{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:33:55Z","timestamp":1787506435806,"version":"build-2736575974"},"publisher-location":"Cham","reference-count":91,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031169960","type":"print"},{"value":"9783031169977","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/7854_2021_265","type":"book-chapter","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T04:50:22Z","timestamp":1642135822000},"page":"193-214","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Safety of Non-brain Penetrating H1-Antihistamines for the Treatment of Allergic Diseases"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-7907","authenticated-orcid":false,"given":"Kazuhiko","family":"Yanai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Church","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"issue":"5","key":"265_CR1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.dmpk.2015.06.005","volume":"30","author":"Y Akamine","year":"2015","unstructured":"Akamine Y, Miura Komori MH, Tamai I, Ieiri I, Yasui-Furukori N, Uno T (2015) The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion. Drug Metab Pharmacokinet 30(5):352\u2013357. https:\/\/doi.org\/10.1016\/j.dmpk.2015.06.005","journal-title":"Drug Metab Pharmacokinet"},{"key":"265_CR2","unstructured":"Bakker RA, Smit MJ, Timmerman H and Leurs R (2001) Constitutive signaling of the human histamine H1 receptor. IN: Watanabe T, Timmerman H, and Yanai K (Eds) Histamine Research in the millennium. Elsevier Science BV, Amsterdam, pp161\u2013166"},{"key":"265_CR3","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3389\/fphar.2017.00667","volume":"8","author":"R Bosma","year":"2017","unstructured":"Bosma R, Witt G, Vaas LAI et al (2017) The target residence time of antihistamines determines their antagonism of the G protein-coupled histamine H1 receptor. Front Pharmacol 8:667. https:\/\/doi.org\/10.3389\/fphar.2017.00667","journal-title":"Front Pharmacol"},{"key":"265_CR4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ejphar.2018.09.011","volume":"838","author":"R Bosma","year":"2018","unstructured":"Bosma R, van den Bor J, Vischer HF et al (2018) The long duration of action of the second generation antihistamine Bilastine coincides with its long residence time at the histamine H1 receptor. Eur J Pharmacol 838:107\u2013111. https:\/\/doi.org\/10.1016\/j.ejphar.2018.09.011","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"265_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jaci.2019.06.049","volume":"145","author":"J Bousquet","year":"2020","unstructured":"Bousquet J, Sch\u00fcnemann HJ, Togias A et al (2020) Next-generation allergic rhinitis and its impact on asthma (ARIA) guidelines for allergic rhinitis based on grading of recommendations assessment, development and evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol 145(1):70\u201380. https:\/\/doi.org\/10.1016\/j.jaci.2019.06.049","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"265_CR6","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1185\/030079906X112660","volume":"22","author":"J Boyle","year":"2006","unstructured":"Boyle J, Eriksson M, Stanley N, Fujita T, Kumagi Y (2006) Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects. Curr Med Res Opin 22(7):1343\u20131351. https:\/\/doi.org\/10.1185\/030079906X112660","journal-title":"Curr Med Res Opin"},{"issue":"6","key":"265_CR7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/s0301-0082(00)00039-3","volume":"63","author":"RE Brown","year":"2001","unstructured":"Brown RE, Stevens DR, Haas HL (2001) The physiology of brain histamine. Prog Neurobiol 63(6):637\u2013672. https:\/\/doi.org\/10.1016\/s0301-0082(00)00039-3","journal-title":"Prog Neurobiol"},{"issue":"Suppl 2","key":"265_CR8","first-page":"2910","volume":"9","author":"PS Burton","year":"2007","unstructured":"Burton PS, Crean C, Kagey M, Neilsen JW (2007) Permeability characteristics of bilastine, a potent and selective H1 receptor antagonist, in caco-2 cells. AAPS J 9(Suppl 2):2910","journal-title":"AAPS J"},{"issue":"5","key":"265_CR9","doi-asserted-by":"publisher","first-page":"S835","DOI":"10.1067\/mai.2003.1550","volume":"111","author":"TB Casale","year":"2003","unstructured":"Casale TB, Blaiss MS, Gelfand E, Gilmore T, Harvey PD, Hindmarch I, Simons FE, Spangler DL, Szefler SJ, Terndrup TE, Waldman SA, Weiler J, Wong DF, Roundtable AI (2003) First do no harm: managing antihistamine impairment in patients with allergic rhinitis. J Allergy Clin Immunol 111(5):S835\u2013S842. https:\/\/doi.org\/10.1067\/mai.2003.1550","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"265_CR10","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1111\/cea.13500","volume":"49","author":"M Cataldi","year":"2019","unstructured":"Cataldi M, Maurer M, Taglialatela M, Church MK (2019) Cardiac safety of second-generation H1-antihistamines when updosed in chronic spontaneous urticaria. Clin Exp Allergy 49(12):1615\u20131623. https:\/\/doi.org\/10.1111\/cea.13500","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"265_CR11","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1124\/dmd.31.3.312","volume":"31","author":"C