{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:26:02Z","timestamp":1769631962151,"version":"3.49.0"},"publisher-location":"Cham","reference-count":236,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030721428","type":"print"},{"value":"9783030721435","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/7854_2020_157","type":"book-chapter","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T19:03:43Z","timestamp":1598641423000},"page":"101-132","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intracellular Signaling Cascades in Bipolar Disorder"],"prefix":"10.1007","author":[{"given":"Gregory H.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha S.","family":"Shariq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Machado-Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,29]]},"reference":[{"key":"157_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.pnpbp.2012.11.015","volume":"43","author":"E Abrial","year":"2013","unstructured":"Abrial E, Etievant A, B\u00e9try C, Scarna H, Lucas G, Haddjeri N, Lamb\u00e1s-Se\u00f1as L (2013) Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats. Prog Neuropsychopharmacol Biol Psychiatry 43:40\u201348","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"157_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.bbi.2015.11.012","volume":"55","author":"MA Ajmone-Cat","year":"2016","unstructured":"Ajmone-Cat MA, D'Urso MC, di Blasio G, Brignone MS, De Simone R, Minghetti L (2016) Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells. Brain Behav Immun 55:225\u2013235","journal-title":"Brain Behav Immun"},{"key":"157_CR3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/j.1399-5618.2006.00363.x","volume":"8","author":"S Akhondzadeh","year":"2006","unstructured":"Akhondzadeh S, Milajerdi MR, Amini H et al (2006) Allopurinol as an adjunct to lithium and haloperidol for treatment of patients with acute mania: a double-blind, randomized, placebo-controlled trial. Bipolar Disord 8:485\u2013489","journal-title":"Bipolar Disord"},{"key":"157_CR4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jad.2014.11.005","volume":"173","author":"U Albert","year":"2015","unstructured":"Albert U et al (2015) Increased uric acid levels in bipolar disorder subjects during different phases of illness. J Affect Disord 173:170\u2013175","journal-title":"J Affect Disord"},{"key":"157_CR5","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.phrs.2006.08.002","volume":"54","author":"M Amadio","year":"2006","unstructured":"Amadio M, Battaini F, Pascale A (2006) The different facets of protein kinases C: old and new players in neuronal signal transduction pathways. Pharmacol Res 54:317\u2013325","journal-title":"Pharmacol Res"},{"issue":"1\u20133","key":"157_CR6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jad.2010.08.015","volume":"129","author":"Z Amrollahi","year":"2011","unstructured":"Amrollahi Z, Rezaei F, Salehi B, Modabbernia AH, Maroufi A, Esfandiari GR, Naderi M, Ghebleh F, Ahmadi-Abhari SA, Sadeghi M, Tabrizi M, Akhondzadeh S (2011) Double-blind, randomized, placebo-controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania. J Affect Disord 129(1\u20133):327\u2013331","journal-title":"J Affect Disord"},{"issue":"2\u20133","key":"157_CR7","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jad.2012.03.007","volume":"141","author":"JD Amsterdam","year":"2012","unstructured":"Amsterdam JD et al (2012) Greater striatal dopamine transporter density may be associated with major depressive episode. J Affect Disord 141(2\u20133):425\u2013431","journal-title":"J Affect Disord"},{"issue":"4","key":"157_CR8","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1399-5618.2011.00936.x","volume":"13","author":"A Anand","year":"2011","unstructured":"Anand A et al (2011) Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disord 13(4):406\u2013413","journal-title":"Bipolar Disord"},{"key":"157_CR9","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/archgenpsychiatry.2010.22","volume":"67","author":"AC Andreazza","year":"2010","unstructured":"Andreazza AC, Shao L, Wang JF, Young LT (2010) Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Arch Gen Psychiatry 67:360\u2013368","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"157_CR10","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/bdi.12324","volume":"17","author":"S Arabzadeh","year":"2015","unstructured":"Arabzadeh S et al (2015) Celecoxib adjunctive therapy for acute bipolar mania: a randomized, double-blind, placebo-controlled trial. Bipolar Disord 17(6):606\u2013614","journal-title":"Bipolar Disord"},{"key":"157_CR11","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s00018-006-6010-1","volume":"63","author":"JC Arevalo","year":"2006","unstructured":"Arevalo JC, Wu SH (2006) Neurotrophin signaling: many exciting surprises! Cell Mol Life Sci 63:1523\u20131537","journal-title":"Cell Mol Life Sci"},{"issue":"8","key":"157_CR12","doi-asserted-by":"publisher","first-page":"e43057","DOI":"10.1371\/journal.pone.0043057","volume":"7","author":"L Backlund","year":"2012","unstructured":"Backlund L et al (2012) P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1. PLoS One 7(8):e43057","journal-title":"PLoS One"},{"issue":"5","key":"157_CR13","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1212\/WNL.41.5.740","volume":"41","author":"FH Bahls","year":"1991","unstructured":"Bahls FH, Ozuna J, Ritchie DE (1991) Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin. Neurology 41(5):740\u2013742","journal-title":"Neurology"},{"key":"157_CR14","doi-asserted-by":"publisher","first-page":"360481","DOI":"10.1155\/2014\/360481","volume":"2014","author":"IG Barbosa","year":"2014","unstructured":"Barbosa IG, Bauer ME, Machado-Vieira R et al (2014) Cytokines in bipolar disorder: paving the way for neuroprogression. Neural Plast 2014:360481","journal-title":"Neural Plast"},{"issue":"4","key":"157_CR15","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1023\/A:1025321609994","volume":"33","author":"M Bartels","year":"2003","unstructured":"Bartels M et al (2003) Heritability of daytime cortisol levels in children. Behav Genet 33(4):421\u2013433","journal-title":"Behav Genet"},{"key":"157_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.comppsych.2016.09.011","volume":"73","author":"F Bartoli","year":"2017","unstructured":"Bartoli F, Crocamo C et al (2017a) Purinergic system dysfunctions in subjects with bipolar disorder: a comparative cross-sectional study. Compr Psychiatry 73:1\u20136","journal-title":"Compr Psychiatry"},{"issue":"6","key":"157_CR17","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/pcn.12518","volume":"71","author":"F Bartoli","year":"2017","unstructured":"Bartoli F, Carr\u00e0 G, Clerici M (2017b) Purinergic dysfunction in bipolar disorder: Any role for the antioxidant uric acid as a trait and state biomarker? Psychiatry Clin Neurosci 71(6):417","journal-title":"Psychiatry Clin Neurosci"},{"issue":"7","key":"157_CR18","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.neuropharm.2012.01.015","volume":"62","author":"G Bartzokis","year":"2012","unstructured":"Bartzokis G (2012) Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments. Neuropharmacology 62(7):2137\u20132153","journal-title":"Neuropharmacology"},{"key":"157_CR20","first-page":"118","volume":"6","author":"W Bechtel","year":"2015","unstructured":"Bechtel W (2015) Circadian rhythms and mood disorders: are the phenomena and mechanisms causally related? Front Psych 6:118","journal-title":"Front Psych"},{"issue":"5","key":"157_CR21","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1097\/00004714-200110000-00009","volume":"21","author":"JK Belanoff","year":"2001","unstructured":"Belanoff JK et al (2001) Rapid reversal of psychotic depression using mifepristone. J Clin Psychopharmacol 21(5):516\u2013521","journal-title":"J Clin Psychopharmacol"},{"issue":"5","key":"157_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/S0006-3223(02)01432-4","volume":"52","author":"JK Belanoff","year":"2002","unstructured":"Belanoff JK et al (2002) An open label trial of C-1073 (mifepristone) for psychotic major depression. Biol Psychiatry 52(5):386\u2013392","journal-title":"Biol Psychiatry"},{"issue":"1","key":"157_CR23","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1755-5949.2009.00116.x","volume":"17","author":"MC Bellingham","year":"2011","unstructured":"Bellingham MC (2011) A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade? CNS Neurosci Ther 17(1):4\u201331","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"157_CR24","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/BF02900200","volume":"247","author":"F Benedetti","year":"1997","unstructured":"Benedetti F et al (1997) Sleep deprivation hastens the antidepressant action of fluoxetine. Eur Arch Psychiatry Clin Neurosci 247(2):100\u2013103","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"157_CR25","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1038\/sj.npp.1301312","volume":"32","author":"M Beneyto","year":"2007","unstructured":"Beneyto M, Kristiansen LV, Oni-Orisan A, McCullumsmith RE, Meador-Woodruff JH (2007) Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders. Neuropsychopharmacology 32:1888\u20131902","journal-title":"Neuropsychopharmacology"},{"key":"157_CR26","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2147\/NDT.S2546","volume":"1","author":"DD Berardis","year":"2008","unstructured":"Berardis DD, De Berardis D (2008) The role of duloxetine in the treatment of anxiety disorders. Neuropsychiatr Dis Treat 1:929","journal-title":"Neuropsychiatr Dis Treat"},{"key":"157_CR27","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.biopsych.2008.04.022","volume":"64","author":"M Berk","year":"2008","unstructured":"Berk M, Copolov DL, Dean O et al (2008) N-acetyl cysteine for depressive symptoms in bipolar disorder\u2013a double-blind randomized placebo-controlled trial. Biol Psychiatry 64:468\u2013475","journal-title":"Biol Psychiatry"},{"key":"157_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1741-7015-10-91","volume":"10","author":"M Berk","year":"2012","unstructured":"Berk M, Dean OM, Cotton SM et al (2012) Maintenance N-acetyl cysteine treatment for bipolar disorder: a double-blind randomized placebo controlled trial. BMC Med 10:91","journal-title":"BMC Med"},{"issue":"74","key":"157_CR29","first-page":"2013","volume":"11","author":"M Berk","year":"2013","unstructured":"Berk M et al (2013) Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness. BMC Med 11(74):2013","journal-title":"BMC