{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:06:04Z","timestamp":1791237964248,"version":"4.1.0"},"publisher-location":"Cham","reference-count":60,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031568312","type":"print"},{"value":"9783031568329","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/5584_2023_781","type":"book-chapter","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T19:01:50Z","timestamp":1689361310000},"page":"93-102","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of Hepatocellular Carcinoma Epithelial-Mesenchymal Transition Mechanism and Targeted Therapeutic Approaches"],"prefix":"10.1007","author":[{"given":"Yelda","family":"Y\u00fcregir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demet","family":"Ka\u00e7aro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seher","family":"Yaylac\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"issue":"9","key":"781_CR1","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3390\/medicina55090526","volume":"55","author":"A Alqahtani","year":"2019","unstructured":"Alqahtani A, Khan Z, Alloghbi A, Said Ahmed TS, Ashraf M, Hammouda DM (2019) Hepatocellular carcinoma: molecular mechanisms and targeted therapies. Medicina 55(9):526. https:\/\/doi.org\/10.3390\/medicina55090526","journal-title":"Medicina"},{"key":"781_CR2","doi-asserted-by":"publisher","unstructured":"Anstee QM, Reeves HL, Kotsiliti E, Govaere O, Heikenwalder M (2019 July) From NASH to HCC: current concepts and future challenges. Nat Rev Gastroenterol Hepatol 16(7):411\u2013428. https:\/\/doi.org\/10.1038\/s41575-019-0145-7. PMID: 31028350","DOI":"10.1038\/s41575-019-0145-7"},{"issue":"7","key":"781_CR4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41575-019-0134-x","volume":"16","author":"S Ben-Moshe","year":"2019","unstructured":"Ben-Moshe S, Itzkovitz S (2019) Spatial heterogeneity in the mammalian liver. Nat Rev Gastroenterol Hepatol 16(7):395\u2013410. https:\/\/doi.org\/10.1038\/s41575-019-0134-x","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"33","key":"781_CR5","doi-asserted-by":"publisher","first-page":"5093","DOI":"10.1038\/sj.onc.1206557","volume":"22","author":"TM Block","year":"2003","unstructured":"Block TM, Mehta AS, Fimmel CJ, Jordan R (2003) Molecular viral oncology of hepatocellular carcinoma. Oncogene 22(33):5093\u20135107. https:\/\/doi.org\/10.1038\/sj.onc.1206557","journal-title":"Oncogene"},{"key":"781_CR6","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.biopha.2017.02.030","volume":"89","author":"J Cao","year":"2017","unstructured":"Cao J, Liu J, Long J, Fu J, Huang L, Li J, Liu C, Zhang X, Yan Y (2017) microRNA-23b suppresses epithelial-mesenchymal transition (EMT) and metastasis in hepatocellular carcinoma via targeting Pyk2. Biomed Pharmacother\/Biomed Pharmacother 89:642\u2013650. https:\/\/doi.org\/10.1016\/j.biopha.2017.02.030","journal-title":"Biomed Pharmacother\/Biomed Pharmacother"},{"key":"781_CR7","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s12094-016-1582-1","volume":"19","author":"L Chang","year":"2017","unstructured":"Chang L, Li K, Guo T (2017) miR-26a-5p suppresses tumor metastasis by regulating EMT and is associated with prognosis in HCC. Clin Transl Oncol 19:695\u2013703. https:\/\/doi.org\/10.1007\/s12094-016-1582-1","journal-title":"Clin Transl Oncol"},{"issue":"4","key":"781_CR8","first-page":"3317","volume":"20","author":"Y Chen","year":"2019","unstructured":"Chen Y et al (2019 Oct) Afatinib, an EGFR inhibitor, decreases EMT and