{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:26:34Z","timestamp":1784075194168,"version":"3.55.0"},"publisher-location":"Berlin, Heidelberg","reference-count":133,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540783503","type":"print"},{"value":"9783540783510","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1007\/400_2007_047","type":"book-chapter","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T14:09:01Z","timestamp":1200665341000},"page":"27-55","source":"Crossref","is-referenced-by-count":73,"title":["Orexins and Orexin Receptors: From Molecules to Integrative Physiology"],"prefix":"10.1007","author":[{"given":"Taizo","family":"Matsuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"47_CR1","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1111\/j.1460-9568.2004.03749.x","volume":"20","author":"M Akiyama","year":"2004","unstructured":"Akiyama M, Yuasa T, Hayasaka N, Horikawa K, Sakurai T, Shibata S (2004) Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. Eur J Neurosci 20:3054\u20133062","journal-title":"Eur J Neurosci"},{"key":"47_CR2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-2826.2001.00655.x","volume":"13","author":"KA Al-Barazanji","year":"2001","unstructured":"Al-Barazanji KA, Wilson S, Baker J, Jessop DS, Harbuz MS (2001) Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotropin releasing factor and arginine vasopressin neurones in conscious rats. J Neuroendocrinol 13:421\u2013424","journal-title":"J Neuroendocrinol"},{"key":"47_CR3","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1469-7793.1999.00679.x","volume":"521","author":"MN Alam","year":"1999","unstructured":"Alam MN, Szymusiak R, Gong H, King J, McGinty D (1999) Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: neuronal recording with microdialysis. J Physiol 521:679\u2013690","journal-title":"J Physiol"},{"key":"47_CR4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0304-3940(02)00195-7","volume":"324","author":"CE Alvarez","year":"2002","unstructured":"Alvarez CE, Sutcliffe JG (2002) Hypocretin is an early member of the incretin gene family. Neurosci Lett 324:169\u2013172","journal-title":"Neurosci Lett"},{"key":"47_CR5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3181\/00379727-77-18766","volume":"77","author":"BK Anand","year":"1951","unstructured":"Anand BK, Brobeck JR (1951) Localization of a feeding center in the hypothalamus of the rat. Proc Soc Exp Biol Med 77:323\u2013324","journal-title":"Proc Soc Exp Biol Med"},{"key":"47_CR6","doi-asserted-by":"crossref","first-page":"R1801","DOI":"10.1152\/ajpregu.2001.281.6.R1801","volume":"281","author":"VR Antunes","year":"2001","unstructured":"Antunes VR, Brailoiu GC, Kwok EH, Scruggs P, Dun NJ (2001) Orexins\/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am J Physiol Regul Integr Comp Physiol 281:R1801\u20131807","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"47_CR7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1460-9568.2004.03093.x","volume":"19","author":"BA Baldo","year":"2004","unstructured":"Baldo BA, Gual-Bonilla L, Sijapati K, Daniel RA, Landry CF, Kelley AE (2004) Activation of a subpopulation of orexin\/hypocretin-containing hypothalamic neurons by GABAA receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment. Eur J Neurosci 19:376\u2013386","journal-title":"Eur J Neurosci"},{"key":"47_CR8","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1523\/JNEUROSCI.22-18-07835.2002","volume":"22","author":"L Bayer","year":"2002","unstructured":"Bayer L, Eggermann E, Saint-Mleux B, Machard D, Jones BE, Muhlethaler M, Serafin M (2002) Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons. J Neurosci 22:7835\u20137839","journal-title":"J Neurosci"},{"key":"47_CR9","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1046\/j.0953-816x.2001.01777.x","volume":"14","author":"L Bayer","year":"2001","unstructured":"Bayer L, Eggermann E, Serafin M, Saint-Mleux B, Machard D, Jones B, Muhlethaler M (2001) Orexins (hypocretins) directly excite tuberomammillary neurons. Eur J Neurosci 14:1571\u20131575","journal-title":"Eur J Neurosci"},{"key":"47_CR10","doi-asserted-by":"crossref","first-page":"6760","DOI":"10.1523\/JNEUROSCI.1783-04.2004","volume":"24","author":"L Bayer","year":"2004","unstructured":"Bayer L, Serafin M, Eggermann E, Saint-Mleux B, Machard D, Jones BE, Muhlethaler M (2004) Exclusive postsynaptic action of hypocretin-orexin on sublayer 6b cortical neurons. J Neurosci 24:6760\u20136764","journal-title":"J Neurosci"},{"key":"47_CR11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0149-7634(95)00015-1","volume":"20","author":"LL Bernardis","year":"1996","unstructured":"Bernardis LL, Bellinger LL (1996) The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev 20:189\u2013287","journal-title":"Neurosci Biobehav Rev"},{"key":"47_CR12","first-page":"551","volume":"9","author":"MJ Bingham","year":"2006","unstructured":"Bingham MJ, Cai J, Deehan MR (2006) Eating, sleeping and rewarding: orexin receptors and their antagonists. Curr Opin Drug Discov Devel 9:551\u2013559","journal-title":"Curr Opin Drug Discov Devel"},{"key":"47_CR13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3959(00)00470-X","volume":"92","author":"S Bingham","year":"2001","unstructured":"Bingham S, Davey PT, Babbs AJ, Irving EA, Sammons MJ, Wyles M, Jeffrey P, Cutler L, Riba I, Johns A et al. (2001) Orexin-A, an hypothalamic peptide with analgesic properties. Pain 92:81\u201390","journal-title":"Pain"},{"key":"47_CR14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.neuroscience.2006.07.018","volume":"142","author":"A Bisetti","year":"2006","unstructured":"Bisetti A, Cvetkovic V, Serafin M, Bayer L, Machard D, Jones BE, Muhlethaler M (2006) Excitatory action of hypocretin\/orexin on neurons of the central medial amygdala. Neuroscience 