{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:32:49Z","timestamp":1789500769896,"version":"build-2803163510"},"publisher-location":"Cham","reference-count":34,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030190583","type":"print"},{"value":"9783030190590","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/5584_2019_342","type":"book-chapter","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T23:14:06Z","timestamp":1550531646000},"page":"79-89","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mold Sensitization in Asthmatic and Non-asthmatic Subjects Diagnosed with Extract-Based Versus Component-Based Allergens"],"prefix":"10.1007","author":[{"given":"S.","family":"Kespohl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Raulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"issue":"Suppl 1","key":"342_CR1","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3109\/13693786.2010.504752","volume":"49","author":"R Agarwal","year":"2011","unstructured":"Agarwal R, Gupta D (2011) Severe asthma and fungi: current evidence. Med Mycol 49(Suppl 1):150\u2013157","journal-title":"Med Mycol"},{"key":"342_CR2","unstructured":"Allergen Nomenclature (2018) WHO\/IUIS allergen nomenclature sub-committee. \n                    https:\/\/www.allergen.org\n                    \n                  . Accessed on 20 Dec 2018"},{"issue":"6","key":"342_CR3","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.jaci.2005.02.012","volume":"115","author":"JA Asturias","year":"2005","unstructured":"Asturias JA, Ibarrola I, Ferrer A, Andreu C, L\u00f3pez-Pascual E, Quiralte J, Florido F, Mart\u00ednez A (2005) Diagnosis of Alternaria alternata sensitization with natural and recombinant Alt a 1 allergens. J Allergy Clin Immunol 115(6):1210\u20131217","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"342_CR4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/cea.12401","volume":"45","author":"B Behbod","year":"2015","unstructured":"Behbod B, Sordillo JE, Hoffman EB, Datta S, Webb TE, Kwan DL, Kamel JA, Muilenberg ML, Scott JA, Chew GL, Platts-Mills TA, Schwartz J, Coull B, Burge H, Gold DR (2015) Asthma and allergy development: contrasting influences of yeasts and other fungal exposures. Clin Exp Allergy 45(1):154\u2013163","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"342_CR5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S1081-1206(10)60139-1","volume":"103","author":"KW Bundy","year":"2009","unstructured":"Bundy KW, Gent JF, Beckett W, Bracken MB, Belanger K, Triche E, Leaderer BP (2009) Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children. Ann Allergy Asthma Immunol 103(1):26\u201330","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"342_CR6","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jaci.2003.11.023","volume":"113","author":"RK Bush","year":"2004","unstructured":"Bush RK, Prochnau JJ (2004) Alternaria-induced asthma. J Allergy Clin Immunol 113(2):227\u2013234","journal-title":"J Allergy Clin Immunol"},{"issue":"148","key":"342_CR7","doi-asserted-by":"publisher","first-page":"170137","DOI":"10.1183\/16000617.0137-2017","volume":"27","author":"Denis Caillaud","year":"2018","unstructured":"Caillaud D, Leynaert B, Keirsbulck M, Nadif R, mold ANSES working group (2018) Indoor mold exposure, asthma and rhinitis: findings from systematic reviews and recent longitudinal studies. Eur Respir Rev 27(148). \n                    https:\/\/doi.org\/10.1183\/16000617.0137-2017","journal-title":"European Respiratory Review"},{"issue":"2","key":"342_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000023889","volume":"115","author":"R Crameri","year":"1998","unstructured":"Crameri R (1998) Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications. Int Arch Allergy Immunol 115(2):99\u2013114","journal-title":"Int Arch Allergy