{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:43:03Z","timestamp":1758818583022,"version":"3.41.0"},"publisher-location":"Cham","reference-count":86,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319524429"},{"type":"electronic","value":"9783319524443"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/7854_2016_16","type":"book-chapter","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T11:34:06Z","timestamp":1476704046000},"page":"263-281","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tripping with Synthetic Cannabinoids (\u201cSpice\u201d): Anecdotal and Experimental Observations in Animals and Man"],"prefix":"10.1007","author":[{"given":"Torbj\u00f6rn U. C.","family":"J\u00e4rbe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimit Girish","family":"Raghav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"16_CR1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/med.20135","volume":"29","author":"LO Hanus","year":"2009","unstructured":"Hanus LO (2009) Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. Med Res Rev 29:213\u2013271","journal-title":"Med Res Rev"},{"key":"16_CR2","first-page":"593","volume-title":"Encyclopedia of psychopharmacology","author":"A Badiani","year":"2010","unstructured":"Badiani A (2010) History of psychopharmacology. In: Stolerman IP (ed) Encyclopedia of psychopharmacology. Springer, Berlin, Heidelberg, pp 593\u2013603"},{"key":"16_CR3","first-page":"1803","volume":"65","author":"H Baruk","year":"1970","unstructured":"Baruk H (1970) The Society Moreau de Tours and Psychopharmacology. Med Klin 65:1803\u20131805","journal-title":"Med Klin"},{"key":"16_CR4","first-page":"279","volume":"14","author":"G Mora","year":"1989","unstructured":"Mora G (1989) Historical antecedents of modern psychopharmacology. Psychiatr J Univ Ott 14:279\u2013281","journal-title":"Psychiatr J Univ Ott"},{"key":"16_CR5","doi-asserted-by":"crossref","unstructured":"J\u00e4rbe TUC, Gifford RS, Zvonok A, Makriyannis A (2015) \u03949-Tetrahydrocannabinol discriminative stimulus effects of AM2201 and related aminoalkylindole analogs in rats. Behav Pharmacol","DOI":"10.1097\/FBP.0000000000000196"},{"key":"16_CR6","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/FBP.0000000000000093","volume":"25","author":"MB Gatch","year":"2014","unstructured":"Gatch MB, Forster MJ (2014) Delta9-Tetrahydrocannabinol-like discriminative stimulus effects of compounds commonly found in K2\/Spice. Behav Pharmacol 25:750\u2013757","journal-title":"Behav Pharmacol"},{"key":"16_CR7","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1021\/acschemneuro.5b00112","volume":"6","author":"SD Banister","year":"2015","unstructured":"Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Glass M, Connor M, McGregor IS, Kassiou M (2015) Pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. ACS Chem Neurosci 6:1546\u20131559","journal-title":"ACS Chem Neurosci"},{"key":"16_CR8","doi-asserted-by":"crossref","unstructured":"Banister SD, Stuart J, Kevin RC, Edington A, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Hibbs DE, Glass M, Connor M, McGregor IS, Kassiou M (2015) Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135. ACS Chem Neurosci","DOI":"10.1021\/acschemneuro.5b00107"},{"key":"16_CR9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnbeh.2011.00060","volume":"5","author":"L Fattore","year":"2011","unstructured":"Fattore L, Fratta W (2011) Beyond THC: the new generation of cannabinoid designer drugs. Front Behav Neurosci 5:60 (1-12)","journal-title":"Front Behav Neurosci"},{"key":"16_CR10","doi-asserted-by":"crossref","first-page":"15150","DOI":"10.1523\/JNEUROSCI.3223-14.2014","volume":"34","author":"MH Baumann","year":"2014","unstructured":"Baumann MH, Solis E Jr, Watterson LR, Marusich JA, Fantegrossi WE, Wiley JL (2014) Baths salts, spice, and related designer drugs: the science behind the headlines. J Neurosci 34:15150\u201315158","journal-title":"J Neurosci"},{"key":"16_CR11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.drugalcdep.2014.08.005","volume":"144","author":"MS Castaneto","year":"2014","unstructured":"Castaneto