Med"},{"issue":"2","key":"157_CR30","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00441-014-1806-z","volume":"357","author":"MJ Berridge","year":"2014","unstructured":"Berridge MJ (2014) Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia. Cell Tissue Res 357(2):477\u2013492","journal-title":"Cell Tissue Res"},{"issue":"1","key":"157_CR31","doi-asserted-by":"publisher","first-page":"S547","DOI":"10.3233\/JAD-179934","volume":"64","author":"RV Bhat","year":"2018","unstructured":"Bhat RV, Andersson U, Andersson S, Kneer L, Bauer U, Sundgren-Andersson AK (2018) The conundrum of GSK3 inhibitors: is it the dawn of a new beginning? J Alzheimers Dis 64(1):S547\u2013S554","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"157_CR32","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/bph.12314","volume":"170","author":"A Bhattacharya","year":"2013","unstructured":"Bhattacharya A et al (2013) Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br J Pharmacol 170(3):624\u2013640","journal-title":"Br J Pharmacol"},{"issue":"4","key":"157_CR34","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.3233\/JAD-2010-1330","volume":"19","author":"GL Bowman","year":"2010","unstructured":"Bowman GL et al (2010) Uric acid as a CNS antioxidant. J Alzheimer\u2019s Dis 19(4):1331\u20131336","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"6529","key":"157_CR35","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1136\/bmj.292.6529.1170-a","volume":"292","author":"MJ Brodie","year":"1986","unstructured":"Brodie MJ, MacPhee GJ (1986) Carbamazepine neurotoxicity precipitated by diltiazem. Br Med J 292(6529):1170\u20131171","journal-title":"Br Med J"},{"issue":"1\u20132","key":"157_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.psychres.2014.04.005","volume":"218","author":"NC Brown","year":"2014","unstructured":"Brown NC, Andreazza AC, Trevor Young L (2014) An updated meta-analysis of oxidative stress markers in bipolar disorder. Psychiatry Res 218(1\u20132):61\u201368","journal-title":"Psychiatry Res"},{"issue":"6","key":"157_CR37","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/j.1399-5618.2007.00507.x","volume":"9","author":"JR Calabrese","year":"2007","unstructured":"Calabrese JR et al (2007) Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data. Bipolar Disord 9(6):628\u2013635","journal-title":"Bipolar Disord"},{"key":"157_CR38","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S0006-3223(03)00173-2","volume":"54","author":"L Capuron","year":"2003","unstructured":"Capuron L, Neurauter G, Musselman DL et al (2003) Interferon-alpha-induced changes in tryptophan metabolism. Relationship to depression and paroxetine treatment. Biol Psychiatry 54:906\u2013914","journal-title":"Biol Psychiatry"},{"issue":"2","key":"157_CR39","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1017\/S0033291700013775","volume":"6","author":"BJ Carroll","year":"1976","unstructured":"Carroll BJ, Curtis GC, Mendels J (1976) Cerebrospinal fluid and plasma free cortisol concentrations in depression. Psychol Med 6(2):235\u2013244","journal-title":"Psychol Med"},{"issue":"3","key":"157_CR40","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/da.20038","volume":"20","author":"P Cassano","year":"2004","unstructured":"Cassano P et al (2004) Pramipexole in treatment-resistant depression: an extended follow-up. Depress Anxiety 20(3):131\u2013138","journal-title":"Depress Anxiety"},{"issue":"2","key":"157_CR41","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2353\/ajpath.2010.081068","volume":"177","author":"AM Cataldo","year":"2010","unstructured":"Cataldo AM, McPhie DL, Lange NT, Punzell S, Elmiligy S, Ye NZ, Froimowitz MP, Hassinger LC, Menesale EB, Sargent LW, Logan DJ, Carpenter AE, Cohen BM (2010) Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. Am J Pathol 177(2):575\u2013585","journal-title":"Am J Pathol"},{"key":"157_CR42","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.bbr.2011.12.026","volume":"228","author":"JS Catches","year":"2012","unstructured":"Catches JS, Xu J, Contractor A (2012) Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice. Behav Brain Res 228:406\u2013414","journal-title":"Behav Brain Res"},{"issue":"5","key":"157_CR43","first-page":"411","volume":"26","author":"P Cervantes","year":"2001","unstructured":"Cervantes P et al (2001) Circadian secretion of cortisol in bipolar disorder. J Psychiatry Neurosci 26(5):411\u2013416","journal-title":"J Psychiatry Neurosci"},{"issue":"1","key":"157_CR44","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1399-5618.2009.00771.x","volume":"12","author":"TT Chang","year":"2010","unstructured":"Chang TT et al (2010) Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1. Bipolar Disord 12(1):102\u2013106","journal-title":"Bipolar Disord"},{"key":"157_CR45","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.drugalcdep.2015.05.033","volume":"153","author":"K-C Chang","year":"2015","unstructured":"Chang K-C et al (2015) Estimation of life expectancy and the expected years of life lost among heroin users in the era of opioid substitution treatment (OST) in Taiwan. Drug Alcohol Depend 153:152\u2013158","journal-title":"Drug Alcohol Depend"},{"issue":"10","key":"157_CR301","doi-asserted-by":"publisher","first-page":"6039","DOI":"10.1074\/jbc.274.10.6039","volume":"274","author":"RW Chen","year":"1999","unstructured":"Chen RW, Chuang DM (1999) Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. J Biol Chem 274(10):6039\u20136042","journal-title":"J Biol Chem"},{"key":"157_CR47","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1046\/j.1471-4159.1994.63062361.x","volume":"63","author":"G Chen","year":"1994","unstructured":"Chen G, Manji HK, Hawver DB, Wright CB, Potter WZ (1994) Chronic sodium valproate selectively decreases protein kinase C alpha and epsilon in vitro. J Neurochem 63:2361\u20132364","journal-title":"J Neurochem"},{"key":"157_CR48","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1034\/j.1399-5618.2000.20303.x","volume":"2","author":"G Chen","year":"2000","unstructured":"Chen G, Masana MI, Manji HK (2000) Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo. Bipolar Disord 2:217\u2013236","journal-title":"Bipolar Disord"},{"issue":"12","key":"157_CR49","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1038\/s41386-019-0480-y","volume":"44","author":"M-H Chen","year":"2019","unstructured":"Chen M-H et al (2019) Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo-control study. Neuropsychopharmacology 44(12):2112\u20132118","journal-title":"Neuropsychopharmacology"},{"key":"157_CR50","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1096\/fj.08-106450","volume":"22","author":"S Chourbaji","year":"2008","unstructured":"Chourbaji S, Vogt MA, Fumagalli F, Sohr R, Frasca A, Brandwein C et al (2008) AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression. FASEB J 22:3129\u20133134","journal-title":"FASEB J"},{"key":"157_CR51","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.neuron.2014.04.003","volume":"82","author":"Y Chu","year":"2014","unstructured":"Chu Y, Fioravante D, Leitges M, Regehr WG (2014) Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity. Neuron 82:859\u2013871","journal-title":"Neuron"},{"issue":"2\u20133","key":"157_CR52","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.psychres.2009.07.012","volume":"180","author":"K-H Chung","year":"2010","unstructured":"Chung K-H, Huang C-C, Lin H-C (2010) Increased risk of gout among patients with bipolar disorder: a nationwide population-based study. Psychiatry Res 180(2\u20133):147\u2013150","journal-title":"Psychiatry Res"},{"issue":"3","key":"157_CR53","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.ijdevneu.2010.08.007","volume":"29","author":"HB Clay","year":"2011","unstructured":"Clay HB, Sillivan S, Konradi C (2011) Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int J Dev Neurosci 29(3):311\u2013324","journal-title":"Int J Dev Neurosci"},{"key":"157_CR54","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.psyneuen.2018.09.020","volume":"99","author":"K Coello","year":"2019","unstructured":"Coello K et al (2019) Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives. Psychoneuroendocrinology 99:183\u2013190","journal-title":"Psychoneuroendocrinology"},{"issue":"21","key":"157_CR55","doi-asserted-by":"publisher","first-page":"5213","DOI":"10.1111\/febs.12407","volume":"280","author":"AR Cole","year":"2013","unstructured":"Cole AR (2013) Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia. FEBS J 280(21):5213\u20135227","journal-title":"FEBS J"},{"issue":"7","key":"157_CR56","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/mp.2008.26","volume":"14","author":"M Colla","year":"2009","unstructured":"Colla M et al (2009) Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol. Mol Psychiatry 14(7):696\u2013704, 647","journal-title":"Mol Psychiatry"},{"issue":"3","key":"157_CR57","doi-asserted-by":"publisher","first-page":"pyu075","DOI":"10.1093\/ijnp\/pyu075","volume":"18","author":"S Comai","year":"2015","unstructured":"Comai S et al (2015) Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice. Int J Neuropsychopharmacol 18(3):pyu075","journal-title":"Int J Neuropsychopharmacol"},{"issue":"8","key":"157_CR58","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/j.1399-5618.2009.00760.x","volume":"11","author":"DA Cousins","year":"2009","unstructured":"Cousins DA, Butts K, Young AH (2009) The role of dopamine in bipolar disorder. Bipolar Disord 11(8):787\u2013806","journal-title":"Bipolar Disord"},{"issue":"9878","key":"157_CR59","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1016\/S0140-6736(13)60855-7","volume":"381","author":"N Craddock","year":"2013","unstructured":"Craddock N, Sklar P (2013) Genetics of bipolar disorder. Lancet 381(9878):1654\u20131662","journal-title":"Lancet"},{"issue":"4","key":"157_CR60","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/bdi.12285","volume":"17","author":"PE Croarkin","year":"2015","unstructured":"Croarkin PE et al (2015) N-acetylaspartate normalization in bipolar depression after lamotrigine treatment. Bipolar Disord 17(4):450\u2013457","journal-title":"Bipolar Disord"},{"key":"157_CR61","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1046\/j.1460-9568.2003.02667.x","volume":"17","author":"JF Cryan","year":"2003","unstructured":"Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van Der Putten H (2003) Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur J Neurosci 17:2409\u20132417","journal-title":"Eur J Neurosci"},{"issue":"7","key":"157_CR62","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1038\/npp.2012.10","volume":"37","author":"C