tumorigenesis of Huh-7 cells by regulating the ERK-VEGF\/MMP9 signaling pathway. Mol Med Rep 20(4):3317","journal-title":"Mol Med Rep"},{"key":"781_CR9","unstructured":"Chen Z, Xie H, Hu M, Huang T, Hu Y, Sang N, Zhao Y (2020 Sept 1) Recent progress in treatment of hepatocellular carcinoma. Am J Cancer Res 10(9):2993\u20133036. PMID: 33042631; PMCID: PMC7539784"},{"issue":"6917","key":"781_CR10","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860\u2013867. https:\/\/doi.org\/10.1038\/nature01322","journal-title":"Nature"},{"issue":"2","key":"781_CR11","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3390\/cancers12020491","volume":"12","author":"M Dimri","year":"2020","unstructured":"Dimri M, Satyanarayana A (2020) Molecular signaling pathways and therapeutic targets in hepatocellular carcinoma. Cancers 12(2):491. https:\/\/doi.org\/10.3390\/cancers12020491","journal-title":"Cancers"},{"issue":"10","key":"781_CR12","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.3390\/cells8101130","volume":"8","author":"F Dituri","year":"2019","unstructured":"Dituri F, Cossu C, Mancarella S, Giannelli G (2019) The interactivity between TGF\u03b2 and BMP signaling in organogenesis, fibrosis, and cancer. Cell 8(10):1130. https:\/\/doi.org\/10.3390\/cells8101130","journal-title":"Cell"},{"key":"781_CR02","doi-asserted-by":"publisher","first-page":"Article ID 2953","DOI":"10.1155\/2016\/2953727","volume":"2016","author":"L Fabris","year":"2016","unstructured":"Fabris L, Brivio S, Cadamuro M, Strazzabosco M (2016) Revisiting epithelial-to-mesenchymal transition in liver fibrosis: clues for a better understanding of the \u201creactive\u201d biliary epithelial phenotype. Stem Cells Int 2016:Article ID 2953727, 10 pages. https:\/\/doi.org\/10.1155\/2016\/2953727","journal-title":"Stem Cells Int"},{"issue":"12","key":"781_CR13","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1111\/febs.13665","volume":"283","author":"I Fabregat","year":"2016","unstructured":"Fabregat I, Moreno-C\u00e0ceres J, S\u00e1nchez A, Dooley S, Dewidar B, Giannelli G, Ten Dijke P, IT-LIVER Consortium (2016) TGF-\u03b2 signalling and liver disease. FEBS J 283(12):2219\u20132232. https:\/\/doi.org\/10.1111\/febs.13665","journal-title":"FEBS J"},{"key":"781_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ebiom.2018.10.032","volume":"37","author":"X Fu","year":"2018","unstructured":"Fu X, Calin GA (2018) miR-122 and hepatocellular carcinoma: from molecular biology to therapeutics. EBioMedicine 37:17\u201318. https:\/\/doi.org\/10.1016\/j.ebiom.2018.10.032","journal-title":"EBioMedicine"},{"key":"781_CR15","doi-asserted-by":"publisher","unstructured":"Fu X, Liu M, Qu S, Ma J, Zhang Y, Shi T, Wen H, Yang Y, Wang S, Wang J, Nan K, Yao Y, Tian T (2018 Mar 12) Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K\/Akt pathway. J Exp Clin Cancer Res 37(1):52. https:\/\/doi.org\/10.1186\/s13046-018-0677-7. PMID: 29530052; PMCID: PMC5846230","DOI":"10.1186\/s13046-018-0677-7"},{"key":"781_CR16","doi-asserted-by":"publisher","unstructured":"Giannelli G, Koudelkova P, Dituri F, Mikulits W (2016 Oct) Role of epithelial to mesenchymal transition in hepatocellular carcinoma. J Hepatol 65(4):798\u2013808. https:\/\/doi.org\/10.1016\/j.jhep.2016.05.007. Epub 2016 May 17. PMID: 27212245","DOI":"10.1016\/j.jhep.2016.05.007"},{"issue":"3","key":"781_CR17","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1053\/j.gastro.2013.01.002","volume":"144","author":"V Hernandez-Gea","year":"2013","unstructured":"Hernandez-Gea