MS, Gorelick DA, Desrosiers NA, Hartman RL, Pirard S, Huestis MA (2014) Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications. Drug Alcohol Depend 144:12\u201341","journal-title":"Drug Alcohol Depend"},{"key":"16_CR12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0091-3057(91)90349-7","volume":"40","author":"BR Martin","year":"1991","unstructured":"Martin BR, Compton DR, Thomas BF, Prescott WR, Little PJ, Razdan RK, Johnson MR, Melvin LS, Mechoulam R, Ward SJ (1991) Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs. Pharmacol Biochem Behav 40:471\u2013478","journal-title":"Pharmacol Biochem Behav"},{"key":"16_CR13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.lfs.2006.08.017","volume":"80","author":"JL Wiley","year":"2006","unstructured":"Wiley JL, Razdan RK, Martin BR (2006) Evaluation of the role of the arachidonic acid cascade in anandamide\u2019s in vivo effects in mice. Life Sci 80:24\u201335","journal-title":"Life Sci"},{"key":"16_CR14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2013.07.011","volume":"97","author":"TUC J\u00e4rbe","year":"2014","unstructured":"J\u00e4rbe TUC, Gifford RS (2014) \u201cHerbal incense\u201d: designer drug blends as cannabimimetics and their assessment by drug discrimination and other in vivo bioassays. Life Sci 97:64\u201371","journal-title":"Life Sci"},{"key":"16_CR15","first-page":"327","volume-title":"Drug discrimination: application in CNS pharmacology","author":"TUC J\u00e4rbe","year":"1982","unstructured":"J\u00e4rbe TUC, Swedberg MDB (1982) A conceptualization of drug discrimination learning. In: Colpaert FC, Slangen JL (eds) Drug discrimination: application in CNS pharmacology. Elsevier\/North-Holland Biomed Press, Amsterdam, pp 327\u2013341"},{"key":"16_CR16","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/nprot.2006.167","volume":"1","author":"M Solinas","year":"2006","unstructured":"Solinas M, Panlilio LV, Justinova Z, Yasar S, Goldberg SR (2006) Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats. Nat Protoc 1:1194\u20131206","journal-title":"Nat Protoc"},{"key":"16_CR17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/9781118023150.ch8","volume-title":"Drug discrimination: applications to medicinal chemistry and drug studies","author":"TUC J\u00e4rbe","year":"2011","unstructured":"J\u00e4rbe TUC (2011) Perceptual drug discriminative aspects of the endocannabinoid signaling system in animals and man. In: Glennon RA, Young R (eds) Drug discrimination: applications to medicinal chemistry and drug studies. Wiley, Hoboken, pp 241\u2013285"},{"key":"16_CR18","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1124\/jpet.113.206003","volume":"346","author":"LK Brents","year":"2013","unstructured":"Brents LK, Zimmerman SM, Saffell AR, Prather PL, Fantegrossi WE (2013) Differential drug-drug interactions of the synthetic cannabinoids JWH-018 and JWH-073: implications for drug abuse liability and pain therapy. J Pharmacol Exp Ther 346:350\u2013361","journal-title":"J Pharmacol Exp Ther"},{"key":"16_CR19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/FBP.0000000000000150","volume":"26","author":"MB Gatch","year":"2015","unstructured":"Gatch MB, Forster MJ (2015) Delta9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market. Behav Pharmacol 26:460\u2013468","journal-title":"Behav Pharmacol"},{"issue":"10","key":"16_CR20","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s00213-016-4237-6","volume":"233","author":"MB Gatch","year":"2016","unstructured":"Gatch MB, Forster MJ (2016) Delta-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids in mice and rats. Psychopharmacology 233(10):1901\u201310","journal-title":"Psychopharmacology"},{"key":"16_CR21","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/FBP.0b013e328349fbd5","volume":"22","author":"TUC J\u00e4rbe","year":"2011","unstructured":"J\u00e4rbe TUC, Deng H, Vadivel SK, Makriyannis A (2011) Cannabinergic aminoalkylindoles, including AM678=JWH018 found in \u2018Spice\u2019, examined using drug (\u03949-THC) discrimination for rats. Behav Pharmacol 22:498\u2013507","journal-title":"Behav