{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:48:07Z","timestamp":1785883687055,"version":"3.56.0"},"publisher-location":"Cham","reference-count":44,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031169960","type":"print"},{"value":"9783031169977","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/7854_2022_359","type":"book-chapter","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T20:02:52Z","timestamp":1655409772000},"page":"427-446","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Brain Mast Cells in Sleep and Behavioral Regulation"],"prefix":"10.1007","author":[{"given":"Seiji","family":"Nishino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"359_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3109\/03009734.2014.967422","volume":"120","author":"E Anvari","year":"2015","unstructured":"Anvari E, Wang X, Sandler S, Welsh N (2015) The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57bl\/6 mice, but not diabetes outcome in female non-obese diabetic (Nod) mice. Ups J Med Sci 120:40\u201346","journal-title":"Ups J Med Sci"},{"key":"359_CR2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1600-065X.2007.00512.x","volume":"217","author":"JA Boyce","year":"2007","unstructured":"Boyce JA (2007) Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation. Immunol Rev 217:168\u2013185","journal-title":"Immunol Rev"},{"key":"359_CR1001","doi-asserted-by":"crossref","unstructured":"Broun RE, Stevens DR, Haas, HL (2001) The physiology of brain histamine. Prog Neurobiol 63:637\u201372","DOI":"10.1016\/S0301-0082(00)00039-3"},{"key":"359_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/335088a0","volume":"335","author":"B Chabot","year":"1988","unstructured":"Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A (1988) The proto-oncogene C-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W-locus. Nature 335:88\u201389","journal-title":"Nature"},{"key":"359_CR4","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0166-4328(97)83335-9","volume":"84","author":"E Challet","year":"1997","unstructured":"Challet E, Pevet P, Malan A (1997) Effect of prolonged fasting and subsequent refeeding on free-running rhythms of temperature and locomotor activity in rats. Behav Brain Res 84:275\u2013284","journal-title":"Behav Brain Res"},{"key":"359_CR5","doi-asserted-by":"publisher","first-page":"E78434","DOI":"10.1371\/journal.pone.0078434","volume":"8","author":"S Chikahisa","year":"2013","unstructured":"Chikahisa S, Kodama T, Soya A, Sagawa Y, Ishimaru Y, Sei H, Nishino S (2013) Histamine from brain resident mast cells promotes wakefulness and modulates behavioral states. PLoS One 8:E78434","journal-title":"PLoS One"},{"key":"359_CR6","doi-asserted-by":"publisher","first-page":"13640","DOI":"10.1038\/s41598-017-14162-w","volume":"7","author":"S Chikahisa","year":"2017","unstructured":"Chikahisa S, Harada S, Shimizu N, Shiuchi T, Otsuka A, Nishino S, Sei H (2017) Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance. Sci Rep 7:13640","journal-title":"Sci Rep"},{"key":"359_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF00428315","volume":"66","author":"AO Donoso","year":"1979","unstructured":"Donoso AO, Broitman ST (1979) Effects of a histamine synthesis inhibitor and antihistamines on the sexual behavior of female rats. Psychopharmacology 66:251\u2013255","journal-title":"Psychopharmacology"},{"key":"359_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1159\/000236338","volume":"99","author":"AM Dvorak","year":"1992","unstructured":"Dvorak AM, Mcleod RS, Onderdonk A, Monahan-Earley RA, Cullen JB, Antonioli DA, Morgan E, Blair JE, Estrella P, Cisneros RL et al (1992) Ultrastructural evidence for piecemeal and anaphylactic degranulation of human gut mucosal mast cells in vivo. Int Arch Allergy Immunol 99:74\u201383","journal-title":"Int Arch Allergy Immunol"},{"key":"359_CR9","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.jdiacomp.2015.01.013","volume":"29","author":"SM El-Haggar","year":"2015","unstructured":"El-Haggar SM, Farrag WF, Kotkata FA (2015) Effect of Ketotifen in obese patients with type 2 diabetes mellitus. J Diabetes Complicat 29:427\u2013432","journal-title":"J Diabetes