{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:52:21Z","timestamp":1780685541170,"version":"3.54.1"},"publisher-location":"Cham","reference-count":34,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319263199","type":"print"},{"value":"9783319263205","type":"electronic"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/5584_2015_5010","type":"book-chapter","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T07:29:34Z","timestamp":1447399774000},"page":"113-120","source":"Crossref","is-referenced-by-count":16,"title":["Increase in Peripheral CD3\u2212CD56brightCD16\u2212 Natural Killer Cells in Hashimoto\u2019s Thyroiditis Associated with HHV-6 Infection"],"prefix":"10.1007","author":[{"given":"Roberta","family":"Rizzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Zatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Rotola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Cassai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Degli Uberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Di Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Caselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,14]]},"reference":[{"key":"5010_CR1","doi-asserted-by":"publisher","unstructured":"Alvarez-Lafuente R, Fernandez-Gutierrez B, de Miguel S, Jover JA, Rollin R, Loza E, Clemente D, Lamas JR (2005) Potential relationship between herpes viruses and rheumatoid arthritis: analysis with quantitative real time polymerase chain reaction. Ann Rheum Dis 64(9):1357\u20131359. doi:64\/9\/1357 [pii] 10.1136\/ard.2004.033514","DOI":"10.1136\/ard.2004.033514"},{"key":"5010_CR2","doi-asserted-by":"publisher","unstructured":"Alvarez-Lafuente R, Martinez A, Garcia-Montojo M, Mas A, De Las Heras V, Dominguez-Mozo MI, Maria Del Carmen C, Lopez-Cavanillas M, Bartolome M, Gomez de la Concha E, Urcelay E, Arroyo R (2010) MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients. Eur J Neurol 17(1):129\u2013135. doi:ENE2758 [pii] 10.1111\/j.1468-1331.2009.02758.x","DOI":"10.1111\/j.1468-1331.2009.02758.x"},{"issue":"6","key":"5010_CR3","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.1365-3083.2010.02389.x","volume":"71","author":"LBPC Bertelsen","year":"2010","unstructured":"Bertelsen LBPC, Kofod-Olsen E, Oster B, H\u00f6llsberg P, Agger R, Hokland M (2010) Human herpesvirus 6B induces phenotypic maturation without IL-10 and IL-12p70 production in dendritic cells. Scand J Immunol 71(6):431\u2013439","journal-title":"Scand J Immunol"},{"key":"5010_CR4","doi-asserted-by":"publisher","unstructured":"Boccara O, Lesage F, Regnault V, Lasne D, Dupic L, Bourdon-Lanoy E, Pannier S, Fraitag S, Audat F, Lecompte T, Hubert P, Bodemer C (2009) Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replication. Br J Dermatol 161(1):181\u2013183. doi:BJD9264 [pii] 10.1111\/j.1365-2133.2009.09264.x","DOI":"10.1111\/j.1365-2133.2009.09264.x"},{"key":"5010_CR5","doi-asserted-by":"publisher","unstructured":"Broccolo F, Drago F, Paolino S, Cassina G, Gatto F, Fusetti L, Matteoli B, Zaccaria E, Parodi A, Lusso P, Ceccherini-Nelli L, Malnati MS (2009) Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases. J Clin Virol 46 (1):43\u201346. doi:S1386-6532(09)00191-7 [pii] 10.1016\/j.jcv.2009.05.010","DOI":"10.1016\/j.jcv.2009.05.010"},{"issue":"4","key":"5010_CR6","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/jmv.10133","volume":"67","author":"A Caruso","year":"2002","unstructured":"Caruso A, Rotola A, Comar M, Favilli F, Galvan M, Tosetti M, Campello C, Caselli E, Alessandri G, Grassi M, Garrafa E, Cassai E, Di Luca D (2002) HHV-6 infects human aortic and heart microvascular endothelial cells, increasing their ability to secrete proinflammatory chemokines. J Med Virol 67(4):528\u2013533","journal-title":"J Med Virol"},{"key":"5010_CR7","doi-asserted-by":"publisher","unstructured":"Caruso A, Caselli E, Fiorentini S, Rotola A, Prandini A, Garrafa