Immunol"},{"issue":"1","key":"342_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1164\/rccm.200805-737OC","volume":"179","author":"DW Denning","year":"2009","unstructured":"Denning DW, O\u2019Driscoll BR, Powell G, Chew F, Atherton GT, Vyas A, Miles J, Morris J, Niven RM (2009) Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med 179(1):11\u201318","journal-title":"Am J Respir Crit Care Med"},{"key":"342_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2045-7022-4-14","volume":"4","author":"DW Denning","year":"2014","unstructured":"Denning DW, Pashley C, Hartl D, Wardlaw A, Godet C, Del Giacco S, Delhaes L, Sergejeva S (2014) Fungal allergy in asthma-state of the art and research needs. Clin Transl Allergy 4:14","journal-title":"Clin Transl Allergy"},{"issue":"4","key":"342_CR11","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.anai.2016.05.012","volume":"118","author":"RE Esch","year":"2017","unstructured":"Esch RE, Codina R (2017) Fungal raw materials used to produce allergen extracts. Ann Allergy Asthma Immunol 118(4):399\u2013405","journal-title":"Ann Allergy Asthma Immunol"},{"key":"342_CR12","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.envres.2012.07.005","volume":"118","author":"JF Gent","year":"2012","unstructured":"Gent JF, Kezik JM, Hill ME, Tsai E, Li DW, Leaderer BP (2012) Household mold and dust allergens: exposure, sensitization and childhood asthma morbidity. Environ Res 118:86\u201393","journal-title":"Environ Res"},{"issue":"5\u20136","key":"342_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00103-012-1658-1","volume":"56","author":"M Haftenberger","year":"2013","unstructured":"Haftenberger M, Lau\u00dfmann D, Ellert U, Kalckl\u00f6sch M, Langen U, Schlaud M, Schmitz R, Thamm M (2013) Pr\u00e4valenz von Sensibilisierungen gegen Inhalations- und Nahrungsmittelallergene: Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1). Bundesgesundheitsblatt 56(5\u20136):687\u2013697","journal-title":"Bundesgesundheitsblatt"},{"issue":"10","key":"342_CR14","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1111\/j.1398-9995.2009.02093.x","volume":"64","author":"LM Heinzerling","year":"2009","unstructured":"Heinzerling LM, Burbach GJ, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S et al (2009) GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. Allergy 64(10):1498\u20131506","journal-title":"Allergy"},{"key":"342_CR15","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s40629-015-0072-2","volume":"24","author":"J Huss-Marp","year":"2015","unstructured":"Huss-Marp J, Raulf M, Jakob T (2015) Spiking with recombinant allergens to improve allergen extracts: benefits and limitations for the use in routine diagnostics. Allergo J Int 24:236\u2013243","journal-title":"Allergo J Int"},{"issue":"3","key":"342_CR16","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.jaci.2005.11.003","volume":"117","author":"MS Jaakkola","year":"2006","unstructured":"Jaakkola MS, Ieromnimon A, Jaakkola JJK (2006) Are atopy and specific IgE to mites and molds important for adult asthma? J Allergy Clin Immunol 117(3):642\u2013648","journal-title":"J Allergy Clin Immunol"},{"key":"342_CR17","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/978-3-319-42499-6_24","volume-title":"Molecular Allergy Diagnostics","author":"S. Kespohl","year":"2017","unstructured":"Kespohl S, Raulf M (2017) Mold allergens and their importance in molecular allergy diagnosis. In: Kleine-Tebbe J, Jakob T (eds) Molecular allergy diagnostics. Springer International Publishing, Switzerland, pp 445\u2013458"},{"issue":"11","key":"342_CR18","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1111\/cea.12186","volume":"43","author":"S Kespohl","year":"2013","unstructured":"Kespohl S, Maryska S, Zahradnik E, Sander I, Bruening T, Raulf-Heimsoth M (2013) Biochemical and