{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:41:39Z","timestamp":1789764099912,"version":"4.0.1"},"publisher-location":"Cham","reference-count":118,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030458928","type":"print"},{"value":"9783030458935","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1007\/5584_2019_463","type":"book-chapter","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T10:26:46Z","timestamp":1576492006000},"page":"33-64","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The Horizon of Gene Therapy in Modern Medicine: Advances and Challenges"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-5006","authenticated-orcid":false,"given":"Babak","family":"Arjmand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-7597","authenticated-orcid":false,"given":"Bagher","family":"Larijani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahareh","family":"Sheikh Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-8395","authenticated-orcid":false,"given":"Moloud","family":"Payab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-7245","authenticated-orcid":false,"given":"Kambiz","family":"Gilany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyvand","family":"Parhizkar Roudsari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobina","family":"Amanollahi Baharvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin sadat","family":"Hoseini Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"463_CR001","doi-asserted-by":"crossref","unstructured":"Adelman ZN, Albritton LM, Boris-Lawrie K, Buchmeier MJ, Cannon P, Cho M, DiGiusto D, Donahue JK, Federoff HJ, Hammarskjold ML, Hardison AD (2018) Protect NIH\u2019s DNA advisory committee. Science (New York, NY) 26;362(6413):409","DOI":"10.1126\/science.aav2483"},{"key":"463_CR002","unstructured":"Anguela XM, High KA (2019) Entering the modern era of gene therapy. Annu Review Med 27(70):273\u201388"},{"key":"463_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/2052-8426-2-27","volume":"2","author":"MH Amer","year":"2014","unstructured":"Amer MH (2014) Gene therapy for cancer: present status and future perspective. Mol Cell Ther 2:27","journal-title":"Mol Cell Ther"},{"issue":"5","key":"463_CR2","first-page":"282","volume":"21","author":"B Arjmand","year":"2017","unstructured":"Arjmand B, Abdollahi M, Larijani B (2017) Study break: precision medicine: a new revolution in healthcare system. Iran Biomed J 21(5):282\u2013283","journal-title":"Iran Biomed J"},{"issue":"5","key":"463_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1136\/archdischild-2012-302158","volume":"99","author":"DK Armstrong","year":"2014","unstructured":"Armstrong DK, Cunningham S, Davies JC, Alton EW (2014) Gene therapy in cystic fibrosis. Arch Dis Child 99(5):465\u2013468","journal-title":"Arch Dis Child"},{"issue":"9911","key":"463_CR4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","volume":"383","author":"MA Atkinson","year":"2014","unstructured":"Atkinson MA, Eisenbarth GS, Michels AW (2014) Type 1 diabetes. Lancet 383(9911):69\u201382","journal-title":"Lancet"},{"issue":"2","key":"463_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1084\/jem.79.2.137","volume":"79","author":"OT Avery","year":"1944","unstructured":"Avery OT, Macleod CM, McCarty M (1944) Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J Exp Med 79(2):137\u2013158","journal-title":"J Exp Med"},{"key":"463_CR6","doi-asserted-by":"crossref","unstructured":"Ayen A, Jimenez Martinez Y, Marchal JA, Boulaiz H (2018) Recent progress in gene therapy for ovarian cancer. Int J Mol Sci 19(7)","DOI":"10.3390\/ijms19071930"},{"issue":"21","key":"463_CR7","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1056\/NEJMoa0802268","volume":"358","author":"JW Bainbridge","year":"2008","unstructured":"Bainbridge JW, Smith AJ, Barker SS, Robbie S, Henderson R, Balaggan K, Viswanathan A, Holder GE, Stockman A, Tyler N, Petersen-Jones S, Bhattacharya SS, Thrasher AJ, Fitzke FW, Carter BJ, Rubin GS, Moore AT, Ali RR (2008) Effect of gene therapy on visual function in Leber\u2019s congenital amaurosis. N Engl J Med 358(21):2231\u20132239","journal-title":"N Engl J Med"},{"issue":"5","key":"463_CR8","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s10529-006-9297-y","volume":"29","author":"L Baldi","year":"2007","unstructured":"Baldi L, Hacker DL, Adam M, Wurm FM (2007) Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives. Biotechnol Lett 29(5):677\u2013684","journal-title":"Biotechnol Lett"},{"issue":"12","key":"463_CR9","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1002\/bies.950181210","volume":"18","author":"A Bank","year":"1996","unstructured":"Bank A (1996) Human somatic cell gene therapy. BioEssays 18(12):999\u20131007","journal-title":"BioEssays"},{"issue":"3","key":"463_CR10","first-page":"127","volume":"2","author":"J Barar","year":"2012","unstructured":"Barar J, Omidi Y (2012) Translational approaches towards cancer gene therapy: hurdles and hopes. Bioimpacts 2(3):127\u2013143","journal-title":"Bioimpacts"},{"issue":"6","key":"463_CR11","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1182\/blood-2002-07-2314","volume":"101","author":"C