V, Toffanin S, Friedman SL, Llovet JM (2013) Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology 144(3):512\u2013527","journal-title":"Gastroenterology"},{"issue":"4","key":"781_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100416","volume":"4","author":"\u00c1 Holczbauer","year":"2021","unstructured":"Holczbauer \u00c1, Wangensteen KJ, Shin S (2021) Cellular origins of regenerating liver and hepatocellular carcinoma. JHEP Rep 4(4):100416. https:\/\/doi.org\/10.1016\/j.jhepr.2021.100416","journal-title":"JHEP Rep"},{"issue":"4","key":"781_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153117","volume":"11","author":"H Huan","year":"2016","unstructured":"Huan H, Wen X, Chen X, Wu L, Liu W, Huang Q (2016) C\/EBP\u03b1 short-activating RNA suppresses metastasis of hepatocellular carcinoma through inhibiting EGFR\/\u03b2-catenin signaling mediated EMT. PLoS One 11(4):e0153117","journal-title":"PLoS One"},{"issue":"11","key":"781_CR20","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1007\/s10529-017-2403-5","volume":"39","author":"C Ji","year":"2017","unstructured":"Ji C, Liu H, Yin Q, Li H, Gao H (2017) miR-93 enhances hepatocellular carcinoma invasion and metastasis by EMT via targeting PDCD4. Biotechnol Lett 39(11):1621\u20131629. https:\/\/doi.org\/10.1007\/s10529-017-2403-5","journal-title":"Biotechnol Lett"},{"key":"781_CR21","doi-asserted-by":"publisher","unstructured":"Jiang L, Li L, Liu Y, Lu L, Zhan M, Yuan S, Liu Y (2023 Feb 13) Drug resistance mechanism of kinase inhibitors in the treatment of hepatocellular carcinoma. Front Pharmacol 14:1097277. https:\/\/doi.org\/10.3389\/fphar.2023.1097277. PMID: 36891274; PMCID: PMC9987615","DOI":"10.3389\/fphar.2023.1097277"},{"issue":"7","key":"781_CR22","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1002\/1878-0261.12083","volume":"11","author":"MK Jolly","year":"2017","unstructured":"Jolly MK, Ware KE, Gilja S, Somarelli JA, Levine H (2017) EMT and MET: necessary or permissive for metastasis? Mol Oncol 11(7):755\u2013769. https:\/\/doi.org\/10.1002\/1878-0261.12083","journal-title":"Mol Oncol"},{"issue":"6","key":"781_CR23","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119(6):1420\u20131428. https:\/\/doi.org\/10.1172\/JCI39104","journal-title":"J Clin Invest"},{"issue":"1","key":"781_CR24","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s40425-019-0749-z","volume":"7","author":"BP Keenan","year":"2019","unstructured":"Keenan BP, Fong L, Kelley RK (2019) Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. J Immunother Cancer 7(1):267. https:\/\/doi.org\/10.1186\/s40425-019-0749-z","journal-title":"J Immunother Cancer"},{"issue":"3","key":"781_CR25","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","volume":"18","author":"T Kisseleva","year":"2021","unstructured":"Kisseleva T, Brenner D (2021) Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol 18(3):151\u2013166. https:\/\/doi.org\/10.1038\/s41575-020-00372-7","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"781_CR26","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nrm3758","volume":"15","author":"S Lamouille","year":"2014","unstructured":"Lamouille S, Xu J, Derynck R (2014) Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol 15(3):178\u2013196. https:\/\/doi.org\/10.1038\/nrm3758","journal-title":"Nat Rev Mol Cell Biol"},{"key":"781_CR27","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3350\/cmh.2019.0056n","volume":"26","author":"S Lee","year":"2020","unstructured":"Lee S, Choi EJ, Cho