{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:56:31Z","timestamp":1790423791682,"version":"4.1.0"},"publisher-location":"Cham","reference-count":46,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030146351","type":"print"},{"value":"9783030146368","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/5584_2018_319","type":"book-chapter","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T06:33:47Z","timestamp":1547102027000},"page":"101-107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Probiotics in the Treatment of Inflammatory Bowel Disease"],"prefix":"10.1007","author":[{"given":"Stefano","family":"Guandalini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naire","family":"Sansotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,11]]},"reference":[{"key":"319_CR1","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.gtc.2017.08.003","volume":"46","author":"BP Abraham","year":"2017","unstructured":"Abraham BP, Quigley EMM (2017) Probiotics in inflammatory bowel disease. Gastroenterol Clin N Am 46:769\u2013782","journal-title":"Gastroenterol Clin N Am"},{"key":"319_CR2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3920\/BM2017.0097","volume":"9","author":"J Alard","year":"2018","unstructured":"Alard J, Peucelle V, Boutillier D, Breton J, Kuylle S, Pot B, Holowacz S, Grangette C (2018) New probiotic strains for inflammatory bowel disease management identified by combining in vitro and in vivo approaches. Benef Microb 9:317\u2013331","journal-title":"Benef Microb"},{"key":"319_CR3","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.gtc.2017.08.002","volume":"46","author":"AR Basson","year":"2017","unstructured":"Basson AR, Lam M, Cominelli F (2017) Complementary and alternative medicine strategies for therapeutic gut microbiota modulation in inflammatory bowel disease and their next-generation approaches. Gastroenterol Clin N Am 46:689\u2013729","journal-title":"Gastroenterol Clin N Am"},{"key":"319_CR4","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.cgh.2013.02.021","volume":"11","author":"A Bourreille","year":"2013","unstructured":"Bourreille A, Cadiot G, Le Dreau G, Laharie D, Beaugerie L, Dupas JL, Marteau P, Rampal P, Moyse D, Saleh A, Le Guern ME, Galmiche JP, Group FS (2013) Saccharomyces boulardii does not prevent relapse of Crohn\u2019s disease. Clin Gastroenterol Hepatol 11:982\u2013987","journal-title":"Clin Gastroenterol Hepatol"},{"key":"319_CR5","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1097\/01.MIB.0000175905.00212.2c","volume":"11","author":"A Bousvaros","year":"2005","unstructured":"Bousvaros A, Guandalini S, Baldassano RN, Botelho C, Evans J, Ferry GD, Goldin B, Hartigan L, Kugathasan S, Levy J, Murray KF, Oliva-Hemker M, Rosh JR, Tolia V, Zholudev A, Vanderhoof JA, Hibberd PL (2005) A randomized, double-blind trial of lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn\u2019s disease. Inflamm Bowel Dis 11:833\u2013839","journal-title":"Inflamm Bowel Dis"},{"key":"319_CR6","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1053\/j.gastro.2011.01.054","volume":"140","author":"B Chassaing","year":"2011","unstructured":"Chassaing B, Darfeuille-Michaud A (2011) The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140:1720\u20131728","journal-title":"Gastroenterology"},{"key":"319_CR7","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1136\/gut.2005.078824","volume":"55","author":"MP Conte","year":"2006","unstructured":"Conte MP, Schippa S, Zamboni I, Penta M, Chiarini F, Seganti L, Osborn J, Falconieri P, Borrelli O, Cucchiara S (2006) Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease. Gut 55:1760\u20131767","journal-title":"Gut"},{"key":"319_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/apt.14203","volume":"46","author":"Y Derwa","year":"2017","unstructured":"Derwa Y, Gracie DJ, Hamlin PJ, Ford AC (2017) Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease. Aliment