142:999\u20131004","journal-title":"Neuroscience"},{"key":"47_CR15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neuron.2006.01.016","volume":"49","author":"SL Borgland","year":"2006","unstructured":"Borgland SL, Taha SA, Sarti F, Fields HL, Bonci A (2006) Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49:589\u2013601","journal-title":"Neuron"},{"key":"47_CR16","doi-asserted-by":"crossref","first-page":"19168","DOI":"10.1073\/pnas.0507480102","volume":"102","author":"B Boutrel","year":"2005","unstructured":"Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L (2005) Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci USA 102:19168\u201319173","journal-title":"Proc Natl Acad Sci USA"},{"key":"47_CR17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nm1544","volume":"13","author":"C Brisbare-Roch","year":"2007","unstructured":"Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, Mueller C, Nayler O, van Gerven J, de Haas SL et al. (2007) Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med 13:150\u2013155","journal-title":"Nat Med"},{"key":"47_CR18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0028-3908(00)00178-7","volume":"40","author":"RE Brown","year":"2001","unstructured":"Brown RE, Sergeeva O, Eriksson KS, Haas HL (2001) Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology 40:457\u2013459","journal-title":"Neuropharmacology"},{"key":"47_CR19","first-page":"8850","volume":"22","author":"RE Brown","year":"2002","unstructured":"Brown RE, Sergeeva OA, Eriksson KS, Haas HL (2002) Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin\/hypocretin, histamine and noradrenaline) J Neurosci 22:8850\u20138859","journal-title":"Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin\/hypocretin, histamine and noradrenaline) J Neurosci"},{"key":"47_CR20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1365-2826.2003.01045.x","volume":"15","author":"PJ Brunton","year":"2003","unstructured":"Brunton PJ, Russell JA (2003) Hypothalamic-pituitary-adrenal responses to centrally administered orexin-A are suppressed in pregnant rats. J Neuroendocrinol 15:633\u2013637","journal-title":"J Neuroendocrinol"},{"key":"47_CR21","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1523\/JNEUROSCI.4925-04.2005","volume":"25","author":"D Burdakov","year":"2005","unstructured":"Burdakov D, Gerasimenko O, Verkhratsky A (2005) Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci 25:2429\u20132433","journal-title":"J Neurosci"},{"key":"47_CR22","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.neuron.2006.04.032","volume":"50","author":"D Burdakov","year":"2006","unstructured":"Burdakov D, Jensen LT, Alexopoulos H, Williams RH, Fearon IM, O'Kelly I, Gerasimenko O, Fugger L, Verkhratsky A (2006) Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron 50:711\u2013722","journal-title":"Neuron"},{"key":"47_CR23","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1523\/JNEUROSCI.23-12-04951.2003","volume":"23","author":"D Burdakov","year":"2003","unstructured":"Burdakov D, Liss B, Ashcroft FM (2003) Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium\u2013calcium exchanger. J Neurosci 23:4951\u20134957","journal-title":"J Neurosci"},{"key":"47_CR24","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1523\/JNEUROSCI.22-07-02862.2002","volume":"22","author":"S Burlet","year":"2002","unstructured":"Burlet S, Tyler CJ, Leonard CS (2002) Direct and indirect excitation of laterodorsal tegmental neurons by hypocretin\/orexin peptides: Implication for wakefulness and Narcolepsy. J Neurosci 22:2862\u20132872","journal-title":"J Neurosci"},{"key":"47_CR25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0166-4328(97)83335-9","volume":"84","author":"E Challet","year":"1997","unstructured":"Challet E, Pevet P, Malan A (1997) Effect of prolonged fasting and subsequent refeeding on free-running rhythms of temperature and locomotor activity in rats. Behav Brain Res 84:275\u2013284","journal-title":"Behav Brain Res"},{"key":"47_CR26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","volume":"98","author":"RM Chemelli","year":"1999","unstructured":"Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell TE, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y et al. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437\u2013451","journal-title":"Cell"},{"key":"47_CR27","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.96.2.748","volume":"96","author":"Y Date","year":"1999","unstructured":"Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M (1999) Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA 96:748\u2013753","journal-title":"Proc Natl Acad Sci USA"},{"key":"47_CR28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(07)60237-2","volume":"369","author":"Y Dauvilliers","year":"2007","unstructured":"Dauvilliers Y, Arnulf I, Mignot E (2007) Narcolepsy with cataplexy. Lancet 369:499\u2013511","journal-title":"Lancet"},{"key":"47_CR29","doi-asserted-by":"crossref","first-page":"10372","DOI":"10.1523\/JNEUROSCI.3118-06.2006","volume":"26","author":"L Lecea de","year":"2006","unstructured":"de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M, DiLeone R (2006) Addiction and arousal: alternative roles of hypothalamic peptides. J Neurosci 26:10372\u201310375","journal-title":"J Neurosci"},{"key":"47_CR30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","volume":"95","author":"L Lecea de","year":"1998","unstructured":"de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS et al. (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95:322\u2013327","journal-title":"Proc Natl Acad Sci USA"},{"key":"47_CR31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0306-4522(01)00512-7","volume":"108","author":"E Eggermann","year":"2001","unstructured":"Eggermann E, Serafin M, Bayer L, Machard D, Saint-Mleux B, Jones BE, Muhlethaler M (2001) Orexins\/hypocretins