Baum","year":"2003","unstructured":"Baum C, Dullmann J, Li Z, Fehse B, Meyer J, Williams DA, von Kalle C (2003) Side effects of retroviral gene transfer into hematopoietic stem cells. Blood 101(6):2099\u20132114","journal-title":"Blood"},{"issue":"2","key":"463_CR12","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1515\/BC.1999.036","volume":"380","author":"J Bischof","year":"1999","unstructured":"Bischof J, Vietor I, Cotten M, Huber LA (1999) Transient transfection of mammary epithelial cells with a PEI\/DNA\/adenovirus system. Biol Chem 380(2):269\u2013273","journal-title":"Biol Chem"},{"issue":"2","key":"463_CR13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1080\/146532400539116","volume":"2","author":"SR Burger","year":"2000","unstructured":"Burger SR (2000) Design and operation of a current good manufacturing practices cell-engineering laboratory. Cytotherapy 2(2):111\u2013122","journal-title":"Cytotherapy"},{"key":"463_CR14","doi-asserted-by":"crossref","unstructured":"Burnight ER, Wiley LA, Mullins RF, Stone EM, Tucker BA (2014) Gene therapy using stem cells. Cold Spring Harb Perspect Med 5(4)","DOI":"10.1101\/cshperspect.a017434"},{"key":"463_CR15","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fmed.2017.00182","volume":"4","author":"M Carvalho","year":"2017","unstructured":"Carvalho M, Sepodes B, Martins AP (2017) Regulatory and scientific advancements in gene therapy: state-of-the-art of clinical applications and of the supporting European regulatory framework. Front Med (Lausanne) 4:182","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"463_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00018-016-2393-9","volume":"74","author":"C Castellani","year":"2017","unstructured":"Castellani C, Assael BM (2017) Cystic fibrosis: a clinical view. Cell Mol Life Sci 74(1):129\u2013140","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"463_CR17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.tcb.2015.07.009","volume":"26","author":"R Ceccaldi","year":"2016","unstructured":"Ceccaldi R, Rondinelli B, D\u2019Andrea AD (2016) Repair pathway choices and consequences at the double-strand break. Trends Cell Biol 26(1):52\u201364","journal-title":"Trends Cell Biol"},{"issue":"11","key":"463_CR18","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.4049\/jimmunol.1600374","volume":"196","author":"S Chakraborti","year":"2016","unstructured":"Chakraborti S, Lewis LA (2016) Phase-variable heptose I glycan extensions modulate efficacy of 2C7 vaccine antibody directed against Neisseria gonorrhoeae Lipooligosaccharide. J Immunol 196(11):4576\u20134586","journal-title":"J Immunol"},{"issue":"5","key":"463_CR19","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.ymthe.2017.02.019","volume":"25","author":"JR Chamberlain","year":"2017","unstructured":"Chamberlain JR, Chamberlain JS (2017) Progress toward gene therapy for duchenne muscular dystrophy. Mol Ther 25(5):1125\u20131131","journal-title":"Mol Ther"},{"issue":"1","key":"463_CR20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.18609\/cgti.2017.005","volume":"3","author":"S Chandrasegaran","year":"2017","unstructured":"Chandrasegaran S (2017) Recent advances in the use of ZFN-mediated gene editing for human gene therapy. Cell Gene Ther Insights 3(1):33\u201341","journal-title":"Cell Gene Ther Insights"},{"issue":"5","key":"463_CR21","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/em.22087","volume":"58","author":"N Chatterjee","year":"2017","unstructured":"Chatterjee N, Walker GC (2017) Mechanisms of DNA damage, repair, and mutagenesis. Environ Mol Mutagen 58(5):235\u2013263","journal-title":"Environ Mol Mutagen"},{"key":"463_CR22","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.biopha.2018.09.138","volume":"108","author":"DK Chellappan","year":"2018","unstructured":"Chellappan DK, Sivam NS, Teoh KX, Leong WP, Fui TZ, Chooi K, Khoo N, Yi FJ, Chellian J, Cheng LL, Dahiya R, Gupta G, Singhvi G, Nammi S, Hansbro PM, Dua K (2018) Gene therapy and type 1 diabetes mellitus. Biomed Pharmacother 108:1188\u20131200","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"463_CR23","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nbt.2507","volume":"31","author":"SW Cho","year":"2013","unstructured":"Cho SW, Kim S, Kim JM, Kim JS (2013) Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol 31(3):230\u2013232","journal-title":"Nat Biotechnol"},{"issue":"2","key":"463_CR24","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/toxsci\/kfw220","volume":"155","author":"RM David","year":"2017","unstructured":"David RM, Doherty AT (2017) Viral vectors: the road to reducing genotoxicity. Toxicol Sci 155(2):315\u2013325","journal-title":"Toxicol Sci"},{"issue":"11","key":"463_CR25","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1038\/mt.2009.223","volume":"17","author":"CT Deakin","year":"2009","unstructured":"Deakin CT, Alexander IE, Kerridge I (2009) Accepting risk in clinical research: is the gene therapy field becoming too risk-averse? Mol Ther 17(11):1842\u20131848","journal-title":"Mol