{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:36:38Z","timestamp":1758814598899,"version":"3.40.3"},"publisher-location":"Cham","reference-count":44,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783031386121"},{"type":"electronic","value":"9783031386138"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/5584_2023_769","type":"book-chapter","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T16:30:02Z","timestamp":1680107402000},"page":"101-116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravenous Infusion of Exosomes Derived from Human Adipose Tissue-Derived Stem Cells Promotes Angiogenesis and Muscle Regeneration: An Observational Study in a Murine Acute Limb Ischemia Model"],"prefix":"10.1007","author":[{"given":"Hue Thi","family":"Doan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuc","family":"Van Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngoc Bich","family":"Vu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"issue":"1","key":"769_CR1","doi-asserted-by":"crossref","first-page":"12861","DOI":"10.1038\/s41598-019-49339-y","volume":"9","author":"Y An","year":"2019","unstructured":"An, Y., et al. (2019). Exosomes from Adipose-Derived Stem Cells (ADSCs) overexpressing miR-21 promote vascularization of endothelial cells. Scientific Reports, 9(1), 12861.","journal-title":"Scientific Reports"},{"issue":"6","key":"769_CR2","doi-asserted-by":"crossref","first-page":"e007800","DOI":"10.1161\/JAHA.117.007800","volume":"7","author":"Y Arima","year":"2018","unstructured":"Arima, Y., et al. (2018). Evaluation of collateral source characteristics with 3-dimensional analysis using micro-X-ray computed tomography. Journal of the American Heart Association, 7(6), e007800.","journal-title":"Journal of the American Heart Association"},{"issue":"1","key":"769_CR3","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1186\/s13287-021-02667-1","volume":"12","author":"A Attar","year":"2021","unstructured":"Attar, A., et al. (2021). Mesenchymal stem cell transplantation after acute myocardial infarction: A meta-analysis of clinical trials. Stem Cell Research & Therapy, 12(1), 600.","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"769_CR4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3988\/jcn.2016.12.1.14","volume":"12","author":"OY Bang","year":"2016","unstructured":"Bang, O. Y. (2016). Clinical trials of adult stem cell therapy in patients with ischemic stroke. Journal of Clinical Neurology, 12(1), 14\u201320.","journal-title":"Journal of Clinical Neurology"},{"issue":"6","key":"769_CR5","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1002\/ehf2.13031","volume":"7","author":"J Bartunek","year":"2020","unstructured":"Bartunek, J., et al. (2020). Cardiopoietic stem cell therapy in ischaemic heart failure: Long-term clinical outcomes. ESC Heart Failure, 7(6), 3345\u20133354.","journal-title":"ESC Heart Failure"},{"issue":"5","key":"769_CR6","first-page":"Cd007231","volume":"5","author":"GB Boncoraglio","year":"2019","unstructured":"Boncoraglio, G. B., et al. (2019). Stem cell transplantation for ischemic stroke. Cochrane Database of Systematic Reviews, 5(5), Cd007231.","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"769_CR7","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3390\/cimb43030104","volume":"43","author":"SE Byun","year":"2021","unstructured":"Byun, S. E., et al. (2021). Skeletal muscle regeneration by the exosomes of adipose tissue-derived mesenchymal stem cells. Current Issues in Molecular Biology, 43(3), 1473\u20131488.","journal-title":"Current Issues in Molecular Biology"},{"issue":"9","key":"769_CR8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ki.2010.278","volume":"78","author":"G Camussi","year":"2010","unstructured":"Camussi, G., et al. (2010). Exosomes\/microvesicles as a mechanism of cell-to-cell communication. Kidney International, 78(9), 838\u2013848.","journal-title":"Kidney International"},{"issue":"1","key":"769_CR9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13287-020-01737-0","volume":"11","author":"H Cheng","year":"2020","unstructured":"Cheng, H., et al. (2020). Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis. Stem Cell Research & Therapy, 11(1), 224.","journal-title":"Stem Cell Research & Therapy"},{"issue":"8","key":"769_CR10","first-page":"1","volume":"3","author":"TT-T Dao","year":"2016","unstructured":"Dao, T. T.