Chen","year":"2003","unstructured":"Chen C, Hanson E, Watson JW, Lee JS (2003) P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos 31(3):312\u2013318. https:\/\/doi.org\/10.1124\/dmd.31.3.312","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"265_CR12","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1517\/14740338.2011.604029","volume":"10","author":"MK Church","year":"2011","unstructured":"Church MK (2011) Safety and efficacy of bilastine: a new H1-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria. Expert Opin Drug Saf 10(5):779\u2013793. https:\/\/doi.org\/10.1517\/14740338.2011.604029","journal-title":"Expert Opin Drug Saf"},{"key":"265_CR13","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/164_2016_85","volume":"241","author":"MK Church","year":"2017","unstructured":"Church MK (2017) Allergy, histamine and antihistamines. Handb Exp Pharmacol 241:321\u2013331. https:\/\/doi.org\/10.1007\/164_2016_85","journal-title":"Handb Exp Pharmacol"},{"issue":"9","key":"265_CR14","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1111\/jdv.14305","volume":"31","author":"MK Church","year":"2017","unstructured":"Church MK, Labeaga L (2017) Bilastine: a new H1-antihistamine with an optimal profile for updosing in urticaria. J Eur Acad Dermatol Venereol 31(9):1447\u20131452. https:\/\/doi.org\/10.1111\/jdv.14305","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"10","key":"265_CR15","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1111\/j.1365-2222.2012.03957.x","volume":"42","author":"MK Church","year":"2012","unstructured":"Church MK, Maurer M (2012) H1-antihistamines and urticaria: how can we predict the best drug for our patient? Clin Exp Allergy 42(10):1423\u20131429. https:\/\/doi.org\/10.1111\/j.1365-2222.2012.03957.x","journal-title":"Clin Exp Allergy"},{"key":"265_CR16","volume-title":"Therapeutic index of antihistamines","author":"MK Church","year":"1992","unstructured":"Church MK, Rihoux JP (1992) Therapeutic index of antihistamines. Hogrefe & Huber Publishers, Lewiston"},{"issue":"4","key":"265_CR17","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1398-9995.2009.02325.x","volume":"65","author":"MK Church","year":"2010","unstructured":"Church MK, Maurer M, Simons FE, Bindslev-Jensen C, van Cauwenberge P, Bousquet J, Holgate ST, Zuberbier T (2010) Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy 65(4):459\u2013466. https:\/\/doi.org\/10.1111\/j.1398-9995.2009.02325.x","journal-title":"Allergy"},{"issue":"3","key":"265_CR18","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1080\/03007995.2019.1681134","volume":"36","author":"MK Church","year":"2020","unstructured":"Church MK, Tiongco-Recto M, Ridolo E, Nov\u00e1k Z (2020) Bilastine: a lifetime companion for the treatment of allergies. Curr Med Res Opin 36(3):445\u2013454. https:\/\/doi.org\/10.1080\/03007995.2019.1681134","journal-title":"Curr Med Res Opin"},{"key":"265_CR20","first-page":"1198","volume":"47","author":"C Crean","year":"2007","unstructured":"Crean C, Valiente Sologuren RA, McLaverty D (2007) Effect of grapefruit juice on the pharmacokinetics of bilastine. J Clin Pharmacol 47:1198","journal-title":"J Clin Pharmacol"},{"issue":"6","key":"265_CR21","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3109\/00498254.2011.643256","volume":"42","author":"A Crowe","year":"2012","unstructured":"Crowe A, Wright C (2012) The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers. Xenobiotica 42(6):538\u2013549. https:\/\/doi.org\/10.3109\/00498254.2011.643256","journal-title":"Xenobiotica"},{"issue":"8","key":"265_CR22","first-page":"866","volume":"27","author":"M Cvetkovic","year":"1999","unstructured":"Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB (1999) OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27(8):866\u2013871","journal-title":"Drug Metab Dispos"},{"key":"265_CR23","doi-asserted-by":"publisher","DOI":"10.1037\/10001-000","volume-title":"The expression of the emotions in man and animals","author":"C Darwin","year":"1872","unstructured":"Darwin C (1872) The expression of the emotions in man and animals. John Murray, London"},{"key":"265_CR24","doi-asserted-by":"publisher","first-page":"CD009345","DOI":"10.1002\/14651858.CD009345.pub2","volume":"11","author":"AI De Sutter","year":"2015","unstructured":"De Sutter AI, Saraswat A, van Driel ML (2015) Antihistamines for the common cold. Cochrane Database Syst Rev 11:CD009345. https:\/\/doi.org\/10.1002\/14651858.CD009345.