Ther"},{"key":"463_CR26","doi-asserted-by":"crossref","unstructured":"Dexheimer TS (2013) DNA repair pathways and mechanisms. DNA repair of cancer stem cells. Springer, pp 19\u201332","DOI":"10.1007\/978-94-007-4590-2_2"},{"issue":"1","key":"463_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2222\/jsv.65.27","volume":"65","author":"K Doi","year":"2015","unstructured":"Doi K, Takeuchi Y (2015) Gene therapy using retrovirus vectors: vector development and biosafety at clinical trials. Uirusu 65(1):27\u201336","journal-title":"Uirusu"},{"issue":"9","key":"463_CR28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1177\/2040620718791933","volume":"9","author":"BS Doshi","year":"2018","unstructured":"Doshi BS, Arruda VR (2018) Gene therapy for hemophilia: what does the future hold? Ther Adv Hematol 9(9):273\u2013293","journal-title":"Ther Adv Hematol"},{"key":"463_CR29","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1089\/aid.2019.0021","volume":"35","author":"K Dub\u00e9","year":"2019","unstructured":"Dub\u00e9 K, Simoni J, Louella M, Sylla L, Mohamed ZH, Patel H, Luter S, Collier AC (2019) Acceptability of cell and gene therapy for curing HIV infection among people living with HIV in the Northwestern United States: a qualitative study. AIDS Res Hum Retrovir 35:649\u2013659","journal-title":"AIDS Res Hum Retrovir"},{"issue":"6372","key":"463_CR30","doi-asserted-by":"publisher","first-page":"eaan4672","DOI":"10.1126\/science.aan4672","volume":"359","author":"CE Dunbar","year":"2018","unstructured":"Dunbar CE, High KA, Joung JK, Kohn DB, Ozawa K, Sadelain M (2018) Gene therapy comes of age. Science 359(6372):eaan4672","journal-title":"Science"},{"key":"463_CR31","unstructured":"Epstein S (1996) Impure science: AIDS, activism, and the politics of knowledge. Med Soc (Berkeley):1\u2013466"},{"key":"463_CR32","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.omtn.2018.09.018","volume":"13","author":"A Falkenhagen","year":"2018","unstructured":"Falkenhagen A, Joshi S (2018) Genetic strategies for HIV treatment and prevention. Mol Ther Nucleic Acids 13:514\u2013533","journal-title":"Mol Ther Nucleic Acids"},{"issue":"5","key":"463_CR33","first-page":"1336","volume":"21","author":"F Fang","year":"2013","unstructured":"Fang F, Zhu P (2013) New hope of gene therapy results from improvements of lentiviral vectors-review. Zhongguo Shi Yan Xue Ye Xue Za Zhi 21(5):1336\u20131339","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"463_CR01","doi-asserted-by":"crossref","unstructured":"Felgner J, Heidorn K, K\u00adrb\u00f0cher D, Frahm SO, Parwaresch R (1999) Cell lineage specificity in G-CSF receptor gene methylation. Leukemia. 1999 Apr;13(4):530\u20134. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10214858","DOI":"10.1038\/sj.leu.2401386"},{"issue":"5","key":"463_CR34","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1089\/hum.2015.28999.tfl","volume":"26","author":"TR Flotte","year":"2015","unstructured":"Flotte TR (2015) Therapeutic germ line alteration: has CRISPR\/Cas9 technology forced the question? Hum Gene Ther 26(5):245\u2013246","journal-title":"Hum Gene Ther"},{"issue":"6","key":"463_CR35","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/mt.2013.97","volume":"21","author":"RM Frederickson","year":"2013","unstructured":"Frederickson RM, Brenner MK (2013) Introducing molecular therapy\u2013methods & clinical development. Mol Ther 21(6):1105","journal-title":"Mol Ther"},{"issue":"7","key":"463_CR36","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.tibtech.2013.04.004","volume":"31","author":"T Gaj","year":"2013","unstructured":"Gaj T, Gersbach CA, Barbas CF 3rd (2013) ZFN, TALEN, and CRISPR\/Cas-based methods for genome engineering. Trends Biotechnol 31(7):397\u2013405","journal-title":"Trends Biotechnol"},{"issue":"96","key":"463_CR37","first-page":"319","volume":"17","author":"M Gao","year":"2014","unstructured":"Gao M, Liu D (2014) Gene therapy for obesity: progress and prospects. Discov Med 17(96):319\u2013328","journal-title":"Discov Med"},{"issue":"5","key":"463_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3015","volume":"20","author":"SL Ginn","year":"2018","unstructured":"Ginn SL, Amaya AK, Alexander IE, Edelstein M, Abedi MR (2018) Gene therapy clinical trials worldwide to 2017: an update. J Gene Med 20(5):e3015","journal-title":"J Gene Med"},{"issue":"3","key":"463_CR39","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1590\/s1679-45082017rb4024","volume":"15","author":"GAR Goncalves","year":"2017","unstructured":"Goncalves GAR, Paiva RMA (2017) Gene therapy: advances, challenges and perspectives. Einstein (Sao Paulo) 15(3):369\u2013375","journal-title":"Einstein (Sao Paulo)"},{"issue":"Suppl 1","key":"463_CR40","doi-asserted-by":"publisher","first-page":"S146","DOI":"10.1038\/sj.gt.3302629","volume":"12","author":"P Gonin","year":"2005","unstructured":"Gonin P, Buchholz CJ, Pallardy M, Mezzina M (2005) Gene therapy bio-safety: scientific and regulatory issues. Gene Ther 12(Suppl 1):S146\u2013S152","journal-title":"Gene Ther"},{"key":"463_CR41","first-page":"168","volume":"29","author":"P