{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:28:10Z","timestamp":1790670490548,"version":"4.1.0"},"publisher-location":"Cham","reference-count":41,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319306582","type":"print"},{"value":"9783319306599","type":"electronic"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/5584_2015_206","type":"book-chapter","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T03:30:51Z","timestamp":1453951851000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Asthma and COPD: Similarities and Differences in the Pathophysiology, Diagnosis and Therapy"],"prefix":"10.1007","author":[{"given":"Josef","family":"Yayan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Rasche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,29]]},"reference":[{"key":"206_CR1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.4104\/pcrj.2011.00103","volume":"21","author":"MJ Abramson","year":"2012","unstructured":"Abramson MJ, Schattner RL, Sulaiman ND, Del Colle EA, Aroni R, Thien F (2012) Accuracy of asthma and COPD diagnosis in Australian general practice: a mixed methods study. Prim Care Respir J 21:167\u2013173","journal-title":"Prim Care Respir J"},{"key":"206_CR2","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/crj.12013","volume":"7","author":"H Anders\u00e9n","year":"2013","unstructured":"Anders\u00e9n H, Lampela P, Nevanlinna A, S\u00e4yn\u00e4j\u00e4kangas O, Keistinen T (2013) High hospital burden in overlap syndrome of asthma and COPD. Clin Respir J 7:342\u2013346","journal-title":"Clin Respir J"},{"key":"206_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1385\/CRIAI:27:1:035","volume":"27","author":"K Aoshiba","year":"2004","unstructured":"Aoshiba K, Nagai A (2004) Differences in airway remodeling between asthma and chronic obstructive pulmonary disease. Clin Rev Allergy Immunol 27:35\u201343","journal-title":"Clin Rev Allergy Immunol"},{"key":"206_CR4","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.6061\/clinics\/2012(11)19","volume":"67","author":"R Athanazio","year":"2012","unstructured":"Athanazio R (2012) Airway disease: similarities and differences between asthma, COPD and bronchiectasis. Clinics (Sao Paulo) 67:1335\u20131343","journal-title":"Clinics (Sao Paulo)"},{"key":"206_CR5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.aller.2011.07.004","volume":"41","author":"\u00d6 Aydin","year":"2013","unstructured":"Aydin \u00d6, Celik GE, \u00d6nen ZP, Yilmaz \u0130, \u00d6zdemir SK, Yildiz \u00d6, Mungan D, Demirel YS (2013) Triggers of asthma and COPD: are they different? Allergol Immunopathol (Madr) 41:30\u201336","journal-title":"Allergol Immunopathol (Madr)"},{"key":"206_CR6","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.rmed.2004.01.004","volume":"98","author":"KM Beeh","year":"2004","unstructured":"Beeh KM, Kornmann O, Beier J, Ksoll M, Buhl R (2004) Clinical application of a simple questionnaire for the differentiation of asthma and chronic obstructive pulmonary disease. Respir Med 98:591\u2013597","journal-title":"Respir Med"},{"key":"206_CR7","doi-asserted-by":"publisher","first-page":"93S","DOI":"10.1378\/chest.126.2_suppl_1.93S","volume":"126","author":"ER Bleecker","year":"2004","unstructured":"Bleecker ER (2004) Similarities and differences in asthma and COPD. The Dutch hypothesis. Chest 126:93S\u201395S","journal-title":"Chest"},{"key":"206_CR8","first-page":"339","volume":"6","author":"D Bumbacea","year":"2011","unstructured":"Bumbacea D, Bogdan MA (2011) Update in pneumology \u2013 focus on asthma and COPD. Maedica (Buchar) 6:339\u2013340","journal-title":"Maedica (Buchar)"},{"key":"206_CR9","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jaci.2013.01.010","volume":"131","author":"BJ Carolan","year":"2013","unstructured":"Carolan BJ, Sutherland ER (2013) Clinical phenotypes of chronic obstructive pulmonary disease and asthma: recent advances. J Allergy Clin Immunol 131:627\u2013634","journal-title":"J