EJ, Lee YB, Lee JH, Yu SJ et al (2020) Inhibition of PI3K\/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail\/GSK-3\/beta-catenin pathway. Clin Mol Hepatol 26:529\u2013539","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"781_CR28","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12964-021-00713-2","volume":"19","author":"SE Leggett","year":"2021","unstructured":"Leggett SE, Hruska AM, Guo M, Wong IY (2021) The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems. Cell Commun Signal 19(1):32. https:\/\/doi.org\/10.1186\/s12964-021-00713-2","journal-title":"Cell Commun Signal"},{"key":"781_CR29","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.ijbiomac.2017.05.108","volume":"103","author":"T Li","year":"2017","unstructured":"Li T, Li M, Hu S, Cheng X, Gao Y, Jiang S, Yu Q, Zhang C, Sun P, Xian W, Song Z, Zhang Y, Zheng Q (2017) MiR-221 mediates the epithelial-mesenchymal transition of hepatocellular carcinoma by targeting AdipoR1. Int J Biol Macromol 103:1054\u20131061","journal-title":"Int J Biol Macromol"},{"issue":"9","key":"781_CR30","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41568-021-00383-9","volume":"21","author":"X Li","year":"2021","unstructured":"Li X, Ramadori P, Pfister D, Seehawer M, Zender L, Heikenwalder M (2021) The immunological and metabolic landscape in primary and metastatic liver cancer. Nat Rev Cancer 21(9):541\u2013557","journal-title":"Nat Rev Cancer"},{"key":"781_CR31","doi-asserted-by":"publisher","unstructured":"Li W, Jiang Y, Pan Q, Yang G (2023) miR-29a-5p regulates the malignant biological process of liver cancer cells through ARID2 regulation of EMT [published online as ahead of print on December 19, 2022]. Adv Clin Exp Med. https:\/\/doi.org\/10.17219\/acem\/156646","DOI":"10.17219\/acem\/156646"},{"issue":"3","key":"781_CR32","first-page":"1080","volume":"12","author":"Q Lin","year":"2020","unstructured":"Lin Q, Zhou CR, Bai MJ, Zhu D, Chen JW, Wang HF, Li MA, Wu C, Li ZR, Huang MS (2020) Exosome-mediated miRNA delivery promotes liver cancer EMT and metastasis. Am J Transl Res 12(3):1080\u20131095","journal-title":"Am J Transl Res"},{"key":"781_CR33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13046-016-0296-0","volume":"35","author":"Y Liu","year":"2016","unstructured":"Liu Y, Li Y, Wang R, Qin S, Liu J, Su F, Yang Y, Zhao F, Wang Z, Wu Q (2016) MiR-130a-3p regulates cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells. J Exp Clin Cancer Res 35:19. https:\/\/doi.org\/10.1186\/s13046-016-0296-0","journal-title":"J Exp Clin Cancer Res"},{"key":"781_CR34","doi-asserted-by":"publisher","first-page":"16018","DOI":"10.1038\/nrdp.2016.18","volume":"2","author":"JM Llovet","year":"2016","unstructured":"Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, Gores G (2016) Hepatocellular carcinoma. Nat Rev Dis Primers 2:16018. https:\/\/doi.org\/10.1038\/nrdp.2016.18","journal-title":"Nat Rev Dis Primers"},{"issue":"7","key":"781_CR35","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.3390\/cells10071587","volume":"10","author":"GD Marconi","year":"2021","unstructured":"Marconi GD, Fonticoli L, Rajan TS, Pierdomenico SD, Trubiani O, Pizzicannella J, Diomede F (2021) Epithelial-mesenchymal transition (EMT): the Type-2 EMT in wound healing, tissue regeneration and organ fibrosis. Cells 10(7):1587. https:\/\/doi.org\/10.3390\/cells10071587","journal-title":"Cells"},{"key":"781_CR36","doi-asserted-by":"publisher","unstructured":"Modi SJ, Tiwari A, Kulkarni VM (2021 Jan) Reversal of