{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:45:31Z","timestamp":1791949531804,"version":"4.3.4"},"publisher-location":"Cham","reference-count":30,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030672157","type":"print"},{"value":"9783030672164","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/5584_2020_541","type":"book-chapter","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T10:03:15Z","timestamp":1591696995000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunoglobulin G Deficiency in Children with Recurrent Respiratory Infections with and Without History of Allergy"],"prefix":"10.1007","author":[{"given":"Aleksandra","family":"Lewandowicz-Uszy\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Pasternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Pento\u015b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"541_CR1","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1365-2249.2009.04062.x","volume":"159","author":"F Abrahamian","year":"2009","unstructured":"Abrahamian F, Agrawal S, Gupta S (2009) Immunological and clinical profile of adult children with selective immunoglobulin subclass deficiency: response to intravenous immunoglobulin therapy. Clin Exp Immunol 159:344\u2013350","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"541_CR2","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1365-2249.2009.04062.x","volume":"159","author":"F Abrahamian","year":"2010","unstructured":"Abrahamian F, Agrawal S, Gupta S (2010) IgG3 deficiency: common in obstructive lung disease. Hereditary in families with immunodeficiency and autoimmune disease. Clin Exp Immunol 159(3):344\u2013350","journal-title":"Clin Exp Immunol"},{"key":"541_CR3","doi-asserted-by":"publisher","first-page":"1405950","DOI":"10.1155\/2016\/1405950","volume":"2016","author":"JC Barton","year":"2016","unstructured":"Barton JC, Bertoli LF, Barton JC, Acton RT (2016) Selective subnormal IgG1 in 54 adult index patients with frequent or severe bacterial respiratory tract infections. J Immunol Res 2016:1405950","journal-title":"J Immunol Res"},{"key":"541_CR4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.rmed.2017.10.016","volume":"132","author":"M Bergera","year":"2017","unstructured":"Bergera M, Gengb B, Cameronc DW, Murphya LM, Schulmand ES (2017) Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease. Respir Med 132:181\u2013188","journal-title":"Respir Med"},{"issue":"2","key":"541_CR5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/00005537-200102000-00008","volume":"111","author":"L Chee","year":"2001","unstructured":"Chee L, Graham SM, Carothers DG, Ballas ZK (2001) Immune dysfunction in refractory sinusitis in a tertiary care setting. Laryngoscope 111(2):233\u2013235","journal-title":"Laryngoscope"},{"issue":"6","key":"541_CR6","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/ccr3.936","volume":"5","author":"G Dine","year":"2017","unstructured":"Dine G, Ali-Ammar N, Brahimi S, Rehn Y (2017) Chronic sinusitis in a patient with selective IgG4 subclass deficiency controlled with enriched immunoglobulins. Clin Case Rep 5(6):792\u2013794","journal-title":"Clin Case Rep"},{"issue":"1","key":"541_CR7","first-page":"89","volume":"79","author":"AE Falconer","year":"1993","unstructured":"Falconer AE, Carson R, Johnstone R, Bird P, Kehoe M, Calvert JE (1993) Distinct IgG1 and IgG3 subclass responses to two streptococcal protein antigens in man: analysis of antibodies to streptolysin O and M protein using standardized subclass-specific enzyme-linked immunosorbent assays. Immunology 79(1):89\u201394","journal-title":"Immunology"},{"issue":"3","key":"541_CR8","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1128\/CMR.00001-09","volume":"22","author":"AJ Fried","year":"2009","unstructured":"Fried AJ, Bonilla FA (2009) Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections. Clin Microbiol Rev 22(3):396\u2013414","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"541_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22420","volume":"32","author":"M Garcia-Prat","year":"2018","unstructured":"Garcia-Prat M, Vila-Pijoan G, Martos Gutierrez S, Gala Yerga G, Garc\u00eda Guantes E, Mart\u00ednez-Gallo M, Mart\u00edn-Nalda A, Soler-Palac\u00edn P, Hern\u00e1ndez-Gonz\u00e1lez M (2018) Age-specific pediatric reference ranges for immunoglobulins and complement proteins on the Optilite\u2122 automated turbidimetric analyzer. J Clin Lab Anal 32(6):e22420","journal-title":"J