Allergy Clin Immunol"},{"key":"206_CR10","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1177\/0885066607304445","volume":"22","author":"J Chang","year":"2007","unstructured":"Chang J, Mosenifar Z (2007) Differentiating COPD from asthma in clinical practice. J Intensive Care Med 22:300\u2013309","journal-title":"J Intensive Care Med"},{"key":"206_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.5455\/msm.2012.24.100-105","volume":"24","author":"V Cukic","year":"2012","unstructured":"Cukic V, Lovre V, Dragisic D, Ustamujic A (2012) Asthma and chronic obstructive pulmonary disease (COPD) \u2013 differences and similarities. Mater Sociomed 24:100\u2013105","journal-title":"Mater Sociomed"},{"key":"206_CR12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1368-5031.2005.00509.x","volume":"59","author":"M Decramer","year":"2005","unstructured":"Decramer M, Selroos O (2005) Asthma and COPD: differences and similarities. With special reference to the usefulness of budesonide\/formoterol in a single inhaler (Symbicort) in both diseases. Int J Clin Pract 59:385\u2013398","journal-title":"Int J Clin Pract"},{"key":"206_CR13","doi-asserted-by":"crossref","unstructured":"G\u00f3rska K, Krenke R, Kosciuch J, Korczynski P, Zukowska M, Domagala-Kulawik J, Maskey-Warzechowska M, Chazan R (2009) Relationship between airway inflammation and remodeling in patients with asthma and chronic obstructive pulmonary disease. Eur J Med Res 14(Suppl 4):90\u201396","DOI":"10.1186\/2047-783X-14-S4-90"},{"key":"206_CR14","first-page":"7","volume":"11","author":"S Guerra","year":"2005","unstructured":"Guerra S (2005) Overlap of asthma and chronic obstructive pulmonary disease. Curr Opin Pulm Med 11:7\u201313","journal-title":"Curr Opin Pulm Med"},{"key":"206_CR15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.2332\/allergolint.09-RAI-0117","volume":"58","author":"T Hoshino","year":"2009","unstructured":"Hoshino T, Toda R, Aizawa H (2009) Pharmacological treatment in asthma and COPD. Allergol Int 58:341\u2013346","journal-title":"Allergol Int"},{"key":"206_CR16","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.5694\/j.1326-5377.2005.tb06916.x","volume":"183","author":"CR Jenkins","year":"2005","unstructured":"Jenkins CR, Thompson PJ, Gibson PG, Wood-Baker R (2005) Distinguishing asthma and chronic obstructive pulmonary disease: why, why not and how? Med J Aust 183:S35\u2013S37","journal-title":"Med J Aust"},{"key":"206_CR17","first-page":"65","volume":"8","author":"Y Kaneko","year":"2013","unstructured":"Kaneko Y, Yatagai Y, Yamada H, Iijima H, Masuko H, Sakamoto T, Hizawa N (2013) The search for common pathways underlying asthma and COPD. Int J Chron Obstruct Pulmon Dis 8:65\u201378","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"206_CR18","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1055\/s-2006-932127","volume":"60","author":"P Kardos","year":"2006","unstructured":"Kardos P, Brutsche M, Buhl R, Gillissen A, Rabe KF, Russi EW, Sauer R, Worth H, Menz G (2006) Combination of asthma and COPD: more frequent as considered to be? Pneumologie 60:366\u2013372","journal-title":"Pneumologie"},{"key":"206_CR19","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1745-7599.2008.00332.x","volume":"20","author":"KK Kuebler","year":"2008","unstructured":"Kuebler KK, Buchsel PC, Balkstra CR (2008) Differentiating chronic obstructive pulmonary disease from asthma. J Am Acad Nurse Pract 20:445\u2013454","journal-title":"J Am Acad Nurse Pract"},{"key":"206_CR20","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2165\/00019053-200523040-00006","volume":"23","author":"CG L\u00f6fdahl","year":"2005","unstructured":"L\u00f6fdahl CG, Ericsson A, Svensson K, Andreasson E (2005) Cost effectiveness of budesonide\/formoterol in a single inhaler for COPD compared with each monocomponent used alone. Pharmacoeconomics 