{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:59:23Z","timestamp":1788386363155,"version":"build-2803163510"},"publisher-location":"New York, NY","reference-count":41,"publisher":"Springer US","isbn-type":[{"value":"9781071642672","type":"print"},{"value":"9781071642689","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/7651_2024_524","type":"book-chapter","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T10:02:28Z","timestamp":1709632948000},"page":"239-260","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Lipidomics Approach to Determine the Role of Lipids and Its Crosstalk with Autophagy in Lung Cancer Metastasis"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3732-3781","authenticated-orcid":false,"given":"Simone C.","family":"da Silva Rosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Vitorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Surendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ravandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biniam","family":"Kidane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Ghavami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"issue":"17","key":"524_CR1","doi-asserted-by":"publisher","first-page":"E601","DOI":"10.1503\/cmaj.212097","volume":"194","author":"DR Brenner","year":"2022","unstructured":"Brenner DR, Poirier A, Woods RR et al (2022) Projected estimates of cancer in Canada in 2022. CMAJ 194(17):E601\u2013E607","journal-title":"CMAJ"},{"key":"524_CR2","unstructured":"Lung Cancer Statistics| How common is lung cancer? [Internet]. [cited 2023 Jul 13]; Available from: https:\/\/www.cancer.org\/cancer\/types\/lung-cancer\/about\/key-statistics.html"},{"key":"524_CR3","doi-asserted-by":"publisher","unstructured":"Expert Consensus Panel, Kidane B, Bott M et al (2023) The American Association for Thoracic Surgery (AATS) 2023 Expert Consensus Document: staging and multidisciplinary management of patients with early-stage non-small cell lung cancer. J Thorac Cardiovasc Surg:S0022-5223(23)00363-X. https:\/\/doi.org\/10.1016\/j.jtcvs.2023.04.039","DOI":"10.1016\/j.jtcvs.2023.04.039"},{"key":"524_CR4","unstructured":"Lung Cancer \u2013 Non-small cell \u2013 Statistics [Internet]. Cancer Net 2012 [cited 2023 Jul 13]; Available from: https:\/\/www.cancer.net\/cancer-types\/lung-cancer-non-small-cell\/statistics"},{"key":"524_CR5","unstructured":"Lung Cancer Survival Rates | 5-Year Survival Rates for Lung Cancer [Internet]. [cited 2023 Jul 13]; Available from: https:\/\/www.cancer.org\/cancer\/types\/lung-cancer\/detection-diagnosis-staging\/survival-rates.html"},{"issue":"8","key":"524_CR6","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","volume":"24","author":"J Debnath","year":"2023","unstructured":"Debnath J, Gammoh N, Ryan KM (2023) Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol 24(8):560\u2013575","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"13","key":"524_CR7","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021110031","volume":"41","author":"RC Russell","year":"2022","unstructured":"Russell RC, Guan K (2022) The multifaceted role of autophagy in cancer. EMBO J 41(13):e110031","journal-title":"EMBO J"},{"key":"524_CR8","doi-asserted-by":"crossref","unstructured":"Chavez-Dominguez R, Perez-Medina M, Lopez-Gonzalez JS, Galicia-Velasco M, Aguilar-Cazares D (2020) The double-edge sword of autophagy in Cancer: from tumor suppression to pro-tumor activity. Front Oncol [Internet] [cited 2023 Dec 1]; 10. Available from: https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2020.578418","DOI":"10.3389\/fonc.2020.578418"},{"key":"524_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.semcdb.2015.02.013","volume":"39","author":"PK Panda","year":"2015","unstructured":"Panda PK, Mukhopadhyay S, Das DN, Sinha N, Naik PP, Bhutia SK (2015) Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics. Semin Cell Dev Biol 39:43\u201355","journal-title":"Semin Cell Dev Biol"},{"issue":"12","key":"524_CR10","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/onc.2016.333","volume":"36","author":"EE Mowers","year":"2017","unstructured":"Mowers EE, Sharifi MN, Macleod KF (2017) Autophagy in cancer metastasis. Oncogene 36(12):1619\u20131630","journal-title":"Oncogene"},{"issue":"1","key":"524_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-020-0134-x","volume":"5","author":"J Fares","year":"2020","unstructured":"Fares J, Fares MY, Khachfe HH, Salhab HA, Fares Y (2020) Molecular principles of metastasis: a hallmark of cancer revisited. Sig Transduct Target Ther 5(1):1\u201317","journal-title":"Sig Transduct Target Ther"},{"issue":"10","key":"524_CR12","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.4161\/cc.20424","volume":"11","author":"RL Macintosh","year":"2012","unstructured":"Macintosh RL, Timpson P, Thorburn J, Anderson KI, Thorburn A, Ryan KM (2012) Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle 11(10):2022\u20132029","journal-title":"Cell