D\u2019Addario","year":"2012","unstructured":"D\u2019Addario C et al (2012) Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII. Neuropsychopharmacology 37(7):1647\u20131655","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"157_CR63","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.psc.2005.01.005","volume":"28","author":"C Daban","year":"2005","unstructured":"Daban C et al (2005) Hypothalamic-pituitary-adrenal axis and bipolar disorder. Psychiatr Clin North Am 28(2):469\u2013480","journal-title":"Psychiatr Clin North Am"},{"issue":"5","key":"157_CR64","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1001\/archpsyc.61.5.450","volume":"61","author":"S Dager","year":"2004","unstructured":"Dager S, Friedman S, Parow A, Demopulos A, Stoll A, Lyoo I, Dunner D, Renshaw P (2004) Brain metabolic alterations in medication-free patients with bipolar disorder. Arch Gen Psychiatry 61(5):450\u2013458","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"157_CR65","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s40263-015-0278-3","volume":"29","author":"A de Bartolomeis","year":"2015","unstructured":"de Bartolomeis A, Tomasetti C, Iasevoli F (2015) Update on the mechanism of action of aripiprazole: translational insights into antipsychotic strategies beyond dopamine receptor antagonism. CNS Drugs 29(9):773\u2013799","journal-title":"CNS Drugs"},{"key":"157_CR300","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jpsychires.2013.11.011","volume":"50","author":"RT de Sousa","year":"2014","unstructured":"de Sousa RT et al (2014) Oxidative stress in early stage bipolar disorder and the association with response to lithium. J Psychiatr Res 50:36\u201341","journal-title":"J Psychiatr Res"},{"issue":"1","key":"157_CR66","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00213-014-3655-6","volume":"232","author":"RT de Sousa","year":"2015","unstructured":"de Sousa RT, Streck EL, Zanetti MV et al (2015a) Lithium increases leukocyte mitochondrial complex I activity in bipolar disorder during depressive episodes. Psychopharmacology (Berl) 232(1):245","journal-title":"Psychopharmacology (Berl)"},{"key":"157_CR67","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jpsychires.2015.01.016","volume":"62","author":"RT de Sousa","year":"2015","unstructured":"de Sousa RT, Zanetti MV, Talib LL, Serpa MH, Chaim TM, Carvalho AF, Brunoni AR, Busatto GF, Gattaz WF, Machado-Vieira R (2015b) Lithium increases platelet serine-9 phosphorylated GSK-3\u03b2 levels in drug-free bipolar disorder during depressive episodes. J Psychiatr Res 62:78\u201383","journal-title":"J Psychiatr Res"},{"issue":"4","key":"157_CR68","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/npp.2016.149","volume":"42","author":"RT de Sousa","year":"2017","unstructured":"de Sousa RT, Loch AA, Carvalho AF, Brunoni AR, Haddad MR, Henter ID, Zarate CA, Machado-Vieira R (2017) Genetic studies on the tripartite glutamate synapse in the pathophysiology and therapeutics of mood disorders. Neuropsychopharmacology 42(4):787\u2013800","journal-title":"Neuropsychopharmacology"},{"issue":"16","key":"157_CR70","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.3748\/wjg.v13.i16.2312","volume":"13","author":"S Desplat-Jego","year":"2007","unstructured":"Desplat-Jego S, Johanet C, Escande A, Goetz J, Fabien N, Olsson N et al (2007) Update on anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: results of a multicenter study. World J Gastroenterol 13(16):2312\u20132318","journal-title":"World J Gastroenterol"},{"issue":"1","key":"157_CR71","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.psychres.2011.11.007","volume":"196","author":"F Dickerson","year":"2012","unstructured":"Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Yolken R (2012a) Markers of gluten sensitivity in acute mania: a longitudinal study. Psychiatry Res 196(1):68\u201371","journal-title":"Psychiatry Res"},{"issue":"5","key":"157_CR72","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/j.1399-5618.2012.01028.x","volume":"14","author":"F Dickerson","year":"2012","unstructured":"Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Yolken R (2012b) Antibodies to the glutamate receptor in mania. Bipolar Disord 14(5):547\u2013553","journal-title":"Bipolar Disord"},{"issue":"9","key":"157_CR73","doi-asserted-by":"publisher","first-page":"e73520","DOI":"10.1371\/journal.pone.0073520","volume":"8","author":"F Dickerson","year":"2013","unstructured":"Dickerson F, Stallings C, Origoni A, Vaughan C, Khushalani S, Yolken R (2013) A combined marker of inflammation in individuals with mania. PLoS One 8(9):e73520","journal-title":"PLoS One"},{"key":"157_CR74","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bbi.2016.12.010","volume":"62","author":"F Dickerson","year":"2017","unstructured":"Dickerson F, Severance E, Yolken R (2017) The microbiome, immunity, and schizophrenia and bipolar disorder. Brain Behav Immun 62:46\u201352","journal-title":"Brain Behav Immun"},{"issue":"5","key":"157_CR75","doi-asserted-by":"publisher","first-page":"656","DOI":"10.2174\/1570159X13666150630175841","volume":"13","author":"S Dodd","year":"2015","unstructured":"Dodd S, Fernandes BS, Dean OM (2015) Future directions for pharmacotherapies for treatment-resistant bipolar disorder. Curr Neuropharmacol 13(5):656\u2013662","journal-title":"Curr Neuropharmacol"},{"issue":"25","key":"157_CR76","doi-asserted-by":"publisher","first-page":"11573","DOI":"10.1073\/pnas.0913138107","volume":"107","author":"J Du","year":"2010","unstructured":"Du J et al (2010) A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proc Natl Acad Sci U S A 107(25):11573\u201311578","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"157_CR77","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1176\/ajp.149.1.118","volume":"149","author":"SL Dubovsky","year":"1992","unstructured":"Dubovsky SL et al (1992) Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 149(1):118\u2013120","journal-title":"Am J Psychiatry"},{"key":"157_CR78","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuropharm.2011.08.044","volume":"62","author":"RS Duman","year":"2012","unstructured":"Duman RS, Li N, Liu RJ, Duric V, Aghajanian G (2012) Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology 62:35\u201341","journal-title":"Neuropharmacology"},{"issue":"9","key":"157_CR79","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s11920-013-0394-z","volume":"15","author":"WC Duncan Jr","year":"2013","unstructured":"Duncan WC Jr, Zarate CA Jr (2013) Ketamine, sleep, and depression: current status and new questions. Curr Psychiatry Rep 15(9):394","journal-title":"Curr Psychiatry Rep"},{"key":"157_CR80","doi-asserted-by":"publisher","first-page":"e89441","DOI":"10.1371\/journal.pone.0089441","volume":"9","author":"LE Duncan","year":"2014","unstructured":"Duncan LE, Holmans PA, Lee PH, O'Dushlaine CT, Kirby AW, Smoller JW et al (2014) Pathway analyses implicate glial cells in schizophrenia. PLoS One 9:e89441","journal-title":"PLoS One"},{"key":"157_CR81","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1017\/S1461145712000016","volume":"16","author":"V Duric","year":"2013","unstructured":"Duric V, Banasr M, Stockmeier CA, Simen AA, Newton SS, Overholser JC et al (2013) Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects. Int J Neuropsychopharmacol 16:69\u201382","journal-title":"Int J Neuropsychopharmacol"},{"issue":"6","key":"157_CR82","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1176\/appi.ajp.2018.18070824","volume":"176","author":"W Earley","year":"2019","unstructured":"Earley W et al (2019) Cariprazine treatment of bipolar depression: a randomized double-blind placebo-controlled phase 3 study. Am J Psychiatry 176(6):439\u2013448","journal-title":"Am J Psychiatry"},{"issue":"1","key":"157_CR83","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0306-4530(02)00135-X","volume":"29","author":"MA Ellenbogen","year":"2004","unstructured":"Ellenbogen MA, Hodgins S, Walker C-D (2004) High levels of cortisol among adolescent offspring of parents with bipolar disorder: a pilot study. Psychoneuroendocrinology 29(1):99\u2013106","journal-title":"Psychoneuroendocrinology"},{"key":"157_CR84","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.neuroscience.2013.04.060","volume":"246","author":"JC Felger","year":"2013","unstructured":"Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246:199\u2013229","journal-title":"Neuroscience"},{"issue":"8","key":"157_CR85","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.jpsychires.2011.03.002","volume":"45","author":"BS Fernandes","year":"2011","unstructured":"Fernandes BS et al (2011) Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. J Psychiatr Res 45(8):995\u20131004","journal-title":"J Psychiatr Res"},{"key":"157_CR86","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12916-015-0529-7","volume":"13","author":"BS Fernandes","year":"2015","unstructured":"Fernandes BS et al (2015) Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies. BMC Med 13:289","journal-title":"BMC Med"},{"key":"157_CR87","doi-asserted-by":"publisher","first-page":"e365","DOI":"10.1038\/tp.2014.8","volume":"4","author":"SG Fillman","year":"2014","unstructured":"Fillman SG, Sinclair D, Fung SJ, Webster MJ, Shannon Weickert C (2014) Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder. Transl Psychiatry 4:e365","journal-title":"Transl Psychiatry"},{"issue":"3","key":"157_CR88","doi-asserted-by":"publisher","first-page":"287","DOI":"10.2174\/157015910792246227","volume":"8","author":"M Fornaro","year":"2010","unstructured":"Fornaro M et al (2010) A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulation. Curr Neuropharmacol 8(3):287\u2013304","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"157_CR89","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/S0006-3223(02)01343-4","volume":"53","author":"MA Frye","year":"2003","unstructured":"Frye MA et al (2003) Low CSF somatostatin associated with response to nimodipine in patents with affective illness. Biol Psychiatry 53(2):180\u2013183","journal-title":"Biol Psychiatry"},{"key":"157_CR90","doi-asserted-by":"crossref","unstructured":"Gallagher P et al (2008) Antiglucocorticoid treatments for mood disorders. Cochrane Database Syst Rev (1):CD005168","DOI":"10.1002\/14651858.CD005168.pub2"},{"issue":"12","key":"157_CR91","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1176\/ajp.141.12.1602","volume":"141","author":"AJ Giannini","year":"1984","unstructured":"Giannini AJ et al (1984) Antimanic effects of verapamil. Am J Psychiatry 141(12):1602\u20131603","journal-title":"Am J