immunological analysis of mold skin prick test solution: current status of standardization. Clin Exp Allergy 43(11):1286\u20131296","journal-title":"Clin Exp Allergy"},{"issue":"7","key":"342_CR19","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1111\/cea.12733","volume":"46","author":"S Kespohl","year":"2016","unstructured":"Kespohl S, Maryska S, B\u00fcnger J, Hagemeyer O, Jakob T, Joest M, Knecht R, Koschel D, Kotschy-Lang N, Merget R, M\u00fclleneisen NK, Rabe U, R\u00f6seler S, Sander I, Stollewerk D, Straube H, Ulmer HM, van Kampen V, Walusiak-Skorupa J, Wiszniewska M, Wurpts G, Br\u00fcning T, Raulf M (2016) How to diagnose mold allergy? Comparison of skin prick tests with specific IgE results. Clin Exp Allergy 46(7):981\u2013991","journal-title":"Clin Exp Allergy"},{"key":"342_CR20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s40629-015-0067-z","volume":"24","author":"J Kleine-Tebbe","year":"2015","unstructured":"Kleine-Tebbe J, Jakob T (2015) Molecular allergy diagnostics using IgE singleplex determinations: methodological and practical considerations for use in clinical routine. Allergo J Int 24:185\u2013197","journal-title":"Allergo J Int"},{"key":"342_CR21","doi-asserted-by":"crossref","unstructured":"Kleine-Tebbe J, Jakob T (2017) Molecular allergy diagnostics. Innovation for a better patient management. Springer International Publishing, Switzerland","DOI":"10.1007\/978-3-319-42499-6"},{"issue":"3","key":"342_CR22","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s40629-015-0051-7","volume":"24","author":"L Klimek","year":"2015","unstructured":"Klimek L, Werfel T, Vogelberg C, Jung K (2015) Authorised allergen products for intracutaneous testing may no longer be available in Germany: allergy textbooks have to be re-written. Allergo J Int 24(3):84\u201393","journal-title":"Allergo J Int"},{"key":"342_CR23","doi-asserted-by":"publisher","first-page":"843763","DOI":"10.1155\/2011\/843763","volume":"2011","author":"AP Knutsen","year":"2011","unstructured":"Knutsen AP, Slavin RG (2011) Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis. Clin Dev Immunol 2011:843763","journal-title":"Clin Dev Immunol"},{"issue":"2","key":"342_CR24","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jaci.2011.12.970","volume":"129","author":"AP Knutsen","year":"2012","unstructured":"Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs A, Greenberger PA, Kariuki B, Kita H, Kurup VP, Moss RB, Niven RM, Pashley CH, Slavin RG, Vijay HM, Wardlaw AJ (2012) Fungi and allergic lower respiratory tract diseases. J Allergy Clin Immunol 129(2):280\u2013291","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"342_CR25","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1046\/j.1365-2222.2000.00837.x","volume":"30","author":"VP Kurup","year":"2000","unstructured":"Kurup VP, Banerjee B, Hemmann S, Greenberger PA, Blaser K, Crameri R (2000) Selected recombinant Aspergillus fumigatus allergens bind specifically to IgE in ABPA. Clin Exp Allergy 30(7):988\u2013993","journal-title":"Clin Exp Allergy"},{"issue":"11","key":"342_CR26","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1111\/j.1365-2222.2009.03339.x","volume":"39","author":"BR O\u2019Driscoll","year":"2009","unstructured":"O\u2019Driscoll BR, Powell G, Chew F, Niven RM, Miles JF, Vyas A, Denning DW (2009) Comparison of skin prick tests with specific serum immunoglobulin E in the diagnosis of fungal sensitization in patients with severe asthma. Clin Exp Allergy 39(11):1677\u20131683","journal-title":"Clin Exp Allergy"},{"issue":"6","key":"342_CR27","doi-asserted-by":"publisher","first-page":"344","DOI":"10.18176\/jiaci.0122","volume":"26","author":"EM Rick","year":"2016","unstructured":"Rick EM, Woolnough K, Pashley CH, Wardlaw AJ (2016) Allergic fungal airway disease. J Investig Allergol Clin Immunol 