{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:15:08Z","timestamp":1783422908309,"version":"3.54.6"},"publisher-location":"Cham","reference-count":133,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030219154","type":"print"},{"value":"9783030219161","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/5584_2019_364","type":"book-chapter","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T03:02:44Z","timestamp":1555988564000},"page":"151-172","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Host Genetic Polymorphisms in Helicobacter pylori Mediated Disease Outcome"],"prefix":"10.1007","author":[{"given":"Marguerite","family":"Clyne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"issue":"20","key":"364_CR1","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.3748\/wjg.v19.i20.3043","volume":"19","author":"MC Alvarez","year":"2013","unstructured":"Alvarez MC, Santos JC, Maniezzo N, Ladeira MS, da Silva AL, Scaletsky IC, Pedrazzoli J Jr, Ribeiro ML (2013) MGMT and MLH1 methylation in Helicobacter pylori -infected children and adults. World J Gastroenterol 19(20):3043\u20133051. https:\/\/doi.org\/10.3748\/wjg.v19.i20.3043","journal-title":"World J Gastroenterol"},{"issue":"26","key":"364_CR2","doi-asserted-by":"publisher","first-page":"9247","DOI":"10.1073\/pnas.0502040102","volume":"102","author":"E Andersen-Nissen","year":"2005","unstructured":"Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, Aderem A (2005) Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A 102(26):9247\u20139252. https:\/\/doi.org\/10.1073\/pnas.0502040102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"364_CR3","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1136\/gut.2005.072942","volume":"55","author":"T Ando","year":"2006","unstructured":"Ando T, El-Omar EM, Goto Y, Nobata K, Watanabe O, Maeda O, Ishiguro K, Minami M, Hamajima N, Goto H (2006) Interleukin 1B proinflammatory genotypes protect against gastro-oesophageal reflux disease through induction of corpus atrophy. Gut 55(2):158\u2013164. https:\/\/doi.org\/10.1136\/gut.2005.072942","journal-title":"Gut"},{"issue":"5","key":"364_CR4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1093\/aje\/kwm344","volume":"167","author":"S Boccia","year":"2008","unstructured":"Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, Fang JY, Gao CM, Gotze T, Graziano F, Lacasana-Navarro M, Lin D, Lopez-Carrillo L, Qiao YL, Shen H, Stolzenberg-Solomon R, Takezaki T, Weng YR, Zhang FF, van Duijn CM, Boffetta P, Taioli E (2008) Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol 167(5):505\u2013516. https:\/\/doi.org\/10.1093\/aje\/kwm344","journal-title":"Am J Epidemiol"},{"issue":"3","key":"364_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/hel.12118","volume":"19","author":"P Bontems","year":"2014","unstructured":"Bontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F, Cadranel S (2014) NF-kappaB activation and severity of gastritis in Helicobacter pylori -infected children and adults. Helicobacter 19(3):157\u2013167. https:\/\/doi.org\/10.1111\/hel.12118","journal-title":"Helicobacter"},{"issue":"10","key":"364_CR6","doi-asserted-by":"publisher","first-page":"5713","DOI":"10.7314\/APJCP.2013.14.10.5713","volume":"14","author":"XY Cao","year":"2013","unstructured":"Cao XY, Jia ZF, Cao DH, Kong F, Jin MS, Suo J, Jiang J (2013) DNMT3a rs1550117 polymorphism association with increased risk of Helicobacter pylori infection. Asian Pac J Cancer Prev 14(10):5713\u20135718","journal-title":"Asian Pac J Cancer Prev"},{"issue":"6","key":"364_CR7","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1093\/ije\/dyn145","volume":"37","author":"G Capella","year":"2008","unstructured":"Capella G, Pera G, Sala N, Agudo A, Rico F, Del Giudicce G, Plebani M, Palli D, Boeing H, Bueno-de-Mesquita HB, Carneiro F, Berrino F, Vineis P, Tumino R, Panico S, Berglund G, Siman H, Nyren O, Hallmans G, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quiros JR, Allen N, Key T, Bingham S, Caldas C, Linseisen J, Nagel G, Overvad K, Tjonneland A, Boshuizen HC, Peeters PH, Numans ME, Clavel-Chapelon F, Trichopoulou A, Lund E, Jenab M, Kaaks R, Riboli E, Gonzalez CA (2008) DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. Int J Epidemiol 37(6):1316\u20131325. https:\/\/doi.org\/10.1093\/ije\/dyn145","journal-title":"Int J Epidemiol"},{"issue":"4","key":"364_CR8","doi-asserted-by":"publisher","first-page":"e60327","DOI":"10.1371\/journal.pone.0060327","volume":"8","author":"N Castano-Rodriguez","year":"2013","unstructured":"Castano-Rodriguez N, Kaakoush NO, Goh KL, Fock KM, Mitchell HM (2013) The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta-analysis. PLoS One 8(4):e60327. https:\/\/doi.org\/10.1371\/journal.pone.0060327","journal-title":"PLoS One"},{"issue":"6","key":"364_CR9","doi-asserted-by":"publisher","first-page":"e98899","DOI":"10.1371\/journal.pone.0098899","volume":"9","author":"N Castano-Rodriguez","year":"2014","unstructured":"Castano-Rodriguez N, Kaakoush NO, Goh KL, Fock KM, Mitchell HM (2014a) The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses. PLoS One 9(6):e98899. https:\/\/doi.org\/10.1371\/journal.pone.0098899","journal-title":"PLoS One"},{"issue":"8","key":"364_CR10","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.humimm.2014.06.001","volume":"75","author":"N Castano-Rodriguez","year":"2014","unstructured":"Castano-Rodriguez N, Kaakoush NO, Pardo AL, Goh KL, Fock KM, Mitchell HM (2014b) Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer. Hum Immunol 75(8):808\u2013815. https:\/\/doi.org\/10.1016\/j.humimm.2014.06.001","journal-title":"Hum Immunol"},{"issue":"5","key":"364_CR11","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/hel.12211","volume":"20","author":"N Castano-Rodriguez","year":"2015","unstructured":"Castano-Rodriguez N, Kaakoush NO, Goh KL, Fock KM, Mitchell HM (2015) Autophagy in Helicobacter pylori infection and related gastric cancer. Helicobacter 20(5):353\u2013369. https:\/\/doi.org\/10.1111\/hel.12211","journal-title":"Helicobacter"},{"issue":"7","key":"364_CR12","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/ni945","volume":"4","author":"M Chamaillard","year":"2003","unstructured":"Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y, Kawasaki A, Fukase K, Kusumoto S, Valvano MA, Foster SJ, Mak TW, Nunez G, Inohara N (2003) An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 4(7):702\u2013707. https:\/\/doi.org\/10.1038\/ni945","journal-title":"Nat Immunol"},{"issue":"9","key":"364_CR13","doi-asserted-by":"publisher","first-page":"e97","DOI":"10.1371\/journal.ppat.0020097","volume":"2","author":"C Chaput","year":"2006","unstructured":"Chaput C, Ecobichon C, Cayet N, Girardin SE, Werts C, Guadagnini S, Prevost MC, Mengin-Lecreulx D, Labigne A, Boneca IG (2006) Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape. PLoS Pathog 2(9):e97. https:\/\/doi.org\/10.1371\/journal.ppat.0020097","journal-title":"PLoS Pathog"},{"issue":"7","key":"364_CR14","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1053\/j.gastro.2014.02.005","volume":"146","author":"R Chaturvedi","year":"2014","unstructured":"Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA Jr, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM Jr, Wilson KT (2014) Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology 146(7):1739\u20131751 e1714. https:\/\/doi.org\/10.1053\/j.gastro.2014.02.005","journal-title":"Gastroenterology"},{"issue":"2","key":"364_CR15","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s11033-011-0863-6","volume":"39","author":"B Chen","year":"2012","unstructured":"Chen B, Zhou Y, Yang P, Wu XT (2012) Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis. Mol Biol Rep 39(2):1305\u20131313. https:\/\/doi.org\/10.1007\/s11033-011-0863-6","journal-title":"Mol Biol Rep"},{"key":"364_CR16","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.12659\/MSM.895771","volume":"22","author":"B Chen","year":"2016","unstructured":"Chen B, Luo MX, Zhou X, Lv Y, Su GQ (2016) Correlation between interleukin-1beta-511 C\/T polymorphism and gastric cancer in chinese populations: a Meta-Analysis. Med Sci Monit 22:1742\u20131750","journal-title":"Med Sci Monit"},{"issue":"8","key":"364_CR17","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1111\/j.1440-1746.2010.06310.x","volume":"25","author":"HH Cheng","year":"2010","unstructured":"Cheng HH, Chang CS, Wang HJ, Wang WC (2010) Interleukin-1beta and \u221210 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients. J Gastroenterol Hepatol 25(8):1443\u20131451. https:\/\/doi.org\/10.1111\/j.1440-1746.2010.06310.