-T., et al. (2016). Human adipose-derived mesenchymal stem cell could participate in angiogenesis in a mouse model of acute hindlimb ischemia. Biomedical Research and Therapy, 3(8), 1\u201310.","journal-title":"Biomedical Research and Therapy"},{"key":"769_CR11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biomaterials.2017.04.030","volume":"133","author":"W Du","year":"2017","unstructured":"Du, W., et al. (2017). Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials, 133, 70\u201381.","journal-title":"Biomaterials"},{"key":"769_CR12","doi-asserted-by":"crossref","unstructured":"Fluck, F., et al. (2020). Current treatment options in acute limb ischemia. In R\u00f6Fo-Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren. \u00a9 Georg Thieme Verlag KG.","DOI":"10.1055\/a-0998-4204"},{"issue":"9","key":"769_CR13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.medcli.2019.01.031","volume":"153","author":"WH Gao","year":"2019","unstructured":"Gao, W. H., et al. (2019). Effectiveness of umbilical cord mesenchymal stem cells in patients with critical limb ischemia. Medicina Cl\u00ednica (Barcelona), 153(9), 341\u2013346.","journal-title":"Medicina Cl\u00ednica (Barcelona)"},{"issue":"3","key":"769_CR14","first-page":"128","volume":"31","author":"T Goto","year":"2006","unstructured":"Goto, T., et al. (2006). Search for appropriate experimental methods to create stable hind-limb ischemia in mouse. The Tokai Journal of Experimental and Clinical Medicine, 31(3), 128\u2013132.","journal-title":"The Tokai Journal of Experimental and Clinical Medicine"},{"key":"769_CR15","doi-asserted-by":"crossref","unstructured":"Hage, A. N., et al. (2018). Acute limb ischemia therapies: When and how to treat endovascularly. In Seminars in interventional radiology. Thieme Medical Publishers.","DOI":"10.1055\/s-0038-1676321"},{"key":"769_CR16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biocel.2019.01.017","volume":"109","author":"Y Han","year":"2019","unstructured":"Han, Y., et al. (2019). Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells enhance angiogenesis through VEGF\/VEGF-R. The International Journal of Biochemistry & Cell Biology, 109, 59\u201368.","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"12","key":"769_CR17","first-page":"1560","volume":"33","author":"X Hu","year":"2019","unstructured":"Hu, X., et al. (2019). Effect of adipose-derived stem cell derived exosomes on angiogenesis after skin flap transplantation in rats. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 33(12), 1560\u20131565.","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"issue":"5","key":"769_CR18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s12265-018-9822-0","volume":"11","author":"C Ju","year":"2018","unstructured":"Ju, C., et al. (2018a). Transplantation of cardiac mesenchymal stem cell-derived exosomes promotes repair in ischemic myocardium. Journal of Cardiovascular Translational Research, 11(5), 420\u2013428.","journal-title":"Journal of Cardiovascular Translational Research"},{"issue":"5","key":"769_CR19","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12265-018-9824-y","volume":"11","author":"C Ju","year":"2018","unstructured":"Ju, C., et al. (2018b). Transplantation of cardiac mesenchymal stem cell-derived exosomes for angiogenesis. Journal of Cardiovascular Translational Research, 11(5), 429\u2013437.","journal-title":"Journal of Cardiovascular Translational Research"},{"issue":"3","key":"769_CR20","first-page":"465","volume":"83","author":"T Kato","year":"2021","unstructured":"Kato, T., et al. (2021). Treatment with adipose-derived regenerative cells enhances ischemia-induced angiogenesis via exosomal microRNA delivery in mice. Nagoya Journal of Medical Science, 83(3), 465\u2013476.","journal-title":"Nagoya Journal of Medical Science"},{"issue":"19","key":"769_CR21","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.3390\/ijms21197380","volume":"21","author":"M Kawabori","year":"2020","unstructured":"Kawabori, M., et al. (2020). Clinical trials of stem cell therapy for cerebral ischemic stroke. International Journal of Molecular Sciences, 21(19), 7380.","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"769_CR22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jvs.2014.03.273","volume":"60","author":"K Kempe","year":"2014","unstructured":"Kempe, K., et al. (2014). Results of surgical management of acute thromboembolic lower extremity ischemia. Journal of Vascular Surgery, 60(3), 702\u2013707.","journal-title":"Journal of Vascular Surgery"},{"key":"769_CR23","volume":"2012","author":"RC Lai","year":"2012","unstructured":"Lai, R. C., et al. (2012). Proteolytic potential of the MSC exosome proteome: Implications for an exosome-mediated delivery of therapeutic proteasome. International Journal of Proteomics, 