Goodarzi","year":"2015","unstructured":"Goodarzi P, Aghayan HR, Larijani B, Soleimani M, Dehpour AR, Sahebjam M, Ghaderi F, Arjmand B (2015) Stem cell-based approach for the treatment of Parkinson\u2019s disease. Med J Islam Repub Iran 29:168","journal-title":"Med J Islam Repub Iran"},{"issue":"364","key":"463_CR42","doi-asserted-by":"publisher","first-page":"364ra153","DOI":"10.1126\/scitranslmed.aag2306","volume":"8","author":"TJ Goodwin","year":"2016","unstructured":"Goodwin TJ, Zhou Y, Musetti SN, Liu R, Huang L (2016) Local and transient gene expression primes the liver to resist cancer metastasis. Sci Transl Med 8(364):364ra153","journal-title":"Sci Transl Med"},{"issue":"5","key":"463_CR43","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1089\/hum.2015.027","volume":"26","author":"U Griesenbach","year":"2015","unstructured":"Griesenbach U, Pytel KM, Alton EW (2015) Cystic fibrosis gene therapy in the UK and elsewhere. Hum Gene Ther 26(5):266\u2013275","journal-title":"Hum Gene Ther"},{"issue":"6","key":"463_CR44","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1097\/MCP.0000000000000327","volume":"22","author":"U Griesenbach","year":"2016","unstructured":"Griesenbach U, Davies JC, Alton E (2016) Cystic fibrosis gene therapy: a mutation-independent treatment. Curr Opin Pulm Med 22(6):602\u2013609","journal-title":"Curr Opin Pulm Med"},{"issue":"2","key":"463_CR45","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1017\/S0022172400031879","volume":"27","author":"F Griffith","year":"1928","unstructured":"Griffith F (1928) The significance of Pneumococcal types. J Hyg (Lond) 27(2):113\u2013159","journal-title":"J Hyg (Lond)"},{"issue":"3","key":"463_CR46","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/14653240310001271","volume":"5","author":"BJ Grilley","year":"2003","unstructured":"Grilley BJ, Gee AP (2003) Gene transfer: regulatory issues and their impact on the clinical investigator and the good manufacturing production facility. Cytotherapy 5(3):197\u2013207","journal-title":"Cytotherapy"},{"issue":"10","key":"463_CR47","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1080\/14712598.2017.1347630","volume":"17","author":"WB Guggino","year":"2017","unstructured":"Guggino WB, Cebotaru L (2017) Adeno-associated virus (AAV) gene therapy for cystic fibrosis: current barriers and recent developments. Expert Opin Biol Ther 17(10):1265\u20131273","journal-title":"Expert Opin Biol Ther"},{"issue":"5","key":"463_CR48","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1080\/07388551.2016.1214557","volume":"37","author":"SK Gupta","year":"2017","unstructured":"Gupta SK, Shukla P (2017) Gene editing for cell engineering: trends and applications. Crit Rev Biotechnol 37(5):672\u2013684","journal-title":"Crit Rev Biotechnol"},{"issue":"6","key":"463_CR49","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1080\/07388551.2017.1419459","volume":"38","author":"S Gutierrez-Granados","year":"2018","unstructured":"Gutierrez-Granados S, Cervera L, Kamen AA, Godia F (2018) Advancements in mammalian cell transient gene expression (TGE) technology for accelerated production of biologics. Crit Rev Biotechnol 38(6):918\u2013940","journal-title":"Crit Rev Biotechnol"},{"issue":"4","key":"463_CR50","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/japp.12249","volume":"34","author":"C Gyngell","year":"2017","unstructured":"Gyngell C, Douglas T, Savulescu J (2017) The ethics of germline gene editing. J Appl Philos 34(4):498\u2013513","journal-title":"J Appl Philos"},{"issue":"1","key":"463_CR51","doi-asserted-by":"publisher","DOI":"10.1080\/20016689.2017.1265293","volume":"5","author":"E Hanna","year":"2017","unstructured":"Hanna E, R\u00e9muzat C, Auquier P, Toumi M (2017) Gene therapies development: slow progress and promising prospect. J Market Access Health Policy 5(1):1265293","journal-title":"J Market Access Health Policy"},{"issue":"8","key":"463_CR52","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.molmed.2015.05.006","volume":"21","author":"T Ishii","year":"2015","unstructured":"Ishii T (2015) Germline genome-editing research and its socioethical implications. Trends Mol Med 21(8):473\u2013481","journal-title":"Trends Mol Med"},{"key":"463_CR53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-3-319-10320-4_2","volume-title":"Animal cell culture","author":"V J\u00e4ger","year":"2015","unstructured":"J\u00e4ger V, B\u00fcssow K, Schirrmann T (2015) Transient recombinant protein expression in mammalian cells. In: Animal cell culture. Springer, Cham, pp 27\u201364"},{"key":"463_CR54","doi-asserted-by":"crossref","unstructured":"Jimenez V, Jambrina C, Casana E, Sacristan V, Munoz S, Darriba S, Rodo J, Mallol C, Garcia M, Leon X, Marco S, Ribera A, Elias I, Casellas A, Grass I, Elias G, Ferre T, Motas S, Franckhauser S, Mulero F, Navarro M, Haurigot V, Ruberte J, Bosch F (2018) FGF21 gene therapy as treatment for obesity and insulin resistance. EMBO Mol Med 10(8)","DOI":"10.15252\/emmm.201708791"},{"issue":"5","key":"463_CR55","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0960-8966(97)00051-5","volume":"7","author":"G