Pharmacol Ther 46:389\u2013400","journal-title":"Aliment Pharmacol Ther"},{"key":"319_CR9","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.crohns.2014.05.006","volume":"8","author":"D Duricova","year":"2014","unstructured":"Duricova D, Burisch J, Jess T, Gower-Rousseau C, Lakatos PL, On Behalf of ECCO-EpiCom (2014) Age-related differences in presentation and course of inflammatory bowel disease: an update on the population-based literature. J Crohns Colitis 8:1351","journal-title":"J Crohns Colitis"},{"key":"319_CR10","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1159\/000068362","volume":"66","author":"S Fiorucci","year":"2002","unstructured":"Fiorucci S, Distrutti E, Mencarelli A, Barbanti M, Palazzini E, Morelli A (2002) Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis. Digestion 66:246\u2013256","journal-title":"Digestion"},{"key":"319_CR11","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/ibd.21339","volume":"17","author":"DN Frank","year":"2011","unstructured":"Frank DN, Robertson CE, Hamm CM, Kpadeh Z, Zhang T, Chen H, Zhu W, Sartor RB, Boedeker EC, Harpaz N, Pace NR, Li E (2011) Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis 17:179\u2013184","journal-title":"Inflamm Bowel Dis"},{"key":"319_CR12","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/jcp.25911","volume":"233","author":"M Ganji-Arjenaki","year":"2018","unstructured":"Ganji-Arjenaki M, Rafieian-Kopaei M (2018) Probiotics are a good choice in remission of inflammatory bowel diseases: a meta analysis and systematic review. J Cell Physiol 233:2091\u20132103","journal-title":"J Cell Physiol"},{"key":"319_CR13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/MPG.0b013e31822d53e5","volume":"54","author":"T Gosiewski","year":"2012","unstructured":"Gosiewski T, Strus M, Fyderek K, Kowalska-Duplaga K, Wedrychowicz A, Jedynak-Wasowicz U, Sladek M, Pieczarkowski S, Adamski P, Heczko PB (2012) Horizontal distribution of the fecal microbiota in adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 54:20\u201327","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"319_CR14","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1023\/A:1005588911207","volume":"45","author":"M Guslandi","year":"2000","unstructured":"Guslandi M, Mezzi G, Sorghi M, Testoni PA (2000) Saccharomyces boulardii in maintenance treatment of Crohn\u2019s disease. Dig Dis Sci 45:1462\u20131464","journal-title":"Dig Dis Sci"},{"key":"319_CR15","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1055\/s-2008-1027463","volume":"46","author":"J Henker","year":"2008","unstructured":"Henker J, Muller S, Laass MW, Schreiner A, Schulze J (2008) Probiotic Escherichia coli Nissle 1917 (EcN) for successful remission maintenance of ulcerative colitis in children and adolescents: an open-label pilot study. Z Gastroenterol 46:874\u2013875","journal-title":"Z Gastroenterol"},{"key":"319_CR16","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1002\/ibd.20816","volume":"15","author":"HQ Huynh","year":"2009","unstructured":"Huynh HQ, Debruyn J, Guan L, Diaz H, Li M, Girgis S, Turner J, Fedorak R, Madsen K (2009) Probiotic preparation De Simone Formulation induces remission in children with mild to moderate acute ulcerative colitis: a pilot study. Inflamm Bowel Dis 15:760\u2013768","journal-title":"Inflamm Bowel Dis"},{"key":"319_CR17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11908-018-0627-8","volume":"20","author":"SR Jeon","year":"2018","unstructured":"Jeon SR, Chai J, Kim C, Lee CH (2018) Current evidence for the management of inflammatory bowel diseases using fecal microbiota transplantation. Curr Infect Dis Rep 20:21","journal-title":"Curr Infect Dis Rep"},{"key":"319_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/MPG.0b013e3182617c16","volume":"55","author":"R Kellermayer","year":"2012","unstructured":"Kellermayer R, Mir