13","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1063\/1.168582","volume":"10","author":"I. Andricioaei","year":"1996","unstructured":"I. Andricioaei, J. E. Straub, Finding the Needle in the Haystack: Algorithms for Conformal Optimization, Computers in Physics 10, 5 (1996) 449.","journal-title":"Computers in Physics"},{"key":"24_CR14","first-page":"3339","volume":"93","author":"L. Piela","year":"1989","unstructured":"L. Piela, J. Kostrowicki, H. A. Scheraga, The Multiple\u2014Minima Problem in the Conformational Analysis of Molecules. Deformation of the Potential Energy Hypersurface by the Diffusion Equation Method, J. Phys. Chem. 93 (1989) 3339\u20133346.","journal-title":"Deformation of the Potential Energy Hypersurface by the Diffusion Equation Method, J. Phys. Chem"},{"key":"24_CR15","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1021\/cr00023a004","volume":"93","author":"P. Kollman","year":"1993","unstructured":"P. Kollman, Free Energy Calculations: Applications to Chemical and Biochemical Phenomena, Chemical Reviews 93 (1993) 2395\u20132417.","journal-title":"Chemical Reviews"},{"key":"24_CR16","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/S0006-3495(97)78756-3","volume":"72","author":"M. K. Gilson","year":"1997","unstructured":"M. K. Gilson et al., The Statistical-Thermodynmic Basis for Computation of Binding Affinities: A Critical review, Biophysical Journal 72 (1997) 1047\u20131069.","journal-title":"Biophysical Journal"},{"key":"24_CR17","first-page":"28","volume":"1","author":"J. D. Hirst","year":"1998","unstructured":"J. D. Hirst, Predicting ligand binding energies, Current Opinion in Drug Discovery and Development 1 (1998) 28\u201333.","journal-title":"Current Opinion in Drug Discovery and Development"},{"key":"24_CR18","unstructured":"M. Rarey, M. Stahl, G. Klebe, Screening of Drug Databases, in Bioinformatics-From Genomes to Drugs (T. Lengauer, ed.), Wiley-VCH, Heidelberg, to appear."},{"key":"24_CR19","unstructured":"E. O. Voit, Computational Analysis of Biochemical Systems, Cambridge University Press (2000)"},{"issue":"1","key":"24_CR20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1093\/bioinformatics\/15.1.72","volume":"15","author":"M. Tomita","year":"1999","unstructured":"M. Tomita et al., E-CELL: Software Environment for Whole-Cell Simulation, Bioinformatics 15, 1 (1999) 72\u201384.","journal-title":"Bioinformatics"},{"key":"24_CR21","unstructured":"A. Zien, R. K\u00fcffner, R. Zimmer., T. Lengauer, Analysis of Gene Expression Data With Pathway Scores, Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology (ISMB2000), AAAI Press (2000) 407\u2013417."},{"key":"24_CR22","doi-asserted-by":"crossref","unstructured":"S. Fuhrman, S. Liang, X. Wen, R. Somogyi, Target Finding in Genomes and Proteomes, in Bioinformatics-From Genomes to Drugs (T. Lengauer, ed.), Wiley-VCH, Heidelberg, to appear.","DOI":"10.1002\/3527601481.ch13"},{"key":"24_CR23","doi-asserted-by":"crossref","unstructured":"P.-A. Binz et al., Proteome Analysis, in Bioinformatics-From Genomes to Drugs (T. Lengauer, ed.), Wiley-VCH, Heidelberg, to appear.","DOI":"10.1002\/3527601481.ch12"},{"key":"24_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/ng0498-313","volume":"18","author":"P. Bork","year":"1998","unstructured":"P., Bork, E.V. Koonin, Predicting Function from Protein Sequences: Where are the Bottlenecks? Nature Genet. 18 (1998) 313\u2013318.","journal-title":"Nature Genet."},{"key":"24_CR25","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S0168-9525(97)01255-9","volume":"13","author":"M. A. Huynen","year":"1997","unstructured":"M. A. Huynen, Y. Diaz-Lazcoz and P. Bork, Differential Genome Display, Trends in Genetics 13 (1997) 389\u2013390.","journal-title":"Trends in Genetics"},{"issue":"5428","key":"24_CR26","first-page":"751","volume":"285","author":"E. M. Marcotte","year":"1999","unstructured":"E. M. Marcotte et al., Detecting Protein Function and Protein-Protein Interactions from Genome Sequences, Science 285, 5428 (1999)751\u2013753.","journal-title":"Detecting Protein Function and Protein-Protein Interactions from Genome Sequences, Science"},{"key":"24_CR27","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/PubMed\/"},{"key":"24_CR28","unstructured":"H. Shatkay et al., Genes, Themes and Microarrays, Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology (ISMB2000), AAAI Press (2000) 317\u2013328."