TGF-\u03b2-induced epithelial-mesenchymal transition in hepatocellular carcinoma by sorafenib, a VEGFR-2 and Raf kinase inhibitor. Curr Res Pharmacol Drug Discov 19(2):100014. https:\/\/doi.org\/10.1016\/j.crphar.2021.100014. PMID: 34909649; PMCID: PMC8663974","DOI":"10.1016\/j.crphar.2021.100014"},{"issue":"1","key":"781_CR37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3390\/ijms23010146","volume":"23","author":"S Niland","year":"2021","unstructured":"Niland S, Riscanevo AX, Eble JA (2021) Matrix metalloproteinases shape the tumor microenvironment in cancer progression. Int J Mol Sci 23(1):146. https:\/\/doi.org\/10.3390\/ijms23010146","journal-title":"Int J Mol Sci"},{"issue":"39","key":"781_CR38","doi-asserted-by":"publisher","first-page":"4436","DOI":"10.3748\/wjg.v24.i39.4436","volume":"24","author":"JM O\u2019Rourke","year":"2018","unstructured":"O\u2019Rourke JM, Sagar VM, Shah T, Shetty S (2018) Carcinogenesis on the background of liver fibrosis: implications for the management of hepatocellular cancer. World J Gastroenterol 24(39):4436\u20134447","journal-title":"World J Gastroenterol"},{"key":"781_CR39","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41556-018-0195-z","volume":"21","author":"D Pei","year":"2019","unstructured":"Pei D, Shu X, Gassama-Diagne A et al (2019) Mesenchymal\u2013epithelial transition in development and reprogramming. Nat Cell Biol 21:44\u201353. https:\/\/doi.org\/10.1038\/s41556-018-0195-z","journal-title":"Nat Cell Biol"},{"key":"781_CR40","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s12307-012-0111-1","volume":"5","author":"LX Qin","year":"2012","unstructured":"Qin LX (2012) Inflammatory immune responses in tumor microenvironment and metastasis of hepatocellular carcinoma. Cancer Microenviron 5:203\u2013209. https:\/\/doi.org\/10.1007\/s12307-012-0111-1","journal-title":"Cancer Microenviron"},{"key":"781_CR41","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s11010-018-3298-8","volume":"447","author":"NM Rashad","year":"2018","unstructured":"Rashad NM, El-Shal AS, Shalaby SM et al (2018) Serum miRNA-27a and miRNA-18b as potential predictive biomarkers of hepatitis C virus-associated hepatocellular carcinoma. Mol Cell Biochem 447:125\u2013136. https:\/\/doi.org\/10.1007\/s11010-018-3298-8","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"781_CR42","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3390\/cancers12030641","volume":"12","author":"MG Refolo","year":"2020","unstructured":"Refolo MG, Messa C, Guerra V, Carr BI, D\u2019Alessandro R (2020) Inflammatory mechanisms of HCC development. Cancers 12(3):641. https:\/\/doi.org\/10.3390\/cancers12030641","journal-title":"Cancers"},{"issue":"2","key":"781_CR43","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1159\/000218339","volume":"27","author":"K Sch\u00fctte","year":"2009","unstructured":"Sch\u00fctte K, Bornschein J, Malfertheiner P (2009) Hepatocellular carcinoma \u2013 epidemiological trends and risk factors. Dig Dis (Basel, Switzerland) 27(2):80\u201392. https:\/\/doi.org\/10.1159\/000218339","journal-title":"Dig Dis (Basel, Switzerland)"},{"key":"781_CR44","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/s41419-019-2173-1","volume":"10","author":"Q Su","year":"2019","unstructured":"Su Q, Fan M, Wang J et al (2019) Sanguinarine inhibits epithelial\u2013mesenchymal transition via targeting HIF-1\u03b1\/TGF-\u03b2 feed-forward loop in hepatocellular carcinoma. Cell Death Dis 10:939. https:\/\/doi.org\/10.1038\/s41419-019-2173-1","journal-title":"Cell