Pharmacol"},{"key":"16_CR22","doi-asserted-by":"crossref","unstructured":"Samano KL, Poklis A, Lichtman AH (2013) Preclinical investigation of the abused synthetic cannabinoid CP47,497. College on Problems of Drug Dependence 75th Annual Meeting. College on Problems of Drug Dependence, San Diego, CA, abstract # 555","DOI":"10.1016\/j.drugalcdep.2014.02.540"},{"key":"16_CR23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1124\/jpet.115.225326","volume":"354","author":"JL Wiley","year":"2015","unstructured":"Wiley JL, Marusich JA, Lefever TW, Antonazzo KR, Wallgren MT, Cortes RA, Patel PR, Grabenauer M, Moore KN, Thomas BF (2015) AB-CHMINACA, AB-PINACA, and FUBIMINA: affinity and potency of novel synthetic cannabinoids in producing Delta9-tetrahydrocannabinol-like effects in mice. J Pharmacol Exp Ther 354:328\u2013339","journal-title":"J Pharmacol Exp Ther"},{"key":"16_CR24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neuropharm.2013.07.022","volume":"75","author":"JL Wiley","year":"2013","unstructured":"Wiley JL, Marusich JA, Lefever TW, Grabenauer M, Moore KN, Thomas BF (2013) Cannabinoids in disguise: Delta9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles. Neuropharmacology 75:145\u2013154","journal-title":"Neuropharmacology"},{"key":"16_CR25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejphar.2014.06.023","volume":"740","author":"JS Rodriguez","year":"2014","unstructured":"Rodriguez JS, McMahon LR (2014) JWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects. Eur J Pharmacol 740:151\u2013159","journal-title":"Eur J Pharmacol"},{"key":"16_CR26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.pbb.2014.05.016","volume":"124","author":"JL Wiley","year":"2014","unstructured":"Wiley JL, Lefever TW, Cortes RA, Marusich JA (2014) Cross-substitution of Delta9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats. Pharmacol Biochem Behav 124:123\u2013128","journal-title":"Pharmacol Biochem Behav"},{"issue":"15","key":"16_CR27","first-page":"30052","volume":"S0361\u20139230","author":"HH Muller","year":"2015","unstructured":"Muller HH, Kornhuber J, Sperling W (2015) The behavioral profile of spice and synthetic cannabinoids in humans. Brain Res Bull S0361\u20139230(15):30052\u20136","journal-title":"Brain Res Bull"},{"issue":"10","key":"16_CR28","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3109\/15563650.2015.1100306","volume":"53","author":"JA Tyndall","year":"2015","unstructured":"Tyndall JA, Gerona R, De Portu G, Trecki J, Elie MC, Lucas J, Slish J, Rand K, Bazydlo L, Holder M, Ryan MF, Myers P, Iovine N, Plourde M, Weeks E, Hanley JR, Endres G, Germaine DS, Dobrowolski PJ, Schwartz M (2015) An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA. Clin Toxicol 53(10):950\u20136","journal-title":"Clin Toxicol"},{"key":"16_CR29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/jat\/bkr018","volume":"36","author":"BC Ginsburg","year":"2012","unstructured":"Ginsburg BC, McMahon LR, Sanchez JJ, Javors MA (2012) Purity of synthetic cannabinoids sold online for recreational use. J Anal Toxicol 36:66\u201368","journal-title":"J Anal Toxicol"},{"issue":"7","key":"16_CR30","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","volume":"79","author":"H-C Lu","year":"2016","unstructured":"Lu H-C, Mackie K (2016) An introduction to the endogenous cannabinoid system. Biol Psychiatry 79(7):516\u201325","journal-title":"Biol Psychiatry."},{"key":"16_CR31","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/cbdv.200790152","volume":"4","author":"MA Huestis","year":"2007","unstructured":"Huestis MA (2007) Human cannabinoid pharmacokinetics. Chem Biodivers 4:1770\u20131804","journal-title":"Chem Biodivers"},{"key":"16_CR32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/346561a0","volume":"346","author":"LA Matsuda","year":"1990","unstructured":"Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561\u2013564","journal-title":"Nature"},{"key":"16_CR33","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/cpt.114","volume":"97","author":"MK Su","year":"2015","unstructured":"Su MK, Seely KA, Moran JH, Hoffman RS (2015) Metabolism of classical cannabinoids and the