excite basal forebrain cholinergic neurones. Neuroscience 108:177\u2013181","journal-title":"Neuroscience"},{"key":"47_CR32","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0896-6273(01)80035-0","volume":"23","author":"CF Elias","year":"1999","unstructured":"Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK (1999) Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775\u2013786","journal-title":"Neuron"},{"key":"47_CR33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/cne.20786","volume":"493","author":"JK Elmquist","year":"2005","unstructured":"Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB (2005) Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 493:63\u201371","journal-title":"J Comp Neurol"},{"key":"47_CR34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-6273(00)81084-3","volume":"22","author":"JK Elmquist","year":"1999","unstructured":"Elmquist JK, Elias CF, Saper CB (1999) From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22:221\u2013232","journal-title":"Neuron"},{"key":"47_CR35","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.yfrne.2004.09.001","volume":"25","author":"M Engelmann","year":"2004","unstructured":"Engelmann M, Landgraf R, Wotjak CT (2004) The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited. Front Neuroendocrinol 25:132\u2013149","journal-title":"Front Neuroendocrinol"},{"key":"47_CR36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0306-4522(02)00017-9","volume":"111","author":"J Fadel","year":"2002","unstructured":"Fadel J, Deutch AY (2002) Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience 111:379\u2013387","journal-title":"Neuroscience"},{"key":"47_CR37","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/35010109","volume":"404","author":"T Gallopin","year":"2000","unstructured":"Gallopin T, Fort P, Eggermann E, Cauli B, Luppi PH, Rossier J, Audinat E, Muhlethaler M, Serafin M (2000) Identification of sleep-promoting neurons in vitro. Nature 404:992\u2013995","journal-title":"Nature"},{"key":"47_CR38","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuroscience.2003.07.008","volume":"122","author":"JC Geerling","year":"2003","unstructured":"Geerling JC, Mettenleiter TC, Loewy AD (2003) Orexin neurons project to diverse sympathetic outflow systems. Neuroscience 122:541\u2013550","journal-title":"Neuroscience"},{"key":"47_CR39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/nn1651","volume":"9","author":"JJ Gooley","year":"2006","unstructured":"Gooley JJ, Schomer A, Saper CB (2006) Nat Neurosci 9:398\u2013407","journal-title":"Nat Neurosci"},{"key":"47_CR40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0304-3940(98)00976-8","volume":"262","author":"B Griffond","year":"1999","unstructured":"Griffond B, Risold PY, Jacquemard C, Colard C, Fellmann D (1999) Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area. Neurosci Lett 262:77\u201380","journal-title":"Neurosci Lett"},{"key":"47_CR41","first-page":"65","volume":"67","author":"C Guilleminault","year":"1995","unstructured":"Guilleminault C, Gelb M (1995) Clinical aspects and features of cataplexy. Adv Neurol 67:65\u201377","journal-title":"Adv Neurol"},{"key":"47_CR42","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1212\/WNL.50.2_Suppl_1.S8","volume":"50","author":"C Guilleminault","year":"1998","unstructured":"Guilleminault C, Heinzer R, Mignot E, Black J (1998) Investigations into the neurologic basis of narcolepsy. Neurology 50:S8\u201315","journal-title":"Neurology"},{"key":"47_CR43","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1073\/pnas.96.19.10911","volume":"96","author":"JJ Hagan","year":"1999","unstructured":"Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P et al. (1999) Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci USA 96:10911\u201310916","journal-title":"Proc Natl Acad Sci USA"},{"key":"47_CR44","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-2826.1999.00378.x","volume":"11","author":"M Hakansson","year":"1999","unstructured":"Hakansson M, de Lecea L, Sutcliffe JG, Yanagisawa M, Meister B (1999) Leptin receptor- and STAT3-immunoreactivities in hypocretin\/orexin neurones of the lateral hypothalamus. J Neuroendocrinol 11:653\u2013663","journal-title":"J Neuroendocrinol"},{"key":"47_CR45","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1159\/000054392","volume":"68","author":"ML Hakansson","year":"1998","unstructured":"Hakansson ML, Meiste RB (1998) Transcription factor STAT3 in leptin target neurons of the rat hypothalamus. Neuroendocrinology 68:420\u2013427","journal-title":"Neuroendocrinology"},{"key":"47_CR46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(01)00293-8","volume":"30","author":"J Hara","year":"2001","unstructured":"Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T (2001) Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30:345\u2013354","journal-title":"Neuron"},{"key":"47_CR47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neulet.2005.01.046","volume":"380","author":"J Hara","year":"2005","unstructured":"Hara J, Yanagisawa M, Sakurai T (2005) Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Neurosci Lett 380:239\u2013242","journal-title":"Neurosci Lett"},{"key":"47_CR48","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature04071","volume":"437","author":"GC Harris","year":"2005","unstructured":"Harris GC, Wimmer M, Aston-Jones G (2005) A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437:556\u2013559","journal-title":"Nature"},{"key":"47_CR49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0167-0115(01)00358-5","volume":"104","author":"AC Haynes","year":"2002","unstructured":"Haynes AC, Chapman H, Taylor C, Moore GB, Cawthorne MA, Tadayyon M, Clapham JC, Arch JR (2002) Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob\/ob mice. Regul Pept 104:153\u2013159","journal-title":"Regul