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"12","key":"364_CR18","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1136\/gut.32.12.1473","volume":"32","author":"JE Crabtree","year":"1991","unstructured":"Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI (1991a) Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 32(12):1473\u20131477","journal-title":"Gut"},{"issue":"9","key":"364_CR19","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1007\/BF01307520","volume":"36","author":"JE Crabtree","year":"1991","unstructured":"Crabtree JE, Shallcross TM, Wyatt JI, Taylor JD, Heatley RV, Rathbone BJ, Losowsky MS (1991b) Mucosal humoral immune response to Helicobacter pylori in patients with duodenitis. Dig Dis Sci 36(9):1266\u20131273","journal-title":"Dig Dis Sci"},{"issue":"2","key":"364_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.gtc.2013.01.003","volume":"42","author":"C Martel de","year":"2013","unstructured":"de Martel C, Forman D, Plummer M (2013) Gastric cancer: epidemiology and risk factors. Gastroenterol Clin N Am 42(2):219\u2013240. https:\/\/doi.org\/10.1016\/j.gtc.2013.01.003","journal-title":"Gastroenterol Clin N Am"},{"issue":"5","key":"364_CR21","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1136\/gutjnl-2011-301839","volume":"61","author":"N Deng","year":"2012","unstructured":"Deng N, Goh LK, Wang H, Das K, Tao J, Tan IB, Zhang S, Lee M, Wu J, Lim KH, Lei Z, Goh G, Lim QY, Tan AL, Sin Poh DY, Riahi S, Bell S, Shi MM, Linnartz R, Zhu F, Yeoh KG, Toh HC, Yong WP, Cheong HC, Rha SY, Boussioutas A, Grabsch H, Rozen S, Tan P (2012) A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut 61(5):673\u2013684. https:\/\/doi.org\/10.1136\/gutjnl-2011-301839","journal-title":"Gut"},{"issue":"6","key":"364_CR22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1056\/NEJM199002083220603","volume":"322","author":"B Drumm","year":"1990","unstructured":"Drumm B, Perez-Perez GI, Blaser MJ, Sherman PM (1990) Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med 322(6):359\u2013363. https:\/\/doi.org\/10.1056\/NEJM199002083220603","journal-title":"N Engl J Med"},{"issue":"4","key":"364_CR23","doi-asserted-by":"publisher","first-page":"13236","DOI":"10.4238\/2015.October.26.20","volume":"14","author":"Y Du","year":"2015","unstructured":"Du Y, Gao L, Zhang K, Wang J (2015) Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis. Genet Mol Res 14(4):13236\u201313246. https:\/\/doi.org\/10.4238\/2015.October.26.20","journal-title":"Genet Mol Res"},{"issue":"6776","key":"364_CR24","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/35006081","volume":"404","author":"EM El-Omar","year":"2000","unstructured":"El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF Jr, Rabkin CS (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404(6776):398\u2013402. https:\/\/doi.org\/10.1038\/35006081","journal-title":"Nature"},{"issue":"5","key":"364_CR26","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/S0016-5085(03)00157-4","volume":"124","author":"EM El-Omar","year":"2003","unstructured":"El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, Fraumeni JF Jr, Chow WH (2003) Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 124(5):1193\u20131201","journal-title":"Gastroenterology"},{"issue":"3","key":"364_CR27","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ni.1703","volume":"10","author":"L Franchi","year":"2009","unstructured":"Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G (2009) The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 10(3):241\u2013247. https:\/\/doi.org\/10.1038\/ni.1703","journal-title":"Nat Immunol"},{"issue":"14","key":"364_CR28","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1002\/1873-3468.12252","volume":"590","author":"A Fulgione","year":"2016","unstructured":"Fulgione A, Di Matteo A, Contaldi F, Manco R, Ianniello F, Incerti G, De Seta M, Esposito N, Crasto A, Iannelli D, Capparelli R (2016) Epistatic interaction between MyD88 and TIRAP against Helicobacter pylori. FEBS Lett 590(14):2127\u20132137. https:\/\/doi.org\/10.1002\/1873-3468.12252","journal-title":"FEBS Lett"},{"issue":"6","key":"364_CR29","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1002\/ijc.29500","volume":"137","author":"MA Garcia-Gonzalez","year":"2015","unstructured":"Garcia-Gonzalez MA, Bujanda L, Quintero E, Santolaria S, Benito R, Strunk M, Sopena F, Thomson C, Perez-Aisa A, Nicolas-Perez D, Hijona E, Carrera-Lasfuentes P, Piazuelo E, Jimenez P, Espinel J, Campo R, Manzano M, Geijo F, Pellise M, Zaballa M, Gonzalez-Huix F, Espinos J, Tito L, Barranco L, Pazo-Cid R, Lanas A (2015) Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease. Int J Cancer 137(6):1362\u20131373. https:\/\/doi.org\/10.1002\/ijc.29500","journal-title":"Int J Cancer"},{"issue":"2","key":"364_CR30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/ijc.20718","volume":"114","author":"E Garza-Gonzalez","year":"2005","unstructured":"Garza-Gonzalez E, Bosques-Padilla FJ, El-Omar E, Hold G, Tijerina-Menchaca R, Maldonado-Garza HJ, Perez-Perez GI (2005) Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico. Int J Cancer 114(2):237\u2013241. https:\/\/doi.org\/10.1002\/ijc.20718","journal-title":"Int J Cancer"},{"issue":"2","key":"364_CR31","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10238-004-0043-2","volume":"4","author":"LL Gatti","year":"2004","unstructured":"Gatti LL, Burbano RR, de Assumpcao PP, Smith Mde A, Payao SL (2004) Interleukin-1beta polymorphisms, Helicobacter pylori infection in individuals from Northern Brazil with gastric adenocarcinoma. Clin Exp Med 4(2):93\u201398","journal-title":"Clin Exp Med"},{"issue":"10","key":"364_CR32","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1038\/nm.2028","volume":"15","author":"F Ghiringhelli","year":"2009","unstructured":"Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L (2009) Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 15(10):1170\u20131178. https:\/\/doi.org\/10.1038\/nm.2028","journal-title":"Nat Med"},{"issue":"5625","key":"364_CR33","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1126\/science.1084677","volume":"300","author":"SE Girardin","year":"2003","unstructured":"Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jehanno M, Viala J, Tedin K, Taha MK, Labigne A, Zahringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ (2003a) Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 300(5625):1584\u20131587. https:\/\/doi.org\/10.1126\/science.1084677","journal-title":"Science"},{"issue":"11","key":"364_CR34","doi-asserted-by":"publisher","first-page":"8869","DOI":"10.1074\/jbc.C200651200","volume":"278","author":"SE