Complicat"},{"key":"359_CR10","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/1096-9861(20000904)424:4<651::AID-CNE7>3.0.CO;2-G","volume":"424","author":"F Florenzano","year":"2000","unstructured":"Florenzano F, Bentivoglio M (2000) Degranulation, density, and distribution of mast cells in the rat thalamus: a light and electron microscopic study in basal conditions and after Intracerebroventricular administration of nerve growth factor. J Comp Neurol 424:651\u2013669","journal-title":"J Comp Neurol"},{"key":"359_CR11","volume-title":"The mouse brain in stereotaxic coodination","author":"KJ Franklin","year":"1997","unstructured":"Franklin KJ, Paxinos G (1997) The mouse brain in stereotaxic coodination. Academic Press, San Diego"},{"key":"359_CR12","first-page":"965","volume":"142","author":"SJ Galli","year":"1993","unstructured":"Galli SJ, Tsai M, Wershil BK (1993) The C-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others. Am J Pathol 142:965\u2013974","journal-title":"Am J Pathol"},{"key":"359_CR13","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/ni.2109","volume":"12","author":"SJ Galli","year":"2011","unstructured":"Galli SJ, Borregaard N, Wynn TA (2011) Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol 12:1035\u20131044","journal-title":"Nat Immunol"},{"key":"359_CR14","volume-title":"Free medical textbook","author":"SJ Galli","year":"2012","unstructured":"Galli SJ, Metcalfe DD, Dvorak AM (2012) Chapter 69 basophils and mast cells and their disorders [online]. In: Free medical textbook. http:\/\/Medtextfree.Wordpress.Com\/2012\/01\/03\/Chapter-69-Basophils-And-Mast-Cells-And-Their-Disorders\/. Accessed 6 Feb 2022"},{"key":"359_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0092-8674(88)90020-7","volume":"55","author":"EN Geissler","year":"1988","unstructured":"Geissler EN, Ryan MA, Housman DE (1988) The dominant-white spotting (W) locus of the mouse encodes the C-kit proto-oncogene. Cell 55:185\u2013192","journal-title":"Cell"},{"key":"359_CR16","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0002-9440(10)62055-X","volume":"167","author":"MA Grimbaldeston","year":"2005","unstructured":"Grimbaldeston MA, Chen CC, Piliponsky AM, Tsai M, Tam SY, Galli SJ (2005) Mast cell-deficient W-sash C-kit mutant kit W-Sh\/W-Sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 167:835\u2013848","journal-title":"Am J Pathol"},{"key":"359_CR1002","doi-asserted-by":"crossref","unstructured":"Haas H, Panula P (2003) The role of histamine and the tuberomamillary nucleus in the nervous system. Nat Rev Neurosci 4:121\u201330","DOI":"10.1038\/nrn1034"},{"key":"359_CR17","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1177\/107385840200800105","volume":"8","author":"O Hayaishi","year":"2002","unstructured":"Hayaishi O, Urade Y (2002) Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. Neuroscientist 8:12\u201315","journal-title":"Neuroscientist"},{"key":"359_CR18","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neulet.2005.09.029","volume":"392","author":"S Hendrix","year":"2006","unstructured":"Hendrix S, Warnke K, Siebenhaar F, Peters EM, Nitsch R, Maurer M (2006) The majority of brain mast cells in B10.Pl mice is present in the hippocampal formation. Neurosci Lett 392:174\u2013177","journal-title":"Neurosci Lett"},{"key":"359_CR19","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1126\/science.290.5499.2155","volume":"290","author":"GS Huh","year":"2000","unstructured":"Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ (2000) Functional requirement for class I Mhc in Cns development and plasticity. Science 290:2155\u20132159","journal-title":"Science"},{"key":"359_CR20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0091-3057(02)00708-6","volume":"72","author":"Y Ikarashi","year":"2002","unstructured":"Ikarashi Y, Yuzurihara M (2002) Experimental anxiety induced by histaminergics in mast cell-deficient and congenitally normal mice. Pharmacol Biochem Behav 72:437\u2013441","journal-title":"Pharmacol Biochem Behav"},{"key":"359_CR21","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/BF00993271","volume":"17","author":"D Johnson","year":"1992","unstructured":"Johnson D, Krenger W (1992) Interactions of mast cells with the nervous system--recent advances. Neurochem Res 17:939\u2013951","journal-title":"Neurochem Res"},{"key":"359_CR22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.brainres.2007.07.034","volume":"1171","author":"M Khalil","year":"2007","unstructured":"Khalil M, Ronda J, Weintraub M, Jain K, Silver R, Silverman AJ (2007) Brain mast cell relationship to neurovasculature during development. Brain Res 1171:18\u201329","journal-title":"Brain Res"},{"key":"359_CR23","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1749-6632.2001.tb05826.x","volume":"933","author":"JM Krueger","year":"2001","unstructured":"Krueger JM, Obal FJ, Fang J, Kubota T, Taishi P (2001) The role of cytokines in physiological sleep regulation. Ann N Y Acad Sci 933:211\u2013221","journal-title":"Ann N Y Acad Sci"},{"key":"359_CR24","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/nm.1994","volume":"15","author":"J Liu","year":"2009","unstructured":"Liu J, Divoux A, Sun J, Zhang J, Clement K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP (2009) Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 15:940\u2013945","journal-title":"Nat Med"},{"key":"359_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0889-1591(03)00032-1","volume":"17","author":"SF Maier","year":"2003","unstructured":"Maier SF (2003) Bi-directional immune-brain communication: implications for understanding stress, pain, and cognition. Brain Behav Immun 17:69\u201385","journal-title":"Brain Behav Immun"},{"key":"359_CR26","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nri1460","volume":"4","author":"JS Marshall","year":"2004","unstructured":"Marshall JS (2004) Mast-cell responses to pathogens. Nat Rev Immunol 4:787\u2013799","journal-title":"Nat Rev Immunol"},{"key":"359_CR27","doi-asserted-by":"publisher","first-page":"18053","DOI":"10.1073\/pnas.0809479105","volume":"105","author":"KM Nautiyal","year":"2008","unstructured":"Nautiyal KM, Ribeiro AC, Pfaff DW, Silver R (2008) Brain mast cells link the immune system to anxiety-like behavior. Proc Natl Acad Sci U S A 105:18053\u201318057","journal-title":"Proc Natl Acad Sci U S A"},{"key":"359_CR28","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1126\/science.1110647","volume":"308","author":"A Nimmerjahn","year":"2005","unstructured":"Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314\u20131318","journal-title":"Science"},{"key":"359_CR29","doi-asserted-by":"publisher","first-page":"17843","DOI":"10.1073\/pnas.0408154101","volume":"101","author":"AL Oliveira","year":"2004","unstructured":"Oliveira AL, Thams S, Lidman O, Piehl F, Hokfelt T, Karre K, Linda H, Cullheim S (2004) A role for Mhc class I molecules in synaptic plasticity and regeneration of neurons after axotomy. Proc Natl Acad Sci U S A 101:17843\u201317848","journal-title":"Proc Natl Acad Sci U S A"},{"key":"359_CR30","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.it.2005.10.002","volume":"27","author":"R Paus","year":"2006","unstructured":"Paus R, Theoharides TC, Arck PC (2006) Neuroimmunoendocrine circuitry of the 'Brain-Skin Connection'. Trends Immunol 27:32\u201339","journal-title":"Trends Immunol"},{"key":"359_CR31","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/j.1460-2075.1988.tb02907.x","volume":"7","author":"FH Qiu","year":"1988","unstructured":"Qiu FH, Ray P, Brown K, Barker PE, Jhanwar S, Ruddle FH, Besmer P (1988) Primary structure of C-kit: relationship with the Csf-1\/Pdgf receptor kinase family \u2013 oncogenic activation of V-Kit involves deletion of extracellular domain and C terminus. EMBO J 7:1003\u20131011","journal-title":"EMBO J"},{"key":"359_CR32","volume-title":"The 44th annual meeting of Japanese Society of Sleep Reseach, Bp1-001","author":"N Sakai","year":"2019","unstructured":"Sakai N, Yagi S, Yoshikawa T, Ono T, Nishimon S, Kubo A, Yanai K, Nishino S (2019) Mast cells induce wakefulness theriough rereasing brain hsitamine. In: The 44th annual meeting of Japanese Society of Sleep Reseach, Bp1-001. https:\/\/Sleepmeeting.Org\/Wp-Content\/Uploads\/2019\/04\/Sleep_42_S1-Website-Final.Pdf. Accessed 6 Feb 2022"},{"key":"359_CR33","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.4049\/jimmunol.1101746","volume":"188","author":"M