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"265_CR25","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.clpt.2004.10.005","volume":"77","author":"GK Dresser","year":"2005","unstructured":"Dresser GK, Kim RB, Bailey DG (2005) Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin Pharmacol Ther 77(3):170\u2013177. https:\/\/doi.org\/10.1016\/j.clpt.2004.10.005","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"265_CR26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00011-020-01422-1","volume":"70","author":"M Ennis","year":"2021","unstructured":"Ennis M, Tiligada K (2021) Histamine receptors and COVID-19. Inflamm Res 70(1):67\u201375. https:\/\/doi.org\/10.1007\/s00011-020-01422-1","journal-title":"Inflamm Res"},{"issue":"5","key":"265_CR27","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/bcp.12421","volume":"78","author":"M Farre","year":"2014","unstructured":"Farre M, Perez-Mana C, Papaseit E, Menoyo E, Perez M, Martin S, Bullich S, Rojas S, Herance JR, Trampal C, Labeaga L, Valiente R (2014) Bilastine vs. hydroxyzine: occupation of brain histamine H1-receptors evaluated by positron emission tomography in healthy volunteers. Br J Clin Pharmacol 78(5):970\u2013980. https:\/\/doi.org\/10.1111\/bcp.12421","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"265_CR28","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1067\/mai.2001.114239","volume":"107","author":"RS Geha","year":"2001","unstructured":"Geha RS, Meltzer EO (2001) Desloratadine: a new, nonsedating, oral antihistamine. J Allergy Clin Immunol 107(4):751\u2013762. https:\/\/doi.org\/10.1067\/mai.2001.114239","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"265_CR29","doi-asserted-by":"publisher","first-page":"366","DOI":"10.2500\/aap.2009.30.3226","volume":"30","author":"S Gillman","year":"2009","unstructured":"Gillman S, Gillard M, Benedetti MS (2009) The concept of receptor occupancy to predict clinical efficacy: a comparison of second generation H1 antihistamines. Allergy Asthma Proc 30(4):366\u2013376. https:\/\/doi.org\/10.2500\/aap.2009.30.3226","journal-title":"Allergy Asthma Proc"},{"issue":"3","key":"265_CR30","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1001\/jamainternmed.2014.7663","volume":"175","author":"SL Gray","year":"2015","unstructured":"Gray SL, Anderson ML, Dublin S, Hanlon JT, Hubbard R, Walker R, Yu O, Crane PK, Larson EB (2015) Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 175(3):401\u2013407. https:\/\/doi.org\/10.1001\/jamainternmed.2014.7663","journal-title":"JAMA Intern Med"},{"key":"265_CR31","doi-asserted-by":"publisher","first-page":"709","DOI":"10.2147\/NSS.S264140","volume":"12","author":"JT Guevarra","year":"2020","unstructured":"Guevarra JT, Hiensch R, Varga AW, Rapoport DM (2020) Pitolisant to treat excessive daytime sleepiness and cataplexy in adults with narcolepsy: rationale and clinical utility. Nat Sci Sleep 12:709\u2013719. https:\/\/doi.org\/10.2147\/NSS.S264140","journal-title":"Nat Sci Sleep"},{"issue":"2","key":"265_CR32","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrn1034","volume":"4","author":"H Haas","year":"2003","unstructured":"Haas H, Panula P (2003) The role of histamine and the tuberomamillary nucleus in the nervous system. Nat Rev Neurosci 4(2):121\u2013130. https:\/\/doi.org\/10.1038\/nrn1034","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"265_CR33","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1542\/peds.2013-2236","volume":"132","author":"LM Hampton","year":"2013","unstructured":"Hampton LM, Nguyen DB, Edwards JR, Budnitz DS (2013) Cough and cold medication adverse events after market withdrawal and labeling revision. Pediatrics 132(6):1047\u20131054. https:\/\/doi.org\/10.1542\/peds.2013-2236","journal-title":"Pediatrics"},{"issue":"5","key":"265_CR34","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/jcph.838","volume":"57","author":"L Hazell","year":"2017","unstructured":"Hazell L, Raschi E, De Ponti F, Thomas SH, Salvo F, Ahlberg Helgee E, Boyer S, Sturkenboom M, Shakir S (2017) Evidence for the hERG liability of antihistamines, antipsychotics, and anti-infective agents: a systematic literature review from the ARITMO project. J Clin Pharmacol 57(5):558\u2013572. https:\/\/doi.org\/10.1002\/jcph.838","journal-title":"J Clin Pharmacol"},{"issue":"6","key":"265_CR35","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s40263-013-0062-1","volume":"27","author":"M He","year":"2013","unstructured":"He M, Deng C, Xu-Feng Huang X-F (2013) The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain. CNS Drugs 27(6):423\u2013434. https:\/\/doi.org\/10.1007\/s40263-013-0062-1","journal-title":"CNS Drugs"},{"key":"265_CR36","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1046\/j.1365-2222.2003.01769.x","volume":"33","author":"ST Holgate","year":"2003","unstructured":"Holgate ST, Canonica GW, Simons FE, Taglialatela M, Tharp M, Timmerman H, Yanai K (2003) Consensus group on new-generation antihistamines (2003) consensus group on new-generation antihistamines. Consensus group on new generation antihistamines (conga): present status and recommendations. This consensus group was convened under the auspices of the British society for allergy and clinical immunology. Clin Exp Allergy 33:1305\u20131324. https:\/\/doi.org\/10.1046\/j.1365-2222.2003.01769.x","journal-title":"Clin Exp Allergy"},{"key":"265_CR37","doi-asserted-by":"publisher","first-page":"109420","DOI":"10.1016\/j.cbi.2021.109420","volume":"338","author":"Y Hou","year":"2021","unstructured":"Hou Y, Ge S, Li X, Wang C, He H, He L (2021) Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis. Chem Biol Interact 338:109420. https:\/\/doi.org\/10.1016\/j.cbi.2021.109420","journal-title":"Chem