Pept"},{"key":"47_CR50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0167-0115(00)00199-3","volume":"96","author":"AC Haynes","year":"2000","unstructured":"Haynes AC, Jackson B, Chapman H, Tadayyon M, Johns A, Porter RA, Arch JR (2000) A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Pept 96:45\u201351","journal-title":"Regul Pept"},{"key":"47_CR51","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0306-4522(01)00033-1","volume":"103","author":"GJ Hervieu","year":"2001","unstructured":"Hervieu GJ, Cluderay JE, Harrison DC, Roberts JC, Leslie RA (2001) Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience 103:777\u2013797","journal-title":"Neuroscience"},{"key":"47_CR52","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/sleep\/9.1.254","volume":"9","author":"Y Honda","year":"1986","unstructured":"Honda Y, Doi Y, Ninomiya R, Ninomiya C (1986) Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients. Sleep 9:254\u2013259","journal-title":"Sleep"},{"key":"47_CR53","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2005.03.003","volume":"1","author":"TL Horvath","year":"2005","unstructured":"Horvath TL, Gao XB (2005) Input organization and plasticity of hypocretin neurons: possible clues to obesity's association with insomnia. Cell Metab 1:279\u2013286","journal-title":"Cell Metab"},{"key":"47_CR54","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1096-9861(19991213)415:2<145::AID-CNE1>3.0.CO;2-2","volume":"415","author":"TL Horvath","year":"1999","unstructured":"Horvath TL, Peyron C, Diano S, Ivanov A, Aston-Jones G, Kilduff TS, van Den Pol AN (1999) Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol 415:145\u2013159","journal-title":"J Comp Neurol"},{"key":"47_CR55","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1152\/jn.00927.2005","volume":"95","author":"H Huang","year":"2006","unstructured":"Huang H, Ghosh P, van den Pol AN (2006) Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus-excited by hypocretin: a feedforward circuit that may enhance cognitive arousal. J Neurophysiol 95:1656\u20131668","journal-title":"J Neurophysiol"},{"key":"47_CR56","doi-asserted-by":"crossref","first-page":"9965","DOI":"10.1073\/pnas.181330998","volume":"98","author":"ZL Huang","year":"2001","unstructured":"Huang ZL, Qu WM, Li WD, Mochizuki T, Eguchi N, Watanabe T, Urade Y, Hayaishi O (2001) Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci USA 98:9965\u20139970","journal-title":"Proc Natl Acad Sci USA"},{"key":"47_CR57","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0091-3057(90)90175-H","volume":"35","author":"T Itoh","year":"1990","unstructured":"Itoh T, Murai S, Nagahama H, Miyate H, Abe E, Fujiwara H, Saito Y (1990) Effects of 24-hr fasting on methamphetamine- and apomorphine-induced locomotor activities, and on monoamine metabolism in mouse corpus striatum and nucleus accumbens. Pharmacol Biochem Behav 35:391\u2013396","journal-title":"Pharmacol Biochem Behav"},{"key":"47_CR58","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.270.5236.644","volume":"270","author":"AS Jansen","year":"1995","unstructured":"Jansen AS, Nguyen XV, Karpitskiy V, Mettenleiter TC, Loewy AD (1995) Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science 270:644\u2013646","journal-title":"Science"},{"key":"47_CR59","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0896-6273(04)00247-8","volume":"42","author":"J John","year":"2004","unstructured":"John J, Wu MF, Boehmer LN, Siegel JM (2004) Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior. Neuron 42:619\u2013634","journal-title":"Neuron"},{"key":"47_CR60","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2005.03.007","volume":"1044","author":"S Kajiyama","year":"2005","unstructured":"Kajiyama S, Kawamoto M, Shiraishi S, Gaus S, Matsunaga A, Suyama H, Yuge O (2005) Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathic pain model rats. Brain Res 1044:76\u201386","journal-title":"Brain Res"},{"key":"47_CR61","doi-asserted-by":"crossref","first-page":"R581","DOI":"10.1152\/ajpregu.00671.2002","volume":"285","author":"Y Kayaba","year":"2003","unstructured":"Kayaba Y, Nakamura A, Kasuya Y, Ohuchi T, Yanagisawa M, Komuro I, Fukuda Y, Kuwaki T (2003) Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol 285:R581\u2013593","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"47_CR62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1523\/JNEUROSCI.23-01-00007.2003","volume":"23","author":"TM Korotkova","year":"2003","unstructured":"Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE (2003) Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins\/hypocretins. J Neurosci 23:7\u201311","journal-title":"J Neurosci"},{"key":"47_CR63","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1097\/00001756-200006260-00034","volume":"11","author":"M Kuru","year":"2000","unstructured":"Kuru M, Ueta Y, Serino R, Nakazato M, Yamamoto Y, Shibuya I, Yamashita H (2000) Centrally administered orexin\/hypocretin activates HPA axis in rats. Neuroreport 11:1977\u20131980","journal-title":"Neuroreport"},{"key":"47_CR64","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0896-6273(03)00598-1","volume":"40","author":"EK Lambe","year":"2003","unstructured":"Lambe EK, Aghajanian GK (2003) Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice. Neuron 40:139\u2013150","journal-title":"Neuron"},{"key":"47_CR65","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/sleep\/19.1.75","volume":"19","author":"GJ Lammers","year":"1996","unstructured":"Lammers GJ, Pijl H, Iestra J, Langius JA, Buunk G, Meinders AE (1996) Spontaneous food choice in narcolepsy. Sleep 19:75\u201376","journal-title":"Sleep"},{"key":"47_CR66","doi-asserted-by":"crossref","first-page":"R1527","DOI":"10.1152\/ajpregu.00874.2005","volume":"290","author":"GJ Landry","year":"2006","unstructured":"Landry GJ, Simon MM, Webb IC, Mistlberger