Sawaguchi","year":"2012","unstructured":"Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, Ishiwata K, Oboki K, Kambayashi T, Watanabe N, Karasuyama H, Nakae S, Inoue H, Kubo M (2012) Role of mast cells and basophils in Ige responses and in allergic airway hyperresponsiveness. J Immunol 188:1809\u20131818","journal-title":"J Immunol"},{"key":"359_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0166-2236(96)81863-7","volume":"19","author":"R Silver","year":"1996","unstructured":"Silver R, Silverman AJ, Vitkovic L, Lederhendler I (1996) Mast cells in the brain: evidence and functional significance. Trends Neurosci 19:25\u201331","journal-title":"Trends Neurosci"},{"key":"359_CR35","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nrendo.2009.23","volume":"5","author":"K Spiegel","year":"2009","unstructured":"Spiegel K, Tasali E, Leproult R, Van Cauter E (2009) Effects of poor and short sleep on glucose metabolism and obesity risk. Nat Rev Endocrinol 5:253\u2013261","journal-title":"Nat Rev Endocrinol"},{"key":"359_CR36","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/ni1078","volume":"5","author":"L Steinman","year":"2004","unstructured":"Steinman L (2004) Elaborate interactions between the immune and nervous systems. Nat Immunol 5:575\u2013581","journal-title":"Nat Immunol"},{"key":"359_CR37","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.brainres.2005.07.022","volume":"1056","author":"OB Taiwo","year":"2005","unstructured":"Taiwo OB, Kovacs KJ, Larson AA (2005) Chronic daily intrathecal injections of a large volume of fluid increase mast cells in the thalamus of mice. Brain Res 1056:76\u201384","journal-title":"Brain Res"},{"key":"359_CR38","doi-asserted-by":"publisher","first-page":"113143","DOI":"10.1016\/j.bbr.2021.113143","volume":"403","author":"D Tanioka","year":"2021","unstructured":"Tanioka D, Chikahisa S, Shimizu N, Shiuchi T, Sakai N, Nishino S, Sei H (2021) Intracranial mast cells contribute to the control of social behavior in male mice. Behav Brain Res 403:113143","journal-title":"Behav Brain Res"},{"key":"359_CR39","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.smrv.2010.06.004","volume":"15","author":"MM Thakkar","year":"2011","unstructured":"Thakkar MM (2011) Histamine in the regulation of wakefulness. Sleep Med Rev 15:65\u201374","journal-title":"Sleep Med Rev"},{"key":"359_CR40","volume-title":"Endogenous sleep substances and sleep regulation","author":"R Ueno","year":"1985","unstructured":"Ueno R, Hayaishi O, Osama H, Honda K, Inou\u00e9 S, Ishikawa Y, Nakayama T (1985) Prostaglandin D2 regulates physiological sleep. In: Inou\u00e9 S, Borbely A (eds) Endogenous sleep substances and sleep regulation. Japan Scientific Societies Press, Tokyo"},{"key":"359_CR41","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1002\/j.1460-2075.1987.tb02655.x","volume":"6","author":"Y Yarden","year":"1987","unstructured":"Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A (1987) Human proto-oncogene C-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6:3341\u20133351","journal-title":"EMBO J"},{"key":"359_CR42","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/nn1629","volume":"9","author":"Y Ziv","year":"2006","unstructured":"Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, Cohen H, Kipnis J, Schwartz M (2006) Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci 9:268\u2013275","journal-title":"Nat Neurosci"}],"container-title":["Current Topics in Behavioral Neurosciences","The Functional Roles of Histamine Receptors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/7854_2022_359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T20:20:08Z","timestamp":1664396408000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/7854_2022_359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031169960","9783031169977"],"references-count":44,"URL":"https:\/\/doi.org\/10.1007\/7854_2022_359","relation":{},"ISSN":["1866-3370","1866-3389"],"issn-type":[{"value":"1866-3370","type":"print"},{"value":"1866-3389","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"17 June 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}