Girardin","year":"2003","unstructured":"Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ (2003b) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278(11):8869\u20138872. https:\/\/doi.org\/10.1074\/jbc.C200651200","journal-title":"J Biol Chem"},{"issue":"1","key":"364_CR35","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1074\/jbc.M307858200","volume":"279","author":"AP Gobert","year":"2004","unstructured":"Gobert AP, Bambou JC, Werts C, Balloy V, Chignard M, Moran AP, Ferrero RL (2004) Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism. J Biol Chem 279(1):245\u2013250. https:\/\/doi.org\/10.1074\/jbc.M307858200","journal-title":"J Biol Chem"},{"issue":"6","key":"364_CR36","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1080\/08820139.2017.1319381","volume":"46","author":"V Goda","year":"2017","unstructured":"Goda V, Jayaraman M, Loganathan R, Nazeer M, Ali M, Karunakaran P, Devaraju P (2017) TLR5 polymorphisms rs2072493, rs5744174, and rs5744168 are not genetic risk factors for chronic Helicobacter pylori infection in Indian tamils. Immunol Investig 46(6):537\u2013543. https:\/\/doi.org\/10.1080\/08820139.2017.1319381","journal-title":"Immunol Investig"},{"issue":"3","key":"364_CR37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.immuni.2012.01.018","volume":"36","author":"O Gross","year":"2012","unstructured":"Gross O, Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, Tschopp J (2012) Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36(3):388\u2013400. https:\/\/doi.org\/10.1016\/j.immuni.2012.01.018","journal-title":"Immunity"},{"issue":"2","key":"364_CR38","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/ng1954","volume":"39","author":"J Hampe","year":"2007","unstructured":"Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Gunther S, Prescott NJ, Onnie CM, Hasler R, Sipos B, Folsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39(2):207\u2013211. https:\/\/doi.org\/10.1038\/ng1954","journal-title":"Nat Genet"},{"issue":"2","key":"364_CR39","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1053\/j.gastro.2007.11.006","volume":"134","author":"PR Harris","year":"2008","unstructured":"Harris PR, Wright SW, Serrano C, Riera F, Duarte I, Torres J, Pena A, Rollan A, Viviani P, Guiraldes E, Schmitz JM, Lorenz RG, Novak L, Smythies LE, Smith PD (2008) Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 134(2):491\u2013499. https:\/\/doi.org\/10.1053\/j.gastro.2007.11.006","journal-title":"Gastroenterology"},{"issue":"6","key":"364_CR40","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1097\/MPG.0000000000000500","volume":"59","author":"C Hernandez","year":"2014","unstructured":"Hernandez C, Serrano C, Einisman H, Villagran A, Pena A, Duarte I, Torres J, Riera F, Harris PR (2014) Peptic ulcer disease in Helicobacter pylori -infected children: clinical findings and mucosal immune response. J Pediatr Gastroenterol Nutr 59(6):773\u2013778. https:\/\/doi.org\/10.1097\/MPG.0000000000000500","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"364_CR41","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/j.1523-5378.2007.00481.x","volume":"12","author":"P Hofner","year":"2007","unstructured":"Hofner P, Gyulai Z, Kiss ZF, Tiszai A, Tiszlavicz L, Toth G, Szoke D, Molnar B, Lonovics J, Tulassay Z, Mandi Y (2007) Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori -induced duodenal ulcer and gastritis. Helicobacter 12(2):124\u2013131. https:\/\/doi.org\/10.1111\/j.1523-5378.2007.00481.x","journal-title":"Helicobacter"},{"issue":"4","key":"364_CR42","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1136\/gut.33.4.429","volume":"33","author":"C Holcombe","year":"1992","unstructured":"Holcombe C (1992) Helicobacter pylori: the African enigma. Gut 33(4):429\u2013431","journal-title":"Gut"},{"issue":"3","key":"364_CR43","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1053\/j.gastro.2006.12.026","volume":"132","author":"GL Hold","year":"2007","unstructured":"Hold GL, Rabkin CS, Chow WH, Smith MG, Gammon MD, Risch HA, Vaughan TL, McColl KE, Lissowska J, Zatonski W, Schoenberg JB, Blot WJ, Mowat NA, Fraumeni JF Jr, El-Omar EM (2007) A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology 132(3):905\u2013912. https:\/\/doi.org\/10.1053\/j.gastro.2006.12.026","journal-title":"Gastroenterology"},{"key":"364_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/oxfordjournals.epirev.a036288","volume":"8","author":"CP Howson","year":"1986","unstructured":"Howson CP, Hiyama T, Wynder EL (1986) The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev 8:1\u201327","journal-title":"Epidemiol Rev"},{"issue":"8","key":"364_CR45","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.1074\/jbc.C200673200","volume":"278","author":"N Inohara","year":"2003","unstructured":"Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, Nunez G (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn\u2019s disease. J Biol Chem 278(8):5509\u20135512. https:\/\/doi.org\/10.1074\/jbc.C200673200","journal-title":"J Biol Chem"},{"issue":"9","key":"364_CR46","doi-asserted-by":"publisher","first-page":"e46058","DOI":"10.1371\/journal.pone.0046058","volume":"7","author":"J Jiang","year":"2012","unstructured":"Jiang J, Jia Z, Cao D, Jin MS, Kong F, Suo J, Cao X (2012) Polymorphisms of the DNA methyltransferase 1 associated with reduced risks of Helicobacter pylori infection and increased risks of gastric atrophy. PLoS One 7(9):e46058. https:\/\/doi.org\/10.1371\/journal.pone.0046058","journal-title":"PLoS One"},{"issue":"12","key":"364_CR47","doi-asserted-by":"publisher","first-page":"9525","DOI":"10.1007\/s13277-015-3703-9","volume":"36","author":"JJ Jing","year":"2015","unstructured":"Jing JJ, Sun LP, Xu Q, Yuan Y (2015) Effect of ERCC8 tagSNPs and their association with H. pylori infection, smoking, and alcohol consumption on gastric cancer and atrophic gastritis risk. Tumour Biol 36(12):9525\u20139535. https:\/\/doi.org\/10.1007\/s13277-015-3703-9","journal-title":"Tumour Biol"},{"issue":"4","key":"364_CR48","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.immuni.2007.10.002","volume":"27","author":"TD Kanneganti","year":"2007","unstructured":"Kanneganti TD, Lamkanfi M, Nunez G (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27(4):549\u2013559. https:\/\/doi.org\/10.1016\/j.immuni.2007.10.002","journal-title":"Immunity"},{"issue":"10","key":"364_CR49","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1002\/eji.201243281","volume":"43","author":"DJ Kim","year":"2013","unstructured":"Kim DJ, Park JH, Franchi L, Backert S, Nunez G (2013a) The Cag pathogenicity island and interaction between TLR2\/NOD2 and NLRP3 regulate IL-1beta production in Helicobacter pylori infected dendritic cells. Eur J Immunol 43(10):2650\u20132658. https:\/\/doi.org\/10.1002\/eji.201243281","journal-title":"Eur J Immunol"},{"issue":"2","key":"364_CR50","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/hel.12020","volume":"18","author":"EJ Kim","year":"2013","unstructured":"Kim EJ, Lee JR, Chung WC, Jung SH, Sung HJ, Lee YW, Oh YS, Kim SB, Paik CN, Lee KM, Noh SJ (2013b) Association between genetic polymorphisms of NOD 1 and Helicobacter pylori -induced gastric mucosal inflammation in healthy Korean population. Helicobacter 18(2):143\u2013150. https:\/\/doi.org\/10.1111\/hel.12020","journal-title":"Helicobacter"},{"issue":"1","key":"364_CR51","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1440-1746.2012.07274.x","volume":"28","author":"JJ Kim","year":"2013","unstructured":"Kim JJ, Kim N, Hwang S, Kim JY, Kim JY, Choi YJ, Lee DH, Jung HC (2013c) Relationship of interleukin-1beta levels and gastroesophageal reflux disease in Korea. J Gastroenterol Hepatol 28(1):90\u201398. https:\/\/doi.org\/10.1111\/j.1440-1746.2012.07274.x","journal-title":"J Gastroenterol Hepatol"},{"key":"364_CR52","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1172\/JCI79337","volume":"125","author":"KN Koch","year":"2015","unstructured":"Koch KN, Hartung ML, Urban S, Kyburz A, Bahlmann AS, Lind J, Backert S, Taube C, M\u00fcller A (2015) Helicobacter urease-induced activation of the TLR2\/NLRP3\/IL-18 axis protects against asthma. J Clin Invest 125:3297\u20133302. https:\/\/doi.org\/10.1172\/JCI79337","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"364_CR53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1046\/j.1365-2036.1999.00002.x","volume":"13","author":"EJ Kuipers","year":"1999","unstructured":"Kuipers EJ (1999) Review article: exploring the link between Helicobacter pylori and gastric cancer. Aliment Pharmacol Ther 13(Suppl 1):3\u201311","journal-title":"Aliment Pharmacol Ther"},{"issue":"5","key":"364_CR54","doi-asserted-by":"publisher","first-page":"e19614","DOI":"10.1371\/journal.pone.0019614","volume":"6","author":"S Kumar Pachathundikandi","year":"2011","unstructured":"Kumar Pachathundikandi S, Brandt S, Madassery J, Backert S (2011) Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-alpha. PLoS One 6(5):e19614. https:\/\/doi.org\/10.1371\/journal.pone.0019614","journal-title":"PLoS One"},{"issue":"3","key":"364_CR55","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.bbrc.2009.07.033","volume":"387","author":"S Kumar","year":"2009","unstructured":"Kumar S, Kumar A, Dixit VK (2009) Evidences showing association of interleukin-1B polymorphisms with increased risk of gastric cancer in an Indian population. Biochem Biophys Res Commun 387(3):456\u2013460. https:\/\/doi.org\/10.1016\/j.bbrc.2009.07.033","journal-title":"Biochem Biophys Res Commun"},{"key":"364_CR56","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/1471-2350-12-112","volume":"12","author":"J Kupcinskas","year":"2011","unstructured":"Kupcinskas J, Wex T, Bornschein J, Selgrad M, Leja M, Juozaityte E, Kiudelis G, Jonaitis L, Malfertheiner P (2011) Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS\/FASL and the presence of Helicobacter pylori -induced premalignant gastric lesions and gastric cancer in Caucasians. BMC Med Genet 12:112. https:\/\/doi.org\/10.1186\/1471-2350-12-112","journal-title":"BMC Med Genet"},{"issue":"4","key":"364_CR57","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1128\/IAI.70.4.2108-2120.2002","volume":"70","author":"T Kwok","year":"2002","unstructured":"Kwok T, Backert S, Schwarz H, Berger J, Meyer TF (2002) Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism. Infect Immun 70(4):2108\u20132120","journal-title":"Infect Immun"},{"issue":"6","key":"364_CR58","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/hel.12067","volume":"18","author":"H Lagunes-Servin","year":"2013","unstructured":"Lagunes-Servin H, Torres J, Maldonado-Bernal C, Perez-Rodriguez M, Huerta-Yepez S, Madrazo de la Garza A, Munoz-Perez L, Flores-Luna L, Ramon-Garcia G, Camorlinga-Ponce M (2013) Toll-like receptors and cytokines are upregulated during Helicobacter pylori infection in children. Helicobacter 18(6):423\u2013432. https:\/\/doi.org\/10.1111\/hel.12067","journal-title":"Helicobacter"},{"issue":"10094","key":"364_CR59","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0140-6736(16)32404-7","volume":"390","author":"A Lanas","year":"2017","unstructured":"Lanas A, Chan FK (2017) Peptic ulcer disease. Lancet 390(10094):613\u2013624. https:\/\/doi.org\/10.1016\/S0140-6736(16)32404-7","journal-title":"Lancet"},{"issue":"8","key":"364_CR60","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/sj.gene.6363798","volume":"2","author":"A Lanas","year":"2001","unstructured":"Lanas A, Garcia-Gonzalez MA, Santolaria S, Crusius JB, Serrano MT, Benito R, Pena AS (2001) TNF and LTA gene polymorphisms reveal different risk in gastric and duodenal ulcer patients. Genes Immun 2(8):415\u2013421. https:\/\/doi.org\/10.1038\/sj.gene.6363798","journal-title":"Genes Immun"},{"issue":"8","key":"364_CR61","doi-asserted-by":"publisher","first-page":"E273","DOI":"10.1111\/j.1469-0691.2012.03849.x","volume":"18","author":"S Lario","year":"2012","unstructured":"Lario S, Ramirez-Lazaro MJ, Aransay AM, Lozano JJ, Montserrat A, Casalots A, Junquera F, Alvarez J, Segura F, Campo R, Calvet X (2012) microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population. Clin Microbiol Infect 18(8):E273\u2013E282. https:\/\/doi.org\/10.1111\/j.1469-0691.2012.03849.x","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"364_CR62","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1053\/j.gastro.2016.01.028","volume":"150","author":"YC Lee","year":"2016","unstructured":"Lee YC, Chiang TH, Chou CK, Tu YK, Liao WC, Wu MS, Graham DY (2016) Association between Helicobacter pylori eradication and gastric cancer incidence: a systematic review and meta-analysis. Gastroenterology 150(5):1113\u20131124 e1115. https:\/\/doi.org\/10.1053\/j.gastro.2016.01.028","journal-title":"Gastroenterology"},{"issue":"7","key":"364_CR63","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1111\/apt.13550","volume":"43","author":"AH Leow","year":"2016","unstructured":"Leow AH, Lim YY, Liew WC, Goh KL (2016) Time trends in upper gastrointestinal diseases and Helicobacter pylori infection in a multiracial Asian population\u2013a 20-year experience over three time periods. Aliment Pharmacol Ther 43(7):831\u2013837. https:\/\/doi.org\/10.1111\/apt.13550","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"364_CR64","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1093\/carcin\/bgp018","volume":"30","author":"WQ Li","year":"2009","unstructured":"Li WQ, Zhang L, Ma JL, Zhang Y, Li JY, Pan KF, You WC (2009) Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population. Carcinogenesis 30(3):500\u2013505. https:\/\/doi.org\/10.1093\/carcin\/bgp018","journal-title":"Carcinogenesis"},{"issue":"5","key":"364_CR65","doi-asserted-by":"publisher","first-page":"e0124949","DOI":"10.1371\/journal.pone.0124949","volume":"10","author":"ZX Li","year":"2015","unstructured":"Li ZX, Wang YM, Tang FB, Zhang L, Zhang Y, Ma JL, Zhou T, You WC, Pan KF (2015) NOD1 and NOD2 genetic variants in association with risk of gastric cancer and its precursors in a Chinese population. PLoS One 10(5):e0124949. https:\/\/doi.org\/10.1371\/journal.pone.0124949","journal-title":"PLoS One"},{"issue":"2","key":"364_CR66","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1056\/NEJM200007133430201","volume":"343","author":"P Lichtenstein","year":"2000","unstructured":"Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K (2000) Environmental and heritable factors in the causation of cancer\u2013analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 343(2):78\u201385. https:\/\/doi.org\/10.1056\/NEJM200007133430201","journal-title":"N Engl J Med"},{"issue":"2","key":"364_CR67","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1053\/j.gastro.2010.11.001","volume":"140","author":"P Lochhead","year":"2011","unstructured":"Lochhead P, Frank B, Hold GL, Rabkin CS, Ng MT, Vaughan TL, Risch HA, Gammon MD, Lissowska J, Weck MN, Raum E, Muller H, Illig T, Klopp N, Dawson A, McColl KE, Brenner H, Chow WH, El-Omar EM (2011) Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals. Gastroenterology 140(2):435\u2013441. https:\/\/doi.org\/10.1053\/j.gastro.2010.11.001","journal-title":"Gastroenterology"},{"issue":"2","key":"364_CR68","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.humimm.2016.12.002","volume":"78","author":"R