Biol Interact"},{"issue":"23","key":"265_CR38","doi-asserted-by":"publisher","first-page":"13316","DOI":"10.1073\/pnas.93.23.13316","volume":"93","author":"I Inoue","year":"1996","unstructured":"Inoue I, Yanai K, Kitamura D, Taniuchi I, Kobayashi T, Niimura K, Watanabe T, Watanabe T (1996) Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors. Proc Natl Acad Sci U S A 93(23):13316\u201313320. https:\/\/doi.org\/10.1073\/pnas.93.23.13316","journal-title":"Proc Natl Acad Sci U S A"},{"key":"265_CR39","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4172\/2167-1052.1000138","volume":"2","author":"WA Jedrychowski","year":"2013","unstructured":"Jedrychowski WA, Flak E, Mroz E, Butscher M, Sowa A (2013) Intake of the first-generation anti-histamines in early childhood may have an adverse effect on cognitive function. Population based pharmacoepidemiologic study in non-asthamtic children. Adv Pharmacoepidemiol Drug Saf 2:4. https:\/\/doi.org\/10.4172\/2167-1052.1000138","journal-title":"Adv Pharmacoepidemiol Drug Saf"},{"issue":"1","key":"265_CR40","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3390\/ijms20010213","volume":"20","author":"H Kawauchi","year":"2019","unstructured":"Kawauchi H, Yanai K, Wang DY, Itahashi K, Kimihiro Okubo K (2019) Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. Int J Mol Sci 20(1):213. https:\/\/doi.org\/10.3390\/ijms20010213","journal-title":"Int J Mol Sci"},{"issue":"9","key":"265_CR41","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1073\/pnas.0611417104","volume":"104","author":"SF Kim","year":"2007","unstructured":"Kim SF, Huang AS, Snowman AM, Teuscher C, Snyder SH (2007) Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A 104(9):3456\u20133459. https:\/\/doi.org\/10.1073\/pnas.0611417104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"265_CR42","doi-asserted-by":"publisher","unstructured":"Kim H, Kim SH, Kim JB (2021) Antihistamines as a common cause of new-onset seizures: a single-center observational study. Neurol Sci. https:\/\/doi.org\/10.1007\/s10072-021-05043-2","DOI":"10.1007\/s10072-021-05043-2"},{"issue":"2","key":"265_CR43","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ejps.2010.03.009","volume":"40","author":"G Lappin","year":"2010","unstructured":"Lappin G, Shishikura Y, Jochemsen R, Weaver RJ, Gesson C, Houston B, Oosterhuis B, Bjerrum OJ, Rowland M, Garner C (2010) Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability. Eur J Pharm Sci 40(2):125\u2013131. https:\/\/doi.org\/10.1016\/j.ejps.2010.03.009","journal-title":"Eur J Pharm Sci"},{"key":"265_CR44","doi-asserted-by":"publisher","unstructured":"Lavorini F, Matucci A, Rossi O, Pistolesi M, SKY study investigators (2020) Concomitant bilastine and montelukast as additive therapy for seasonal allergic rhinoconjunctivits and mild-to-moderate asthma. The SKY study. Allergy 75(3): 675\u2013677. doi: https:\/\/doi.org\/10.1111\/all.14007","DOI":"10.1111\/all.14007"},{"issue":"4","key":"265_CR45","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1046\/j.0954-7894.2002.01314.x","volume":"32","author":"R Leurs","year":"2002","unstructured":"Leurs R, Church MK, Taglialatela M (2002) H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 32(4):489\u2013498. https:\/\/doi.org\/10.1046\/j.0954-7894.2002.01314.x","journal-title":"Clin Exp Allergy"},{"issue":"Suppl 1","key":"265_CR46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3109\/01480545.2012.682653","volume":"35","author":"ML Lucero","year":"2012","unstructured":"Lucero ML, Gonzalo A, Ganza A, Leal N, Soengas I, Ioja E, Gedey S, Jahic M, Bednarczyk D (2012) Interactions of bilastine, a new oral H1 antihistamine, with human transporter systems. Drug Chem Toxicol 35(Suppl 1):8\u201317. https:\/\/doi.org\/10.3109\/01480545.2012.682653","journal-title":"Drug Chem Toxicol"},{"issue":"18","key":"265_CR47","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1517\/14656566.2013.850490","volume":"14","author":"M Makris","year":"2013","unstructured":"Makris M, Maurer M, Zuberbier T (2013) Pharmacotherapy of chronic spontaneous urticaria. Expert Opin Pharmacother 14(18):2511\u20132519. https:\/\/doi.org\/10.1517\/14656566.2013.850490","journal-title":"Expert Opin Pharmacother"},{"issue":"3","key":"265_CR48","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1398-9995.2010.02496.x","volume":"66","author":"M Maurer","year":"2011","unstructured":"Maurer M, Weller K, Bindslev-Jensen C, Gimenez-Arnau A, Bousquet PJ, Bousquet J, Canonica GW, Church MK, Godse KV, Grattan CE, Greaves MW, Hide M, Kalogeromitros D, Kaplan AP, Saini SS, Zhu XJ, Zuberbier T (2011) Unmet clinical needs in chronic spontaneous urticaria. A GA(2)LEN task force report. Allergy 66(3):317\u2013330. https:\/\/doi.org\/10.1111\/j.1398-9995.2010.02496.x","journal-title":"Allergy"},{"issue":"6","key":"265_CR49","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3390\/pharmaceutics12060525","volume":"12","author":"H Mizuguchi","year":"2020","unstructured":"Mizuguchi H, Wakugawa T, Sadakata H, Kamimura S, Takemoto M, Nakagawa T, Yabumoto M, Kitamura Y, Takeda N, Fukui H (2020) Elucidation of inverse agonist activity of bilastine. Pharmaceutics 12(6):525. https:\/\/doi.org\/10.3390\/pharmaceutics12060525","journal-title":"Pharmaceutics"},{"issue":"Suppl 3","key":"265_CR50","first-page":"9","volume":"21","author":"J Montoro","year":"2011","unstructured":"Montoro J, Mullol J, Davila I, Ferrer M, Sastre J, Bartra J, Jauregui I, del Cuvillo A, Valero A (2011) Bilastine and the central nervous system. J Investig Allergol Clin Immunol 21(Suppl 3):9\u201315","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"4","key":"265_CR51","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/pds.5191","volume":"30","author":"DR Morales","year":"2021","unstructured":"Morales DR, Macfarlane T, MacDonald TM, Hallas J, Ernst MT, Herings RMC, Smits E, Overbeek JA, Mitchell L, Morant S, Mackenzie I, Doney A, Robertson C, Bennie M, Wei L, Nicholson L, Morris C, Flynn RWF (2021) Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: an interrupted time series regression analysis. Pharmacoepidemiol Drug Saf 30(4):482\u2013491. https:\/\/doi.org\/10.1002\/pds.5191","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"4","key":"265_CR52","doi-asserted-by":"publisher","first-page":"e00499","DOI":"10.1002\/prp2.499","volume":"7","author":"T Nakamura","year":"2019","unstructured":"Nakamura T, Hiraoka K, Harada R, Matsuzawa T, Ishikawa Y, Funaki Y, Yoshikawa T, Tashiro M, Yanai K, Okamura N (2019) Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine. Pharmacol Res Perspect 7(4):e00499. https:\/\/doi.org\/10.1002\/prp2.499","journal-title":"Pharmacol Res Perspect"},{"issue":"3","key":"265_CR53","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/bph.14696","volume":"177","author":"I Obara","year":"2020","unstructured":"Obara I, Telezhkin V, Alrashdi I, Chazot PL (2020) Histamine, histamine receptors, and neuropathic pain relief. Br J Pharmacol 177(3):580\u2013599. https:\/\/doi.org\/10.1111\/bph.14696","journal-title":"Br J Pharmacol"},{"issue":"3","key":"265_CR54","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.alit.2017.12.005","volume":"67","author":"K Okubo","year":"2018","unstructured":"Okubo K, Uchida E, Terahara T, Akiyama K, Kobayashi S, Tanaka Y (2018) Efficacy and safety of the emedastine patch, a novel transdermal drug delivery system for allergic rhinitis: phase III, multicenter, randomized, double-blinded, placebo-controlled, parallel-group comparative study in patients with seasonal allergic rhinitis. Allergol Int 67(3):371\u2013379. https:\/\/doi.org\/10.1016\/j.alit.2017.12.005","journal-title":"Allergol Int"},{"issue":"7109","key":"265_CR55","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/443261a","volume":"443","author":"H Pearson","year":"2006","unstructured":"Pearson H (2006) Medicine: sleep it off. Nature 443(7109):261\u2013263. https:\/\/doi.org\/10.1038\/443261a","journal-title":"Nature"},{"issue":"3","key":"265_CR56","doi-asserted-by":"publisher","first-page":"e0119551","DOI":"10.1371\/journal.pone.0119551","volume":"10","author":"E Poluzzi","year":"2015","unstructured":"Poluzzi E, Raschi E, Godman B, Koci A, Moretti U, Kalaba M, Wettermark B, Sturkenboom M, De Ponti F (2015) Pro-arrhythmic potential of oral antihistamines (H1): combining adverse event reports with drug utilization data across Europe. PLoS One 10(3):e0119551. https:\/\/doi.org\/10.1371\/journal.pone.0119551","journal-title":"PLoS One"},{"key":"265_CR57","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.neuropharm.2015.07.002","volume":"106","author":"G Provensi","year":"2016","unstructured":"Provensi G, Blandina P, Passani MB (2016) The histaminergic system as a target for the prevention of obesity and metabolic syndrome. Neuropharmacology 106:3\u201312. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.07.002","journal-title":"Neuropharmacology"},{"key":"265_CR58","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.bbrc.2020.11.095","volume":"538","author":"LR Reznikov","year":"2021","unstructured":"Reznikov LR, Norris MH, Vashisht R, Bluhm AP, Li D, Liao YJ, Brown A, Butte AJ, Ostrov DA (2021) Identification of antiviral antihistamines for COVID-19 repurposing. Biochem Biophys Res Commun 538:173\u2013179. https:\/\/doi.org\/10.1016\/j.bbrc.2020.11.095","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"265_CR59","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.pbb.2008.07.011","volume":"91","author":"JA Rojas-Zamorano","year":"2009","unstructured":"Rojas-Zamorano JA, Esqueda-Leon E, Jimenez-Anguiano A, Cintra-McGlone L, Mendoza Melendez MA, Velazquez Moctezuma J (2009) The H1 histamine receptor blocker, chlorpheniramine, completely prevents the increase in REM sleep induced by immobilization stress in rats. Pharmacol Biochem Behav 91(3):291\u2013294. https:\/\/doi.org\/10.1016\/j.pbb.2008.07.011","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"265_CR60","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/S0009-9236(98)90052-2","volume":"64","author":"T Russell","year":"1998","unstructured":"Russell T, Stoltz M, Weir S (1998) Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers. Clin Pharmacol Ther 