Cycle"},{"issue":"1","key":"524_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01110-y","volume":"7","author":"F Peng","year":"2022","unstructured":"Peng F, Liao M, Qin R et al (2022) Regulated cell death (RCD) in cancer: key pathways and targeted therapies. Sig Transduct Target Ther 7(1):1\u201366","journal-title":"Sig Transduct Target Ther"},{"key":"524_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101529","volume":"63","author":"C Zhang","year":"2022","unstructured":"Zhang C, Zhu N, Li H et al (2022) New dawn for cancer cell death: emerging role of lipid metabolism. Mol Metab 63:101529","journal-title":"Mol Metab"},{"issue":"1","key":"524_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/mco2.27","volume":"2","author":"Y Fu","year":"2020","unstructured":"Fu Y, Zou T, Shen X et al (2020) Lipid metabolism in cancer progression and therapeutic strategies. MedComm 2(1):27\u201359","journal-title":"MedComm"},{"issue":"11","key":"524_CR16","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.tcb.2017.07.006","volume":"27","author":"AM Thelen","year":"2017","unstructured":"Thelen AM, Zoncu R (2017) Emerging roles for the lysosome in lipid metabolism. Trends Cell Biol 27(11):833\u2013850","journal-title":"Trends Cell Biol"},{"issue":"9","key":"524_CR17","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1194\/jlr.R067520","volume":"57","author":"B Jaishy","year":"2016","unstructured":"Jaishy B, Abel ED (2016) Lipids, lysosomes, and autophagy. J Lipid Res 57(9):1619\u20131635","journal-title":"J Lipid Res"},{"key":"524_CR18","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-nutr-071714-034355","volume":"35","author":"A Caron","year":"2015","unstructured":"Caron A, Richard D, Laplante M (2015) The roles of mTOR complexes in lipid metabolism. Annu Rev Nutr 35:321\u2013348","journal-title":"Annu Rev Nutr"},{"key":"524_CR19","doi-asserted-by":"crossref","unstructured":"Xie Y, Li J, Kang R, Tang D (2020) Interplay between lipid metabolism and autophagy. Front Cell Dev Biol [Internet] [cited 2023 Nov 17]; 8. Available from: https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2020.00431","DOI":"10.3389\/fcell.2020.00431"},{"issue":"4","key":"524_CR20","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.bbalip.2016.01.006","volume":"1861","author":"C Ward","year":"2016","unstructured":"Ward C, Martinez-Lopez N, Otten EG et al (2016) Autophagy, lipophagy and lysosomal lipid storage disorders. Biochim Biophys Acta (BBA) 1861(4):269\u2013284","journal-title":"Biochim Biophys Acta (BBA)"},{"issue":"3\u20134","key":"524_CR21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1101\/gad.320481.118","volume":"33","author":"V Bhatt","year":"2019","unstructured":"Bhatt V, Khayati K, Hu ZS et al (2019) Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis. Genes Dev 33(3\u20134):150\u2013165","journal-title":"Genes Dev"},{"issue":"7534","key":"524_CR22","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nature14190","volume":"517","author":"A Efeyan","year":"2015","unstructured":"Efeyan A, Comb WC, Sabatini DM (2015) Nutrient-sensing mechanisms and pathways. Nature 517(7534):302\u2013310","journal-title":"Nature"},{"issue":"8","key":"524_CR23","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.3390\/cancers15082195","volume":"15","author":"J Alizadeh","year":"2023","unstructured":"Alizadeh J, Kavoosi M, Singh N et al (2023) Regulation of autophagy via carbohydrate and lipid metabolism in Cancer. Cancers (Basel) 15(8):2195","journal-title":"Cancers (Basel)"},{"issue":"13","key":"524_CR24","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1101\/gad.219642.113","volume":"27","author":"JY Guo","year":"2013","unstructured":"Guo JY, Karsli-Uzunbas G, Mathew R et al (2013) Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev 27(13):1447\u20131461","journal-title":"Genes Dev"},{"issue":"5","key":"524_CR25","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1111\/febs.15069","volume":"287","author":"S Shojaei","year":"2020","unstructured":"Shojaei S, Koleini N, Samiei E et al (2020) Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes. FEBS J 287(5):1005\u20131034","journal-title":"FEBS J"},{"key":"524_CR26","doi-asserted-by":"publisher","first-page":"44841","DOI":"10.1038\/srep44841","volume":"7","author":"J Alizadeh","year":"2017","unstructured":"Alizadeh J, Zeki AA, Mirzaei N et al (2017) Mevalonate Cascade inhibition by simvastatin induces the intrinsic apoptosis pathway via depletion of isoprenoids in tumor cells. Sci Rep 7:44841","journal-title":"Sci Rep"},{"issue":"1","key":"524_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/metabo2010019","volume":"2","author":"HC K\u00f6feler","year":"2012","unstructured":"K\u00f6feler HC, Fauland A, Rechberger GN, Tr\u00f6tzm\u00fcller M (2012) Mass spectrometry based Lipidomics: an overview of technological platforms. Metabolites 2(1):19\u201338","journal-title":"Metabolites"},{"issue":"11","key":"524_CR28","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41568-022-00502-0","volume":"22","author":"P