Karpati","year":"1997","unstructured":"Karpati G, Lochm\u00fcller H (1997) The scope of gene therapy in humans: scientific, safety and ethical considerations. Neuromuscul Disord 7(5):273\u2013276","journal-title":"Neuromuscul Disord"},{"issue":"11","key":"463_CR56","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1002\/emmm.201202287","volume":"5","author":"KB Kaufmann","year":"2013","unstructured":"Kaufmann KB, Buning H, Galy A, Schambach A, Grez M (2013) Gene therapy on the move. EMBO Mol Med 5(11):1642\u20131661","journal-title":"EMBO Mol Med"},{"issue":"1","key":"463_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0425-5","volume":"25","author":"S Khan","year":"2018","unstructured":"Khan S, Mahmood MS, Rahman SU, Zafar H, Habibullah S, Khan Z, Ahmad A (2018) CRISPR\/Cas9: the Jedi against the dark empire of diseases. J Biomed Sci 25(1):29","journal-title":"J Biomed Sci"},{"issue":"5","key":"463_CR58","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/1050-1738(95)00078-N","volume":"5","author":"KF Kozarsky","year":"1995","unstructured":"Kozarsky KF, Wilson JM (1995) Gene therapy of hypercholesterolemic disorders. Trends Cardiovasc Med 5(5):205\u2013209","journal-title":"Trends Cardiovasc Med"},{"issue":"4","key":"463_CR59","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012583","volume":"5","author":"HE Krokan","year":"2013","unstructured":"Krokan HE, Bjoras M (2013) Base excision repair. Cold Spring Harb Perspect Biol 5(4):a012583","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"463_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-8730-6_1","volume":"1850","author":"D L\u2019Abbe","year":"2018","unstructured":"L\u2019Abbe D, Bisson L, Gervais C, Grazzini E, Durocher Y (2018) Transient gene expression in suspension HEK293-EBNA1 cells. Methods Mol Biol 1850:1\u201316","journal-title":"Methods Mol Biol"},{"issue":"4","key":"463_CR61","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s10561-011-9273-1","volume":"13","author":"B Larijani","year":"2012","unstructured":"Larijani B, Arjmand B, Amoli MM, Ao Z, Jafarian A, Mahdavi-Mazdah M, Ghanaati H, Baradar-Jalili R, Sharghi S, Norouzi-Javidan A, Aghayan HR (2012) Establishing a cGMP pancreatic islet processing facility: the first experience in Iran. Cell Tissue Bank 13(4):569\u2013575","journal-title":"Cell Tissue Bank"},{"key":"463_CR62","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.procbio.2017.01.020","volume":"55","author":"J-H Lee","year":"2017","unstructured":"Lee J-H, Lim S-M, Park S-H, Min J-K, Lee GM, Kim Y-G (2017) Investigation of relationship between EBNA-1 expression level and specific foreign protein productivity in transient gene expression of HEK293 cells. Process Biochem 55:182\u2013186","journal-title":"Process Biochem"},{"issue":"7","key":"463_CR63","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1089\/hum.2015.069","volume":"26","author":"L Li","year":"2015","unstructured":"Li L, He Z-Y, Wei X-W, Gao G-P, Wei Y-Q (2015) Challenges in CRISPR\/CAS9 delivery: potential roles of nonviral vectors. Hum Gene Ther 26(7):452\u2013462","journal-title":"Hum Gene Ther"},{"key":"463_CR64","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/B978-0-12-418687-3.00018-5","volume":"529","author":"PA Longo","year":"2013","unstructured":"Longo PA, Kavran JM, Kim MS, Leahy DJ (2013) Transient mammalian cell transfection with polyethylenimine (PEI). Methods Enzymol 529:227\u2013240","journal-title":"Methods Enzymol"},{"issue":"7","key":"463_CR65","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1134\/S0006297916070063","volume":"81","author":"AN Lukashev","year":"2016","unstructured":"Lukashev AN, Zamyatnin AA Jr (2016) Viral vectors for gene therapy: current state and clinical perspectives. Biochemistry (Mosc) 81(7):700\u2013708","journal-title":"Biochemistry (Mosc)"},{"key":"463_CR66","doi-asserted-by":"crossref","unstructured":"Lundstrom K (2018) Viral vectors in gene therapy. Diseases 6(2)","DOI":"10.3390\/diseases6020042"},{"issue":"5","key":"463_CR67","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.hoc.2017.05.002","volume":"31","author":"CT Lux","year":"2017","unstructured":"Lux CT, Scharenberg AM (2017) Therapeutic gene editing safety and specificity. Hematol Oncol Clin North Am 31(5):787\u2013795","journal-title":"Hematol Oncol Clin North Am"},{"issue":"18","key":"463_CR68","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.4155\/bio-2017-0116","volume":"9","author":"M Ma","year":"2017","unstructured":"Ma M, Balasubramanian N, Dodge R, Zhang Y (2017) Challenges and opportunities in bioanalytical support for gene therapy medicinal product development. Bioanalysis 9(18):1423\u20131430","journal-title":"Bioanalysis"},{"issue":"3","key":"463_CR69","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/mt.2016.10","volume":"24","author":"ML Maeder","year":"2016","unstructured":"Maeder ML, Gersbach CA (2016) Genome-editing technologies for gene and cell therapy. Mol Ther 24(3):430\u2013446","journal-title":"Mol Ther"},{"issue":"6121","key":"463_CR70","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1126\/science.1232033","volume":"339","author":"P