64(6):612\u2013621. https:\/\/doi.org\/10.1016\/S0009-9236(98)90052-2","journal-title":"Clin Pharmacol Ther"},{"issue":"12","key":"265_CR61","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3390\/children7120305","volume":"7","author":"M Saad","year":"2020","unstructured":"Saad M, Syed S, Ilyas M, Gashev AA (2020) Antihistamines increase body mass index percentiles and Z-scores in hispanic children. Children (Basel) 7(12):305. https:\/\/doi.org\/10.3390\/children7120305","journal-title":"Children (Basel)"},{"issue":"2","key":"265_CR62","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00213-013-3146-1","volume":"230","author":"H Sato","year":"2013","unstructured":"Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K (2013) Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers. Psychopharmacology (Berl) 230(2):227\u2013234. https:\/\/doi.org\/10.1007\/s00213-013-3146-1","journal-title":"Psychopharmacology (Berl)"},{"issue":"19","key":"265_CR63","doi-asserted-by":"publisher","first-page":"3497","DOI":"10.1007\/s00213-015-4002-2","volume":"232","author":"H Sato","year":"2015","unstructured":"Sato H, Ito C, Hiraoka K, Tashiro M, Shibuya K, Funaki Y, Yoshikawa T, Iwata R, Matsuoka H, Yanai K (2015) Histamine H1 receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers. Psychopharmacology (Berl) 232(19):3497\u20133505. https:\/\/doi.org\/10.1007\/s00213-015-4002-2","journal-title":"Psychopharmacology (Berl)"},{"issue":"2\u20133","key":"265_CR64","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/s0169-409x(98)00085-4","volume":"36","author":"AH Schinkel","year":"1999","unstructured":"Schinkel AH (1999) P-glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 36(2\u20133):179\u2013194. https:\/\/doi.org\/10.1016\/s0169-409x(98)00085-4","journal-title":"Adv Drug Deliv Rev"},{"key":"265_CR65","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neubiorev.2014.03.009","volume":"42","author":"EH Schneider","year":"2014","unstructured":"Schneider EH, Neumann D, Seifert R (2014) Modulation of behavior by the histaminergic system: lessons from H1R-and H2R-deficient mice. Neurosci Biobehav Rev 42:252\u2013266. https:\/\/doi.org\/10.1016\/j.neubiorev.2014.03.009","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"265_CR66","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s0928-0987(00)00177-9","volume":"12","author":"A Seelig","year":"2000","unstructured":"Seelig A, Landwojtowicz E (2000) Structure-activity relationship of P-glycoprotein substrates and modifiers. Eur J Pharm Sci 12(1):31\u201340. https:\/\/doi.org\/10.1016\/s0928-0987(00)00177-9","journal-title":"Eur J Pharm Sci"},{"issue":"7354","key":"265_CR67","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature10236","volume":"475","author":"T Shimamura","year":"2011","unstructured":"Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S (2011) Structure of the human histamine H1 receptor complex with doxepin. Nature 475(7354):65\u201370. https:\/\/doi.org\/10.1038\/nature10236","journal-title":"Nature"},{"issue":"10","key":"265_CR68","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1124\/dmd.105.004622","volume":"33","author":"M Shimizu","year":"2005","unstructured":"Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y (2005) Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos 33(10):1477\u20131481. https:\/\/doi.org\/10.1124\/dmd.105.004622","journal-title":"Drug Metab Dispos"},{"issue":"21","key":"265_CR69","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1056\/NEJMra033121","volume":"351","author":"FE Simons","year":"2004","unstructured":"Simons FE (2004) Advances in H1-antihistamines. N Engl J Med 351(21):2203\u20132217. https:\/\/doi.org\/10.1056\/NEJMra033121","journal-title":"N Engl J Med"},{"issue":"23","key":"265_CR70","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1056\/NEJM199406093302307","volume":"330","author":"FE Simons","year":"1994","unstructured":"Simons FE, Simons KJ (1994) The pharmacology and use of H1-receptor-antagonist drugs. N Engl J Med 330(23):1663\u20131670. https:\/\/doi.org\/10.1056\/NEJM199406093302307","journal-title":"N Engl J Med"},{"issue":"6","key":"265_CR71","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.jaci.2011.09.005","volume":"128","author":"FE Simons","year":"2011","unstructured":"Simons FE, Simons KJ (2011) Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol 128(6):1139\u20131150.e4. https:\/\/doi.org\/10.1016\/j.jaci.2011.09.005","journal-title":"J Allergy Clin Immunol"},{"key":"265_CR72","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.ejphar.2018.12.003","volume":"844","author":"R Singh","year":"2019","unstructured":"Singh R, Bansal Y, Medhi B, Kuhad A (2019) Antipsychotics-induced metabolic alterations: recounting the mechanistic insights, therapeutic targets and pharmacological alternatives. Eur J Pharmacol 844:231\u2013240. https:\/\/doi.org\/10.1016\/j.ejphar.2018.12.003","journal-title":"Eur J Pharmacol"},{"issue":"9","key":"265_CR73","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.2215\/CJN.12991216","volume":"12","author":"S Snitker","year":"2017","unstructured":"Snitker