RE (2006) Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats. Am J Physiol Regul Integr Comp Physiol 290:R1527\u20131534","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"47_CR67","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1523\/JNEUROSCI.1887-05.2005","volume":"25","author":"MG Lee","year":"2005","unstructured":"Lee MG, Hassani OK, Jones BE (2005) Discharge of identified orexin\/hypocretin neurons across the sleep-waking cycle. J Neurosci 25:6716\u20136720","journal-title":"J Neurosci"},{"key":"47_CR68","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0896-6273(02)01132-7","volume":"36","author":"Y Li","year":"2002","unstructured":"Li Y, Gao XB, Sakurai T, van den Pol AN (2002) Hypocretin\/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36:1169\u20131181","journal-title":"Neuron"},{"key":"47_CR69","doi-asserted-by":"crossref","first-page":"13037","DOI":"10.1523\/JNEUROSCI.3380-06.2006","volume":"26","author":"Y Li","year":"2006","unstructured":"Li Y, van den Pol AN (2006) Differential target-dependent actions of coexpressed inhibitory dynorphin and excitatory hypocretin\/orexin neuropeptides. J Neurosci 26:13037\u201313047","journal-title":"J Neurosci"},{"key":"47_CR70","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1523\/JNEUROSCI.22-21-09453.2002","volume":"22","author":"RJ Liu","year":"2002","unstructured":"Liu RJ, van den Pol AN, Aghajanian GK (2002) Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J Neurosci 22:9453\u20139464","journal-title":"J Neurosci"},{"key":"47_CR71","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1523\/JNEUROSCI.22-11-04568.2002","volume":"22","author":"J Lu","year":"2002","unstructured":"Lu J, Bjorkum AA, Xu M, Gaus SE, Shiromani PJ, Saper CB (2002) Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep. J Neurosci 22:4568\u20134576","journal-title":"J Neurosci"},{"key":"47_CR72","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/bbrc.1998.9750","volume":"253","author":"M Lubkin","year":"1998","unstructured":"Lubkin M, Stricker-Krongrad A (1998) Independent feeding and metabolic actions of orexins in mice. Biochem Biophys Res Commun 253:241\u2013245","journal-title":"Biochem Biophys Res Commun"},{"key":"47_CR73","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1523\/JNEUROSCI.3583-06.2007","volume":"27","author":"X Ma","year":"2007","unstructured":"Ma X, Zubcevic L, Bruning JC, Ashcroft FM, Burdakov D (2007) Electrical inhibition of identified anorexigenic POMC neurons by orexin\/hypocretin. J Neurosci 27:1529\u20131533","journal-title":"J Neurosci"},{"key":"47_CR74","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","volume":"435","author":"JN Marcus","year":"2001","unstructured":"Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435:6\u201325","journal-title":"J Comp Neurol"},{"key":"47_CR75","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1073\/pnas.0604189103","volume":"103","author":"M Mieda","year":"2006","unstructured":"Mieda M, Williams SC, Richardson JA, Tanaka K, Yanagisawa M (2006) The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker. Proc Natl Acad Sci USA 103:12150\u201312155","journal-title":"Proc Natl Acad Sci USA"},{"key":"47_CR76","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1523\/JNEUROSCI.3171-04.2004","volume":"24","author":"M Mieda","year":"2004","unstructured":"Mieda M, Williams SC, Sinton CM, Richardson JA, Sakurai T, Yanagisawa M (2004) Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J Neurosci 24:10493\u201310501","journal-title":"J Neurosci"},{"key":"47_CR77","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1073\/pnas.0400590101","volume":"101","author":"M Mieda","year":"2004","unstructured":"Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M (2004) Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci USA 101:4649\u20134654","journal-title":"Proc Natl Acad Sci USA"},{"key":"47_CR78","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/sleep\/28.6.754","volume":"28","author":"E Mignot","year":"2005","unstructured":"Mignot E, Nishino S (2005) Emerging therapies in narcolepsy-cataplexy. Sleep 28:754\u2013763","journal-title":"Sleep"},{"key":"47_CR79","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuron.2005.04.035","volume":"46","author":"BY Mileykovskiy","year":"2005","unstructured":"Mileykovskiy BY, Kiyashchenko LI, Siegel JM (2005) Behavioral correlates of activity in identified hypocretin\/orexin neurons. Neuron 46:787\u2013798","journal-title":"Neuron"},{"key":"47_CR80","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/cne.20719","volume":"493","author":"S Mitsuyoshi","year":"2005","unstructured":"Mitsuyoshi S (2005) Role of Barrington's nucleus in micturition. J Comp Neurol 493:21\u201326","journal-title":"J Comp Neurol"},{"key":"47_CR81","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.peptides.2005.01.001","volume":"26","author":"JI Mobarakeh","year":"2005","unstructured":"Mobarakeh JI, Takahashi K, Sakurada S, Nishino S, Watanabe H, Kato M, Yanai K (2005) Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice. Peptides 26:767\u2013777","journal-title":"Peptides"},{"key":"47_CR82","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/j.1460-9568.2005.04309.x","volume":"22","author":"M Monda","year":"2005","unstructured":"Monda M, Viggiano AN, Viggiano A, Viggiano E, Lanza A, De Luca V (2005) Hyperthermic reactions induced by orexin A: role of the ventromedial hypothalamus. Eur J Neurosci 22:1169\u20131175","journal-title":"Eur J Neurosci"},{"key":"47_CR83","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3940(99)00177-9","volume":"264","author":"T Moriguchi","year":"1999","unstructured":"Moriguchi T, Sakurai T, Nambu T, Yanagisawa M, Goto K (1999) Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia. Neurosci Lett 264:101\u2013104","journal-title":"Neurosci