E, Saba E, Alessandri G, Cassai E, Di Luca D (2009) U94 of human herpesvirus 6 inhibits in vitro angiogenesis and lymphangiogenesis. Proc Natl Acad Sci U S A 106(48):20446\u201320451. doi:0905535106 [pii] 10.1073\/pnas.0905535106","DOI":"10.1073\/pnas.0905535106"},{"issue":"3","key":"5010_CR8","first-page":"173","volume":"30","author":"E Caselli","year":"2007","unstructured":"Caselli E, Di Luca D (2007) Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiol 30(3):173\u2013187","journal-title":"New Microbiol"},{"issue":"11","key":"5010_CR9","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1128\/JCM.40.11.4131-4137.2002","volume":"40","author":"E Caselli","year":"2002","unstructured":"Caselli E, Boni M, Bracci A, Rotola A, Cermelli C, Castellazzi M, Di Luca D, Cassai E (2002) Detection of antibodies directed against human herpesvirus 6 U94\/REP in sera of patients affected by multiple sclerosis. J Clin Microbiol 40(11):4131\u20134137","journal-title":"J Clin Microbiol"},{"issue":"2","key":"5010_CR10","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.virol.2005.11.018","volume":"346","author":"E Caselli","year":"2006","unstructured":"Caselli E, Bracci A, Galvan M, Boni M, Rotola A, Bergamini C, Cermelli C, Dal Monte P, Gompels UA, Cassai E, Di Luca D (2006) Human herpesvirus 6 (HHV-6) U94\/REP protein inhibits betaherpesvirus replication. Virology 346(2):402\u2013414","journal-title":"Virology"},{"key":"5010_CR11","doi-asserted-by":"publisher","unstructured":"Caselli E, Zatelli MC, Rizzo R, Benedetti S, Martorelli D, Trasforini G, Cassai E, Degli Uberti EC, Di Luca D, Dolcetti R (2012a) Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto\u2019s Thyroiditis. PLoS Pathog 8(10):e1002951. doi: 10.1371\/journal.ppat.1002951 PPATHOGENS-D-12-01343 [pii]","DOI":"10.1371\/journal.ppat.1002951"},{"key":"5010_CR12","doi-asserted-by":"publisher","first-page":"e1002951","DOI":"10.1371\/journal.ppat.1002951","volume":"8","author":"E Caselli","year":"2012","unstructured":"Caselli E, Zatelli M, Rizzo R, Benedetti S, Martorelli D, Trasforini G, Cassai E, degli Uberti EC, Di Luca D, Dolcetti R (2012b) Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto\u2019s thyroiditis. PLoS Pathog 8:e1002951","journal-title":"PLoS Pathog"},{"issue":"16","key":"5010_CR13","doi-asserted-by":"publisher","first-page":"7440","DOI":"10.1073\/pnas.92.16.7440","volume":"92","author":"PB Challoner","year":"1995","unstructured":"Challoner PB, Smith KT, Parker JD, MacLeod DL, Coulter SN, Rose TM, Schultz ER, Bennett JL, Garber RL, Chang M et al (1995) Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci U S A 92(16):7440\u20137444","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"5010_CR14","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","volume":"22","author":"MAFT Cooper","year":"2001","unstructured":"Cooper MAFT, Caligiuri MA (2001) The biology of human natural killer-cell subsets. Trends Immunol 22(11):633\u2013640","journal-title":"Trends Immunol"},{"issue":"1","key":"5010_CR15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/infdis\/170.1.211","volume":"170","author":"D Luca Di","year":"1994","unstructured":"Di Luca D, Dolcetti R, Mirandola P, De Re V, Secchiero P, Carbone A, Boiocchi M, Cassai E (1994) Human herpesvirus 6: a survey of presence and variant distribution in normal peripheral lymphocytes and lymphoproliferative disorders. J Infect Dis 170(1):211\u2013215","journal-title":"J Infect Dis"},{"issue":"4","key":"5010_CR16","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/0896-8411(89)90174-1","volume":"2","author":"RI Fox","year":"1989","unstructured":"Fox RI, Saito I, Chan EK, Josephs S, Salahuddin SZ, Ahlashi DV, Staal FW, Gallo R, Pei-Ping H, Le CS (1989) Viral genomes in lymphomas of patients with Sjogren\u2019s syndrome. J Autoimmun 2(4):449\u2013455","journal-title":"J