S, Doerfler RM, Soliman EZ, Deo R, St Peter WL, Kramlik S, Fischer MJ, Navaneethan S, Delafontaine P, Jaar BG, Ojo A, Makos GK, Slaven A, Weir MR, Zhan M, Fink JC (2017) Association of QT-prolonging medication use in CKD with electrocardiographic manifestations. Clin J Am Soc Nephrol 12(9):1409\u20131417. https:\/\/doi.org\/10.2215\/CJN.12991216","journal-title":"Clin J Am Soc Nephrol"},{"issue":"Suppl 3","key":"265_CR74","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1046\/j.1365-2222.1999.0290s3182.x","volume":"29","author":"M Taglialatela","year":"1999","unstructured":"Taglialatela M, Castaldo P, Pannaccione A, Giorgio G, Genovese A, Marone G, Annunziato L (1999) Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity. Clin Exp Allergy 29(Suppl 3):182\u2013189. https:\/\/doi.org\/10.1046\/j.1365-2222.1999.0290s3182.x","journal-title":"Clin Exp Allergy"},{"key":"265_CR75","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.pediatrneurol.2009.11.001","volume":"42","author":"T Takano","year":"2010","unstructured":"Takano T, Sakaue Y, Sokoda T, Sawai C, Akabori S, Maruo Y, Taga T, Ohno M, Takeuchi Y (2010) Seizure susceptibility due to antihistamines in febrile seizures. Pediatr Neurol 42:277\u2013279. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2009.11.001","journal-title":"Pediatr Neurol"},{"issue":"5","key":"265_CR76","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1254\/fpj.152.246","volume":"152","author":"N Tanida","year":"2018","unstructured":"Tanida N, Akiyama K, Terahara T (2018) Pharmacological profile and clinical efficacy of transdermal patch containing emedastine difumarate (ALLESAGA\u00ae TAPE). Nihon Yakurigaku Zasshi 152(5):246\u2013255. https:\/\/doi.org\/10.1254\/fpj.152.246","journal-title":"Nihon Yakurigaku Zasshi"},{"issue":"5","key":"265_CR77","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0009-9236(03)00238-8","volume":"74","author":"C Tannergren","year":"2003","unstructured":"Tannergren C, Petri N, Knutson L, Hedeland M, Bondesson U, Lennernas H (2003) Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine. Clin Pharmacol Ther 74(5):423\u2013436. https:\/\/doi.org\/10.1016\/S0009-9236(03)00238-8","journal-title":"Clin Pharmacol Ther"},{"issue":"7","key":"265_CR78","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/hup.1051","volume":"24","author":"M Tashiro","year":"2009","unstructured":"Tashiro M, Kato M, Miyake M, Watanuki S, Funaki Y, Ishikawa Y, Iwata R, Yanai K (2009) Dose dependency of brain histamine H1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin. Hum Psychopharmacol 24(7):540\u2013548. https:\/\/doi.org\/10.1002\/hup.1051","journal-title":"Hum Psychopharmacol"},{"issue":"Suppl 60","key":"265_CR79","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1034\/j.1398-9995.2000.055supp60005.x","volume":"55","author":"H Timmerman","year":"2000","unstructured":"Timmerman H (2000) Factors involved in the absence of sedative effects by the second-generation antihistamines. Allergy 55(Suppl 60):5\u201310. https:\/\/doi.org\/10.1034\/j.1398-9995.2000.055supp60005.x","journal-title":"Allergy"},{"issue":"12","key":"265_CR80","doi-asserted-by":"publisher","first-page":"e041577","DOI":"10.1136\/bmjopen-2020-041577","volume":"10","author":"A Vila-C\u00f3rcoles","year":"2020","unstructured":"Vila-C\u00f3rcoles A, Ochoa-Gondar O, Satu\u00e9-Gracia EM, Torrente-Fraga C, Gomez-Bertomeu F, Vila-Rovira A, Hospital-Guardiola I, de Diego-Cabanes C, Bejarano-Romero F, Basora-Gallis\u00e0 J (2020) Influence of prior comorbidities and chronic medications use on the risk of COVID-19 in adults: a population-based cohort study in Tarragona, Spain. BMJ Open 10(12):e041577. https:\/\/doi.org\/10.1136\/bmjopen-2020-041577","journal-title":"BMJ Open"},{"issue":"1","key":"265_CR81","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s10194-019-0984-1","volume":"20","author":"J Worm","year":"2019","unstructured":"Worm J, Falkenberg K, Olesen J (2019) Histamine and migraine revisited: mechanisms and possible drug targets. J Headache Pain 20(1):30. https:\/\/doi.org\/10.1186\/s10194-019-0984-1","journal-title":"J Headache Pain"},{"issue":"4","key":"265_CR82","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1053\/j.gastro.2015.12.034","volume":"150","author":"MM Wouters","year":"2016","unstructured":"Wouters MM, Balemans D, Van Wanrooy S, Dooley J, Cibert-Goton V, Alpizar YA, Valdez-Morales EE, Nasser Y, Van Veldhoven PP, Vanbrabant W, Van der Merwe S, Mols R, Ghesqui\u00e8re B, Cirillo C, Kortekaas I, Carmeliet P, Peetermans WE, Vermeire S, Rutgeerts P, Augustijns P, Hellings PW, Belmans A, Vanner S, Bulmer DC, Talavera K, Vanden Berghe P, Liston A, Boeckxstaens GE (2016) Histamine receptor H1-mediated sensitization of TRPV1 mediates visceral hypersensitivity and symptoms in patients with irritable bowel syndrome. Gastroenterology 150(4):875\u201387.e9. https:\/\/doi.org\/10.1053\/j.gastro.2015.12.034","journal-title":"Gastroenterology"},{"issue":"1","key":"265_CR83","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1038\/s41467-021-22427-2","volume":"12","author":"R Xia","year":"2021","unstructured":"Xia