Psychiatry"},{"issue":"1","key":"157_CR92","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0165-1781(99)00116-X","volume":"93","author":"AJ Giannini","year":"2000","unstructured":"Giannini AJ et al (2000) Magnesium oxide augmentation of verapamil maintenance therapy in mania. Psychiatry Res 93(1):83\u201387","journal-title":"Psychiatry Res"},{"key":"157_CR93","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.4088\/JCP.08r04505","volume":"70","author":"BI Goldstein","year":"2009","unstructured":"Goldstein BI, Kemp DE, Soczynska JK et al (2009) Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry 70:1078\u20131090","journal-title":"J Clin Psychiatry"},{"issue":"4","key":"157_CR94","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1080\/09540260902962131","volume":"21","author":"AS Gonul","year":"2009","unstructured":"Gonul AS, Coburn K, Kula M (2009) Cerebral blood flow, metabolic, receptor, and transporter changes in bipolar disorder: the role of PET and SPECT studies. Int Rev Psychiatry 21(4):323\u2013335","journal-title":"Int Rev Psychiatry"},{"key":"157_CR95","volume-title":"Manic-depressive illness","author":"FK Goodwin","year":"2007","unstructured":"Goodwin FK, Jamison K (2007) Manic-depressive illness, 2nd edn. Oxford University Press, New York","edition":"2"},{"issue":"4","key":"157_CR96","doi-asserted-by":"publisher","first-page":"243","DOI":"10.4306\/pi.2010.7.4.243","volume":"7","author":"I Grande","year":"2010","unstructured":"Grande I, Fries GR, Kunz M, Kapczinski F (2010) The role of BDNF as a mediator of neuroplasticity in bipolar disorder. Psychiatry Investig 7(4):243\u2013250","journal-title":"Psychiatry Investig"},{"key":"157_CR97","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.psychres.2016.10.007","volume":"246","author":"C Gubert","year":"2016","unstructured":"Gubert C et al (2016) Peripheral adenosine levels in euthymic patients with bipolar disorder. Psychiatry Res 246:421\u2013426","journal-title":"Psychiatry Res"},{"issue":"2","key":"157_CR98","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/bdi.12142","volume":"16","author":"BCM Haarman","year":"2014","unstructured":"Haarman BCM et al (2014a) Relationship between clinical features and inflammation-related monocyte gene expression in bipolar disorder \u2013 towards a better understanding of psychoimmunological interactions. Bipolar Disord 16(2):137\u2013150","journal-title":"Bipolar Disord"},{"key":"157_CR99","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bbi.2014.03.016","volume":"40","author":"BC Haarman","year":"2014","unstructured":"Haarman BC, Riemersma-Van der Lek RF, de Groot JC et al (2014b) Neuroinflammation in bipolar disorder \u2013 A [(11)C]-(R)-PK11195 positron emission tomography study. Brain Behav Immun 40:219\u2013225","journal-title":"Brain Behav Immun"},{"issue":"2","key":"157_CR100","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1017\/S1461145713001119","volume":"17","author":"CN Haile","year":"2014","unstructured":"Haile CN et al (2014) Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression. Int J Neuropsychopharmacol 17(2):331\u2013336","journal-title":"Int J Neuropsychopharmacol"},{"key":"157_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.conb.2015.07.002","volume":"36","author":"PJ Harrison","year":"2016","unstructured":"Harrison PJ (2016) Molecular neurobiological clues to the pathogenesis of bipolar disorder. Curr Opin Neurobiol 36:1\u20136","journal-title":"Curr Opin Neurobiol"},{"key":"157_CR102","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.pneurobio.2015.09.002","volume":"134","author":"S Heyes","year":"2015","unstructured":"Heyes S et al (2015) Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders. Prog Neurobiol 134:36\u201354","journal-title":"Prog Neurobiol"},{"issue":"5","key":"157_CR103","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1080\/07420520701657730","volume":"24","author":"FC Hirata","year":"2007","unstructured":"Hirata FC et al (2007) Depression in medical school: the influence of morningness-eveningness. Chronobiol Int 24(5):939\u2013946","journal-title":"Chronobiol Int"},{"key":"157_CR104","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.neubiorev.2014.09.005","volume":"47","author":"SM Hussaini","year":"2014","unstructured":"Hussaini SM, Choi CI, Cho CH, Kim HJ, Jun H, Jang MH (2014) Wnt signaling in neuropsychiatric disorders: ties with adult hippocampal neurogenesis and behavior. Neurosci Biobehav Rev 47:369\u2013383","journal-title":"Neurosci Biobehav Rev"},{"issue":"8","key":"157_CR105","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.neuint.2009.07.009","volume":"55","author":"M Inden","year":"2009","unstructured":"Inden M et al (2009) Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice. Neurochem Int 55(8):760\u2013767","journal-title":"Neurochem Int"},{"issue":"12","key":"157_CR106","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1001\/archpsyc.61.12.1235","volume":"61","author":"H Jahn","year":"2004","unstructured":"Jahn H et al (2004) Metyrapone as additive treatment in major depression. Arch Gen Psychiatry 61(12):1235","journal-title":"Arch Gen Psychiatry"},{"issue":"7","key":"157_CR107","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1176\/ajp.155.7.972","volume":"155","author":"PG Janicak","year":"1998","unstructured":"Janicak PG et al (1998) Verapamil for the treatment of acute mania: a double-blind, placebo-controlled trial. Am J Psychiatry 155(7):972\u2013973","journal-title":"Am J Psychiatry"},{"key":"157_CR109","doi-asserted-by":"publisher","first-page":"28","DOI":"10.5607\/en.2014.23.1.28","volume":"23","author":"C Jun","year":"2014","unstructured":"Jun C, Choi Y, Lim SM, Bae S, Hong YS, Kim JE, Lyoo IK (2014) Disturbance of the glutamatergic system in mood disorders. Exp Neurobiol 23:28\u201335","journal-title":"Exp Neurobiol"},{"issue":"8","key":"157_CR110","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1017\/S1461145710001495","volume":"14","author":"M Kalinichev","year":"2011","unstructured":"Kalinichev M, Dawson LA (2011) Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania. Int J Neuropsychopharmacol 14(8):1051\u20131067","journal-title":"Int J Neuropsychopharmacol"},{"key":"157_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2017.01.007","volume":"171","author":"LK Kanazawa","year":"2017","unstructured":"Kanazawa LK, Vecchia DD, Wendler EM, Hocayen PA, Berao PS Jr, de Melo ML, Dos Reis Livero FA, Corso CR, Stipp MC, Acco A, Andreatini R (2017) Effects of acute and chronic quercetin administration on methylphenidate-induced hyperlocomotion and oxidative stress. Life Sci 171:1\u20138","journal-title":"Life Sci"},{"issue":"2","key":"157_CR112","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/15622970902717024","volume":"10","author":"S Kasper","year":"2009","unstructured":"Kasper S, Hamon M (2009) Beyond the monoaminergic hypothesis: agomelatine, a new antidepressant with an innovative mechanism of action. World J Biol Psychiatry 10(2):117\u2013126","journal-title":"World J Biol Psychiatry"},{"key":"157_CR113","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.schres.2016.10.037","volume":"187","author":"T Kato","year":"2017","unstructured":"Kato T (2017) Neurobiological basis of bipolar disorder: mitochondrial dysfunction hypothesis and beyond. Schizophr Res 187:62\u201366","journal-title":"Schizophr Res"},{"issue":"9","key":"157_CR114","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/pcn.12852","volume":"73","author":"T Kato","year":"2019","unstructured":"Kato T (2019) Current understanding of bipolar disorder: toward integration of biological basis and treatment strategies. Psychiatry Clin Neurosci 73(9):526\u2013540","journal-title":"Psychiatry Clin Neurosci"},{"issue":"10","key":"157_CR115","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0006-3223(97)00012-7","volume":"42","author":"T Kato","year":"1997","unstructured":"Kato T, Stine O, McMahon F, Crowe R (1997) Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder. Biol Psychiatry 42(10):871\u2013875","journal-title":"Biol Psychiatry"},{"issue":"1","key":"157_CR116","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.1016\/S0165-0327(00)00177-4","volume":"59","author":"PE Keck Jr","year":"2000","unstructured":"Keck PE Jr et al (2000) A review of randomized, controlled clinical trials in acute mania. J Affect Disord 59(1):S31\u2013S37","journal-title":"J Affect Disord"},{"key":"157_CR117","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s40263-014-0158-2","volume":"28","author":"DE Kemp","year":"2014","unstructured":"Kemp DE, Schinagle M, Gao K et al (2014) PPAR-gamma agonism as a modulator of mood: proof-of-concept for pioglitazone in bipolar depression. CNS Drugs 28:571\u2013581","journal-title":"CNS Drugs"},{"issue":"1","key":"157_CR118","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1034\/j.1399-5618.2002.40101.x","volume":"4","author":"G Kempermann","year":"2002","unstructured":"Kempermann G (2002) Regulation of adult hippocampal neurogenesis \u2013 implications for novel theories of major depression. Bipolar Disord 4(1):17\u201333","journal-title":"Bipolar Disord"},{"key":"157_CR119","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","volume":"62","author":"RC Kessler","year":"2005","unstructured":"Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:593\u2013602","journal-title":"Arch Gen Psychiatry"},{"key":"157_CR120","volume-title":"Handbook of diagnosis and treatment of bipolar disorders","author":"TA Ketter","year":"2009","unstructured":"Ketter TA (2009) Handbook of diagnosis and treatment of bipolar disorders. American Psychiatric Pub, Washington"},{"issue":"5","key":"157_CR121","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1124\/mol.108.052357","volume":"75","author":"HJ Kim","year":"2009","unstructured":"Kim HJ, Thayer SA (2009) Lithium increases synapse formation between hippocampal neurons by depleting phosphoinositides. Mol Pharmacol 75(5):1021\u20131030","journal-title":"Mol Pharmacol"},{"issue":"16","key":"157_CR122","doi-asserted-by":"publisher","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","volume":"93","author":"PS Klein","year":"1996","unstructured":"Klein PS, Melton DA (1996) A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A 93(16):8455\u20138459","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"157_CR124","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/j.1399-5618.2010.00803.x","volume":"12","author":"A Koukopoulos","year":"2010","unstructured":"Koukopoulos A et al (2010) Antimanic and mood-stabilizing effect of memantine as an augmenting agent in treatment-resistant