23:365\u2013375","journal-title":"Pharmacoeconomics"},{"key":"206_CR21","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2174\/138161207779313777","volume":"13","author":"P Mallia","year":"2007","unstructured":"Mallia P, Contoli M, Caramori G, Pandit A, Johnston SL, Papi A (2007) Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): focus on virus induced exacerbations. Curr Pharm Des 13:73\u201397","journal-title":"Curr Pharm Des"},{"key":"206_CR22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3810\/pgm.2005.03.1593","volume":"117","author":"FJ Martinez","year":"2005","unstructured":"Martinez FJ, Standiford C, Gay SE (2005) Is it asthma or COPD? The answer determines proper therapy for chronic airflow obstruction. Postgrad Med 117:19\u201326","journal-title":"Postgrad Med"},{"key":"206_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1874306401206010001","volume":"6","author":"N Miglino","year":"2012","unstructured":"Miglino N, Roth M, Tamm M, Borger P (2012) Asthma and COPD \u2013 The C\/EBP connection. Open Respir Med J 6:1\u201313","journal-title":"Open Respir Med J"},{"key":"206_CR24","doi-asserted-by":"publisher","first-page":"e68","DOI":"10.3399\/bjgp12X625111","volume":"62","author":"M Miravitlles","year":"2012","unstructured":"Miravitlles M, Andreu I, Romero Y, Sitjar S, Alt\u00e9s A, Anton E (2012) Difficulties in differential diagnosis of COPD and asthma in primary care. Br J Gen Pract 62:e68\u2013e75","journal-title":"Br J Gen Pract"},{"key":"206_CR25","doi-asserted-by":"publisher","first-page":"333","DOI":"10.2332\/allergolint.09-RAI-0131","volume":"58","author":"M Mishima","year":"2009","unstructured":"Mishima M (2009) Physiological differences and similarities in asthma and COPD \u2013 based on respiratory function testing. Allergol Int 58:333\u2013340","journal-title":"Allergol Int"},{"key":"206_CR26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.pupt.2006.10.006","volume":"21","author":"AH Morice","year":"2008","unstructured":"Morice AH, Hochmuth L, Ekelund J, Thor\u00e9n A, Puterman AS (2008) Comparable long-term safety and efficacy of a novel budesonide\/formoterol pressurized metered-dose inhaler versus budesonide\/formoterol turbuhaler in adolescents and adults with asthma. Pulm Pharmacol Ther 21:32\u201339","journal-title":"Pulm Pharmacol Ther"},{"key":"206_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3810\/pgm.2009.05.2009","volume":"121","author":"Z Mosenifar","year":"2009","unstructured":"Mosenifar Z (2009) Differentiating COPD from asthma in clinical practice. Postgrad Med 121:105\u2013112","journal-title":"Postgrad Med"},{"key":"206_CR28","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3122\/jabfm.2013.04.120256","volume":"26","author":"MO Nakawah","year":"2013","unstructured":"Nakawah MO, Hawkins C, Barbandi F (2013) Asthma, chronic obstructive pulmonary disease (COPD), and the overlap syndrome. J Am Board Fam Med 26:470\u2013477","journal-title":"J Am Board Fam Med"},{"key":"206_CR29","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2332\/allergolint.10-RA-0184","volume":"59","author":"T Oga","year":"2010","unstructured":"Oga T, Tsukino M, Hajiro T, Ikeda A, Koyama H, Mishima M, Chin K, Nishimura K (2010) Multidimensional analyses of long-term clinical courses of asthma and chronic obstructive pulmonary disease. Allergol Int 59:257\u2013265","journal-title":"Allergol Int"},{"key":"206_CR30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1513\/pats.2306024","volume":"1","author":"RA Pauwels","year":"2004","unstructured":"Pauwels RA (2004) Similarities and differences in asthma and chronic obstructive pulmonary disease exacerbations. Proc Am Thorac Soc 1:73\u201376","journal-title":"Proc Am Thorac Soc"},{"key":"206_CR31","doi-asserted-by":"publisher","first-page":"S187","DOI":"10.1164\/ajrccm.158.supplement_2.13tac170","volume":"158","author":"DS Postma","year":"1998","unstructured":"Postma DS, Kerstjens HA (1998) Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158:S187\u2013S192","journal-title":"Am