Lett"},{"key":"47_CR84","doi-asserted-by":"crossref","first-page":"16985","DOI":"10.1074\/jbc.M107962200","volume":"277","author":"T Moriguchi","year":"2002","unstructured":"Moriguchi T, Sakurai T, Takahashi S, Goto K, Yamamoto M (2002) The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus. J Biol Chem 277:16985\u201316992","journal-title":"J Biol Chem"},{"key":"47_CR85","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00001756-200001170-00021","volume":"11","author":"MA Mullett","year":"2000","unstructured":"Mullett MA, Billington CJ, Levine AS, Kotz CM (2000) Hypocretin I in the lateral hypothalamus activates key feeding-regulatory brain sites. Neuroreport 11:103\u2013108","journal-title":"Neuroreport"},{"key":"47_CR86","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1523\/JNEUROSCI.1027-04.2004","volume":"24","author":"Y Muraki","year":"2004","unstructured":"Muraki Y, Yamanaka A, Tsujino N, Kilduff TS, Goto K, Sakurai T (2004) Serotonergic regulation of the orexin\/hypocretin neurons through the 5-HT1A receptor. J Neurosci 24:7159\u20137166","journal-title":"J Neurosci"},{"key":"47_CR87","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/j.1460-9568.2004.03255.x","volume":"19","author":"S Muroya","year":"2004","unstructured":"Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M et al. (2004) Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci 19:1524\u20131534","journal-title":"Eur J Neurosci"},{"key":"47_CR88","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(00)02555-5","volume":"873","author":"T Nakamura","year":"2000","unstructured":"Nakamura T, Uramura K, Nambu T, Yada T, Goto K, Yanagisawa M, Sakurai T (2000) Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res 873:181\u2013187","journal-title":"Brain Res"},{"key":"47_CR89","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01336-0","volume":"827","author":"T Nambu","year":"1999","unstructured":"Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, Goto K (1999) Distribution of orexin neurons in the adult rat brain. Brain Res 827:243\u2013260","journal-title":"Brain Res"},{"key":"47_CR90","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1523\/JNEUROSCI.2761-05.2006","volume":"26","author":"M Narita","year":"2006","unstructured":"Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T (2006) Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 26:398\u2013405","journal-title":"J Neurosci"},{"key":"47_CR91","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","volume":"18","author":"C Peyron","year":"1998","unstructured":"Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996\u201310015","journal-title":"J Neurosci"},{"key":"47_CR92","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.regpep.2003.12.014","volume":"118","author":"F Sakamoto","year":"2004","unstructured":"Sakamoto F, Yamada S, Ueta Y (2004) Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons. Regul Pept 118:183\u2013191","journal-title":"Regul Pept"},{"key":"47_CR93","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.regpep.2004.08.006","volume":"126","author":"T Sakurai","year":"2005","unstructured":"Sakurai T (2005) Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology. Regul Pept 126:3\u201310","journal-title":"Regul Pept"},{"key":"47_CR94","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrn2092","volume":"8","author":"T Sakurai","year":"2007","unstructured":"Sakurai T (2007) The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 8:171\u2013181","journal-title":"Nat Rev Neurosci"},{"key":"47_CR95","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","volume":"92","author":"T Sakurai","year":"1998","unstructured":"Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573\u2013585","journal-title":"Cell"},{"key":"47_CR96","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.274.25.17771","volume":"274","author":"T Sakurai","year":"1999","unstructured":"Sakurai T, Moriguchi T, Furuya K, Kajiwara N, Nakamura T, Yanagisawa M, Goto K (1999) Structure and function of human prepro-orexin gene. J Biol Chem 274:17771\u201317776","journal-title":"J Biol Chem"},{"key":"47_CR97","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuron.2005.03.010","volume":"46","author":"T Sakurai","year":"2005","unstructured":"Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K et al. (2005) Input of Orexin\/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice. Neuron 46:297\u2013308","journal-title":"Neuron"},{"key":"47_CR98","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nature04284","volume":"437","author":"CB Saper","year":"2005","unstructured":"Saper CB, Scammell TE, Lu J (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257\u20131263","journal-title":"Nature"},{"key":"47_CR99","doi-asserted-by":"crossref","unstructured":"Schuld A, Hebebrand J, Geller F, Pollmacher T (2000) Increased body-mass index in patients with narcolepsy. Lancet, pp 1274\u20131275","DOI":"10.1016\/S0140-6736(05)74704-8"},{"key":"47_CR100","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neuroscience.2004.05.012","volume":"127","author":"O Selbach","year":"2004","unstructured":"Selbach O, Doreulee N, Bohla C, Eriksson KS, Sergeeva OA, Poelchen W, Brown RE, Haas HL (2004) Orexins\/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling. Neuroscience 127:519\u2013528","journal-title":"Neuroscience"},{"key":"47_CR101","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1523\/JNEUROSCI.18-12-04705.1998","volume":"18","author":"JE Sherin","year":"1998","unstructured":"Sherin JE, Elmquist JK, Torrealba F, Saper CB (1998) Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J Neurosci 18:4705\u20134721","journal-title":"J Neurosci"},{"key":"47_CR102","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0196-9781(99)00120-5","volume":"20","author":"M Shibahara","year":"1999","unstructured":"Shibahara