synthetic cannabinoid JWH-018. Clin Pharmacol Ther 97:562\u2013564","journal-title":"Clin Pharmacol Ther"},{"key":"16_CR34","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/dta.1796","volume":"7","author":"C Erratico","year":"2015","unstructured":"Erratico C, Negreira N, Norouzizadeh H, Covaci A, Neels H, Maudens K, van Nuijs AL (2015) In vitro and in vivo human metabolism of the synthetic cannabinoid AB-CHMINACA. Drug Test Anal 7:866\u2013876","journal-title":"Drug Test Anal"},{"key":"16_CR35","first-page":"53","volume":"26","author":"SM Gurney","year":"2014","unstructured":"Gurney SM, Scott KS, Kacinko SL, Presley BC, Logan BK (2014) Pharmacology, toxicology, and adverse effects of synthetic cannabinoid drugs. Forensic Sci Rev 26:53\u201378","journal-title":"Forensic Sci Rev"},{"key":"16_CR36","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.2174\/092986710790980050","volume":"17","author":"RG Pertwee","year":"2010","unstructured":"Pertwee RG (2010) Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists. Curr Med Chem 17:1360\u20131381","journal-title":"Curr Med Chem"},{"key":"16_CR37","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1124\/dmd.112.047530","volume":"40","author":"KC Chimalakonda","year":"2012","unstructured":"Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH (2012) Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2\/Spice: identification of novel cannabinoid receptor ligands. Drug Metab Dispos 40:2174\u20132184","journal-title":"Drug Metab Dispos"},{"key":"16_CR38","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.drugalcdep.2012.05.034","volume":"126","author":"JM Wiebelhaus","year":"2012","unstructured":"Wiebelhaus JM, Poklis JL, Poklis A, Vann RE, Lichtman AH, Wise LE (2012) Inhalation exposure to smoke from synthetic \u201cmarijuana\u201d produces potent cannabimimetic effects in mice. Drug Alcohol Depend 126:316\u2013323","journal-title":"Drug Alcohol Depend"},{"key":"16_CR39","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pbb.2014.05.010","volume":"124","author":"R Marshell","year":"2014","unstructured":"Marshell R, Kearney-Ramos T, Brents LK, Hyatt WS, Tai S, Prather PL, Fantegrossi WE (2014) In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid Delta9-THC in mice: inhalation versus intraperitoneal injection. Pharmacol Biochem Behav 124:40\u201347","journal-title":"Pharmacol Biochem Behav"},{"key":"16_CR40","first-page":"52","volume":"9","author":"K Donohue","year":"2012","unstructured":"Donohue K, Steiner R (2012) JWH-018 and JWH-022 as combustion products of AM2201. Microgram J 9:52\u201356","journal-title":"Microgram J"},{"key":"16_CR41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00213-009-1708-z","volume":"208","author":"TUC J\u00e4rbe","year":"2010","unstructured":"J\u00e4rbe TUC, Li C, Vadivel SK, Makriyannis A (2010) Discriminative stimulus functions of methanandamide and \u03949-THC in rats: tests with aminoalkylindoles (WIN55,212-2 and AM678) and ethanol. Psychopharmacology (Berl) 208:87\u201398","journal-title":"Psychopharmacology (Berl)"},{"key":"16_CR42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1124\/jpet.111.187757","volume":"340","author":"BC Ginsburg","year":"2012","unstructured":"Ginsburg BC, Schulze DR, Hruba L, McMahon LR (2012) JWH-018 and JWH-073: Delta(9)-tetrahydrocannabinol-like discriminative stimulus effects in monkeys. J Pharmacol Exp Ther 340:37\u201345","journal-title":"J Pharmacol Exp Ther"},{"key":"16_CR43","unstructured":"Vann RE, Walentiny DM (2011) Preclinical evaluation of marijuana\u2019s appetitive, rewarding and psychoactive properties. The 21st Annual Symposium of the International Cannabinoid Research Society. International Cannabinoid Research Society, Research Triangle Park, NC, USA, Pheasant Run, St. Charles, IL, USA"},{"key":"16_CR44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ejphar.2014.01.041","volume":"727","author":"L Hruba","year":"2014","unstructured":"Hruba L, McMahon LR (2014) The cannabinoid agonist HU-210: pseudo-irreversible discriminative stimulus effects in rhesus monkeys. Eur J Pharmacol 727:35\u201342","journal-title":"Eur