bipolar disorder. Bipolar Disord 12(3):348\u2013349","journal-title":"Bipolar Disord"},{"key":"157_CR125","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jad.2016.08.046","volume":"208","author":"H Kubo","year":"2017","unstructured":"Kubo H et al (2017) 1H-magnetic resonance spectroscopy study of glutamate-related abnormality in bipolar disorder. J Affect Disord 208:139\u2013144","journal-title":"J Affect Disord"},{"issue":"2","key":"157_CR126","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.pharmthera.2013.01.005","volume":"138","author":"L Lanfumey","year":"2013","unstructured":"Lanfumey L, Mongeau R, Hamon M (2013) Biological rhythms and melatonin in mood disorders and their treatments. Pharmacol Ther 138(2):176\u2013184","journal-title":"Pharmacol Ther"},{"issue":"1","key":"157_CR127","first-page":"53","volume":"18","author":"DR Lara","year":"2003","unstructured":"Lara DR et al (2003) Allopurinol for the treatment of aggressive behaviour in patients with dementia. Int Clin Psychopharmacol 18(1):53\u201355","journal-title":"Int Clin Psychopharmacol"},{"issue":"4","key":"157_CR128","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.pnpbp.2006.02.002","volume":"30","author":"DR Lara","year":"2006","unstructured":"Lara DR et al (2006) Involvement of adenosine in the neurobiology of schizophrenia and its therapeutic implications. Prog Neuropsychopharmacol Biol Psychiatry 30(4):617\u2013629","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"157_CR129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jad.2011.12.049","volume":"141","author":"M Leboyer","year":"2012","unstructured":"Leboyer M et al (2012) Can bipolar disorder be viewed as a multi-system inflammatory disease? J Affect Disord 141(1):1\u201310","journal-title":"J Affect Disord"},{"issue":"7","key":"157_CR130","doi-asserted-by":"publisher","first-page":"e0133283","DOI":"10.1371\/journal.pone.0133283","volume":"10","author":"YT Lee","year":"2015","unstructured":"Lee YT, Hu LY, Shen CC, Huang MW, Tsai SJ, Yang AC et al (2015) Risk of psychiatric disorders following irritable bowel syndrome: a nationwide population-based cohort study. PLoS One 10(7):e0133283","journal-title":"PLoS One"},{"issue":"8","key":"157_CR132","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1001\/archpsyc.1994.03950080028004","volume":"51","author":"P Linkowski","year":"1994","unstructured":"Linkowski P et al (1994) The 24-hour profiles of cortisol, prolactin, and growth hormone secretion in mania. Arch Gen Psychiatry 51(8):616\u2013624","journal-title":"Arch Gen Psychiatry"},{"issue":"1\u20132","key":"157_CR133","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jad.2009.05.023","volume":"121","author":"TM Lorenzi","year":"2010","unstructured":"Lorenzi TM et al (2010) Association of serum uric acid levels with emotional and affective temperaments. J Affect Disord 121(1\u20132):161\u2013164","journal-title":"J Affect Disord"},{"key":"157_CR134","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","volume":"523","author":"A Louveau","year":"2015","unstructured":"Louveau A, Smirnov I, Keyes TJ et al (2015) Structural and functional features of central nervous system lymphatic vessels. Nature 523:337\u2013341","journal-title":"Nature"},{"issue":"2","key":"157_CR135","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.mehy.2012.04.042","volume":"79","author":"R-B Lu","year":"2012","unstructured":"Lu R-B et al (2012) Neuroprotective and neurogenesis agent for treating bipolar II disorder: add-on memantine to mood stabilizer works. Med Hypotheses 79(2):280\u2013283","journal-title":"Med Hypotheses"},{"issue":"6","key":"157_CR137","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/00004714-200112000-00017","volume":"21","author":"R Machado-Vieira","year":"2001","unstructured":"Machado-Vieira R et al (2001) Therapeutic efficacy of allopurinol in mania associated with hyperuricemia. J Clin Psychopharmacol 21(6):621\u2013622","journal-title":"J Clin Psychopharmacol"},{"issue":"4","key":"157_CR138","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1054\/mehy.2001.1543","volume":"58","author":"R Machado-Vieira","year":"2002","unstructured":"Machado-Vieira R et al (2002) Purinergic dysfunction in mania: an integrative model. Med Hypotheses 58(4):297\u2013304","journal-title":"Med Hypotheses"},{"issue":"1","key":"157_CR139","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neulet.2007.05.016","volume":"421","author":"R Machado-Vieira","year":"2007","unstructured":"Machado-Vieira R et al (2007) Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects. Neurosci Lett 421(1):33\u201336","journal-title":"Neurosci Lett"},{"issue":"8","key":"157_CR140","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.4088\/JCP.v69n0806","volume":"69","author":"R Machado-Vieira","year":"2008","unstructured":"Machado-Vieira R et al (2008) A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J Clin Psychiatry 69(8):1237\u20131245","journal-title":"J Clin Psychiatry"},{"key":"157_CR303","doi-asserted-by":"publisher","unstructured":"Machado-Vieira R, Manji HK, Zarate CA Jr (2009) The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis. Bipolar Disord:92\u2013109. https:\/\/doi.org\/10.1111\/j.1399-5618.2009.00714.x","DOI":"10.1111\/j.1399-5618.2009.00714.x"},{"issue":"4","key":"157_CR141","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.biopsych.2010.10.019","volume":"69","author":"R Machado-Vieira","year":"2011","unstructured":"Machado-Vieira R et al (2011) The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder. Biol Psychiatry 69(4):344\u2013352","journal-title":"Biol Psychiatry"},{"issue":"4","key":"157_CR142","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.pbb.2011.09.010","volume":"100","author":"R Machado-Vieira","year":"2012","unstructured":"Machado-Vieira R et al (2012) Novel glutamatergic agents for major depressive disorder and bipolar disorder. Pharmacol Biochem Behav 100(4):678\u2013687","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"157_CR143","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1080\/14737159.2017.1270758","volume":"17","author":"R Machado-Vieira","year":"2017","unstructured":"Machado-Vieira R, Salem H et al (2017a) Convergent lines of evidence support the role of uric acid levels as a potential biomarker in bipolar disorder. Expert Rev Mol Diagn 17(2):107\u2013108","journal-title":"Expert Rev Mol Diagn"},{"issue":"1","key":"157_CR144","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/JCP.0000000000000616","volume":"37","author":"R Machado-Vieira","year":"2017","unstructured":"Machado-Vieira R, Zanetti MV et al (2017b) Increased brain lactate during depressive episodes and reversal effects by lithium monotherapy in drug-naive bipolar disorder. J Clin Psychopharmacol 37(1):40\u201345","journal-title":"J Clin Psychopharmacol"},{"key":"157_CR145","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.pnpbp.2010.12.017","volume":"35","author":"M Maes","year":"2011","unstructured":"Maes M, Leonard BE, Myint AM et al (2011) The new \u20185-HT\u2019 hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuro-Psychopharmacology Biol Psychiatry 35:702\u2013721","journal-title":"Prog Neuro-Psychopharmacology Biol Psychiatry"},{"issue":"8","key":"157_CR146","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/j.1399-5618.2008.00636.x","volume":"10","author":"AG Mallinger","year":"2008","unstructured":"Mallinger AG et al (2008) Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. Bipolar Disord 10(8):856\u2013866","journal-title":"Bipolar Disord"},{"key":"157_CR147","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.brainres.2005.11.061","volume":"1073-1074","author":"PJ Marro","year":"2006","unstructured":"Marro PJ, Mishra OP, Delivoria-Papadopoulos M (2006) Effect of allopurinol on brain adenosine levels during hypoxia in newborn piglets. Brain Res 1073-1074:444\u2013450","journal-title":"Brain Res"},{"issue":"1","key":"157_CR148","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/glia.22904","volume":"64","author":"A Masuch","year":"2016","unstructured":"Masuch A et al (2016) Mechanism of microglia neuroprotection: involvement of P2X7, TNF\u03b1, and valproic acid. Glia 64(1):76\u201389","journal-title":"Glia"},{"key":"157_CR149","doi-asserted-by":"publisher","first-page":"e318","DOI":"10.1038\/tp.2013.90","volume":"3","author":"MJ McCarthy","year":"2013","unstructured":"McCarthy MJ, Wei H, Marnoy Z, Darvish RM, McPhie DL, Cohen BM, Welsh DK (2013) Genetic and clinical factors predict lithium\u2019s effects on PER2 gene expression rhythms in cells from bipolar disorder patients. Transl Psychiatry 3:e318","journal-title":"Transl Psychiatry"},{"issue":"4","key":"157_CR150","first-page":"215","volume":"22","author":"TL McCloud","year":"2016","unstructured":"McCloud TL et al (2016) Ketamine and other glutamate receptor modulators for depression in bipolar disorder in adults. BJ Psych Advances 22(4):215\u2013215","journal-title":"BJ Psych Advances"},{"issue":"5","key":"157_CR151","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.metabol.2005.01.008","volume":"54","author":"BS McEwen","year":"2005","unstructured":"McEwen BS (2005) Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metab Clin Exp 54(5). Suppl 1:20\u201323","journal-title":"Metab Clin Exp"},{"key":"157_CR153","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.smrv.2016.06.007","volume":"34","author":"MCA Melo","year":"2017","unstructured":"Melo MCA et al (2017) Chronotype and circadian rhythm in bipolar disorder: a systematic review. Sleep Med Rev 34:46\u201358","journal-title":"Sleep Med Rev"},{"issue":"7576","key":"157_CR154","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nature15526","volume":"527","author":"J Mertens","year":"2015","unstructured":"Mertens J et al (2015) Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature 527(7576):95\u201399","journal-title":"Nature"},{"key":"157_CR155","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1038\/npp.2013.140","volume":"38","author":"A Miller","year":"2013","unstructured":"Miller A (2013) Conceptual confluence: the kynurenine pathway as a common target for ketamine and the convergence of the inflammation and glutamate hypotheses of depression. Neuropsychopharmacology 38:1607\u20131608","journal-title":"Neuropsychopharmacology"},{"key":"157_CR156","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.ogc.2009.10.005","volume":"36","author":"D Mischoulon","year":"2009","unstructured":"Mischoulon D (2009) Update and critique of natural remedies as antidepressant treatments. Obstet Gynecol Clin North Am 36:789\u2013807","journal-title":"Obstet