2012, 971907.","journal-title":"International Journal of Proteomics"},{"issue":"6","key":"769_CR24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/0003319710364213","volume":"61","author":"GP Lasala","year":"2010","unstructured":"Lasala, G. P., et al. (2010). Combination stem cell therapy for the treatment of severe limb ischemia: Safety and efficacy analysis. Angiology, 61(6), 551\u2013556.","journal-title":"Angiology"},{"issue":"8","key":"769_CR25","volume":"54","author":"S Li","year":"2021","unstructured":"Li, S., et al. (2021). Dental pulp stem cell-derived exosomes alleviate cerebral ischaemia-reperfusion injury through suppressing inflammatory response. Cell Proliferation, 54(8), e13093.","journal-title":"Cell Proliferation"},{"key":"769_CR26","volume":"341","author":"X Liu","year":"2021","unstructured":"Liu, X., et al. (2021). Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1\/M2 phenotypes. Experimental Neurology, 341, 113700.","journal-title":"Experimental Neurology"},{"issue":"3","key":"769_CR27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/scd.2020.0167","volume":"30","author":"Z Luo","year":"2021","unstructured":"Luo, Z., et al. (2021). Bone marrow stromal cell-derived exosomes promote muscle healing following contusion through macrophage polarization. Stem Cells and Development, 30(3), 135\u2013148.","journal-title":"Stem Cells and Development"},{"issue":"13 Supplement 1","key":"769_CR28","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1212\/WNL.0b013e31826959d2","volume":"79","author":"V Misra","year":"2012","unstructured":"Misra, V., et al. (2012). Stem cell therapy in ischemic stroke: Role of IV and intra-arterial therapy. Neurology, 79(13 Supplement 1), S207\u2013S212.","journal-title":"Neurology"},{"issue":"1","key":"769_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10741-020-10001-9","volume":"26","author":"T Moghiman","year":"2021","unstructured":"Moghiman, T., et al. (2021). Therapeutic angiogenesis with exosomal microRNAs: An effectual approach for the treatment of myocardial ischemia. Heart Failure Reviews, 26(1), 205\u2013213.","journal-title":"Heart Failure Reviews"},{"key":"769_CR30","doi-asserted-by":"crossref","unstructured":"Morrison, H. L. (2006). Catheter-directed thrombolysis for acute limb ischemia. In Seminars in interventional radiology. Copyright\u00a9 2006 by Thieme Medical Publishers, Inc.","DOI":"10.1055\/s-2006-948765"},{"issue":"11","key":"769_CR31","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.febslet.2015.03.031","volume":"589","author":"Y Nakamura","year":"2015","unstructured":"Nakamura, Y., et al. (2015). Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Letters, 589(11), 1257\u20131265.","journal-title":"FEBS Letters"},{"key":"769_CR32","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnmol.2011.00014","volume":"4","author":"AB Persson","year":"2011","unstructured":"Persson, A. B., & Buschmann, I. R. (2011). Vascular growth in health and disease. Frontiers in Molecular Neuroscience, 4, 14.","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"1","key":"769_CR33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11010-021-04251-w","volume":"477","author":"L Pi","year":"2022","unstructured":"Pi, L., et al. (2022). Exosomal microRNA-125a-3p from human adipose-derived mesenchymal stem cells promotes angiogenesis of wound healing through inhibiting PTEN. Molecular and Cellular Biochemistry, 477(1), 115\u2013127.","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"5","key":"769_CR34","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12006","volume":"2","author":"U Sachdev","year":"2014","unstructured":"Sachdev, U., et al. (2014). MyD88 and TRIF mediate divergent inflammatory and regenerative responses to skeletal muscle ischemia. Physiological Reports, 2(5), e12006.","journal-title":"Physiological Reports"},{"issue":"1","key":"769_CR35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13287-022-02723-4","volume":"13","author":"K Song","year":"2022","unstructured":"Song, K., et al. (2022). Exosomes from tendon derived stem cells promote tendon repair through miR-144-3p-regulated tenocyte proliferation and migration. Stem Cell Research & Therapy, 13(1), 80.","journal-title":"Stem Cell Research & Therapy"},{"issue":"5","key":"769_CR36","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s13577-022-00732-2","volume":"35","author":"Y Sun","year":"2022","unstructured":"Sun, Y., Ju, Y., & Fang, B. (2022). Exosomes from human adipose-derived mesenchymal stromal\/stem cells accelerate angiogenesis in wound healing: Implication of the