SA, Nagy-Szakal D, Cox SB, Dowd SE, Kaplan JL, Sun Y, Reddy S, Bronsky J, Winter HS (2012) Microbiota separation and C-reactive protein elevation in treatment-naive pediatric granulomatous Crohn disease. J Pediatr Gastroenterol Nutr 55:243\u2013250","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"319_CR19","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/jgh.14362","volume":"34","author":"Da Hye Kim","year":"2018","unstructured":"Kim DH, Kim S, Lee JH, Kim JH, Che X, Ma HW, Seo DH, Kim TI, Kim WH, Kim SW, Cheon JH (2018) Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress. J Gastroenterol Hepatol. https:\/\/doi.org\/10.1111\/jgh.14362","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"319_CR20","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.gtc.2017.08.012","volume":"46","author":"ER Lane","year":"2017","unstructured":"Lane ER, Lee D, Suskind DL (2017) Dietary therapies in pediatric inflammatory bowel disease: an evolving inflammatory bowel disease paradigm. Gastroenterol Clin North Am 46:731\u2013744","journal-title":"Gastroenterol Clin North Am"},{"key":"319_CR21","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","volume":"126","author":"EV Loftus Jr","year":"2004","unstructured":"Loftus EV Jr (2004) Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126:1504\u20131517","journal-title":"Gastroenterology"},{"key":"319_CR22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3390\/nu3020245","volume":"3","author":"DR Mack","year":"2011","unstructured":"Mack DR (2011) Probiotics in inflammatory bowel diseases and associated conditions. Nutrients 3:245\u2013264","journal-title":"Nutrients"},{"key":"319_CR23","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1136\/gut.2005.073817","volume":"55","author":"C Manichanh","year":"2006","unstructured":"Manichanh C, Rigottier-Gois L, bonnaud E, Gloux K, Pelletier E, Frangeul L, Nalin R, Jarrin C, Chardon P, Marteau P, Roca J, Dore J (2006) Reduced diversity of faecal microbiota in Crohn\u2019s disease revealed by a metagenomic approach. Gut 55:205\u2013211","journal-title":"Gut"},{"key":"319_CR24","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1097\/MIB.0000000000000084","volume":"20","author":"HE Mardini","year":"2014","unstructured":"Mardini HE, Grigorian AY (2014) Probiotic mix De Simone Formulation is effective adjunctive therapy for mild to moderately active ulcerative colitis: a meta-analysis. Inflamm Bowel Dis 20:1562\u20131567","journal-title":"Inflamm Bowel Dis"},{"key":"319_CR25","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1572-0241.2007.01592.x","volume":"103","author":"C Martinez","year":"2008","unstructured":"Martinez C, Antolin M, Santos J, Torrejon A, Casellas F, Borruel N, Guarner F, Malagelada JR (2008) Unstable composition of the fecal microbiota in ulcerative colitis during clinical remission. Am J Gastroenterol 103:643\u2013648","journal-title":"Am J Gastroenterol"},{"key":"319_CR26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/apt.14384","volume":"47","author":"J Mcilroy","year":"2018","unstructured":"Mcilroy J, Ianiro G, Mukhopadhya I, Hansen R, Hold GL (2018) Review article: the gut microbiome in inflammatory bowel disease-avenues for microbial management. Aliment Pharmacol Ther 47:26\u201342","journal-title":"Aliment Pharmacol Ther"},{"key":"319_CR27","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/ajg.2008.118","volume":"104","author":"E Miele","year":"2009","unstructured":"Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A (2009) Effect of a probiotic preparation (De Simone Formulation) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol 104:437\u2013443","journal-title":"Am J Gastroenterol"},{"key":"319_CR28","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/MPG.0000000000001896","volume":"66","author":"E Miele","year":"2018","unstructured":"Miele E, Shamir R, Aloi M, Assa A, Braegger C, Bronsky