J Pharmacol"},{"key":"16_CR45","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0022-3565(25)22722-7","volume":"250","author":"TUC J\u00e4rbe","year":"1989","unstructured":"J\u00e4rbe TUC, Hiltunen AJ, Mechoulam R (1989) Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-\u03948-tetrahydrocannabinol in rats and pigeons. J Pharmacol Exp Ther 250:1000\u20131005","journal-title":"J Pharmacol Exp Ther"},{"key":"16_CR46","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1021\/jm00089a018","volume":"35","author":"WA Devane","year":"1992","unstructured":"Devane WA, Breuer A, Sheskin T, J\u00e4rbe TUC, Eisen MS, Mechoulam R (1992) A novel probe for the cannabinoid receptor. J Med Chem 35:2065\u20132069","journal-title":"J Med Chem"},{"key":"16_CR47","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF00432178","volume":"75","author":"TUC J\u00e4rbe","year":"1981","unstructured":"J\u00e4rbe TUC, Swedberg MD, Mechoulam R (1981) A repeated test procedure to assess onset and duration of the cue properties of (-) \u03949-THC, (-) \u03948-THC-DMH and (+) \u03948-THC. Psychopharmacology (Berl) 75:152\u2013157","journal-title":"Psychopharmacology (Berl)"},{"key":"16_CR48","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00213-011-2491-1","volume":"220","author":"TUC J\u00e4rbe","year":"2012","unstructured":"J\u00e4rbe TUC, Tai S, Lemay BJ, Nikas SP, Shukla VG, Zvonok A, Makriyannis A (2012) AM2389, a high-affinity, in vivo potent CB(1)-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice. Psychopharmacology (Berl) 220:417\u2013426","journal-title":"Psychopharmacology (Berl)"},{"key":"16_CR49","doi-asserted-by":"crossref","first-page":"771","DOI":"10.15585\/mmwr.mm6428a6","volume":"64","author":"JB Hancock-Allen","year":"2015","unstructured":"Hancock-Allen JB, Barker L, VanDyke M, Holmes DB (2015) Notes from the field: death following ingestion of an Edible Marijuana Product--Colorado, March 2014. MMWR Morb Mortal Wkly Rep 64:771\u2013772","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"16_CR50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnbeh.2011.00057","volume":"5","author":"C Zanettini","year":"2011","unstructured":"Zanettini C, Panlilio LV, Alicki M, Goldberg SR, Haller J, Yasar S (2011) Effects of endocannabinoid system modulation on cognitive and emotional behavior. Front Behav Neurosci 5:57","journal-title":"Front Behav Neurosci"},{"key":"16_CR51","first-page":"73","volume":"5","author":"H Tan","year":"2014","unstructured":"Tan H, Ahmad T, Loureiro M, Zunder J, Laviolette SR (2014) The role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia. Front Psychiatry 5:73","journal-title":"Front Psychiatry"},{"key":"16_CR52","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/cpt.118","volume":"97","author":"LV Panlilio","year":"2015","unstructured":"Panlilio LV, Goldberg SR, Justinova Z (2015) Cannabinoid abuse and addiction: clinical and preclinical findings. Clin Pharmacol Ther 97:616\u2013627","journal-title":"Clin Pharmacol Ther"},{"key":"16_CR53","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fpsyt.2014.00092","volume":"5","author":"G Panagis","year":"2014","unstructured":"Panagis G, Mackey B, Vlachou S (2014) Cannabinoid regulation of brain reward processing with an emphasis on the role of CB1 receptors: a step back into the future. Front Psychiatry 5:92","journal-title":"Front Psychiatry"},{"key":"16_CR54","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fpsyt.2014.00140","volume":"5","author":"MA De Luca","year":"2014","unstructured":"De Luca MA, Valentini V, Bimpisidis Z, Cacciapaglia F, Caboni P, Di Chiara G (2014) Endocannabinoid 2-arachidonoylglycerol self-administration by Sprague-Dawley rats and stimulation of in vivo dopamine transmission in the nucleus accumbens shell. Front Psychiatry 5:140","journal-title":"Front Psychiatry"},{"key":"16_CR55","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.neuropharm.2015.08.041","volume":"99","author":"MA De Luca","year":"2015","unstructured":"De Luca MA, Bimpisidis Z, Melis M, Marti M, Caboni P, Valentini V, Margiani G, Pintori N, Polis I, Marsicano G, Parsons LH, Di