Clin Lab Anal"},{"issue":"5\u20136","key":"541_CR10","first-page":"377","volume":"42","author":"H Gregorek","year":"1994","unstructured":"Gregorek H, Imielska D, Gornicki J, Miko\u0142ajewicz J, Przeradzka B, Madali\u0144ski K (1994) Development of IgG subclasses in healthy polish children. Arch Immunol Ther Exp 42(5\u20136):377\u2013382","journal-title":"Arch Immunol Ther Exp"},{"issue":"6","key":"541_CR11","doi-asserted-by":"publisher","first-page":"526","DOI":"10.4168\/aair.2017.9.6.526","volume":"9","author":"JH Kim","year":"2017","unstructured":"Kim JH, Ye YM, Ban GY, Shin YS, Lee HY, Nam YH, Lee SK, Cho YS, Jang SH, Jung KS, Park HS (2017) Effects of immunoglobulin replacement on asthma exacerbation in adult asthmatics with IgG subclass deficiency. Allergy Asthma Immunol Res 9(6):526\u2013533","journal-title":"Allergy Asthma Immunol Res"},{"issue":"2","key":"541_CR12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1399-3038.2006.00491.x","volume":"18","author":"N Kutukculer","year":"2007","unstructured":"Kutukculer N, Karaca NE, Demircioglu O, Aksu G (2007) Increases in serum immunoglobulins to age-related normal levels in children with IgA and\/or IgG subclass deficiency. Pediatr Allergy Immunol 18(2):167\u2013173","journal-title":"Pediatr Allergy Immunol"},{"issue":"1","key":"541_CR13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12931-018-0733-z","volume":"19","author":"FS Leitao Filho","year":"2018","unstructured":"Leitao Filho FS, Ra SW, Mattman A, Schellenberg RS, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Paul Man SF, Aaron SD, Reed RM, Sin DD, Canadian Respiratory Research Network (CRRN) (2018) Serum IgG subclass levels and risk of exacerbations and hospitalizations in children with COPD. Respir Res 19(1):30","journal-title":"Respir Res"},{"issue":"6","key":"541_CR14","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1111\/j.1365-3083.2009.02338.x","volume":"70","author":"TE Michaelsen","year":"2009","unstructured":"Michaelsen TE, Sandlie I, Bratlie DB, Sandin RH, Ihle O (2009) Structural difference in the complement activation site of human IgG1 and IgG3. Scand J Immunol 70(6):553\u2013564","journal-title":"Scand J Immunol"},{"key":"541_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1080\/00365540600951192","volume":"39","author":"AM Olinder-Nielsen","year":"2007","unstructured":"Olinder-Nielsen AM, Granert C, Forsberg P, Friman V, Vietorisz A, Bjorkander J (2007) Immunoglobulin prophylaxis in 350 adults with IgG subclass deficiency and recurrent respiratory tract infections: a long-term follow-up. Scand J Infect Dis 39:44\u201350","journal-title":"Scand J Infect Dis"},{"key":"541_CR16","first-page":"19","volume":"17","author":"VA Oxelius","year":"1974","unstructured":"Oxelius VA (1974) Chronic infections in a family with hereditary deficiency of IgG2 and IgG4. Clin Exp Immunol 17:19\u201327","journal-title":"Clin Exp Immunol"},{"key":"541_CR016","unstructured":"Ozkan H, Atlihan F, Genel F, Targan S, Gunvar T (2005) IgA and\/or IgG subclass deficiency in children with recurrent respiratory infections and its relationship with chronic pulmonary damage. J Investig Allergol Clin Immunol 15(1):69\u201374"},{"issue":"4","key":"541_CR17","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/labmed\/lmx058","volume":"48","author":"AR Parker","year":"2017","unstructured":"Parker AR, Skold M, Ramsden DR, Ocejo-Vinyals JG, L\u00f3pez-Hoyos M, Harding S (2017) The clinical utility of measuring IgG subclass immunoglobulins during immunological investigation for suspected primary antibody deficiencies. Lab Med 48(4):314\u2013325","journal-title":"Lab Med"},{"key":"541_CR18","doi-asserted-by":"publisher","first-page":"33198","DOI":"10.1038\/srep33198","volume":"6","author":"M Pezer","year":"2016","unstructured":"Pezer M, Stambuk J, Perica M, Razdorov G, Banic I, Vuckovic F, Gospic AM, Ugrina I, Vecenaj A, Bakovic MP, Lokas SB, Zivkovic J, Plavec D, Devereux G, Turkalj M, Lauc G (2016) Effects of allergic diseases and age on the composition of serum IgG glycome in children. Sci Rep 6:33198","journal-title":"Sci Rep"},{"issue":"4","key":"541_CR19","first-page":"375","volume":"61","author":"W Rastawicki","year":"2009","unstructured":"Rastawicki W, Rokosz N, Jagielski M (2009) Subclass distribution of human igg antibodies to mycoplasma pneumoniae in the course of mycoplasmosis. Med Dosw Mikrobiol 61(4):375\u2013379. (Article in Polish)","journal-title":"Med