J, De Ridder L, Escher JC, Hojsak I, Kolacek S, Koletzko S, Levine A, Lionetti P, Martinelli M, Ruemmele F, Russell RK, Boneh RS, Van Limbergen J, Veereman G, Staiano A (2018) Nutrition in pediatric inflammatory bowel disease: a position paper on behalf of the porto inflammatory bowel disease group of the European Society of pediatric gastroenterology, hepatology and nutrition. J Pediatr Gastroenterol Nutr 66:687\u2013708","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"319_CR29","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","volume":"14","author":"J Ni","year":"2017","unstructured":"Ni J, Wu GD, Albenberg L, Tomov VT (2017) Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol 14:573\u2013584","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"319_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","volume":"11","author":"A Nishida","year":"2018","unstructured":"Nishida A, Inoue R, Inatomi O, Bamba S, Naito Y, Andoh A (2018) Gut microbiota in the pathogenesis of inflammatory bowel disease. Clin J Gastroenterol 11:1\u201310","journal-title":"Clin J Gastroenterol"},{"key":"319_CR31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ijmm.2009.08.005","volume":"300","author":"TA Oelschlaeger","year":"2010","unstructured":"Oelschlaeger TA (2010) Mechanisms of probiotic actions \u2013 a review. Int J Med Microbiol 300:57\u201362","journal-title":"Int J Med Microbiol"},{"key":"319_CR32","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1365-2036.2011.04939.x","volume":"35","author":"S Oliva","year":"2012","unstructured":"Oliva S, Di Nardo G, Ferrari F, Mallardo S, Rossi P, Patrizi G, Cucchiara S, Stronati L (2012) Randomised clinical trial: the effectiveness of lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis. Aliment Pharmacol Ther 35:327\u2013334","journal-title":"Aliment Pharmacol Ther"},{"key":"319_CR33","doi-asserted-by":"publisher","first-page":"11505","DOI":"10.3748\/wjg.v20.i33.11505","volume":"20","author":"R Orel","year":"2014","unstructured":"Orel R, Kamhi Trop T (2014) Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease. World J Gastroenterol 20:11505\u201311524","journal-title":"World J Gastroenterol"},{"key":"319_CR34","first-page":"1207","volume":"55","author":"SJ Ott","year":"2006","unstructured":"Ott SJ, Schreiber S (2006) Reduced microbial diversity in inflammatory bowel diseases. Gut 55:1207","journal-title":"Gut"},{"key":"319_CR35","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1136\/gut.2003.025403","volume":"53","author":"SJ Ott","year":"2004","unstructured":"Ott SJ, Musfeldt M, Wenderoth DF, Hampe J, Brant O, Folsch UR, Timmis KN, Schreiber S (2004) Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut 53:685\u2013693","journal-title":"Gut"},{"key":"319_CR36","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/j.crohns.2014.06.001","volume":"8","author":"AM Petersen","year":"2014","unstructured":"Petersen AM, Mirsepasi H, Halkjaer SI, Mortensen EM, Nordgaard-Lassen I, Krogfelt KA (2014) Ciprofloxacin and probiotic Escherichia coli nissle add-on treatment in active ulcerative colitis: a double-blind randomized placebo controlled clinical trial. J Crohns Colitis 8:1498\u20131505","journal-title":"J Crohns Colitis"},{"key":"319_CR37","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1080\/00365521.2016.1216587","volume":"51","author":"M Prosberg","year":"2016","unstructured":"Prosberg M, Bendtsen F, Vind I, Petersen AM, Gluud LL (2016) The association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis. Scand J Gastroenterol 51:1407\u20131415","journal-title":"Scand J Gastroenterol"},{"key":"319_CR38","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3389\/fphar.2018.00468","volume":"9","author":"A Rodriguez-Nogales","year":"2018","unstructured":"Rodriguez-Nogales A, Algieri F, Garrido-Mesa J, Vezza T, Utrilla MP, Chueca N, Fernandez-Caballero JA, Garcia F, Rodriguez-Cabezas