Mali","year":"2013","unstructured":"Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM (2013) RNA-guided human genome engineering via Cas9. Science 339(6121):823\u2013826","journal-title":"Science"},{"issue":"18","key":"463_CR71","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1089\/ars.2012.5036","volume":"18","author":"JP Melis","year":"2013","unstructured":"Melis JP, van Steeg H, Luijten M (2013) Oxidative DNA damage and nucleotide excision repair. Antioxid Redox Signal 18(18):2409\u20132419","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"463_CR72","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1128\/MCB.16.5.2164","volume":"16","author":"JK Moore","year":"1996","unstructured":"Moore JK, Haber JE (1996) Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell Biol 16(5):2164\u20132173","journal-title":"Mol Cell Biol"},{"issue":"5","key":"463_CR73","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.stem.2017.10.010","volume":"21","author":"RA Morgan","year":"2017","unstructured":"Morgan RA, Gray D, Lomova A, Kohn DB (2017) Hematopoietic stem cell gene therapy: progress and lessons learned. Cell Stem Cell 21(5):574\u2013590","journal-title":"Cell Stem Cell"},{"key":"463_CR74","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/2277-9175.98152","volume":"1","author":"N Nayerossadat","year":"2012","unstructured":"Nayerossadat N, Maedeh T, Ali PA (2012) Viral and nonviral delivery systems for gene delivery. Adv Biomed Res 1:27","journal-title":"Adv Biomed Res"},{"issue":"6271","key":"463_CR75","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1126\/science.aad5143","volume":"351","author":"CE Nelson","year":"2016","unstructured":"Nelson CE, Hakim CH, Ousterout DG, Thakore PI, Moreb EA, Castellanos Rivera RM, Madhavan S, Pan X, Ran FA, Yan WX, Asokan A, Zhang F, Duan D, Gersbach CA (2016) In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science 351(6271):403\u2013407","journal-title":"Science"},{"issue":"15","key":"463_CR76","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/j.febslet.2015.06.013","volume":"589","author":"H Nishitsuji","year":"2015","unstructured":"Nishitsuji H, Sawada L, Sugiyama R, Takaku H (2015) ZNF10 inhibits HIV-1 LTR activity through interaction with NF-\u03baB and Sp1 binding motifs. FEBS Lett 589(15):2019\u20132025","journal-title":"FEBS Lett"},{"key":"463_CR77","doi-asserted-by":"crossref","unstructured":"Ohmori T (2018) Advances in gene therapy for hemophilia: basis, current status, and future perspectives. Int J Hematol","DOI":"10.1007\/s12185-018-2513-4"},{"key":"463_CR78","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-3-319-18618-4_2","volume":"871","author":"M O\u2019Reilly","year":"2015","unstructured":"O\u2019Reilly M, Jambou R, Rosenthal E, Montgomery M, Hassani M, Gargiulo L, Corrigan-Curay J (2015) The National Institutes of Health oversight of human gene transfer research: enhancing science and safety. Adv Exp Med Biol 871:31\u201347","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"463_CR79","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00018-009-8740-3","volume":"66","author":"B Pardo","year":"2009","unstructured":"Pardo B, Gomez-Gonzalez B, Aguilera A (2009) DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship. Cell Mol Life Sci 66(6):1039\u20131056","journal-title":"Cell Mol Life Sci"},{"key":"463_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/5584_2018_227","volume":"1089","author":"M Payab","year":"2018","unstructured":"Payab M, Goodarzi P, Foroughi Heravani N, Hadavandkhani M, Zarei Z, Falahzadeh K, Larijani B, Rahim F, Arjmand B (2018) Stem cell and obesity: current state and future perspective. Adv Exp Med Biol 1089:1\u201322","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"463_CR81","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1097\/GCO.0000000000000255","volume":"28","author":"E Pergament","year":"2016","unstructured":"Pergament E (2016) The promise of gene therapy. Curr Opin Obstet Gynecol 28(2):132\u2013135","journal-title":"Curr Opin Obstet Gynecol"},{"key":"463_CR82","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fphar.2019.00121","volume":"10","author":"I Pranke","year":"2019","unstructured":"Pranke I, Golec A, Hinzpeter A, Edelman A, Sermet-Gaudelus I (2019) Emerging therapeutic approaches for cystic fibrosis. From gene editing to personalized medicine. Front Pharmacol 10:121","journal-title":"Front Pharmacol"},{"issue":"4","key":"463_CR83","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.trsl.2012.12.001","volume":"161","author":"M Prickett","year":"2013","unstructured":"Prickett M, Jain M (2013) Gene therapy in cystic fibrosis. Transl Res 161(4):255\u2013264","journal-title":"Transl Res"},{"issue":"10","key":"463_CR84","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0787-1","volume":"17","author":"N Raghavan","year":"2017","unstructured":"Raghavan N, Tosto G (2017) Genetics of Alzheimer\u2019s disease: the importance of polygenic and epistatic components. Curr Neurol Neurosci Rep 