Gynecol Clin North Am"},{"key":"157_CR157","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.biopsych.2013.01.007","volume":"74","author":"A Modabbernia","year":"2013","unstructured":"Modabbernia A, Taslimi S, Brietzke E et al (2013) Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry 74:15\u201325","journal-title":"Biol Psychiatry"},{"issue":"7","key":"157_CR158","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/mp.2013.105","volume":"19","author":"ML Molendijk","year":"2014","unstructured":"Molendijk ML et al (2014) Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Mol Psychiatry 19(7):791\u2013800","journal-title":"Mol Psychiatry"},{"issue":"2","key":"157_CR159","doi-asserted-by":"publisher","first-page":"100","DOI":"10.9758\/cpn.2017.15.2.100","volume":"15","author":"A Muneer","year":"2017","unstructured":"Muneer A (2017) Wnt and GSK3 signaling pathways in bipolar disorder: clinical and therapeutic implications. Clin Psychopharmacol Neurosci 15(2):100\u2013114","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"157_CR160","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.jpsychires.2013.05.018","volume":"47","author":"K Munkholm","year":"2013","unstructured":"Munkholm K, Brauner JV, Kessing LV et al (2013) Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis. J Psychiatr Res 47:1119\u20131133","journal-title":"J Psychiatr Res"},{"issue":"3","key":"157_CR161","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/acps.12983","volume":"139","author":"K Munkholm","year":"2019","unstructured":"Munkholm K et al (2019) A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder. Acta Psychiatr Scand 139(3):227\u2013236","journal-title":"Acta Psychiatr Scand"},{"issue":"3","key":"157_CR163","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.psychres.2014.11.038","volume":"225","author":"M Muti","year":"2015","unstructured":"Muti M et al (2015) Serum uric acid levels and different phases of illness in bipolar I patients treated with lithium. Psychiatry Res 225(3):604\u2013608","journal-title":"Psychiatry Res"},{"key":"157_CR164","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/1096-9861(20001016)426:2<243::AID-CNE6>3.0.CO;2-8","volume":"426","author":"MU Naik","year":"2000","unstructured":"Naik MU, Benedikz E, Hernandez I, Libien J, Hrabe J, Valsamis M, Dow-Edwards D, Osman M, Sacktor TC (2000) Distribution of protein kinase Mzeta and the complete protein kinase C isoform family in rat brain. J Comp Neurol 426:243\u2013258","journal-title":"J Comp Neurol"},{"key":"157_CR165","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jat.3093","volume":"35","author":"Y Nam","year":"2015","unstructured":"Nam Y, Wie MB, Shin EJ, Nguyen TT, Nah SY, Ko SK, Jeong JH, Jang CG, Kim HC (2015) Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C delta in human neuroblastoma dopaminergic SH-SY5Y cell lines. J Appl Toxicol 35:927\u2013944","journal-title":"J Appl Toxicol"},{"key":"157_CR166","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.smrv.2014.06.006","volume":"20","author":"TH Ng","year":"2015","unstructured":"Ng TH et al (2015) Sleep-wake disturbance in interepisode bipolar disorder and high-risk individuals: a systematic review and meta-analysis. Sleep Med Rev 20:46\u201358","journal-title":"Sleep Med Rev"},{"issue":"1","key":"157_CR167","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/0004867412449303","volume":"47","author":"AA Nierenberg","year":"2013","unstructured":"Nierenberg AA et al (2013) Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development. Aust N Z J Psychiatry 47(1):26\u201342","journal-title":"Aust N Z J Psychiatry"},{"issue":"5","key":"157_CR168","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1073\/pnas.95.5.2642","volume":"95","author":"S Nonaka","year":"1998","unstructured":"Nonaka S, Hough CJ, Chuang DM (1998) Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proc Natl Acad Sci U S A 95(5):2642\u20132647","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"157_CR169","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1001\/archpsyc.57.6.572","volume":"57","author":"JI Nurnberger Jr","year":"2000","unstructured":"Nurnberger JI Jr et al (2000) Melatonin suppression by light in euthymic bipolar and unipolar patients. Arch Gen Psychiatry 57(6):572\u2013579","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"157_CR170","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1001\/jamapsychiatry.2014.176","volume":"71","author":"JI Nurnberger Jr","year":"2014","unstructured":"Nurnberger JI Jr et al (2014) Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiat 71(6):657\u2013664","journal-title":"JAMA Psychiat"},{"key":"157_CR171","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jpsychires.2018.08.028","volume":"105","author":"S Ogawa","year":"2018","unstructured":"Ogawa S, Tsuchimine S, Kunugi H (2018) Cerebrospinal fluid monoamine metabolite concentrations in depressive disorder: a meta-analysis of historic evidence. J Psychiatr Res 105:137\u2013146","journal-title":"J Psychiatr Res"},{"issue":"3","key":"157_CR172","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/bdi.12708","volume":"21","author":"PMS Oliveira","year":"2019","unstructured":"Oliveira PMS et al (2019) Serum uric acid as a predictor of bipolarity in individuals with a major depressive episode. Bipolar Disord 21(3):235\u2013243","journal-title":"Bipolar Disord"},{"key":"157_CR173","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1749-6632.2009.04984.x","volume":"1179","author":"TW Pace","year":"2009","unstructured":"Pace TW, Miller AH (2009) Cytokines and glucocorticoid receptor signaling. Relevance to major depression. Ann N Y Acad Sci 1179:86\u2013105","journal-title":"Ann N Y Acad Sci"},{"key":"157_CR174","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3390\/membranes4030565","volume":"4","author":"S Pahl","year":"2014","unstructured":"Pahl S, Tapken D, Haering SC, Hollmann M (2014) Trafficking of kainate receptors. Membranes 4:565\u2013595","journal-title":"Membranes"},{"key":"157_CR175","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/bdi.12228","volume":"17","author":"GN Pandey","year":"2015","unstructured":"Pandey GN, Rizavi HS, Tripathi M, Ren X (2015) Region-specific dysregulation of glycogen synthase kinase-3\u03b2 and \u03b2-catenin in the postmortem brains of subjects with bipolar disorder and schizophrenia. Bipolar Disord 17:160\u2013171","journal-title":"Bipolar Disord"},{"key":"157_CR176","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-2999(94)90516-9","volume":"263","author":"M Papp","year":"1994","unstructured":"Papp M, Moryl E (1994) Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression. Eur J Pharmacol 263:1\u20137","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"157_CR177","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/sj.bjp.0704368","volume":"134","author":"CM Pariante","year":"2001","unstructured":"Pariante CM et al (2001) Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters. Br J Pharmacol 134(6):1335\u20131343","journal-title":"Br J Pharmacol"},{"issue":"3","key":"157_CR178","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/JCP.0000000000000693","volume":"37","author":"LT Park","year":"2017","unstructured":"Park LT et al (2017) A double-blind, placebo-controlled, pilot study of riluzole monotherapy for acute bipolar depression. J Clin Psychopharmacol 37(3):355\u2013358","journal-title":"J Clin Psychopharmacol"},{"issue":"5","key":"157_CR179","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1097\/00004714-199810000-00009","volume":"18","author":"PJ Pazzaglia","year":"1998","unstructured":"Pazzaglia PJ et al (1998) Nimodipine monotherapy and carbamazepine augmentation in patients with refractory recurrent affective illness. J Clin Psychopharmacol 18(5):404\u2013413","journal-title":"J Clin Psychopharmacol"},{"key":"157_CR180","first-page":"95","volume":"107C","author":"G Perugi","year":"2014","unstructured":"Perugi G, Quaranta G, Belletti S et al (2014) General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases. J Affect Disord 107C:95\u2013103","journal-title":"J Affect Disord"},{"issue":"5","key":"157_CR181","doi-asserted-by":"publisher","first-page":"e805","DOI":"10.1038\/tp.2016.78","volume":"6","author":"B Pfaffenseller","year":"2016","unstructured":"Pfaffenseller B et al (2016) Differential expression of transcriptional regulatory units in the prefrontal cortex of patients with bipolar disorder: potential role of early growth response gene 3. Transl Psychiatry 6(5):e805\u2013e805","journal-title":"Transl Psychiatry"},{"key":"157_CR182","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fnbeh.2018.00015","volume":"12","author":"B Pfaffenseller","year":"2018","unstructured":"Pfaffenseller B et al (2018) Immediate early gene and the brain-derived neurotrophic factor in bipolar disorder. Front Behav Neurosci 12:15","journal-title":"Front Behav Neurosci"},{"issue":"23","key":"157_CR184","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.2174\/13816128113196660736","volume":"20","author":"F Pilar-C\u00faellar","year":"2014","unstructured":"Pilar-C\u00faellar F, Vidal R, D\u00edaz A, Castro E, dos Anjos S, Vargas V, Romero B, Valdiz\u00e1n EM (2014) Signaling pathways involved in antidepressant-induced cell proliferation and synaptic plasticity. Curr Pharm Des 20(23):3776\u20133794","journal-title":"Curr Pharm Des"},{"issue":"8","key":"157_CR185","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1038\/npp.2010.43","volume":"35","author":"A Polter","year":"2010","unstructured":"Polter A, Beurel E, Yang S, Garner R, Song L, Miller CA, Sweatt JD, McMahon L, Bartolucci AA, Li X, Jope RS (2010) Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. Neuropsychopharmacology 35(8):1761\u20131774","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"157_CR186","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/j.1552-4604.1986.tb02980.x","volume":"26","author":"WA Price","year":"1986","unstructured":"Price WA, James Giannini A (1986) Neurotoxicity caused by lithium-verapamil synergism. J Clin Pharmacol 26(8):717\u2013719","journal-title":"J Clin Pharmacol"},{"issue":"1","key":"157_CR187","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2174\/157015908783769671","volume":"6","author":"G Rammes","year":"2008","unstructured":"Rammes G, Danysz W, Parsons CG (2008) Pharmacodynamics of memantine: an update. Curr Neuropharmacol 6(1):55\u201378","journal-title":"Curr Neuropharmacol"},{"key":"157_CR188","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/mp.2009.47","volume":"15","author":"JS