M, Sakurai T, Nambu T, Takenouchi T, Iwaasa H, Egashira SI, Ihara M, Goto K (1999) Structure, tissue distribution, and pharmacological characterization of Xenopus orexins. Peptides 20:1169\u20131176","journal-title":"Peptides"},{"key":"47_CR103","first-page":"R1780","volume":"277","author":"T Shirasaka","year":"1999","unstructured":"Shirasaka T, Nakazato M, Matsukura S, Takasaki M, Kannan H (1999) Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol 277:R1780\u2013R1785","journal-title":"Am J Physiol"},{"key":"47_CR104","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/ncpneuro0300","volume":"2","author":"JM Siegel","year":"2006","unstructured":"Siegel JM, Boehmer LN (2006) Narcolepsy and the hypocretin system \u2013 where motion meets emotion. Nat Clin Pract Neurol 2:548\u2013556","journal-title":"Nat Clin Pract Neurol"},{"key":"47_CR105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1440-1819.2002.00967.x","volume":"56","author":"K Takahashi","year":"2002","unstructured":"Takahashi K, Koyama Y, Kayama Y, Yamamoto M (2002) Effects of orexin on the laterodorsal tegmental neurones. Psychiat Clin Neurosci 56:335\u2013336","journal-title":"Psychiat Clin Neurosci"},{"issue":"Pt 3","key":"47_CR106","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1113\/jphysiol.2005.085829","volume":"568","author":"K Takakusaki","year":"2005","unstructured":"Takakusaki K, Takahashi K, Saitoh K, Harada H, Okumura T, Kayama Y, Koyama Y (2005) Orexinergic projections to the midbrain mediate alternation of emotional behavioral states from locomotion to cataplexy. J Physiol 568(Pt 3):1003\u20131020","journal-title":"J Physiol"},{"key":"47_CR107","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2005.05.045","volume":"1050","author":"AJ Thorpe","year":"2005","unstructured":"Thorpe AJ, Kotz CM (2005) Orexin A in the nucleus accumbens stimulates feeding and locomotor activity. Brain Res 1050:156\u2013162","journal-title":"Brain Res"},{"key":"47_CR108","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1523\/JNEUROSCI.19-08-03171.1999","volume":"19","author":"AN Pol van den","year":"1999","unstructured":"van den Pol AN (1999) Hypothalamic hypocretin (orexin): robust innervation of the spinal cord. J Neurosci 19:3171\u20133182","journal-title":"J Neurosci"},{"key":"47_CR109","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0896-6273(04)00251-X","volume":"42","author":"AN Pol van den","year":"2004","unstructured":"van den Pol AN, Acuna-Goycolea C, Clark KR, Ghosh PK (2004) Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 42:635\u2013652","journal-title":"Neuron"},{"key":"47_CR110","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1523\/JNEUROSCI.18-19-07962.1998","volume":"18","author":"AN Pol van den","year":"1998","unstructured":"van den Pol AN, Gao XB, Obrietan K, Kilduff TS, Belousov AB (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin\/orexin. J Neurosci 18:7962\u20137971","journal-title":"J Neurosci"},{"key":"47_CR111","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1113\/jphysiol.2002.017426","volume":"541","author":"AN Pol van den","year":"2002","unstructured":"van den Pol AN, Ghosh PK, Liu RJ, Li Y, Aghajanian GK, Gao XB (2002) Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. J Physiol 541:169\u2013185","journal-title":"J Physiol"},{"key":"47_CR112","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nn1226","volume":"7","author":"M Top van den","year":"2004","unstructured":"van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D (2004) Orexigen-sensitive NPY\/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 7:493\u2013494","journal-title":"Nat Neurosci"},{"key":"47_CR113","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1113\/jphysiol.2002.033290","volume":"549","author":"M Top van den","year":"2003","unstructured":"van den Top M, Nolan MF, Lee K, Richardson PJ, Buijs RM, Davies CH, Spanswick D (2003) Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones. J Physiol 549:809\u2013821","journal-title":"J Physiol"},{"key":"47_CR114","first-page":"195","volume":"298","author":"G Vanni-Mercier","year":"1984","unstructured":"Vanni-Mercier G, Sakai K, Jouvet M (1984) Neurons specifiques de l'eveil dans l'hypothalamus posterieur du chat. CR Acad Sci III 298:195\u2013200","journal-title":"CR Acad Sci III"},{"key":"47_CR115","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0896-6273(03)00330-1","volume":"38","author":"JT Willie","year":"2003","unstructured":"Willie JT, Chemelli RM, Sinton CM, Tokita S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA et al. (2003) Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 38:715\u2013730","journal-title":"Neuron"},{"key":"47_CR116","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.neuro.24.1.429","volume":"24","author":"JT Willie","year":"2001","unstructured":"Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001) To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci 24:429\u2013458","journal-title":"Annu Rev Neurosci"},{"key":"47_CR117","doi-asserted-by":"crossref","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","volume":"24","author":"R Winsky-Sommerer","year":"2004","unstructured":"Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L (2004) Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci 24:11439\u201311448","journal-title":"J Neurosci"},{"key":"47_CR118","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1523\/JNEUROSCI.5364-03.2004","volume":"24","author":"M Wu","year":"2004","unstructured":"Wu M, Zaborszky L, Hajszan T, van den Pol AN, Alreja M (2004) Hypocretin\/orexin innervation and excitation of identified septohippocampal cholinergic neurons. J Neurosci 24:3527\u20133536","journal-title":"J Neurosci"},{"key":"47_CR119","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1523\/JNEUROSCI.22-17-07754.2002","volume":"22","author":"M