J Respir Crit Care Med"},{"key":"206_CR32","doi-asserted-by":"crossref","unstructured":"Rothe T (2012) COPD and asthma: same but different. Praxis (Bern 1994) 101:233\u2013237","DOI":"10.1024\/1661-8157\/a000835"},{"key":"206_CR33","doi-asserted-by":"publisher","first-page":"117S","DOI":"10.1016\/S0012-3692(15)31481-1","volume":"126","author":"FC Sciurba","year":"2004","unstructured":"Sciurba FC (2004) Physiologic similarities and differences between COPD and asthma. Chest 126:117S\u2013124S","journal-title":"Chest"},{"key":"206_CR34","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1590\/S1806-37132008000900007","volume":"34","author":"IC Silvestri","year":"2008","unstructured":"Silvestri IC, Pereira CA, Rodrigues SC (2008) Comparison of spirometric changes in the response to bronchodilators of patients with asthma or chronic obstructive pulmonary disease. J Bras Pneumol 34:675\u2013682","journal-title":"J Bras Pneumol"},{"issue":"Suppl 1","key":"206_CR35","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1752-699X.2010.00193.x","volume":"4","author":"CM Sk\u00f6ld","year":"2010","unstructured":"Sk\u00f6ld CM (2010) Remodeling in asthma and COPD-differences and similarities. Clin Respir J 4(Suppl 1):20\u201327","journal-title":"Clin Respir J"},{"key":"206_CR36","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/1874434601307010029","volume":"7","author":"P Spencer","year":"2013","unstructured":"Spencer P, Krieger B (2013) The differentiation of chronic obstructive pulmonary disease from asthma: a review of current diagnostic and treatment recommendations. Open Nurs J 7:29\u201334","journal-title":"Open Nurs J"},{"key":"206_CR37","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0091-6749(03)02011-6","volume":"112","author":"ER Sutherland","year":"2003","unstructured":"Sutherland ER, Martin RJ (2003) Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. J Allergy Clin Immunol 112:819\u2013827","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 1","key":"206_CR38","doi-asserted-by":"crossref","first-page":"P8","DOI":"10.1186\/1939-4551-6-S1-P8","volume":"6","author":"S Tandon","year":"2013","unstructured":"Tandon S, Khutarkar A, Ansari S (2013) Asthma diagnosis and treatment \u2013 1008. Is small airways disease a widely prevalent yet underdiagnosed phenotype of asthma and COPD in India? World Allergy Organ J 6(Suppl 1):P8","journal-title":"World Allergy Organ J"},{"key":"206_CR39","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1080\/02770900500448738","volume":"43","author":"DG Tinkelman","year":"2006","unstructured":"Tinkelman DG, Price DB, Nordyke RJ, Halbert RJ (2006) Misdiagnosis of COPD and asthma in primary care patients 40 years of age and over. J Asthma 43:75\u201380","journal-title":"J Asthma"},{"issue":"Suppl 2","key":"206_CR40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.etp.2006.02.004","volume":"57","author":"T Welte","year":"2006","unstructured":"Welte T, Groneberg DA (2006) Asthma and COPD. Exp Toxicol Pathol 57(Suppl 2):35\u201340","journal-title":"Exp Toxicol Pathol"},{"issue":"1","key":"206_CR41","first-page":"20","volume":"11","author":"BP Yawn","year":"2009","unstructured":"Yawn BP (2009) Differential assessment and management of asthma vs chronic obstructive pulmonary disease. Medscape J Med 11(1):20; Epub 2009","journal-title":"Medscape J Med"}],"container-title":["Advances in Experimental Medicine and Biology","Respiratory Medicine and Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2015_206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T14:45:59Z","timestamp":1676472359000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/5584_2015_206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9783319306582","9783319306599"],"references-count":41,"URL":"https:\/\/doi.org\/10.1007\/5584_2015_206","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"29 January 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}