Rao","year":"2010","unstructured":"Rao JS, Harry GJ, Rapoport SI et al (2010) Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry 15:384\u2013392","journal-title":"Mol Psychiatry"},{"issue":"8","key":"157_CR190","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/bdi.12121","volume":"15","author":"LB Rizzo","year":"2013","unstructured":"Rizzo LB et al (2013) Immunosenescence is associated with human cytomegalovirus and shortened telomeres in type I bipolar disorder. Bipolar Disord 15(8):832\u2013838","journal-title":"Bipolar Disord"},{"issue":"7","key":"157_CR191","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.eurpsy.2013.04.001","volume":"28","author":"R Robillard","year":"2013","unstructured":"Robillard R et al (2013) Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. Eur Psychiatry 28(7):412\u2013416","journal-title":"Eur Psychiatry"},{"key":"157_CR192","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev.physiol.70.021507.105852","volume":"70","author":"Y Rong","year":"2008","unstructured":"Rong Y, Distelhorst CW (2008) Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis. Annu Rev Physiol 70:73\u201391","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"157_CR193","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/acps.12414","volume":"132","author":"JD Rosenblat","year":"2015","unstructured":"Rosenblat JD, McIntyre RS (2015) Are medical comorbid conditions of bipolar disorder due to immune dysfunction? Acta Psychiatr Scand 132(3):180\u2013191","journal-title":"Acta Psychiatr Scand"},{"key":"157_CR195","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pnpbp.2014.01.013","volume":"53","author":"JD Rosenblat","year":"2014","unstructured":"Rosenblat JD, Cha DS, Mansur RB et al (2014) Inflamed moods: a review of the interactions between inflammation and mood disorders. Prog Neuropsychopharmacol Biol Psychiatry 53:23\u201334","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"8","key":"157_CR196","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1038\/npp.2017.32","volume":"42","author":"IM Rosso","year":"2017","unstructured":"Rosso IM, Crowley DJ, Silveri MM, Rauch SL, Jensen JE (2017) Hippocampus glutamate and N-acetyl aspartate markers of excitotoxic neuronal compromise in posttraumatic stress disorder. Neuropsychopharmacology 42(8):1698\u20131705","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"157_CR197","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1192\/bjp.2018.144","volume":"213","author":"T Rowland","year":"2018","unstructured":"Rowland T, Perry BI, Upthegrove R, Barnes N, Chatterjee J, Gallacher D, Marwaha S (2018) Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: systematic review and meta-analyses. Br J Psychiatry 213(3):514\u2013525","journal-title":"Br J Psychiatry"},{"issue":"6","key":"157_CR198","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.pnpbp.2010.02.027","volume":"34","author":"G Salvadore","year":"2010","unstructured":"Salvadore G et al (2010) Increased uric acid levels in drug-na\u00efve subjects with bipolar disorder during a first manic episode. Prog Neuropsychopharmacol Biol Psychiatry 34(6):819\u2013821","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"4","key":"157_CR199","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1001\/jamapsychiatry.2017.0080","volume":"74","author":"G Sanacora","year":"2017","unstructured":"Sanacora G et al (2017) A consensus statement on the use of ketamine in the treatment of mood disorders. JAMA Psychiat 74(4):399\u2013405","journal-title":"JAMA Psychiat"},{"key":"157_CR200","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1753-4887.2009.00180.x","volume":"67","author":"J Sarris","year":"2009","unstructured":"Sarris J, Schoendorfer N, Kavanagh DJ (2009) Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments. Nutr Rev 67:125\u2013131","journal-title":"Nutr Rev"},{"key":"157_CR201","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1399-5618.2011.00945.x","volume":"13","author":"J Sarris","year":"2011","unstructured":"Sarris J, Mischoulon D, Schweitzer I (2011) Adjunctive nutraceuticals with standard pharmacotherapies in bipolar disorder: a systematic review of clinical trials. Bipolar Disord 13:454\u2013465","journal-title":"Bipolar Disord"},{"issue":"22","key":"157_CR202","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.2174\/1381612824666180803112304","volume":"24","author":"SK Satyanarayanan","year":"2018","unstructured":"Satyanarayanan SK et al (2018) Circadian rhythm and melatonin in the treatment of depression. Curr Pharm Des 24(22):2549\u20132555","journal-title":"Curr Pharm Des"},{"issue":"2","key":"157_CR204","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000480349","volume":"3","author":"A Saxena","year":"2017","unstructured":"Saxena A, Scaini G, Bavaresco DV et al (2017) Role of protein kinase C in bipolar disorder: a review of the current literature [published correction appears in Mol Neuropsychiatry. 2018 Feb;3(3):180. Valvassoria, Samira S [corrected to Valvassori, Samira S]]. Mol Neuropsychiatry 3(2):108\u2013124","journal-title":"Mol Neuropsychiatry"},{"key":"157_CR206","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fgene.2012.00103","volume":"3","author":"A Sequeira","year":"2012","unstructured":"Sequeira A, Martin M, Rollins B, Moon E, Bunney W, Macciardi F, Lupoli S, Smith E, Kelsoe J, Magnan C, van Oven M, Baldi P, Wallace D, Vawter M (2012) Mitochondrial mutations and polymorphisms in psychiatric disorders. Front Genet 3:103","journal-title":"Front Genet"},{"issue":"5","key":"157_CR207","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/JCP.0b013e31829b62ba","volume":"33","author":"G Serra","year":"2013","unstructured":"Serra G et al (2013) Antimanic and long-lasting mood stabilizing effect of memantine in bipolar I mood disorder: two case reports. J Clin Psychopharmacol 33(5):715\u2013717","journal-title":"J Clin Psychopharmacol"},{"issue":"1","key":"157_CR208","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.schres.2012.02.025","volume":"138","author":"EG Severance","year":"2012","unstructured":"Severance EG, Alaedini A, Yang S, Halling M, Gressitt KL, Stallings CR et al (2012) Gastrointestinal inflammation and associated immune activation in schizophrenia. Schizophr Res 138(1):48\u201353","journal-title":"Schizophr Res"},{"issue":"3","key":"157_CR209","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/bdi.12159","volume":"16","author":"EG Severance","year":"2014","unstructured":"Severance EG, Gressitt KL, Yang S, Stallings CR, Origoni AE, Vaughan C et al (2014) Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder. Bipolar Disord 16(3):230\u2013240","journal-title":"Bipolar Disord"},{"issue":"5","key":"157_CR210","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11920-015-0574-0","volume":"17","author":"EG Severance","year":"2015","unstructured":"Severance EG, Prandovszky E, Castiglione J, Yolken RH (2015) Gastroenterology issues in schizophrenia: why the gut matters. Curr Psychiatry Rep 17(5):27","journal-title":"Curr Psychiatry Rep"},{"issue":"1","key":"157_CR211","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.coph.2006.07.005","volume":"7","author":"G Shaltiel","year":"2007","unstructured":"Shaltiel G, Chen G, Manji HK (2007) Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder. Curr Opin Pharmacol 7(1):22\u201326","journal-title":"Curr Opin Pharmacol"},{"issue":"2","key":"157_CR212","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1399-5618.2009.00706.x","volume":"11","author":"E Shorter","year":"2009","unstructured":"Shorter E (2009) The history of lithium therapy. Bipolar Disord 11(2):4\u20139","journal-title":"Bipolar Disord"},{"issue":"3","key":"157_CR213","first-page":"276","volume":"25","author":"PH Silverstone","year":"2000","unstructured":"Silverstone PH, Birkett L (2000) Diltiazem as augmentation therapy in patients with treatment-resistant bipolar disorder: a retrospective study. J Psychiatry Neurosci 25(3):276\u2013280","journal-title":"J Psychiatry Neurosci"},{"issue":"2","key":"157_CR304","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0165-1781(00)00175-X","volume":"95","author":"JC Soares","year":"2000","unstructured":"Soares JC et al (2000) Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study. Psychiatry Res 95(2):109\u2013118","journal-title":"Psychiatry Res"},{"issue":"4","key":"157_CR214","first-page":"231","volume":"14","author":"B Sperlagh","year":"2012","unstructured":"Sperlagh B et al (2012) The role of purinergic signaling in depressive disorders. Neuropsychopharmacol Hung 14(4):231\u2013238","journal-title":"Neuropsychopharmacol Hung"},{"key":"157_CR215","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/YCO.0b013e32835aa4b4","volume":"26","author":"L Stertz","year":"2013","unstructured":"Stertz L, Magalhaes PV, Kapczinski F (2013) Is bipolar disorder an inflammatory condition? The relevance of microglial activation. Curr Opin Psychiatry 26:19\u201326","journal-title":"Curr Opin Psychiatry"},{"issue":"3","key":"157_CR216","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1365-2125.2012.04398.x","volume":"75","author":"J Stevens","year":"2013","unstructured":"Stevens J et al (2013) Bayesian model of Hamilton Depression Rating Score (HDRS) with memantine augmentation in bipolar depression. Br J Clin Pharmacol 75(3):791\u2013798","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"157_CR217","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.biopsych.2013.02.024","volume":"75","author":"AR Sutin","year":"2014","unstructured":"Sutin AR et al (2014) Impulsivity is associated with uric acid: evidence from humans and mice. Biol Psychiatry 75(1):31\u201337","journal-title":"Biol Psychiatry"},{"issue":"3","key":"157_CR218","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/JCP.0000000000000492","volume":"36","author":"A Talaei","year":"2016","unstructured":"Talaei A et al (2016) Tamoxifen: a protein kinase C inhibitor to treat mania: a systematic review and meta-analysis of randomized, placebo-controlled trials. J Clin Psychopharmacol 36(3):272\u2013275","journal-title":"J Clin Psychopharmacol"},{"key":"157_CR219","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neuint.2016.06.008","volume":"99","author":"J Thomas","year":"2016","unstructured":"Thomas J, Khanam R, Vohora D (2016) Augmentation of antidepressant effects of venlafaxine by agomelatine in mice are independent of kynurenine pathway. Neurochem Int 99:103\u2013109","journal-title":"Neurochem Int"},{"issue":"5","key":"157_CR220","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1192\/bjp.bp.112.108357","volume":"201","author":"M