17(10):78","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"463_CR85","first-page":"GE01","volume":"9","author":"M Ramamoorth","year":"2015","unstructured":"Ramamoorth M, Narvekar A (2015) Non viral vectors in gene therapy-an overview. J Clin Diagn Res 9(1):GE01\u2013GE06","journal-title":"J Clin Diagn Res"},{"issue":"12","key":"463_CR86","doi-asserted-by":"publisher","first-page":"5560","DOI":"10.1093\/nar\/gks179","volume":"40","author":"CL Ramirez","year":"2012","unstructured":"Ramirez CL, Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK (2012) Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Res 40(12):5560\u20135568","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"463_CR87","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1136\/archdischild-2016-310459","volume":"101","author":"M Redman","year":"2016","unstructured":"Redman M, King A, Watson C, King D (2016) What is CRISPR\/Cas9? Arch Dis Child Educ Pract 101(4):213\u2013215","journal-title":"Arch Dis Child Educ Pract"},{"issue":"1","key":"463_CR88","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0163-7258(98)00020-5","volume":"80","author":"PD Robbins","year":"1998","unstructured":"Robbins PD, Ghivizzani SC (1998) Viral vectors for gene therapy. Pharmacol Ther 80(1):35\u201347","journal-title":"Pharmacol Ther"},{"issue":"5","key":"463_CR89","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.hoc.2017.06.008","volume":"31","author":"GL Rogers","year":"2017","unstructured":"Rogers GL, Cannon PM (2017) Gene therapy approaches to human immunodeficiency virus and other infectious diseases. Hematol Oncol Clin North Am 31(5):883\u2013895","journal-title":"Hematol Oncol Clin North Am"},{"key":"463_CR90","doi-asserted-by":"publisher","first-page":"556","DOI":"10.2741\/4324","volume":"20","author":"GL Rogers","year":"2015","unstructured":"Rogers GL, Herzog RW (2015) Gene therapy for hemophilia. Front Biosci (Landmark Ed) 20:556\u2013603","journal-title":"Front Biosci (Landmark Ed)"},{"key":"463_CR91","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-3-319-56017-5_17","volume":"996","author":"S Roy","year":"2017","unstructured":"Roy S (2017) Impact of UV radiation on genome stability and human health. Adv Exp Med Biol 996:207\u2013219","journal-title":"Adv Exp Med Biol"},{"key":"463_CR92","unstructured":"Sahu S, Roy P, Datta K, Rao GH, Sen D (2018) Gene therapy to treat obesity. Gene Ther Mol Biol 18"},{"key":"463_CR93","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-3-319-18618-4_6","volume":"871","author":"P Salmikangas","year":"2015","unstructured":"Salmikangas P, Schuessler-Lenz M, Ruiz S, Celis P, Reischl I, Menezes-Ferreira M, Flory E, Renner M, Ferry N (2015) Marketing regulatory oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: the EMA\/CAT perspective. Adv Exp Med Biol 871:103\u2013130","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"463_CR94","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nbt.2842","volume":"32","author":"JD Sander","year":"2014","unstructured":"Sander JD, Joung JK (2014) CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol 32(4):347","journal-title":"Nat Biotechnol"},{"issue":"2","key":"463_CR95","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1089\/ars.2013.5668","volume":"21","author":"WL Santivasi","year":"2014","unstructured":"Santivasi WL, Xia F (2014) Ionizing radiation-induced DNA damage, response, and repair. Antioxid Redox Signal 21(2):251\u2013259","journal-title":"Antioxid Redox Signal"},{"issue":"6","key":"463_CR96","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/aps.2017.2","volume":"38","author":"G Shim","year":"2017","unstructured":"Shim G, Kim D, Park GT, Jin H, Suh S-K, Oh Y-K (2017) Therapeutic gene editing: delivery and regulatory perspectives. Acta Pharmacol Sin 38(6):738","journal-title":"Acta Pharmacol Sin"},{"issue":"5","key":"463_CR97","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1084\/jem.54.5.701","volume":"54","author":"RH Sia","year":"1931","unstructured":"Sia RH, Dawson MH (1931) In vitro transformation of Pneumococcal types: II. The nature of the factor responsible for the transformation of Pneumococcal types. J Exp Med 54(5):701\u2013710","journal-title":"J Exp Med"},{"issue":"1","key":"463_CR98","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2174\/156652311794520111","volume":"11","author":"G Silva","year":"2011","unstructured":"Silva G, Poirot L, Galetto R, Smith J, Montoya G, Duchateau P, Paques F (2011) Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. Curr Gene Ther 11(1):11\u201327","journal-title":"Curr Gene Ther"},{"issue":"2","key":"463_CR99","first-page":"149","volume":"91","author":"YS Stafeev","year":"2019","unstructured":"Stafeev YS, Menshikov MY, Parfyonova YV (2019) Gene therapy of type 2 diabetes mellitus: state of art. Ter Arkh 91(2):149\u2013152","journal-title":"Ter Arkh"},{"key":"463_CR100","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.yapd.2019.04.001","volume":"66","author":"DHM Steffin","year":"2019","unstructured":"Steffin DHM, Hsieh EM, Rouce RH (2019) Gene therapy: Current applications and future possibilities. Adv Pediatr 66:37\u201354","journal-title":"Adv Pediatr"},{"issue":"2","key":"463_CR101","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.soncn.2019.02.001","volume":"35","author":"C Stewart","year":"2019","unstructured":"Stewart C, Ralyea C, Lockwood S (2019) Ovarian Cancer: an integrated review. Semin Oncol Nurs 35(2):151\u2013156","journal-title":"Semin Oncol Nurs"},{"key":"463_CR102","doi-asserted-by":"crossref","unstructured":"Swindle S (2018) Biosafety in handling gene transfer vectors. Curr Protoc Hum Genet 96(1):12.11. 