},{"key":"24_CR29","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/35020106","volume":"406","author":"E. A. Clark","year":"2000","unstructured":"E. A. Clark et al., Genomic Analysis of Metastasis Reveals an Essential Role for RhoC, Nature 406 (2000)532\u2013535.","journal-title":"Nature"},{"issue":"7\/8","key":"24_CR30","first-page":"463","volume":"9","author":"B. Kramer","year":"1999","unstructured":"B. Kramer, G. Metz, M. Rarey, T. Lengauer, Ligand Docking and Screening with FlexX, Medical Chemistry Research 9, 7\/8 (1999) 463\u2013478.","journal-title":"Medical Chemistry Research"},{"issue":"5","key":"24_CR31","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1023\/A:1008068904628","volume":"12","author":"M. Rarey","year":"1998","unstructured":"M. Rarey, J. S. Dixon, Feature Trees: A New Molecular Similarity Measure Based on Tree Matching, J Comput Aided Mol Des. 12, 5 (1998) 471\u2013490.","journal-title":"J Comput Aided Mol Des"},{"key":"24_CR32","unstructured":"M. J. Rieder, D. A. Nickerson, Analysis of Sequence Variations, in Bioinformatics-From Genomes to Drugs (T. Lengauer, ed.), Wiley-VCH, Heidelberg, to appear."},{"key":"24_CR33","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1006\/jmbi.1994.1104","volume":"235","author":"A. Krogh","year":"1994","unstructured":"A. Krogh, M. Brown, I. S. Mian, K. Sj\u00f6lander, D. Haussler, Hidden Markov Models in Computational Biology: Application to Protein Modeling, J. Mol. Biol. 235 (1994) 1501\u20131531.","journal-title":"J. Mol. Biol"},{"issue":"9","key":"24_CR34","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/bioinformatics\/14.9.755","volume":"14","author":"S. R. Eddy","year":"1998","unstructured":"S. R. Eddy, Profile Hidden Markov Models, Bioinformatics 14,9 (1998) 755\u2013763.","journal-title":"Bioinformatics"},{"key":"24_CR35","unstructured":"T. Jaakola, M. Diekhans, D. Haussler, Using the Fisher Kernel Method to Detect Remote Protein Homologies, Proceedings of the Seventh International Conference on Intelligent Systems for Molecular Biology (ISMB\u201999), AAAI Press (1999) 149\u2013158."},{"key":"24_CR36","doi-asserted-by":"crossref","unstructured":"A. Zien et al., Engineering Support Vector Machines Kernels that Recognize Translation Initiation Sites, Bioinformatics (2000) to appear.","DOI":"10.1093\/bioinformatics\/16.9.799"},{"key":"24_CR37","doi-asserted-by":"crossref","unstructured":"A. Zien, R. Zimmer, T. Lengauer, A Simple Iterative Approach to Parameter Optimization, Proceedings of the Fourth Annual Conference on Research in Computational Molecular Biology (RECOMB\u201900), ACM Press (2000) 318\u2013327.","DOI":"10.1145\/332306.332570"},{"key":"24_CR38","doi-asserted-by":"crossref","unstructured":"R. Zimmer, T. Lengauer, Fast and Numerically Stable Parametric Alignment of Biosequences. Proceedings of the First Annual Conference on Research in Computational Molecular Biology (RECOMB\u201997) (1997) 344\u2013353.","DOI":"10.1145\/267521.267894"},{"key":"24_CR39","unstructured":"http:\/\/scop.mrc-lmb.cam.ac.uk\/scop\/"},{"key":"24_CR40","unstructured":"http:\/\/www.biochem.ucl.ac.uk\/bsm\/cath\/"}],"container-title":["Lecture Notes in Computer Science","Informatics"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/3-540-44577-3_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T19:00:14Z","timestamp":1547751614000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/3-540-44577-3_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"ISBN":["9783540416357","9783540445777"],"references-count":40,"URL":"https:\/\/doi.org\/10.1007\/3-540-44577-3_24","relation":{},"ISSN":["0302-9743"],"issn-type":[{"type":"print","value":"0302-9743"}],"subject":[],"published":{"date-parts":[[2001]]}}}