EGR-1\/lncRNA-SENCR\/DKC1\/VEGF-A axis. Human Cell, 35(5), 1375\u20131390.","journal-title":"Human Cell"},{"issue":"4","key":"769_CR37","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s13770-021-00334-3","volume":"18","author":"TT Van Nguyen","year":"2021","unstructured":"Van Nguyen, T. T., Vu, N. B., & Van Pham, P. (2021). Mesenchymal stem cell transplantation for ischemic diseases: Mechanisms and challenges. Tissue Engineering and Regenerative Medicine, 18(4), 587\u2013611.","journal-title":"Tissue Engineering and Regenerative Medicine"},{"issue":"16","key":"769_CR38","doi-asserted-by":"crossref","first-page":"8877","DOI":"10.3390\/ijms22168877","volume":"22","author":"S-C Wu","year":"2021","unstructured":"Wu, S.-C., et al. (2021). Increased angiogenesis by exosomes secreted by adipose-derived stem cells upon lipopolysaccharide stimulation. International Journal of Molecular Sciences, 22(16), 8877.","journal-title":"International Journal of Molecular Sciences"},{"key":"769_CR39","first-page":"7528464","volume":"2018","author":"B Xie","year":"2018","unstructured":"Xie, B., et al. (2018). Autologous stem cell therapy in critical limb ischemia: A meta-analysis of randomized controlled trials. Stem Cells International, 2018, 7528464.","journal-title":"Stem Cells International"},{"issue":"1","key":"769_CR40","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s12031-018-1071-9","volume":"65","author":"Y Yang","year":"2018","unstructured":"Yang, Y., et al. (2018). Exosomes secreted by adipose-derived stem cells contribute to angiogenesis of brain microvascular endothelial cells following oxygen-glucose deprivation in vitro through MicroRNA-181b\/TRPM7 Axis. Journal of Molecular Neuroscience, 65(1), 74\u201383.","journal-title":"Journal of Molecular Neuroscience"},{"issue":"2","key":"769_CR41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0741-5214(92)90260-F","volume":"15","author":"RA Yeager","year":"1992","unstructured":"Yeager, R. A., et al. (1992). Surgical management of severe acute lower extremity ischemia. Journal of Vascular Surgery, 15(2), 385\u2013393.","journal-title":"Journal of Vascular Surgery"},{"issue":"7","key":"769_CR42","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/cvr\/cvz040","volume":"115","author":"J Zhao","year":"2019","unstructured":"Zhao, J., et al. (2019). Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization. Cardiovascular Research, 115(7), 1205\u20131216.","journal-title":"Cardiovascular Research"},{"issue":"1","key":"769_CR43","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1186\/s13287-022-02980-3","volume":"13","author":"Y Zhou","year":"2022","unstructured":"Zhou, Y., et al. (2022). Human adipose-derived mesenchymal stem cells-derived exosomes encapsulated in pluronic F127 hydrogel promote wound healing and regeneration. Stem Cell Research & Therapy, 13(1), 407.","journal-title":"Stem Cell Research & Therapy"},{"key":"769_CR44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2021.08.010","volume":"162","author":"D Zhu","year":"2022","unstructured":"Zhu, D., et al. (2022). Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31\/FIH1\/HIF-1\u03b1 pathway. Journal of Molecular and Cellular Cardiology, 162, 10\u201319.","journal-title":"Journal of Molecular and Cellular Cardiology"}],"container-title":["Advances in Experimental Medicine and Biology","Advances in Mesenchymal Stem Cells and Tissue Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2023_769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T15:10:29Z","timestamp":1698333029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/5584_2023_769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9783031386121","9783031386138"],"references-count":44,"URL":"https:\/\/doi.org\/10.1007\/5584_2023_769","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"type":"print","value":"0065-2598"},{"type":"electronic","value":"2214-8019"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"30 March 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"ICRRM","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference Innovations in Cancer Research and Regenerative Medicine","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2023","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"12 December 2023","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"13 December 2023","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"5","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"icrrm12023","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"https:\/\/icrrm.com\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}}]}}