Chiara G (2015) Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid. Neuropharmacology 99:705\u2013714","journal-title":"Neuropharmacology"},{"key":"16_CR56","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4062\/biomolther.2014.039","volume":"22","author":"HJ Cha","year":"2014","unstructured":"Cha HJ, Lee KW, Song MJ, Hyeon YJ, Hwang JY, Jang CG, Ahn JI, Jeon SH, Kim HU, Kim YH, Seong WK, Kang H, Yoo HS, Jeong HS (2014) Dependence potential of the synthetic cannabinoids JWH-073, JWH-081, and JWH-210: in vivo and in vitro approaches. Biomol Ther (Seoul) 22:363\u2013369","journal-title":"Biomol Ther (Seoul)"},{"key":"16_CR57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pbb.2014.01.002","volume":"118","author":"TW Lefever","year":"2014","unstructured":"Lefever TW, Marusich JA, Antonazzo KR, Wiley JL (2014) Evaluation of WIN 55,212-2 self-administration in rats as a potential cannabinoid abuse liability model. Pharmacol Biochem Behav 118:30\u201335","journal-title":"Pharmacol Biochem Behav"},{"key":"16_CR58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejphar.2004.10.043","volume":"506","author":"D Braida","year":"2004","unstructured":"Braida D, Iosue S, Pegorini S, Sala M (2004) Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats. Eur J Pharmacol 506:63\u201369","journal-title":"Eur J Pharmacol"},{"key":"16_CR59","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0014-2999(01)00766-X","volume":"413","author":"D Braida","year":"2001","unstructured":"Braida D, Pozzi M, Parolaro D, Sala M (2001) Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system. Eur J Pharmacol 413:227\u2013234","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"16_CR60","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s00213-016-4211-3","volume":"233","author":"CW Schindler","year":"2016","unstructured":"Schindler CW, Scherma M, Redhi GH, Vadivel SK, Makriyannis A, Goldberg SR, Justinova Z (2016) Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys. Psychopharmacology 233(10):1867\u201377","journal-title":"Psychopharmacology"},{"key":"16_CR61","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.2174\/13816128113199990433","volume":"20","author":"S Vlachou","year":"2014","unstructured":"Vlachou S, Panagis G (2014) Regulation of brain reward by the endocannabinoid system: a critical review of behavioral studies in animals. Curr Pharm Des 20:2072\u20132088","journal-title":"Curr Pharm Des"},{"key":"16_CR62","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/FBP.0b013e32835a3907","volume":"23","author":"JX Li","year":"2012","unstructured":"Li JX, Koek W, France CP (2012) Interactions between Delta(9)-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys. Behav Pharmacol 23:754\u2013761","journal-title":"Behav Pharmacol"},{"key":"16_CR63","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1476-5381.2010.00775.x","volume":"160","author":"LV Panlilio","year":"2010","unstructured":"Panlilio LV, Justinova Z, Goldberg SR (2010) Animal models of cannabinoid reward. Br J Pharmacol 160:499\u2013510","journal-title":"Br J Pharmacol"},{"key":"16_CR64","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1369-1600.2007.00095.x","volume":"13","author":"ZD Cooper","year":"2008","unstructured":"Cooper ZD, Haney M (2008) Cannabis reinforcement and dependence: role of the cannabinoid CB1 receptor. Addict Biol 13:188\u2013195","journal-title":"Addict Biol"},{"key":"16_CR65","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pbb.2005.01.026","volume":"81","author":"Z Justinova","year":"2005","unstructured":"Justinova Z, Goldberg SR, Heishman SJ, Tanda G (2005) Self-administration of cannabinoids by experimental animals and human marijuana smokers. Pharmacol Biochem Behav 81:285\u2013299","journal-title":"Pharmacol Biochem Behav"},{"key":"16_CR66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s002130000569","volume":"153","author":"MT Bardo","year":"2000","unstructured":"Bardo MT, Bevins RA (2000) Conditioned place preference: what does it add to our preclinical understanding of drug reward? Psychopharmacology (Berl) 153:31\u201343","journal-title":"Psychopharmacology (Berl)"},{"key":"16_CR67","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1369-1600.2007.00070.x","volume":"12","author":"TM Tzschentke","year":"2007","unstructured":"Tzschentke TM (2007) Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade. Addict Biol 12:227\u2013462","journal-title":"Addict Biol"},{"key":"16_CR68","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/0024-3205(95)00191-8","volume":"56","author":"M Lepore","year":"1995","unstructured":"Lepore M, Vorel SR, Lowinson J, Gardner EL (1995) Conditioned place preference induced by delta 9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward. Life Sci 56:2073\u20132080","journal-title":"Life Sci"},{"key":"16_CR69","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s002130050013","volume":"147","author":"E Valjent","year":"2000","unstructured":"Valjent E, Maldonado R (2000) A behavioural model to reveal place preference to delta 9-tetrahydrocannabinol in mice. Psychopharmacology (Berl) 147:436\u2013438","journal-title":"Psychopharmacology (Berl)"},{"key":"16_CR70","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00213-009-1542-3","volume":"205","author":"P Pandolfo","year":"2009","unstructured":"Pandolfo P, Vendruscolo LF, Sordi R, Takahashi RN (2009) Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat-an animal model of attention deficit hyperactivity disorder. Psychopharmacology (Berl) 205:319\u2013326","journal-title":"Psychopharmacology (Berl)"},{"key":"16_CR71","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/FBP.0000000000000034","volume":"25","author":"WS Hyatt","year":"2014","unstructured":"Hyatt WS, Fantegrossi WE (2014) Delta9-THC exposure attenuates aversive effects and reveals appetitive effects of K2\/\u2018Spice\u2019 constituent JWH-018 in mice. Behav Pharmacol 25:253\u2013257","journal-title":"Behav Pharmacol"},{"key":"16_CR72","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4062\/biomolther.2015.120","volume":"23","author":"R Tampus","year":"2015","unstructured":"Tampus R, Yoon SS, de la Pena JB, Botanas CJ, Kim HJ, Seo JW, Jeong EJ, Jang CG, Cheong JH (2015) Assessment of the abuse liability of synthetic cannabinoid agonists JWH-030, JWH-175, and JWH-176. Biomol Ther (Seoul) 23:590\u2013596","journal-title":"Biomol Ther (Seoul)"},{"key":"16_CR73","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1124\/pr.112.007419","volume":"66","author":"SS Negus","year":"2014","unstructured":"Negus SS, Miller LL (2014) Intracranial self-stimulation to evaluate abuse potential of drugs. Pharmacol Rev 66:869\u2013917","journal-title":"Pharmacol Rev"},{"key":"16_CR74","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1124\/jpet.112.198374","volume":"344","author":"RI Desai","year":"2013","unstructured":"Desai RI, Thakur GA, Vemuri VK, Bajaj S, Makriyannis A, Bergman J (2013) Analysis of tolerance and behavioral\/physical dependence during chronic CB1 agonist treatment: effects of CB1 agonists, antagonists, and noncannabinoid drugs. J Pharmacol Exp Ther 344:319\u2013328","journal-title":"J Pharmacol Exp Ther"},{"key":"16_CR75","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00213-010-2162-7","volume":"215","author":"H Singh","year":"2011","unstructured":"Singh H, Schulze DR, McMahon LR (2011) Tolerance and cross-tolerance to cannabinoids in mice: schedule-controlled responding and hypothermia. Psychopharmacology (Berl) 215:665\u2013675","journal-title":"Psychopharmacology (Berl)"},{"key":"16_CR76","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(95)01113-7","volume":"706","author":"F Fan","year":"1996","unstructured":"Fan F, Tao Q, Abood M, Martin BR (1996) Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice. Brain Res 706:13\u201320","journal-title":"Brain Res"},{"key":"16_CR77","first-page":"60","volume":"1","author":"DC D\u2019Souza","year":"2016","unstructured":"D\u2019Souza DC, Cortes-Briones JA, Ranganathan M, Thurnauer H, Creatura G, Surti T, Planeta B, Neumeister A, Pittman B, Normandin M, Kapinos M, Ropchan J, Huang Y, Carson RE, Skosnik PD (2016) Rapid changes in CB1 receptor availability in cannabis dependent males after abstinence from