Wu","year":"2002","unstructured":"Wu M, Zhang Z, Leranth C, Xu C, van den Pol AN, Alreja M (2002) Hypocretin increases impulse flow in the septohippocampal GABAergic pathway: implications for arousal via a mechanism of hippocampal disinhibition. J Neurosci 22:7754\u20137765","journal-title":"J Neurosci"},{"key":"47_CR120","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-8993(01)02317-4","volume":"901","author":"M Xi","year":"2001","unstructured":"Xi M, Morales FR, Chase MH (2001) Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat. Brain Res 901:259\u2013264","journal-title":"Brain Res"},{"key":"47_CR121","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1113\/jphysiol.2006.108266","volume":"574","author":"X Xie","year":"2006","unstructured":"Xie X, Crowder TL, Yamanaka A, Morairty SR, Lewinter RD, Sakurai T, Kilduff TS (2006) GABA(B) receptor-mediated modulation of hypocretin\/orexin neurones in mouse hypothalamus. J Physiol 574:399\u2013414","journal-title":"J Physiol"},{"key":"47_CR122","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1999.1998","volume":"267","author":"H Yamada","year":"2000","unstructured":"Yamada H, Okumura T, Motomura W, Kobayashi Y, Kohgo Y (2000) Inhibition of food intake by central injection of anti-orexin antibody in fasted rats. Biochem Biophys Res Commun 267:527\u2013531","journal-title":"Biochem Biophys Res Commun"},{"key":"47_CR123","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/sj.bjp.0704851","volume":"137","author":"T Yamamoto","year":"2002","unstructured":"Yamamoto T, Nozaki-Taguchi N, Chiba T (2002) Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test. Br J Pharmacol 137:170\u2013176","journal-title":"Br J Pharmacol"},{"key":"47_CR124","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0896-6273(03)00331-3","volume":"38","author":"A Yamanaka","year":"2003","unstructured":"Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K et al. (2003a) Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38:701\u2013713","journal-title":"Neuron"},{"key":"47_CR125","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0006-8993(00)02043-6","volume":"24","author":"A Yamanaka","year":"2000","unstructured":"Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, Sakurai T (2000) Orexin-induced food intake involves neuropeptide Y pathway. Brain Res 24:404\u2013409","journal-title":"Brain Res"},{"key":"47_CR126","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1152\/jn.01361.2005","volume":"96","author":"A Yamanaka","year":"2006","unstructured":"Yamanaka A, Muraki Y, Ichiki K, Tsujino N, Kilduff TS, Goto K, Sakurai T (2006) Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner. J Neurophysiol 96:284\u2013298","journal-title":"J Neurophysiol"},{"key":"47_CR127","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-291X(03)00299-7","volume":"303","author":"A Yamanaka","year":"2003","unstructured":"Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T (2003b) Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun 303:120\u2013129","journal-title":"Biochem Biophys Res Commun"},{"key":"47_CR128","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1006\/bbrc.2001.6318","volume":"290","author":"A Yamanaka","year":"2002","unstructured":"Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T (2002) Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun 290:1237\u20131245","journal-title":"Biochem Biophys Res Commun"},{"key":"47_CR129","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0091-3057(97)00022-1","volume":"58","author":"ZJ Yang","year":"1997","unstructured":"Yang ZJ, Meguid MM, Chai JK, Chen C, Oler A (1997) Bilateral hypothalamic dopamine infusion in male Zucker rat suppresses feeding due to reduced meal size. Pharmacol Biochem Behav 58:631\u2013635","journal-title":"Pharmacol Biochem Behav"},{"key":"47_CR130","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/cne.20859","volume":"494","author":"K Yoshida","year":"2006","unstructured":"Yoshida K, McCormack S, Espana RA, Crocker A, Scammell TE (2006) Afferents to the orexin neurons of the rat brain. J Comp Neurol 494:845\u2013861","journal-title":"J Comp Neurol"},{"key":"47_CR131","doi-asserted-by":"crossref","first-page":"R1654","DOI":"10.1152\/ajpregu.00704.2005","volume":"290","author":"W Zhang","year":"2006","unstructured":"Zhang W, Sakurai T, Fukuda Y, Kuwaki T (2006) Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice. Am J Physiol Regul Integr Comp Physiol 290:R1654\u20131663","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"47_CR132","doi-asserted-by":"crossref","first-page":"R1773","DOI":"10.1152\/ajpregu.00019.2002","volume":"282","author":"H Zheng","year":"2002","unstructured":"Zheng H, Corkern MM, Crousillac SM, Patterson LM, Phifer CB, Berthoud HR (2002) Neurochemical phenotype of hypothalamic neurons showing Fos expression 23\u2009h after intracranial AgRP. Am J Physiol Regul Integr Comp Physiol 282:R1773\u20131781","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"47_CR133","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1254\/jphs.92.259","volume":"92","author":"Y Zhu","year":"2003","unstructured":"Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K (2003) Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J Pharmacol Sci 92:259\u2013266","journal-title":"J Pharmacol Sci"}],"container-title":["Results and Problems in Cell Differentiation","Orphan G Protein-Coupled Receptors and Novel Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/400_2007_047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T01:36:21Z","timestamp":1619573781000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/400_2007_047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[null]]},"ISBN":["9783540783503","9783540783510"],"references-count":133,"URL":"https:\/\/doi.org\/10.1007\/400_2007_047","relation":{},"subject":[]}}