26(6):344\u2013354","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"6","key":"342_CR28","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/jes.2009.27","volume":"20","author":"PF Rosenbaum","year":"2010","unstructured":"Rosenbaum PF, Crawford JA, Anagnost SE, Wang CJK, Hunt A, Anbar RD, Hargrave TM, Hall EG, Liu CC, Abraham JL (2010) Indoor airborne fungi and wheeze in the first year of life among a cohort of infants at risk for asthma. J Expo Sci Environ Epidemiol 20(6):503\u2013515","journal-title":"J Expo Sci Environ Epidemiol"},{"issue":"4","key":"342_CR29","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.jaci.2006.07.037","volume":"118","author":"PM Salo","year":"2006","unstructured":"Salo PM, Arbes SJ, Sever M, Jaramillo R, Cohn RD, London SJ, Zeldin DC (2006) Exposure to Alternaria alternata in US homes is associated with asthma symptoms. J Allergy Clin Immunol 118(4):892\u2013898","journal-title":"J Allergy Clin Immunol"},{"key":"342_CR30","unstructured":"Szewzyk R, Becker K, H\u00fcnken A, Pick-Fu\u00df H, Kolossa-Gehring M (2011) Kinder-Umwelt-Survey (KUS) 2003\/06 Sensibilisierung gegen\u00fcber Innenraum Schimmelpilzen. In: Schriftreihe Umwelt & Gesundheit im Auftrag des Umweltbundesamt. \n                    http:\/\/www.uba.de\/uba-info-medien\/4176.html\n                    \n                  . Accessed on 20 Dec 2018"},{"issue":"12","key":"342_CR31","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1046\/j.1365-2222.2001.00745.x","volume":"31","author":"LD Vailes","year":"2001","unstructured":"Vailes LD, Perzanowski MS, Wheatley LM, Platts-Mills TA, Chapman MD (2001) IgE and IgG antibody responses to recombinant Alt a 1 as a marker of sensitization to Alternaria in asthma and atopic dermatitis. Clin Exp Allergy 31(12):1891\u20131895","journal-title":"Clin Exp Allergy"},{"issue":"5","key":"342_CR32","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/all.12116","volume":"68","author":"V Kampen van","year":"2013","unstructured":"van Kampen V, de Blay F, Folletti I, Kobierski P, Moscato G, Olivieri M, Quirce S, Sastre J, Walusiak-Skorupa J, Kotschy-Lang N, M\u00fcsken H, Mahler V, Schliemann S, Ochmann U, S\u00fcltz J, Worm M, Sander I, Zahradnik E, Br\u00fcning T, Merget R, Raulf-Heimsoth M (2013) Evaluation of commercial skin prick test solutions for selected occupational allergens. Allergy 68(5):651\u2013658","journal-title":"Allergy"},{"issue":"3","key":"342_CR33","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1159\/000063624","volume":"69","author":"M Zureik","year":"2002","unstructured":"Zureik M, Orehek J (2002) Diagnosis and severity of asthma in the elderly: results of a large survey in 1485 asthmatics recruited by lung specialists. Respiration 69(3):223\u2013228","journal-title":"Respiration"},{"issue":"7361","key":"342_CR34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/bmj.325.7361.411","volume":"325","author":"M Zureik","year":"2002","unstructured":"Zureik M, Neukirch C, Leynaert B, Liard R, Bousquet L, Neukirch F, European Community Respiratory Health Survey (2002) Sensitisation to airborne molds and severity of asthma: cross sectional study from European Community respiratory health survey. BMJ 325(7361):11\u2013414","journal-title":"BMJ"}],"container-title":["Advances in Experimental Medicine and Biology","Medical Science and Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2019_342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T01:07:22Z","timestamp":1561165642000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/5584_2019_342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030190583","9783030190590"],"references-count":34,"URL":"https:\/\/doi.org\/10.1007\/5584_2019_342","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"20 February 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}