cannabis. Biol Psychiatry Cogn Neurosci Neuroimaging 1:60\u201367","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"16_CR78","doi-asserted-by":"publisher","unstructured":"Gifford RS, Raghav JG, J\u00e4rbe TUC (2016) Does agonist efficacy alter the in vivo effects of cannabinoids: girl, could we get much \u201chigher\u201d? In: Preedy VR (ed) Neuropathology of drug addictions and substance misuse, vol 1. Elsevier Inc. doi:10.1016\/B978-0-12-800213-1.00067-5","DOI":"10.1016\/B978-0-12-800213-1.00067-5"},{"key":"16_CR79","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s40429-014-0014-y","volume":"1","author":"S Tai","year":"2014","unstructured":"Tai S, Fantegrossi WE (2014) Synthetic cannabinoids: pharmacology, behavioral effects, and abuse potential. Curr Addict Rep 1:129\u2013136","journal-title":"Curr Addict Rep"},{"key":"16_CR80","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1007\/s00213-015-3907-0","volume":"232","author":"S Tai","year":"2015","unstructured":"Tai S, Nikas SP, Shukla VG, Vemuri K, Makriyannis A, Jarbe TU (2015) Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist. Psychopharmacology (Berl) 232:2751\u20132761","journal-title":"Psychopharmacology (Berl)"},{"key":"16_CR81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.phrs.2015.09.006","volume":"102","author":"S Tai","year":"2015","unstructured":"Tai S, Hyatt WS, Gu C, Franks LN, Vasiljevik T, Brents LK, Prather PL, Fantegrossi WE (2015) Repeated administration of phytocannabinoid Delta-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner. Pharmacol Res 102:22\u201332","journal-title":"Pharmacol Res"},{"key":"16_CR82","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2015.05.021","volume":"300","author":"A Ossato","year":"2015","unstructured":"Ossato A, Vigolo A, Trapella C, Seri C, Rimondo C, Serpelloni G, Marti M (2015) JWH-018 impairs sensorimotor functions in mice. Neuroscience 300:174\u2013188","journal-title":"Neuroscience"},{"key":"16_CR83","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuropharm.2015.02.008","volume":"95","author":"A Vigolo","year":"2015","unstructured":"Vigolo A, Ossato A, Trapella C, Vincenzi F, Rimondo C, Seri C, Varani K, Serpelloni G, Marti M (2015) Novel halogenated derivates of JWH-018: behavioral and binding studies in mice. Neuropharmacology 95:68\u201382","journal-title":"Neuropharmacology"},{"key":"16_CR84","doi-asserted-by":"crossref","first-page":"597","DOI":"10.4062\/biomolther.2015.057","volume":"23","author":"HJ Cha","year":"2015","unstructured":"Cha HJ, Seong YH, Song MJ, Jeong HS, Shin J, Yun J, Han K, Kim YH, Kang H, Kim HS (2015) Neurotoxicity of synthetic cannabinoids JWH-081 and JWH-210. Biomol Ther (Seoul) 23:597\u2013603","journal-title":"Biomol Ther (Seoul)"},{"key":"16_CR85","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/hipo.22213","volume":"24","author":"BS Basavarajappa","year":"2014","unstructured":"Basavarajappa BS, Subbanna S (2014) CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice\/K2 preparations. Hippocampus 24:178\u2013188","journal-title":"Hippocampus"},{"key":"16_CR86","doi-asserted-by":"publisher","unstructured":"Wiley JL, Marusich JA, Huffman JW, Balster RL, Thomas BF (2011) Hijacking of basic research: the case of synthetic cannabinoids. Methods Rep RTI Press. doi:10.3768\/rtipress.2011.op.0007.1111","DOI":"10.3768\/rtipress.2011.op.0007.1111"}],"container-title":["Current Topics in Behavioral Neurosciences","Neuropharmacology of New Psychoactive Substances (NPS)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/7854_2016_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T15:24:33Z","timestamp":1749655473000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/7854_2016_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9783319524429","9783319524443"],"references-count":86,"URL":"https:\/\/doi.org\/10.1007\/7854_2016_16","relation":{},"ISSN":["1866-3370","1866-3389"],"issn-type":[{"type":"print","value":"1866-3370"},{"type":"electronic","value":"1866-3389"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"18 October 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}