Tohen","year":"2012","unstructured":"Tohen M et al (2012) Randomised, double-blind, placebo-controlled study of olanzapine in patients with bipolar I depression. Br J Psychiatry J Ment Sci 201(5):376\u2013382","journal-title":"Br J Psychiatry J Ment Sci"},{"issue":"6","key":"157_CR221","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.euroneuro.2016.03.001","volume":"26","author":"P-T Tseng","year":"2016","unstructured":"Tseng P-T et al (2016) Light therapy in the treatment of patients with bipolar depression: a meta-analytic study. Eur Neuropsychopharmacol 26(6):1037\u20131047","journal-title":"Eur Neuropsychopharmacol"},{"issue":"2","key":"157_CR222","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/acps.13055","volume":"140","author":"A Tundo","year":"2019","unstructured":"Tundo A, de Filippis R, De Crescenzo F (2019) Pramipexole in the treatment of unipolar and bipolar depression. A systematic review and meta-analysis. Acta Psychiatr Scand 140(2):116\u2013125","journal-title":"Acta Psychiatr Scand"},{"issue":"1","key":"157_CR223","first-page":"1","volume":"5","author":"AJ Valvezan","year":"2012","unstructured":"Valvezan AJ, Klein PS (2012) GSK-3 and Wnt signaling in neurogenesis and bipolar disorder. Front Mol Neurosci 5(1):1","journal-title":"Front Mol Neurosci"},{"key":"157_CR224","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/0006-3223(95)00611-7","volume":"40","author":"HY Wang","year":"1996","unstructured":"Wang HY, Friedman E (1996) Enhanced protein kinase C activity and translocation in bipolar affective disorder brains. Biol Psychiatry 40:568\u2013575","journal-title":"Biol Psychiatry"},{"key":"157_CR225","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0022-3956(98)90057-7","volume":"33","author":"HY Wang","year":"1999","unstructured":"Wang HY, Markowitz P, Levinson D, Undie AS, Friedman E (1999) Increased membrane-associated protein kinase C activity and translocation in blood platelets from bipolar affective disorder patients. J Psychiatr Res 33:171\u2013179","journal-title":"J Psychiatr Res"},{"issue":"3\u20134","key":"157_CR226","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.cnr.2004.09.012","volume":"4","author":"JJ Warsh","year":"2004","unstructured":"Warsh JJ, Andreopoulos S, Li PP (2004) Role of intracellular calcium signaling in the pathophysiology and pharmacotherapy of bipolar disorder: current status. Clin Neurosci Res 4(3\u20134):201\u2013213","journal-title":"Clin Neurosci Res"},{"key":"157_CR227","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1192\/bjp.184.6.496","volume":"184","author":"S Watson","year":"2004","unstructured":"Watson S et al (2004) Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder. Br J Psychiatry 184:496\u2013502","journal-title":"Br J Psychiatry"},{"issue":"11","key":"157_CR228","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.biopsych.2012.05.029","volume":"72","author":"S Watson","year":"2012","unstructured":"Watson S et al (2012) A randomized trial to examine the effect of mifepristone on neuropsychological performance and mood in patients with bipolar depression. Biol Psychiatry 72(11):943\u2013949","journal-title":"Biol Psychiatry"},{"key":"157_CR229","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.brainres.2018.04.031","volume":"1694","author":"H Weina","year":"2018","unstructured":"Weina H et al (2018) Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity. Brain Res 1694:55\u201362","journal-title":"Brain Res"},{"issue":"2","key":"157_CR230","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1001\/archneurpsyc.1922.02190140070006","volume":"8","author":"PG Weston","year":"1922","unstructured":"Weston PG (1922) The determination of sodium, potassium, calcium, and magnesium in the blood and spinal fluid of patients suffering from manic depressive insanity. Arch Neurol Psychiatry 8(2):179","journal-title":"Arch Neurol Psychiatry"},{"issue":"7","key":"157_CR231","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1017\/S003329170500437X","volume":"35","author":"A Wirz-Justice","year":"2005","unstructured":"Wirz-Justice A et al (2005) Chronotherapeutics (light and wake therapy) in affective disorders. Psychol Med 35(7):939\u2013944","journal-title":"Psychol Med"},{"key":"157_CR232","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1002\/glia.22491","volume":"61","author":"P Xu","year":"2013","unstructured":"Xu P, Rosen KM, Hedstrom K, Rey O, Guha S, Hart C, Corfas G (2013) Nerve injury induces glial cell line-derived neurotrophic factor (GDNF) expression in Schwann cells through purinergic signaling and the PKC-PKD pathway. Glia 61:1029\u20131040","journal-title":"Glia"},{"key":"157_CR233","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000430823","volume":"96","author":"H Xu","year":"2015","unstructured":"Xu H, Czerwinski P, Xia N, Forstermann U, Li H (2015) Downregulation of BDNF expression by PKC and by TNF-alpha in human endothelial cells. Pharmacology 96:1\u201310","journal-title":"Pharmacology"},{"issue":"3","key":"157_CR234","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1001\/archgenpsychiatry.2007.43","volume":"65","author":"A Yildiz","year":"2008","unstructured":"Yildiz A et al (2008) Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen. Arch Gen Psychiatry 65(3):255\u2013263","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"157_CR235","first-page":"125","volume":"1","author":"A Yildiz","year":"2016","unstructured":"Yildiz A et al (2016) Antimanic treatment with tamoxifen affects brain chemistry: a double-blind, placebo-controlled proton magnetic resonance spectroscopy study. Biol Psychiatry Cogn Neurosci Neuroimaging 1(2):125\u2013131","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"issue":"2","key":"157_CR237","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/mp.2014.143","volume":"20","author":"T Yoshimizu","year":"2015","unstructured":"Yoshimizu T et al (2015) Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry 20(2):162\u2013169","journal-title":"Mol Psychiatry"},{"issue":"8","key":"157_CR238","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/sj.npp.1300471","volume":"29","author":"AH Young","year":"2004","unstructured":"Young AH et al (2004) Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology 29(8):1538\u20131545","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"157_CR239","doi-asserted-by":"publisher","first-page":"150","DOI":"10.4088\/JCP.08m04995gre","volume":"71","author":"AH Young","year":"2010","unstructured":"Young AH et al (2010) A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I). J Clin Psychiatry 71(2):150\u2013162","journal-title":"J Clin Psychiatry"},{"key":"157_CR241","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1196\/annals.1300.017","volume":"1003","author":"CA Zarate Jr","year":"2003","unstructured":"Zarate CA Jr, Du J, Quiroz J, Gray NA, Denicoff KD, Singh J, Charney DS, Manji HK (2003) Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system. Ann N Y Acad Sci 1003:273\u2013291","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"157_CR242","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.biopsych.2004.03.013","volume":"56","author":"CA Zarate Jr","year":"2004","unstructured":"Zarate CA Jr et al (2004) Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biol Psychiatry 56(1):54\u201360","journal-title":"Biol Psychiatry"},{"key":"157_CR243","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.biopsych.2005.10.021","volume":"59","author":"CA Zarate Jr","year":"2006","unstructured":"Zarate CA Jr, Singh J, Manji HK (2006) Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder. Biol Psychiatry 59:1006\u20131020","journal-title":"Biol Psychiatry"},{"issue":"7","key":"157_CR244","doi-asserted-by":"publisher","first-page":"569","DOI":"10.2165\/00023210-200923070-00003","volume":"23","author":"CA Zarate","year":"2009","unstructured":"Zarate CA, Manji HK (2009) Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder. CNS Drugs 23(7):569\u2013582","journal-title":"CNS Drugs"},{"key":"157_CR245","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/da.22340","volume":"32","author":"A Zeinoddini","year":"2015","unstructured":"Zeinoddini A, Sorayani M, Hassanzadeh E et al (2015) Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: a randomized, double-blind, placebo-controlled trial. Depress Anxiety 32:167\u2013173","journal-title":"Depress Anxiety"},{"key":"157_CR246","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0197-0186(00)00099-1","volume":"38","author":"J Zhang","year":"2001","unstructured":"Zhang J, Terreni L, De Simoni MG et al (2001) Peripheral interleukin-6 administration increases extracellular concentrations of serotonin and the evoked release of serotonin in the rat striatum. Neurochem Int 38:303\u2013308","journal-title":"Neurochem Int"},{"key":"157_CR247","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.schres.2019.05.019","volume":"209","author":"W Zheng","year":"2019","unstructured":"Zheng W et al (2019) Adjunctive memantine for major mental disorders: a systematic review and meta-analysis of randomized double-blind controlled trials. Schizophr Res 209:12\u201321","journal-title":"Schizophr Res"},{"issue":"2","key":"157_CR248","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0022-3956(01)00013-9","volume":"35","author":"AW Zobel","year":"2001","unstructured":"Zobel AW et al (2001) Cortisol response in the combined dexamethasone\/CRH test as predictor of relapse in patients with remitted depression. a prospective study. J Psychiatr Res 35(2):83\u201394","journal-title":"J Psychiatr Res"},{"key":"157_CR249","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3389\/fnins.2017.00493","volume":"11","author":"GS Zuccoli","year":"2017","unstructured":"Zuccoli GS et al (2017) The energy metabolism dysfunction in psychiatric disorders postmortem brains: focus on proteomic evidence. Front Neurosci 11:493","journal-title":"Front Neurosci"}],"container-title":["Current Topics in Behavioral Neurosciences","Bipolar Disorder: From Neuroscience to Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/7854_2020_157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T02:17:18Z","timestamp":1649816238000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/7854_2020_157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030721428","9783030721435"],"references-count":236,"URL":"https:\/\/doi.org\/10.1007\/7854_2020_157","relation":{},"ISSN":["1866-3370","1866-3389"],"issn-type":[{"value":"1866-3370","type":"print"},{"value":"1866-3389","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"29 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}