Loganathan","year":"2017","unstructured":"Loganathan R, Nazeer M, Goda V, Devaraju P, Ali M, Karunakaran P, Jayaraman M (2017) Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils. Hum Immunol 78(2):216\u2013220. https:\/\/doi.org\/10.1016\/j.humimm.2016.12.002","journal-title":"Hum Immunol"},{"issue":"4","key":"364_CR69","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1053\/gast.2001.28000","volume":"121","author":"JC Machado","year":"2001","unstructured":"Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, Amorim A, Seruca R, Caldas C, Carneiro F, Sobrinho-Simoes M (2001) Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 121(4):823\u2013829","journal-title":"Gastroenterology"},{"issue":"2","key":"364_CR70","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0016-5085(03)00899-0","volume":"125","author":"JC Machado","year":"2003","unstructured":"Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Castro Alves C, Campos ML, Van Doorn LJ, Caldas C, Seruca R, Carneiro F, Sobrinho-Simoes M (2003) A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 125(2):364\u2013371","journal-title":"Gastroenterology"},{"issue":"48","key":"364_CR71","doi-asserted-by":"publisher","first-page":"44856","DOI":"10.1074\/jbc.M105381200","volume":"276","author":"S Maeda","year":"2001","unstructured":"Maeda S, Akanuma M, Mitsuno Y, Hirata Y, Ogura K, Yoshida H, Shiratori Y, Omata M (2001) Distinct mechanism of Helicobacter pylori -mediated NF-kappa B activation between gastric cancer cells and monocytic cells. J Biol Chem 276(48):44856\u201344864. https:\/\/doi.org\/10.1074\/jbc.M105381200","journal-title":"J Biol Chem"},{"issue":"12","key":"364_CR72","doi-asserted-by":"publisher","first-page":"982","DOI":"10.7326\/0003-4819-120-12-199406150-00002","volume":"120","author":"HM Malaty","year":"1994","unstructured":"Malaty HM, Engstrand L, Pedersen NL, Graham DY (1994) Helicobacter pylori infection: genetic and environmental influences. A study of twins. Ann Intern Med 120(12):982\u2013986","journal-title":"Ann Intern Med"},{"issue":"30","key":"364_CR73","doi-asserted-by":"publisher","first-page":"e7612","DOI":"10.1097\/MD.0000000000007612","volume":"96","author":"MO Marginean","year":"2017","unstructured":"Marginean MO, Marginean CO, Melit LE, Voidazan S, Moldovan V, Banescu C (2017) The impact of host\u2019s genetic susceptibility on Helicobacter pylori infection in children. Medicine (Baltimore) 96(30):e7612. https:\/\/doi.org\/10.1097\/MD.0000000000007612","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"364_CR74","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1002\/ijc.24519","volume":"125","author":"K Matsuo","year":"2009","unstructured":"Matsuo K, Tajima K, Suzuki T, Kawase T, Watanabe M, Shitara K, Misawa K, Ito S, Sawaki A, Muro K, Nakamura T, Yamao K, Yamamura Y, Hamajima N, Hiraki A, Tanaka H (2009) Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese. Int J Cancer 125(8):1961\u20131964. https:\/\/doi.org\/10.1002\/ijc.24519","journal-title":"Int J Cancer"},{"issue":"17","key":"364_CR75","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMcp1001110","volume":"362","author":"KE McColl","year":"2010","unstructured":"McColl KE (2010) Clinical practice. Helicobacter pylori infection. N Engl J Med 362(17):1597\u20131604. https:\/\/doi.org\/10.1056\/NEJMcp1001110","journal-title":"N Engl J Med"},{"issue":"3","key":"364_CR76","first-page":"287","volume":"48","author":"KE McColl","year":"1997","unstructured":"McColl KE, El-Omar EM, Gillen D (1997) The role of H. pylori infection in the pathophysiology of duodenal ulcer disease. J Physiol Pharmacol 48(3):287\u2013295","journal-title":"J Physiol Pharmacol"},{"key":"364_CR77","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.cyto.2017.04.020","volume":"96","author":"JL Melchiades","year":"2017","unstructured":"Melchiades JL, Zabaglia LM, Sallas ML, Orcini WA, Chen E, Smith MAC, Payao SLM, Rasmussen LT (2017) Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori. Cytokine 96:203\u2013207. https:\/\/doi.org\/10.1016\/j.cyto.2017.04.020","journal-title":"Cytokine"},{"issue":"12","key":"364_CR78","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.3748\/wjg.15.1465","volume":"15","author":"HP Melo Barbosa","year":"2009","unstructured":"Melo Barbosa HP, Martins LC, Dos Santos SE, Demachki S, Assumpcao MB, Aragao CD, de Oliveira Corvelo TC (2009) Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population. World J Gastroenterol 15(12):1465\u20131471","journal-title":"World J Gastroenterol"},{"issue":"12","key":"364_CR79","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1586\/17474124.2015.1095089","volume":"9","author":"M Miftahussurur","year":"2015","unstructured":"Miftahussurur M, Yamaoka Y (2015) Helicobacter pylori virulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease. Expert Rev Gastroenterol Hepatol 9(12):1535\u20131547. https:\/\/doi.org\/10.1586\/17474124.2015.1095089","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"3","key":"364_CR80","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1053\/j.gastro.2007.01.049","volume":"132","author":"V Necchi","year":"2007","unstructured":"Necchi V, Candusso ME, Tava F, Luinetti O, Ventura U, Fiocca R, Ricci V, Solcia E (2007) Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori. Gastroenterology 132(3):1009\u20131023. https:\/\/doi.org\/10.1053\/j.gastro.2007.01.049","journal-title":"Gastroenterology"},{"issue":"6","key":"364_CR81","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00428-010-0996-3","volume":"457","author":"EH Neves Filho","year":"2010","unstructured":"Neves Filho EH, Alves MK, Lima VP, Rabenhorst SH (2010) MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection. Virchows Arch 457(6):627\u2013633. https:\/\/doi.org\/10.1007\/s00428-010-0996-3","journal-title":"Virchows Arch"},{"issue":"3","key":"364_CR82","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1128\/IAI.01226-09","volume":"78","author":"MT Ng","year":"2010","unstructured":"Ng MT, Van\u2019t Hof R, Crockett JC, Hope ME, Berry S, Thomson J, McLean MH, McColl KE, El-Omar EM, Hold GL (2010) Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T\/C polymorphism is associated with Helicobacter pylori -induced gastric disease. Infect Immun 78(3):1345\u20131352. https:\/\/doi.org\/10.1128\/IAI.01226-09","journal-title":"Infect Immun"},{"key":"364_CR83","doi-asserted-by":"publisher","first-page":"454","DOI":"10.4161\/gmic.27001","volume":"4","author":"SK Pachathundikandi","year":"2013","unstructured":"Pachathundikandi SK, Tegtmeyer N, Backert S (2013) Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells. Gut Microbes 4:454\u2013474. https:\/\/doi.org\/10.4161\/gmic.27001","journal-title":"Gut Microbes"},{"key":"364_CR84","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-3-319-41171-2_6","volume":"397","author":"SK Pachathundikandi","year":"2016","unstructured":"Pachathundikandi SK, M\u00fcller A, Backert S (2016) Inflammasome Activation by Helicobacter pylori and its implications for persistence and immunity. Curr Top Microbiol Immunol 397:117\u2013131. https:\/\/doi.org\/10.1007\/978-3-319-41171-2_6","journal-title":"Curr Top Microbiol Immunol"},{"issue":"1","key":"364_CR85","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11033-014-3748-7","volume":"42","author":"MJ Park","year":"2015","unstructured":"Park MJ, Hyun MH, Yang JP, Yoon JM, Park S (2015) Effects of the interleukin-1beta-511 C\/T gene polymorphism on the risk of gastric cancer in the context of the relationship between