Dosw Mikrobiol"},{"issue":"2","key":"541_CR20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s10875-016-0236-y","volume":"36","author":"EJ Schatorj\u00e9","year":"2016","unstructured":"Schatorj\u00e9 EJ, de Jong E, van Hout RW, Garc\u00eda Vivas Y, de Vries E (2016) The challenge of immunoglobulin-G subclass deficiency and specific polysaccharide antibody deficiency \u2013 a Dutch Pediatric Cohort Study. J Clin Immunol 36(2):141\u2013148","journal-title":"J Clin Immunol"},{"issue":"1","key":"541_CR21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/iid3.192","volume":"6","author":"TH Scott-Taylor","year":"2018","unstructured":"Scott-Taylor TH, Axinia SC, Amin S, Pettengell R (2018) Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy. Immun Inflamm Dis 6(1):13\u201333","journal-title":"Immun Inflamm Dis"},{"issue":"2","key":"541_CR22","first-page":"69","volume":"7","author":"P Tabatabaie","year":"2008","unstructured":"Tabatabaie P, Aghamohammadi A, Mamishi S, Isaeian A, Heidari G, Abdollahzade S, Pirouzi P, Rezaei N, Heidarnazhad H, Mirsaeid Ghazi B, Yeganeh M, Cheraghi T, Abolhasani H, Saghafi S, Alizadeh H, Anaraki MR (2008) Evaluation of humoral immune function in children with bronchiectasis. Iran J Allergy Asthma Immunol 7(2):69\u201377","journal-title":"Iran J Allergy Asthma Immunol"},{"issue":"3","key":"541_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.anorl.2013.11.002","volume":"131","author":"N Tran Khai Hoan","year":"2014","unstructured":"Tran Khai Hoan N, Karmochkine M, Laccourreye O, Bonfilsa P (2014) Nasal polyposis and immunoglobulin-G subclass deficiency. Eur Ann Otorhinolaryngol Head Neck Dis 131(3):171\u2013175","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"issue":"20","key":"541_CR24","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1056\/NEJM198511143132002","volume":"313","author":"DT Umetsu","year":"1985","unstructured":"Umetsu DT, Ambrosino DM, Quinti I, Siber GR, Geha RS (1985) Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG-subclass deficiency. N Engl J Med 313(20):1247\u20131251","journal-title":"N Engl J Med"},{"key":"541_CR25","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.jaci.2013.01.014","volume":"131","author":"W van de Veen","year":"2013","unstructured":"van de Veen W, Stanic B, Yaman G, Wawrzyniak M, S\u00f6llner S, Akdis DG, R\u00fcckert B, Akdis CA, Akdis M (2013) IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses. J Allergy Clin Immunol 131:1204\u20131212","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"541_CR26","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1046\/j.1365-2249.1999.01023.x","volume":"118","author":"DA Van Kessel","year":"1999","unstructured":"Van Kessel DA, Horikx PE, Van Houte AJ, De Graaff CS, Van Velzen-Blads H, Rijkers GT (1999) Clinical and immunological evaluation of patients with mild IgG1 deficiency. Clin Exp Immunol 118(1):102\u2013107","journal-title":"Clin Exp Immunol"},{"key":"541_CR27","first-page":"161","volume":"2","author":"L Vanlerberghe","year":"2006","unstructured":"Vanlerberghe L, Joniau S, Jorissen M (2006) The prevalence of humoral immunodeficiency in refractory rhinosinusitis: a retrospective analysis. B-ENT 2:161\u2013166","journal-title":"B-ENT"},{"key":"541_CR28","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","volume":"5","author":"G Vidarsson","year":"2014","unstructured":"Vidarsson G, Dekkers G, Rispens T (2014) IgG subclasses and allotypes: from structure to effector functions. Front Immunol 5:520","journal-title":"Front Immunol"},{"issue":"6","key":"541_CR29","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/pai.12757","volume":"28","author":"V Wahn","year":"2017","unstructured":"Wahn V, von Bernuth H (2017) IgG subclass deficiencies in children: facts and fiction. Pediatr Allergy Immunol 28(6):521\u2013524","journal-title":"Pediatr Allergy Immunol"}],"container-title":["Advances in Experimental Medicine and Biology","Medical and Biomedical Updates"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2020_541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T12:57:31Z","timestamp":1611579451000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/5584_2020_541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030672157","9783030672164"],"references-count":30,"URL":"https:\/\/doi.org\/10.1007\/5584_2020_541","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"10 June 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}