11\u201312.11. 17","DOI":"10.1002\/cphg.54"},{"key":"463_CR103","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1073\/pnas.48.12.2026","volume":"48","author":"EH Szybalska","year":"1962","unstructured":"Szybalska EH, Szybalski W (1962) Genetics of human cess line. IV. DNA-mediated heritable transformation of a biochemical trait. Proc Natl Acad Sci U S A 48:2026\u20132034","journal-title":"Proc Natl Acad Sci U S A"},{"key":"463_CR104","first-page":"351","volume":"165","author":"B Thorne","year":"2018","unstructured":"Thorne B, Takeya R, Vitelli F, Swanson X (2018) Gene therapy. Adv Biochem Eng Biotechnol 165:351\u2013399","journal-title":"Adv Biochem Eng Biotechnol"},{"issue":"98","key":"463_CR105","first-page":"151","volume":"18","author":"D Wang","year":"2014","unstructured":"Wang D, Gao G (2014) State-of-the-art human gene therapy: part II. Gene therapy strategies and clinical applications. Discov Med 18(98):151\u2013161","journal-title":"Discov Med"},{"issue":"15","key":"463_CR106","doi-asserted-by":"publisher","first-page":"9874","DOI":"10.1021\/acs.chemrev.6b00799","volume":"117","author":"H-X Wang","year":"2017","unstructured":"Wang H-X, Li M, Lee CM, Chakraborty S, Kim H-W, Bao G, Leong KW (2017) CRISPR\/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery. Chem Rev 117(15):9874\u20139906","journal-title":"Chem Rev"},{"issue":"2","key":"463_CR107","first-page":"149","volume":"2","author":"T Wirth","year":"2014","unstructured":"Wirth T, Yl\u00e4-Herttuala S (2014) Gene therapy used in cancer treatment. Biomedicine 2(2):149\u2013162","journal-title":"Biomedicine"},{"issue":"2","key":"463_CR108","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.gene.2013.03.137","volume":"525","author":"T Wirth","year":"2013","unstructured":"Wirth T, Parker N, Yla-Herttuala S (2013) History of gene therapy. Gene 525(2):162\u2013169","journal-title":"Gene"},{"issue":"1","key":"463_CR109","doi-asserted-by":"publisher","first-page":"a012575","DOI":"10.1101\/cshperspect.a012575","volume":"5","author":"C Yi","year":"2013","unstructured":"Yi C, He C (2013) DNA repair by reversal of DNA damage. Cold Spring Harb Perspect Biol 5(1):a012575","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"8","key":"463_CR110","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nrg3763","volume":"15","author":"H Yin","year":"2014","unstructured":"Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG (2014) Non-viral vectors for gene-based therapy. Nat Rev Genet 15(8):541","journal-title":"Nat Rev Genet"},{"key":"463_CR111","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.dnarep.2014.03.018","volume":"19","author":"J Zhang","year":"2014","unstructured":"Zhang J, Walter JC (2014) Mechanism and regulation of incisions during DNA interstrand cross-link repair. DNA Repair (Amst) 19:135\u2013142","journal-title":"DNA Repair (Amst)"},{"issue":"9","key":"463_CR112","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jgg.2017.09.002","volume":"44","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Mu W, Wang H (2017) Gene editing in T cell therapy. J Genet Genomics 44(9):415\u2013422","journal-title":"J Genet Genomics"},{"issue":"4","key":"463_CR113","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.ymthe.2019.01.014","volume":"27","author":"HX Zhang","year":"2019","unstructured":"Zhang HX, Zhang Y, Yin H (2019) Genome editing with mRNA encoding ZFN, TALEN, and Cas9. Mol Ther 27(4):735\u2013746","journal-title":"Mol Ther"},{"key":"463_CR114","doi-asserted-by":"crossref","unstructured":"Zhao L, Washington MT (2017) Translesion synthesis: insights into the selection and switching of DNA polymerases. Genes (Basel) 8(1)","DOI":"10.3390\/genes8010024"},{"issue":"5","key":"463_CR115","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1128\/JB.64.5.679-699.1952","volume":"64","author":"ND Zinder","year":"1952","unstructured":"Zinder ND, Lederberg J (1952) Genetic exchange in Salmonella. J Bacteriol 64(5):679\u2013699","journal-title":"J Bacteriol"}],"container-title":["Advances in Experimental Medicine and Biology","Cell Biology and Translational Medicine, Volume 8"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2019_463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T15:22:40Z","timestamp":1665242560000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/5584_2019_463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9783030458928","9783030458935"],"references-count":118,"URL":"https:\/\/doi.org\/10.1007\/5584_2019_463","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"17 December 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}