Autoimmun"},{"issue":"3","key":"5010_CR17","doi-asserted-by":"publisher","first-page":"e58122","DOI":"10.1371\/journal.pone.0058122","volume":"8","author":"RK Gustafsson","year":"2013","unstructured":"Gustafsson RK, Engdahl EE, Hammarfjord O, Adikari SB, Lourda M, Klingstr\u00f6m J, Svensson M, Fogdell-Hahn A (2013) Human herpesvirus 6A partially suppresses functional properties of DC without viral replication. PLoS One 8(3):e58122","journal-title":"PLoS One"},{"key":"5010_CR18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3109\/08916939209035161","volume":"11","author":"YAN Hidaka","year":"1992","unstructured":"Hidaka YAN, Iwatani Y, Kaneda T, Nasu M, Mitsuda N, Tanizawa O, Miyai K (1992) Increase in peripheral natural killer cell activity in patients with autoimmune thyroid disease. Autoimmunity 11:239","journal-title":"Autoimmunity"},{"issue":"Pt 6","key":"5010_CR19","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1099\/0022-1317-72-6-1401","volume":"72","author":"K Kondo","year":"1991","unstructured":"Kondo K, Kondo T, Okuno T, Takahashi M, Yamanishi K (1991) Latent human herpesvirus 6 infection of human monocytes\/macrophages. J Gen Virol 72(Pt 6):1401\u20131408","journal-title":"J Gen Virol"},{"issue":"3","key":"5010_CR20","first-page":"217","volume":"5","author":"GR Krueger","year":"1991","unstructured":"Krueger GR, Sander C, Hoffmann A, Barth A, Koch B, Braun M (1991) Isolation of human herpesvirus-6 (HHV-6) from patients with collagen vascular diseases. Vivo 5(3):217\u2013225","journal-title":"Vivo"},{"key":"5010_CR21","doi-asserted-by":"crossref","unstructured":"Kubo T SK, Kobayashi D, Motegi A, Kobayashi O, Takeshita S, Nonoyama S (2006) A case of HHV-6 associated acute necrotizing encephalopathy with increase of CD56bright NKcells. Scand J Infect Dis 38(11\u201312):1122\u20131125","DOI":"10.1080\/00365540600740520"},{"issue":"6","key":"5010_CR22","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/jmv.20625","volume":"78","author":"TYT Kumagai","year":"2006","unstructured":"Kumagai TYT, Yoshida M, Okui T, Ihira M, Nagata N, Yano S, Shiraki K, Yamada M, Ichihara K, Asano Y (2006) Time course characteristics of human herpesvirus 6 specific cellular immune response and natural killer cell activity in patients with exanthema subitum. J Med Virol 78(6):792\u2013799","journal-title":"J Med Virol"},{"issue":"2","key":"5010_CR23","doi-asserted-by":"publisher","first-page":"150","DOI":"10.5603\/EP.2014.0021","volume":"65","author":"HMM Miko\u015b","year":"2014","unstructured":"Miko\u015b HMM, Obara-Moszy\u0144ska M, Niedziela M (2014) The role of the immune system and cytokines involved in the pathogenesis of autoimmune thyroid disease(AITD). Endokrynol Pol 65(2):150\u2013155","journal-title":"Endokrynol Pol"},{"key":"5010_CR24","doi-asserted-by":"publisher","unstructured":"Poli A, Michel T, Theresine M, Andres E, Hentges F, Zimmer J (2009) CD56bright natural killer (NK) cells: an important NK cell subset. Immunology 126(4):458\u2013465. doi:IMM3027 [pii] 10.1111\/j.1365-2567.2008.03027.x","DOI":"10.1111\/j.1365-2567.2008.03027.x"},{"key":"5010_CR25","doi-asserted-by":"publisher","unstructured":"Potenza L, Luppi M, Barozzi P, Rossi G, Cocchi S, Codeluppi M, Pecorari M, Masetti M, Di Benedetto F, Gennari W, Portolani M, Gerunda GE, Lazzarotto T, Landini MP, Schulz TF, Torelli G, Guaraldi G (2008) HHV-6A in syncytial giant-cell hepatitis. N Engl J Med 359(6):593\u2013602. doi:359\/6\/593 [pii] 10.1056\/NEJMoa074479","DOI":"10.1056\/NEJMoa074479"},{"issue":"6","key":"5010_CR26","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1093\/clinids\/19.6.1159","volume":"19","author":"S Ranger-Rogez","year":"1994","unstructured":"Ranger-Rogez S, Vidal E, Liozon F, Denis F (1994) Primary Sjogren\u2019s syndrome and antibodies to human herpesvirus type 6. Clin Infect Dis 19(6):1159\u20131160","journal-title":"Clin Infect