Death Dis"},{"issue":"1","key":"781_CR45","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/jcm5010009","volume":"5","author":"K Taura","year":"2016","unstructured":"Taura K, Iwaisako K, Hatano E, Uemoto S (2016) Controversies over the epithelial-to-mesenchymal transition in liver fibrosis. J Clin Med 5(1):9. https:\/\/doi.org\/10.3390\/jcm5010009","journal-title":"J Clin Med"},{"key":"781_CR46","doi-asserted-by":"publisher","first-page":"20065","DOI":"10.1038\/srep20065","volume":"6","author":"T Thurnherr","year":"2016","unstructured":"Thurnherr T, Mah WC, Lei Z, Jin Y, Rozen SG, Lee CG (2016) Differentially expressed miRNAs in hepatocellular carcinoma target genes in the genetic information processing and metabolism pathways. Sci Rep 6:20065. https:\/\/doi.org\/10.1038\/srep20065","journal-title":"Sci Rep"},{"issue":"4","key":"781_CR47","doi-asserted-by":"publisher","first-page":"863","DOI":"10.22034\/APJCP.2017.18.4.863","volume":"18","author":"NM Tunissiolli","year":"2017","unstructured":"Tunissiolli NM, Castanhole-Nunes MMU, Biselli-Chicote PM, Pavarino EC, da Silva RF, da Silva RC, Goloni-Bertollo EM (2017) Hepatocellular carcinoma: a comprehensive review of biomarkers, clinical aspects, and therapy. Asian Pac J Cancer Prev 18(4):863\u2013872. https:\/\/doi.org\/10.22034\/APJCP.2017.18.4.863","journal-title":"Asian Pac J Cancer Prev"},{"key":"781_CR48","doi-asserted-by":"publisher","unstructured":"Van Zijl F, Zulehner G, Petz M, Schneller D, Kornauth C, Hau M, Machat G, Grubinger M, Huber H, Mikulits W (2009 Oct) Epithelial-mesenchymal transition in hepatocellular carcinoma. Future Oncol 5(8):1169\u20131179. https:\/\/doi.org\/10.2217\/fon.09.91. PMID: 19852728; PMCID: PMC2963061","DOI":"10.2217\/fon.09.91"},{"key":"781_CR49","doi-asserted-by":"publisher","first-page":"7919","DOI":"10.2147\/OTT.S180971","volume":"11","author":"X Wang","year":"2018","unstructured":"Wang X, Lu J, Cao J, Ma B, Gao C, Qi F (2018) MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10. Onco Targets Ther 11:7919\u20137934. https:\/\/doi.org\/10.2147\/OTT.S180971","journal-title":"Onco Targets Ther"},{"key":"781_CR50","unstructured":"Wang Z, Zhu Q, Li X, Ren X, Li J, Zhang Y, Zeng S, Xu L, Dong X, Zhai B (2022 Sept 15) TOP2A inhibition reverses drug resistance of hepatocellular carcinoma to regorafenib. Am J Cancer Res 12(9):4343\u20134360. PMID: 36225636; PMCID: PMC9548008"},{"issue":"12","key":"781_CR51","doi-asserted-by":"publisher","first-page":"5158","DOI":"10.26355\/eurrev_201906_18180","volume":"23","author":"GY Wei","year":"2019","unstructured":"Wei GY, Hu M, Zhao L, Guo WS (2019) MiR-451a suppresses cell proliferation, metastasis and EMT via targeting YWHAZ in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci 23(12):5158\u20135167. https:\/\/doi.org\/10.26355\/eurrev_201906_18180","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"781_CR52","doi-asserted-by":"publisher","unstructured":"Xia YH, Ren L, Li JZ, Gao F (2019 Dec) Role of miR-541-3p\/TMPRSS4 in the metastasis and EMT of hepatocellular carcinoma. Eur Rev Med Pharmacol Sci 23(24):10721\u201310728. https:\/\/doi.org\/10.26355\/eurrev_201912_19773. PMID: 31858539","DOI":"10.26355\/eurrev_201912_19773"},{"issue":"5","key":"781_CR01","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064235","volume":"8","author":"C Xie","year":"2013","unstructured":"Xie C, Wu J, Yun J, Lai J, Yuan Y, Gao Z, Li M, Li J, Song L (2013) MACC1 as a prognostic biomarker for early-stage and AFP-normal