race and H. pylori infection: a meta-analysis of 20,000 subjects. Mol Biol Rep 42(1):119\u2013134. https:\/\/doi.org\/10.1007\/s11033-014-3748-7","journal-title":"Mol Biol Rep"},{"key":"364_CR86","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1478-811X-11-77","volume":"11","author":"G Posselt","year":"2013","unstructured":"Posselt G, Backert S, Wessler S (2013) The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Commun Signal 11:77. https:\/\/doi.org\/10.1186\/1478-811X-11-77","journal-title":"Cell Commun Signal"},{"issue":"5","key":"364_CR87","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1053\/j.gastro.2007.03.034","volume":"132","author":"NJ Prescott","year":"2007","unstructured":"Prescott NJ, Fisher SA, Franke A, Hampe J, Onnie CM, Soars D, Bagnall R, Mirza MM, Sanderson J, Forbes A, Mansfield JC, Lewis CM, Schreiber S, Mathew CG (2007) A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn\u2019s disease and is independent of CARD15 and IBD5. Gastroenterology 132(5):1665\u20131671. https:\/\/doi.org\/10.1053\/j.gastro.2007.03.034","journal-title":"Gastroenterology"},{"issue":"1","key":"364_CR88","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1053\/j.gastro.2004.03.069","volume":"127","author":"DM Queiroz","year":"2004","unstructured":"Queiroz DM, Guerra JB, Rocha GA, Rocha AM, Santos A, De Oliveira AG, Cabral MM, Nogueira AM, De Oliveira CA (2004) IL1B and IL1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis. Gastroenterology 127(1):73\u201379","journal-title":"Gastroenterology"},{"issue":"12","key":"364_CR89","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.micinf.2009.07.008","volume":"11","author":"DM Queiroz","year":"2009","unstructured":"Queiroz DM, Saraiva IE, Rocha GA, Rocha AM, Gomes LI, Melo FF, Bittencourt PF (2009) IL2-330G polymorphic allele is associated with decreased risk of Helicobacter pylori infection in adulthood. Microbes Infect 11(12):980\u2013987. https:\/\/doi.org\/10.1016\/j.micinf.2009.07.008","journal-title":"Microbes Infect"},{"issue":"7","key":"364_CR90","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1053\/j.gastro.2009.02.066","volume":"136","author":"R Rad","year":"2009","unstructured":"Rad R, Ballhorn W, Voland P, Eisenacher K, Mages J, Rad L, Ferstl R, Lang R, Wagner H, Schmid RM, Bauer S, Prinz C, Kirschning CJ, Krug A (2009) Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136(7):2247\u20132257. https:\/\/doi.org\/10.1053\/j.gastro.2009.02.066","journal-title":"Gastroenterology"},{"issue":"5","key":"364_CR91","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1053\/j.gastro.2012.01.043","volume":"142","author":"D Raju","year":"2012","unstructured":"Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL (2012) Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology 142(5):1160\u20131171. https:\/\/doi.org\/10.1053\/j.gastro.2012.01.043","journal-title":"Gastroenterology"},{"issue":"7","key":"364_CR92","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/j.1462-5822.2006.00701.x","volume":"8","author":"P Rosenstiel","year":"2006","unstructured":"Rosenstiel P, Hellmig S, Hampe J, Ott S, Till A, Fischbach W, Sahly H, Lucius R, Folsch UR, Philpott D, Schreiber S (2006) Influence of polymorphisms in the NOD1\/CARD4 and NOD2\/CARD15 genes on the clinical outcome of Helicobacter pylori infection. Cell Microbiol 8(7):1188\u20131198. https:\/\/doi.org\/10.1111\/j.1462-5822.2006.00701.x","journal-title":"Cell Microbiol"},{"issue":"1","key":"364_CR93","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1053\/j.gastro.2005.11.004","volume":"130","author":"M Rowland","year":"2006","unstructured":"Rowland M, Daly L, Vaughan M, Higgins A, Bourke B, Drumm B (2006) Age-specific incidence of Helicobacter pylori. Gastroenterology 130(1):65\u201372.; quiz 211. https:\/\/doi.org\/10.1053\/j.gastro.2005.11.004","journal-title":"Gastroenterology"},{"issue":"9","key":"364_CR94","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1590\/S0100-879X2012007500099","volume":"45","author":"JC Santos","year":"2012","unstructured":"Santos JC, Ladeira MS, Pedrazzoli J Jr, Ribeiro ML (2012) Relationship of IL-1 and TNF-alpha polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population. Braz J Med Biol Res 45(9):811\u2013817","journal-title":"Braz J Med Biol Res"},{"key":"364_CR95","unstructured":"Schistosomes, liver flukes and Helicobacter pylori . IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994 (1994) IARC Monogr Eval Carcinog Risks Hum 61:1\u2013241"},{"issue":"8","key":"364_CR96","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1086\/368133","volume":"187","author":"C Semino-Mora","year":"2003","unstructured":"Semino-Mora C, Doi SQ, Marty A, Simko V, Carlstedt I, Dubois A (2003) Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric precancerous intestinal metaplasia and adenocarcinoma. J Infect Dis 187(8):1165\u20131177. https:\/\/doi.org\/10.1086\/368133","journal-title":"J Infect Dis"},{"issue":"5","key":"364_CR97","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/mi.2012.133","volume":"6","author":"C Serrano","year":"2013","unstructured":"Serrano C, Wright SW, Bimczok D, Shaffer CL, Cover TL, Venegas A, Salazar MG, Smythies LE, Harris PR, Smith PD (2013) Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori -infected children. Mucosal Immunol 6(5):950\u2013959. https:\/\/doi.org\/10.1038\/mi.2012.133","journal-title":"Mucosal Immunol"},{"issue":"1","key":"364_CR98","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.canlet.2013.07.034","volume":"340","author":"Y Shigematsu","year":"2013","unstructured":"Shigematsu Y, Niwa T, Rehnberg E, Toyoda T, Yoshida S, Mori A, Wakabayashi M, Iwakura Y, Ichinose M, Kim YJ, Ushijima T (2013) Interleukin-1beta induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett 340(1):141\u2013147. https:\/\/doi.org\/10.1016\/j.canlet.2013.07.034","journal-title":"Cancer Lett"},{"issue":"10","key":"364_CR99","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1111\/j.1440-1746.2008.05479.x","volume":"23","author":"WG Shin","year":"2008","unstructured":"Shin WG, Jang JS, Kim HS, Kim SJ, Kim KH, Jang MK, Lee JH, Kim HJ, Kim HY (2008) Polymorphisms of interleukin-1 and interleukin-2 genes in patients with gastric cancer in Korea. J Gastroenterol Hepatol 23(10):1567\u20131573. https:\/\/doi.org\/10.1111\/j.1440-1746.2008.05479.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"7","key":"364_CR100","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1136\/gutjnl-2016-312888","volume":"67","author":"JC Sierra","year":"2018","unstructured":"Sierra JC, Asim M, Verriere TG, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado AG, Wroblewski LE, Barry DP, Peek RM Jr, Gobert AP, Wilson KT (2018) Epidermal growth factor receptor inhibition downregulates Helicobacter pylori -induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut 67(7):1247\u20131260. https:\/\/doi.org\/10.1136\/gutjnl-2016-312888","journal-title":"Gut"},{"issue":"4","key":"364_CR101","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/jso.23077","volume":"106","author":"IJ Silva-Fernandes","year":"2012","unstructured":"Silva-Fernandes IJ, da Silva TA, Agnez-Lima LF, Ferreira MV, Rabenhorst SH (2012) Helicobacter pylori genotype and polymorphisms in DNA repair enzymes: where do they correlate in gastric cancer? J Surg Oncol 106(4):448\u2013455. https:\/\/doi.org\/10.1002\/jso.23077","journal-title":"J Surg Oncol"},{"issue":"3","key":"364_CR102","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/glycob\/cwj061","volume":"16","author":"MF Smith Jr","year":"2006","unstructured":"Smith MF Jr, Novotny