Dis"},{"key":"5010_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jneuroim.2012.07.004","volume":"251","author":"RGV Rizzo","year":"2012","unstructured":"Rizzo RGV, Casetta I, Caselli E, De Gennaro R, Granieri E, Cassai E, Di Luca D, Rotola A (2012) Altered natural killer cells\u2019 response to herpes virus infection in multiple sclerosis involves KIR2DL2 expression. J Neuroimmunol 251:55\u201364","journal-title":"J Neuroimmunol"},{"issue":"23","key":"5010_CR28","doi-asserted-by":"publisher","first-page":"13911","DOI":"10.1073\/pnas.95.23.13911","volume":"95","author":"A Rotola","year":"1998","unstructured":"Rotola A, Ravaioli T, Gonelli A, Dewhurst S, Cassai E, Di Luca D (1998) U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture. Proc Natl Acad Sci U S A 95(23):13911\u201313916","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"5010_CR29","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1191\/1352458504ms1045oa","volume":"10","author":"A Rotola","year":"2004","unstructured":"Rotola A, Merlotti I, Caniatti L, Caselli E, Granieri E, Tola MR, Di Luca D, Cassai E (2004) Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease. Mult Scler 10(4):348\u2013354","journal-title":"Mult Scler"},{"issue":"3","key":"5010_CR30","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<973::AID-IMMU973>3.0.CO;2-P","volume":"29","author":"E Scotet","year":"1999","unstructured":"Scotet E, Peyrat MA, Saulquin X, Retiere C, Couedel C, Davodeau F, Dulphy N, Toubert A, Bignon JD, Lim A, Vie H, Hallet MM, Liblau R, Weber M, Berthelot JM, Houssaint E, Bonneville M (1999) Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes. Eur J Immunol 29(3):973\u2013985","journal-title":"Eur J Immunol"},{"issue":"6","key":"5010_CR31","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.4049\/jimmunol.138.6.1657","volume":"138","author":"WJHD Storkus","year":"1987","unstructured":"Storkus WJHD, Salter RD, Dawson JR, Cresswell P (1987) NK susceptibility varies inversely with target cell class I HLA antigen expression. J Immunol 138(6):1657\u20131659","journal-title":"J Immunol"},{"issue":"1","key":"5010_CR32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1055\/s-2007-956171","volume":"116","author":"D Thomas","year":"2008","unstructured":"Thomas D, Liakos V, Michou V, Kapranos N, Kaltsas G, Tsilivakos V, Tsatsoulis A (2008) Detection of herpes virus DNA in post-operative thyroid tissue specimens of patients with autoimmune thyroid disease. Exp Clin Endocrinol Diabetes 116(1):35\u201339","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"6","key":"5010_CR33","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/eji.200425100","volume":"34","author":"M Vitale","year":"2004","unstructured":"Vitale M, Della Chiesa M, Carlomagno S, Romagnani C, Thiel A, Moretta L, Moretta A (2004) The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells. Eur J Immunol 34(6):1715\u20131722. doi: 10.1002\/eji.200425100","journal-title":"Eur J Immunol"},{"issue":"5","key":"5010_CR34","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1128\/JVI.03489-14","volume":"89","author":"ZSC Wu","year":"2015","unstructured":"Wu ZSC, Reichel JJ, Just M, Mertens T (2015) Natural killer cells can inhibit the transmission of human cytomegalovirus in cell culture by using mechanisms from innate and adaptive immune responses. J Virol 89(5):2906\u20132917","journal-title":"J Virol"}],"container-title":["Advances in Experimental Medicine and Biology","Advances in Microbiology, Infectious Diseases and Public Health"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2015_5010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T17:14:10Z","timestamp":1692119650000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/5584_2015_5010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9783319263199","9783319263205"],"references-count":34,"URL":"https:\/\/doi.org\/10.1007\/5584_2015_5010","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}