hepatocellular carcinoma. PLoS One 8(5):e64235. https:\/\/doi.org\/10.1371\/journal.pone.0064235. PMID: 23717574; PMCID: PMC3662710","journal-title":"PLoS One"},{"key":"781_CR53","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1186\/s12935-021-02326-8","volume":"21","author":"D Xu","year":"2021","unstructured":"Xu D, Wang Y, Wu J et al (2021) Identification and clinical validation of EMT-associated prognostic features based on hepatocellular carcinoma. Cancer Cell Int 21:621. https:\/\/doi.org\/10.1186\/s12935-021-02326-8","journal-title":"Cancer Cell Int"},{"key":"781_CR54","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s13046-018-0887-z","volume":"37","author":"L Yan","year":"2018","unstructured":"Yan L, Xu F, Dai C (2018) Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma. J Exp Clin Cancer Res 37:203. https:\/\/doi.org\/10.1186\/s13046-018-0887-z","journal-title":"J Exp Clin Cancer Res"},{"key":"781_CR55","doi-asserted-by":"publisher","unstructured":"Yang X, Jiang W, Kong X, Zhou X, Zhu D, Kong L (2022 Sept 22) Genistein restricts the epithelial mesenchymal transformation (EMT) and stemness of hepatocellular carcinoma via upregulating miR-1275 to inhibit the EIF5A2\/PI3K\/Akt pathway. Biology (Basel) 11(10):1383. https:\/\/doi.org\/10.3390\/biology11101383. PMID: 36290289; PMCID: PMC9598820","DOI":"10.3390\/biology11101383"},{"key":"781_CR56","doi-asserted-by":"publisher","first-page":"8891876","DOI":"10.1155\/2020\/8891876","volume":"2020","author":"LC Yin","year":"2020","unstructured":"Yin LC, Xiao G, Zhou R, Huang XP, Li NL, Tan CL, Xie FJ, Weng J, Liu LX (2020) MicroRNA-361-5p inhibits tumorigenesis and the EMT of HCC by targeting Twist1. Biomed Res Int 2020:8891876. https:\/\/doi.org\/10.1155\/2020\/8891876","journal-title":"Biomed Res Int"},{"key":"781_CR57","doi-asserted-by":"publisher","first-page":"42","DOI":"10.20517\/2394-5079.2018.23","volume":"4","author":"SK Yoon","year":"2018","unstructured":"Yoon SK (2018) Molecular mechanism of hepatocellular carcinoma. Hepatoma Res 4:42. https:\/\/doi.org\/10.20517\/2394-5079.2018.23","journal-title":"Hepatoma Res"},{"issue":"10","key":"781_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108005","volume":"9","author":"J Zhao","year":"2014","unstructured":"Zhao J, Tang N, Wu K, Dai W, Ye C, Shi J, Zhang J, Ning B, Zeng X, Lin Y (2014) MiR-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis. PLoS One 9(10):e108005. https:\/\/doi.org\/10.1371\/journal.pone.0108005","journal-title":"PLoS One"},{"issue":"3","key":"781_CR03","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3892\/br.2016.578","volume":"4","author":"YL Zhao","year":"2016","unstructured":"Zhao YL, Zhu RT, Sun YL (2016) Epithelial-mesenchymal transition in liver fibrosis. Biomed Rep. 4(3):269\u2013274. https:\/\/doi.org\/10.3892\/br.2016.578. Epub 2016 Jan 25. PMID: 26998262; PMCID: PMC4774315","journal-title":"Biomed Rep."}],"container-title":["Advances in Experimental Medicine and Biology","Cell Biology and Translational Medicine, Volume 21"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/5584_2023_781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T13:03:34Z","timestamp":1713445414000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/5584_2023_781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9783031568312","9783031568329"],"references-count":60,"URL":"https:\/\/doi.org\/10.1007\/5584_2023_781","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"15 July 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}