J, Carl VS, Comeau LD (2006) Helicobacter pylori and toll-like receptor agonists induce syndecan-4 expression in an NF-kappaB-dependent manner. Glycobiology 16(3):221\u2013229. https:\/\/doi.org\/10.1093\/glycob\/cwj061","journal-title":"Glycobiology"},{"issue":"4","key":"364_CR103","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.4049\/jimmunol.1000864","volume":"186","author":"SM Smith","year":"2011","unstructured":"Smith SM, Moran AP, Duggan SP, Ahmed SE, Mohamed AS, Windle HJ, O\u2019Neill LA, Kelleher DP (2011) Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide. J Immunol 186(4):2462\u20132471. https:\/\/doi.org\/10.4049\/jimmunol.1000864","journal-title":"J Immunol"},{"issue":"5","key":"364_CR104","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1523-5378.2009.00715.x","volume":"14","author":"K Stec-Michalska","year":"2009","unstructured":"Stec-Michalska K, Peczek L, Michalski B, Wisniewska-Jarosinska M, Krakowiak A, Nawrot B (2009) Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients. Helicobacter 14(5):126\u2013134. https:\/\/doi.org\/10.1111\/j.1523-5378.2009.00715.x","journal-title":"Helicobacter"},{"issue":"6","key":"364_CR105","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ng.152","volume":"40","author":"H Sakamoto","year":"2008","unstructured":"Study Group of Millennium Genome Project for C, Sakamoto H, Yoshimura K, Saeki N, Katai H, Shimoda T, Matsuno Y, Saito D, Sugimura H, Tanioka F, Kato S, Matsukura N, Matsuda N, Nakamura T, Hyodo I, Nishina T, Yasui W, Hirose H, Hayashi M, Toshiro E, Ohnami S, Sekine A, Sato Y, Totsuka H, Ando M, Takemura R, Takahashi Y, Ohdaira M, Aoki K, Honmyo I, Chiku S, Aoyagi K, Sasaki H, Ohnami S, Yanagihara K, Yoon KA, Kook MC, Lee YS, Park SR, Kim CG, Choi IJ, Yoshida T, Nakamura Y, Hirohashi S (2008) Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet 40(6):730\u2013740. https:\/\/doi.org\/10.1038\/ng.152","journal-title":"Nat Genet"},{"issue":"6","key":"364_CR106","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.1128\/IAI.71.6.3496-3502.2003","volume":"71","author":"B Su","year":"2003","unstructured":"Su B, Ceponis PJ, Lebel S, Huynh H, Sherman PM (2003) Helicobacter pylori activates toll-like receptor 4 expression in gastrointestinal epithelial cells. Infect Immun 71(6):3496\u20133502","journal-title":"Infect Immun"},{"issue":"1","key":"364_CR107","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1440-1746.2006.04442.x","volume":"22","author":"M Sugimoto","year":"2007","unstructured":"Sugimoto M, Furuta T, Shirai N, Nakamura A, Xiao F, Kajimura M, Sugimura H, Hishida A (2007) Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer. J Gastroenterol Hepatol 22(1):51\u201359. https:\/\/doi.org\/10.1111\/j.1440-1746.2006.04442.x","journal-title":"J Gastroenterol Hepatol"},{"key":"364_CR108","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.micpath.2015.07.010","volume":"86","author":"X Sun","year":"2015","unstructured":"Sun X, Xu Y, Zhang F, Jing T, Han J, Zhang J (2015) Association between the IL1B -31C > T polymorphism and Helicobacter pylori infection in Asian and Latin American population: a meta-analysis. Microb Pathog 86:45\u201352. https:\/\/doi.org\/10.1016\/j.micpath.2015.07.010","journal-title":"Microb Pathog"},{"issue":"1","key":"364_CR109","doi-asserted-by":"publisher","first-page":"e0147410","DOI":"10.1371\/journal.pone.0147410","volume":"11","author":"X Sun","year":"2016","unstructured":"Sun X, Xu Y, Wang L, Zhang F, Zhang J, Fu X, Jing T, Han J (2016) Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis. PLoS One 11(1):e0147410. https:\/\/doi.org\/10.1371\/journal.pone.0147410","journal-title":"PLoS One"},{"issue":"7221","key":"364_CR110","first-page":"115","volume":"1","author":"M Susser","year":"1962","unstructured":"Susser M, Stein Z (1962) Civilisation and peptic ulcer. Lancet 1(7221):115\u2013119","journal-title":"Lancet"},{"key":"364_CR111","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fcimb.2018.00022","volume":"8","author":"M Tafreshi","year":"2018","unstructured":"Tafreshi M, Guan J, Gorrell RJ, Chew N, Xin Y, Deswaerte V, Rohde M, Daly RJ, Peek RM Jr, Jenkins BJ, Davies EM, Kwok T (2018) Helicobacter pylori type IV secretion system and its adhesin subunit, CagL, mediate potent inflammatory responses in primary human endothelial cells. Front Cell Infect Microbiol 8:22. https:\/\/doi.org\/10.3389\/fcimb.2018.00022","journal-title":"Front Cell Infect Microbiol"},{"issue":"Pt 12","key":"364_CR112","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1099\/mic.0.27527-0","volume":"150","author":"R Takenaka","year":"2004","unstructured":"Takenaka R, Yokota K, Ayada K, Mizuno M, Zhao Y, Fujinami Y, Lin SN, Toyokawa T, Okada H, Shiratori Y, Oguma K (2004) Helicobacter pylori heat-shock protein 60 induces inflammatory responses through the Toll-like receptor-triggered pathway in cultured human gastric epithelial cells. Microbiology 150(Pt 12):3913\u20133922. https:\/\/doi.org\/10.1099\/mic.0.27527-0","journal-title":"Microbiology"},{"key":"364_CR113","doi-asserted-by":"publisher","unstructured":"Tanaka S, Nagashima H, Uotani T, Graham DY, Yamaoka Y (2017) Autophagy-related genes in Helicobacter pylori infection. Helicobacter 22(3). https:\/\/doi.org\/10.1111\/hel.12376","DOI":"10.1111\/hel.12376"},{"issue":"4","key":"364_CR114","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/ng.1109","volume":"44","author":"C Tanikawa","year":"2012","unstructured":"Tanikawa C, Urabe Y, Matsuo K, Kubo M, Takahashi A, Ito H, Tajima K, Kamatani N, Nakamura Y, Matsuda K (2012) A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. Nat Genet 44(4):430\u2013434., S431\u2013432. https:\/\/doi.org\/10.1038\/ng.1109","journal-title":"Nat Genet"},{"key":"364_CR115","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.chom.2017.09.005","volume":"22","author":"N Tegtmeyer","year":"2017","unstructured":"Tegtmeyer N, Wessler S, Necchi V, Rohde M, Harrer A, Rau TT, Asche CI, Boehm M, Loessner H, Figueiredo C, Naumann M, Palmisano R, Solcia E, Ricci V, Backert S (2017) Helicobacter pylori employs a unique basolateral type IV secretion mechanism for CagA delivery. Cell Host Microbe 22:552\u2013560.e555. https:\/\/doi.org\/10.1016\/j.chom.2017.09.005","journal-title":"Cell Host Microbe"},{"issue":"3","key":"364_CR116","doi-asserted-by":"publisher","first-page":"370","DOI":"10.4161\/auto.5.3.7663","volume":"5","author":"MR Terebiznik","year":"2009","unstructured":"Terebiznik MR, Raju D, Vazquez CL, Torbricki K, Kulkarni R, Blanke SR, Yoshimori T, Colombo MI, Jones NL (2009) Effect of Helicobacter pylori \u2018s vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy 5(3):370\u2013379","journal-title":"Autophagy"},{"issue":"3","key":"364_CR117","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1523-5378.2005.00308.x","volume":"10","author":"S Togawa","year":"2005","unstructured":"Togawa S, Joh T, Itoh M, Katsuda N, Ito H, Matsuo K, Tajima K, Hamajima N (2005) Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection. Helicobacter 10(3):172\u2013178. https:\/\/doi.org\/10.1111\/j.1523-5378.2005.00308.x","journal-title":"Helicobacter"},{"issue":"7","key":"364_CR118","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1177\/1753425915587130","volume":"21","author":"OA Trejo-de la","year":"2015","unstructured":"Trejo-de la OA, Torres J, Sanchez-Zauco N, Perez-Rodriguez M, Camorlinga-Ponce M, Flores-Luna L, Lazcano-Ponce E, Maldonado-Bernal C (2015) Polymorphisms in TLR9 but not in TLR5 increase the risk for duodenal ulcer and alter cytokine expression in the gastric mucosa. Innate Immun 