R, Wang N, Xu Z, Lu Y, Song J, Zhang A, Guo C, He Y (2021) Cryo-EM structure of the human histamine H1 receptor\/Gq complex. Nat Commun 12(1):2086. https:\/\/doi.org\/10.1038\/s41467-021-22427-2","journal-title":"Nat Commun"},{"issue":"2","key":"265_CR84","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1471-4159.1990.tb04152.x","volume":"55","author":"K Yanai","year":"1990","unstructured":"Yanai K, Yagi N, Watanabe T, Itoh M, Ishiwata K, Ido T, Matsuzawa T (1990) Specific binding of [3H]pyrilamine to histamine H1 receptors in guinea pig brain in vivo: determination of binding parameters by a kinetic four-compartment model. J Neurochem 55(2):409\u2013420. https:\/\/doi.org\/10.1111\/j.1471-4159.1990.tb04152.x","journal-title":"J Neurochem"},{"issue":"1","key":"265_CR85","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1111\/j.1476-5381.1995.tb16386.x","volume":"116","author":"K Yanai","year":"1995","unstructured":"Yanai K, Ryu JH, Watanabe T, Iwata R, Ido T, Sawai Y, Ito K, Itoh M (1995) Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography. Br J Pharmacol 116(1):1649\u20131655. https:\/\/doi.org\/10.1111\/j.1476-5381.1995.tb16386.x","journal-title":"Br J Pharmacol"},{"issue":"5","key":"265_CR86","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1254\/fpj.122.391","volume":"122","author":"K Yanai","year":"2003","unstructured":"Yanai K, Mobarakeh JI, Kuramasu A, Sakurada S (2003) Roles of histamine receptors in pain perception: a study using receptors gene knockout mice. Nihon Yakurigaku Zasshi 122(5):391\u2013399. https:\/\/doi.org\/10.1254\/fpj.122.391","journal-title":"Nihon Yakurigaku Zasshi"},{"issue":"4","key":"265_CR87","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1517\/14740338.2011.562889","volume":"10","author":"K Yanai","year":"2011","unstructured":"Yanai K, Zhang D, Tashiro M, Yoshikawa T, Naganuma F, Harada R, Nakamura T, Shibuya K, Okamura N (2011) Positron emission tomography evaluation of sedative properties of antihistamines. Expert Opin Drug Saf 10(4):613\u2013622. https:\/\/doi.org\/10.1517\/14740338.2011.562889","journal-title":"Expert Opin Drug Saf"},{"key":"265_CR88","isbn-type":"print","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/978-3-319-40308-3_13","volume-title":"Histamine receptors: preclinical and clinical aspects","author":"K Yanai","year":"2016","unstructured":"Yanai K, Hiraoka K, K\u00e1rp\u00e1ti A, Naganuma F, Okamura N, Tashiro M, Nakamura T, Yoshikawa T (2016) Histamine H1 receptor occupancy in human brain. In: Blandina P, Passani BM (eds) Histamine receptors: preclinical and clinical aspects. Springer, Cham, pp 311\u2013325. isbn:978-3-319-40306-9","ISBN":"https:\/\/id.crossref.org\/isbn\/9783319403069"},{"key":"265_CR89","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.pharmthera.2017.04.004","volume":"178","author":"K Yanai","year":"2017","unstructured":"Yanai K, Yoshikawa T, Yanai A, Nakamura T, Iida T, Leurs R, Tashiro M (2017) The clinical pharmacology of non-sedating antihistamines. Pharmacol Ther 178:148\u2013156. https:\/\/doi.org\/10.1016\/j.pharmthera.2017.04.004","journal-title":"Pharmacol Ther"},{"issue":"4","key":"265_CR90","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/bph.15220","volume":"178","author":"T Yoshikawa","year":"2021","unstructured":"Yoshikawa T, Nakamura T, Yanai K (2021) Histaminergic neurons in the tuberomammillary nucleus as a control centre for wakefulness. Br J Pharmacol 178(4):750\u2013769. https:\/\/doi.org\/10.1111\/bph.15220","journal-title":"Br J Pharmacol"},{"issue":"6","key":"265_CR91","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/jcp.0b013e3181fa8526","volume":"30","author":"D Zhang","year":"2010","unstructured":"Zhang D, Tashiro M, Shibuya K, Okamura N, Funaki Y, Yoshikawa T, Kato M, Yanai K (2010) Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography. J Clin Psychopharmacol 30(6):694\u2013701. https:\/\/doi.org\/10.1097\/jcp.0b013e3181fa8526","journal-title":"J Clin Psychopharmacol"},{"issue":"10","key":"265_CR92","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1111\/j.1398-9995.2009.02178.x","volume":"64","author":"T Zuberbier","year":"2009","unstructured":"Zuberbier T, Asero R, Bindslev-Jensen C et al (2009) EAACI\/GA(2)LEN\/EDF\/WAO guideline: management of urticaria. Allergy 64(10):1427\u20131443. https:\/\/doi.org\/10.1111\/j.1398-9995.2009.02178.x","journal-title":"Allergy"}],"container-title":["Current Topics in Behavioral Neurosciences","The Functional Roles of Histamine Receptors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/7854_2021_265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T16:18:46Z","timestamp":1664381926000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/7854_2021_265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783031169960","9783031169977"],"references-count":91,"URL":"https:\/\/doi.org\/10.1007\/7854_2021_265","relation":{},"ISSN":["1866-3370","1866-3389"],"issn-type":[{"value":"1866-3370","type":"print"},{"value":"1866-3389","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"8 October 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}