ME, Galvez J (2018) The administration of Escherichia coli nissle 1917 ameliorates development of DSS-induced colitis in mice. Front Pharmacol 9:468","journal-title":"Front Pharmacol"},{"key":"319_CR39","doi-asserted-by":"publisher","first-page":"5505","DOI":"10.3748\/wjg.v22.i24.5505","volume":"22","author":"F Scaldaferri","year":"2016","unstructured":"Scaldaferri F, Gerardi V, Mangiola F, Lopetuso LR, Pizzoferrato M, Petito V, Papa A, Stojanovic J, Poscia A, Cammarota G, Gasbarrini A (2016) Role and mechanisms of action of Escherichia coli nissle 1917 in the maintenance of remission in ulcerative colitis patients: an update. World J Gastroenterol 22:5505\u20135511","journal-title":"World J Gastroenterol"},{"key":"319_CR40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/MOG.0b013e328353e61e","volume":"28","author":"M Scharl","year":"2012","unstructured":"Scharl M, Rogler G (2012) Inflammatory bowel disease pathogenesis: what is new? Curr Opin Gastroenterol 28:301\u2013309","journal-title":"Curr Opin Gastroenterol"},{"key":"319_CR41","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1136\/gut.52.2.237","volume":"52","author":"P Seksik","year":"2003","unstructured":"Seksik P, Rigottier-Gois L, Gramet G, Sutren M, Pochart P, Marteau P, Jian R, Dore J (2003) Alterations of the dominant faecal bacterial groups in patients with Crohn\u2019s disease of the colon. Gut 52:237\u2013242","journal-title":"Gut"},{"key":"319_CR42","doi-asserted-by":"publisher","unstructured":"Singh S, Stroud AM, Holubar SD, Sandborn WJ, Pardi DS (2015) Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. Cochrane Database Syst Rev:CD001176. https:\/\/doi.org\/10.1002\/14651858.CD001176.pub3","DOI":"10.1002\/14651858.CD001176.pub3"},{"issue":"6","key":"319_CR43","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/08923973.2018.1469143","volume":"40","author":"Kavitha Sivananthan","year":"2018","unstructured":"Sivananthan K, Petersen AM (2018) Review of saccharomyces boulardii as a treatment option in IBD. Immunopharmacol Immunotoxicol:1\u201311. https:\/\/doi.org\/10.1080\/08923973.2018.1469143","journal-title":"Immunopharmacology and Immunotoxicology"},{"key":"319_CR44","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/01.MIB.0000200323.38139.c6","volume":"12","author":"H Sokol","year":"2006","unstructured":"Sokol H, Seksik P, Rigottier-Gois L, Lay C, Lepage P, Podglajen I, Marteau P, Dore J (2006) Specificities of the fecal microbiota in inflammatory bowel disease. Inflamm Bowel Dis 12:106\u2013111","journal-title":"Inflamm Bowel Dis"},{"key":"319_CR45","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1053\/gast.2002.30294","volume":"122","author":"A Swidsinski","year":"2002","unstructured":"Swidsinski A, Ladhoff A, Pernthaler A, Swidsinski S, Loening-Baucke V, Ortner M, Weber J, Hoffmann U, Schreiber S, Dietel M, Lochs H (2002) Mucosal flora in inflammatory bowel disease. Gastroenterology 122:44\u201354","journal-title":"Gastroenterology"},{"key":"319_CR46","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.3389\/fmicb.2018.02247","volume":"9","author":"T Zuo","year":"2018","unstructured":"Zuo T, Ng SC (2018) The gut microbiota in the pathogenesis and therapeutics of inflammatory bowel disease. Front Microbiol 9:2247","journal-title":"Front Microbiol"}],"container-title":["Advances in Experimental Medicine and Biology","Probiotics and Child Gastrointestinal Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2018_319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:10:17Z","timestamp":1649808617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/5584_2018_319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030146351","9783030146368"],"references-count":46,"URL":"https:\/\/doi.org\/10.1007\/5584_2018_319","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"11 January 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}