Jiang","year":"2022","unstructured":"Jiang P, Sinha S, Aldape K, Hannenhalli S, Sahinalp C, Ruppin E (2022) Big data in basic and translational cancer research. Nat Rev Cancer 22(11):625\u2013639","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"524_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.103828","volume":"25","author":"A Surendran","year":"2022","unstructured":"Surendran A, Atefi N, Ismail U, Shah A, Ravandi A (2022) Impact of myocardial reperfusion on human plasma lipidome. iScience 25(2):103828","journal-title":"iScience"},{"issue":"suppl_2","key":"524_CR30","doi-asserted-by":"publisher","first-page":"W652","DOI":"10.1093\/nar\/gkp356","volume":"37","author":"J Xia","year":"2009","unstructured":"Xia J, Psychogios N, Young N, Wishart DS (2009) MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Res 37(suppl_2):W652\u2013W660","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"524_CR31","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1038\/s41596-022-00710-w","volume":"17","author":"Z Pang","year":"2022","unstructured":"Pang Z, Zhou G, Ewald J et al (2022) Using MetaboAnalyst 5.0 for LC\u2013HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data. Nat Protoc 17(8):1735\u20131761","journal-title":"Nat Protoc"},{"issue":"1","key":"524_CR32","doi-asserted-by":"publisher","first-page":"bbac553","DOI":"10.1093\/bib\/bbac553","volume":"24","author":"Y Lu","year":"2023","unstructured":"Lu Y, Pang Z, Xia J (2023) Comprehensive investigation of pathway enrichment methods for functional interpretation of LC\u2013MS global metabolomics data. Brief Bioinform 24(1):bbac553","journal-title":"Brief Bioinform"},{"issue":"Database issue","key":"524_CR33","doi-asserted-by":"publisher","first-page":"D521","DOI":"10.1093\/nar\/gkl923","volume":"35","author":"DS Wishart","year":"2007","unstructured":"Wishart DS, Tzur D, Knox C et al (2007) HMDB: the human metabolome database. Nucleic Acids Res 35(Database issue):D521\u2013D526","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"524_CR34","doi-asserted-by":"publisher","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","volume":"50","author":"DS Wishart","year":"2022","unstructured":"Wishart DS, Guo A, Oler E et al (2022) HMDB 5.0: the human metabolome database for 2022. Nucleic Acids Res 50(D1):D622\u2013D631","journal-title":"Nucleic Acids Res"},{"issue":"23","key":"524_CR35","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1093\/bioinformatics\/btt540","volume":"29","author":"D Gfeller","year":"2013","unstructured":"Gfeller D, Michielin O, Zoete V (2013) Shaping the interaction landscape of bioactive molecules. Bioinformatics 29(23):3073\u20133079","journal-title":"Bioinformatics"},{"issue":"W1","key":"524_CR36","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina A, Michielin O, Zoete V (2019) SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res 47(W1):W357\u2013W364","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"524_CR37","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1093\/nar\/28.18.3442","volume":"28","author":"B Snel","year":"2000","unstructured":"Snel B, Lehmann G, Bork P, Huynen MA (2000) STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res 28(18):3442\u20133444","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"524_CR38","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk D, Gable AL, Nastou KC et al (2021) The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res 49(D1):D605\u2013D612","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"524_CR39","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M et al (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51(D1):D638\u2013D646","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"524_CR40","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1194\/jlr.P035808","volume":"54","author":"JM Weir","year":"2013","unstructured":"Weir JM, Wong G, Barlow CK et al (2013) Plasma lipid profiling in a large population-based cohort. J Lipid Res 54(10):2898\u20132908","journal-title":"J Lipid Res"},{"issue":"1","key":"524_CR41","doi-asserted-by":"publisher","first-page":"bbab353","DOI":"10.1093\/bib\/bbab353","volume":"23","author":"S Taylor","year":"2022","unstructured":"Taylor S, Ponzini M, Wilson M, Kim K (2022) Comparison of imputation and imputation-free methods for statistical analysis of mass spectrometry data with missing data. Brief Bioinform 23(1):bbab353","journal-title":"Brief Bioinform"}],"container-title":["Methods in Molecular Biology","Autophagy in Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/7651_2024_524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T18:28:55Z","timestamp":1739816935000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/7651_2024_524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9781071642672","9781071642689"],"references-count":41,"URL":"https:\/\/doi.org\/10.1007\/7651_2024_524","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"6 March 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}