21(7):706\u2013713. https:\/\/doi.org\/10.1177\/1753425915587130","journal-title":"Innate Immun"},{"issue":"5","key":"364_CR119","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ccr.2008.10.011","volume":"14","author":"S Tu","year":"2008","unstructured":"Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG, Wang TC (2008) Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 14(5):408\u2013419. https:\/\/doi.org\/10.1016\/j.ccr.2008.10.011","journal-title":"Cancer Cell"},{"issue":"1","key":"364_CR120","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/1751-2980.12309","volume":"17","author":"T Uotani","year":"2016","unstructured":"Uotani T, Sugimoto M, Ichikawa H, Tanaka S, Nagashima H, Uchida T, Graham DY, Yamaoka Y (2016) Prostate stem cell antigen gene TT genotype and development of intestinal metaplasia in Helicobacter pylori infection. J Dig Dis 17(1):20\u201327. https:\/\/doi.org\/10.1111\/1751-2980.12309","journal-title":"J Dig Dis"},{"issue":"11","key":"364_CR121","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/ni1131","volume":"5","author":"J Viala","year":"2004","unstructured":"Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, Athman R, Memet S, Huerre MR, Coyle AJ, DiStefano PS, Sansonetti PJ, Labigne A, Bertin J, Philpott DJ, Ferrero RL (2004) Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 5(11):1166\u20131174. https:\/\/doi.org\/10.1038\/ni1131","journal-title":"Nat Immunol"},{"issue":"1","key":"364_CR122","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1053\/j.gastro.2007.05.008","volume":"133","author":"KT Wilson","year":"2007","unstructured":"Wilson KT, Crabtree JE (2007) Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 133(1):288\u2013308. https:\/\/doi.org\/10.1053\/j.gastro.2007.05.008","journal-title":"Gastroenterology"},{"issue":"19","key":"364_CR123","doi-asserted-by":"publisher","first-page":"31016","DOI":"10.18632\/oncotarget.16050","volume":"8","author":"T Xu","year":"2017","unstructured":"Xu T, Fu D, Ren Y, Dai Y, Lin J, Tang L, Ji J (2017a) Genetic variations of TLR5 gene interacted with Helicobacter pylori infection among carcinogenesis of gastric cancer. Oncotarget 8(19):31016\u201331022. https:\/\/doi.org\/10.18632\/oncotarget.16050","journal-title":"Oncotarget"},{"issue":"1","key":"364_CR124","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.clinre.2016.05.014","volume":"41","author":"Y Xu","year":"2017","unstructured":"Xu Y, Cao X, Jiang J, Chen Y, Wang K (2017b) TNF-alpha-308\/\u2212238 polymorphisms are associated with gastric cancer: a case-control family study in China. Clin Res Hepatol Gastroenterol 41(1):103\u2013109. https:\/\/doi.org\/10.1016\/j.clinre.2016.05.014","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"12","key":"364_CR125","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.2169\/internalmedicine.47.0975","volume":"47","author":"Y Yamaoka","year":"2008","unstructured":"Yamaoka Y, Kato M, Asaka M (2008) Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains. Intern Med 47(12):1077\u20131083","journal-title":"Intern Med"},{"issue":"8","key":"364_CR126","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/jso.23199","volume":"106","author":"YW Yin","year":"2012","unstructured":"Yin YW, Sun QQ, Hu AM, Wang Q, Liu HL, Hou ZZ, Zeng YH, Xu RJ, Shi LB, Ma JB (2012) Associations between interleukin-6 gene \u2212174 C\/G and \u2212572 C\/G polymorphisms and the risk of gastric cancer: a meta-analysis. J Surg Oncol 106(8):987\u2013993. https:\/\/doi.org\/10.1002\/jso.23199","journal-title":"J Surg Oncol"},{"issue":"3","key":"364_CR127","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/jcmm.12737","volume":"20","author":"HY Ying","year":"2016","unstructured":"Ying HY, Yu BW, Yang Z, Yang SS, Bo LH, Shan XY, Wang HJ, Zhu YJ, Wu XS (2016) Interleukin-1B 31 C>T polymorphism combined with Helicobacter pylori -modified gastric cancer susceptibility: evidence from 37 studies. J Cell Mol Med 20(3):526\u2013536. https:\/\/doi.org\/10.1111\/jcmm.12737","journal-title":"J Cell Mol Med"},{"issue":"1","key":"364_CR128","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1128\/IAI.00903-09","volume":"78","author":"S Yokota","year":"2010","unstructured":"Yokota S, Okabayashi T, Rehli M, Fujii N, Amano K (2010) Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1\/2-ERK1\/2 mitogen-activated protein kinase pathway. Infect Immun 78(1):468\u2013476. https:\/\/doi.org\/10.1128\/IAI.00903-09","journal-title":"Infect Immun"},{"issue":"7","key":"364_CR129","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1111\/j.1349-7006.2010.01590.x","volume":"101","author":"T Yoshida","year":"2010","unstructured":"Yoshida T, Ono H, Kuchiba A, Saeki N, Sakamoto H (2010) Genome-wide germline analyses on cancer susceptibility and GeMDBJ database: gastric cancer as an example. Cancer Sci 101(7):1582\u20131589. https:\/\/doi.org\/10.1111\/j.1349-7006.2010.01590.x","journal-title":"Cancer Sci"},{"issue":"6","key":"364_CR130","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1007\/s11033-008-9336-y","volume":"36","author":"Q Zhang","year":"2009","unstructured":"Zhang Q, Li Y, Li X, Zhou W, Shi B, Chen H, Yuan W (2009) PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population. Mol Biol Rep 36(6):1461\u20131467. https:\/\/doi.org\/10.1007\/s11033-008-9336-y","journal-title":"Mol Biol Rep"},{"issue":"2","key":"364_CR131","doi-asserted-by":"publisher","first-page":"e57167","DOI":"10.1371\/journal.pone.0057167","volume":"8","author":"BB Zhang","year":"2013","unstructured":"Zhang BB, Liu XZ, Sun J, Yin YW, Sun QQ (2013) Association between TNF alpha gene polymorphisms and the risk of duodenal ulcer: a meta-analysis. PLoS One 8(2):e57167. https:\/\/doi.org\/10.1371\/journal.pone.0057167","journal-title":"PLoS One"},{"key":"364_CR132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2017.04.038","volume":"623","author":"JZ Zhang","year":"2017","unstructured":"Zhang JZ, Liu CM, Peng HP, Zhang Y (2017) Association of genetic variations in IL-6\/IL-6R pathway genes with gastric cancer risk in a Chinese population. Gene 623:1\u20134. https:\/\/doi.org\/10.1016\/j.gene.2017.04.038","journal-title":"Gene"},{"issue":"Pt 2","key":"364_CR133","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1099\/jmm.0.46882-0","volume":"56","author":"Y Zhao","year":"2007","unstructured":"Zhao Y, Yokota K, Ayada K, Yamamoto Y, Okada T, Shen L, Oguma K (2007) Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes. J Med Microbiol 56(Pt 2):154\u2013164. https:\/\/doi.org\/10.1099\/jmm.0.46882-0","journal-title":"J Med Microbiol"},{"issue":"3","key":"364_CR134","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3892\/mco.2013.70","volume":"1","author":"J Zhao","year":"2013","unstructured":"Zhao J, Geng P, Li Z, Cui S, Zhao J, Wang L, Li J, Ji F, Li G, Shen G, Lin M, Shen C (2013) Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori -negative gastric cancer among various populations in China. Mol Clin Oncol 1(3):493\u2013498. https:\/\/doi.org\/10.3892\/mco.2013.70","journal-title":"Mol Clin Oncol"}],"container-title":["Advances in Experimental Medicine and Biology","Helicobacter pylori in Human Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2019_364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T01:14:40Z","timestamp":1582938880000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/5584_2019_364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030219154","9783030219161"],"references-count":133,"URL":"https:\/\/doi.org\/10.1007\/5584_2019_364","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"24 April 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}