{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:34:44Z","timestamp":1789176884865,"version":"build-2803163510"},"publisher-location":"Cham","reference-count":123,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031264405","type":"print"},{"value":"9783031264412","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/7854_2022_396","type":"book-chapter","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T05:02:51Z","timestamp":1667278971000},"page":"437-461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Relationship Between Cannabis, Cognition, and Schizophrenia: It\u2019s Complicated"],"prefix":"10.1007","author":[{"given":"Hakan","family":"Kayir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ruffolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"McCunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibran Y.","family":"Khokhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"issue":"6","key":"396_CR1","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1007\/s00213-019-5171-1","volume":"236","author":"AR Abela","year":"2019","unstructured":"Abela AR et al (2019) Adolescent exposure to \u03949-tetrahydrocannabinol delays acquisition of paired-associates learning in adulthood. Psychopharmacology (Berl) 236(6):1875\u20131886. https:\/\/doi.org\/10.1007\/s00213-019-5171-1","journal-title":"Psychopharmacology (Berl)"},{"key":"396_CR2","doi-asserted-by":"publisher","unstructured":"Accordino M, Hart CL (2006) Neuropsychological deficits in long-term frequent cannabis users. Neurology:1902. https:\/\/doi.org\/10.1212\/01.wnl.0000249081.67635.ef","DOI":"10.1212\/01.wnl.0000249081.67635.ef"},{"key":"396_CR3","doi-asserted-by":"publisher","unstructured":"American Psychiatric Association (2013) DSM 5. Am J Psychiatry. https:\/\/doi.org\/10.1176\/appi.books.9780890425596.744053","DOI":"10.1176\/appi.books.9780890425596.744053"},{"issue":"5044","key":"396_CR4","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1126\/science.1736359","volume":"255","author":"A Baddeley","year":"1992","unstructured":"Baddeley A (1992) Working memory. Science 255(5044):556\u2013559. https:\/\/doi.org\/10.1126\/science.1736359","journal-title":"Science"},{"key":"396_CR5","doi-asserted-by":"publisher","unstructured":"Batalla A et al (2019) The potential of cannabidiol as a treatment for psychosis and addiction: who benefits most? A systematic review. Clin Med 8(7). https:\/\/doi.org\/10.3390\/JCM8071058","DOI":"10.3390\/JCM8071058"},{"issue":"4","key":"396_CR6","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1080\/13803395.2014.893996","volume":"36","author":"MP Becker","year":"2014","unstructured":"Becker MP, Collins PF, Luciana M (2014) Neurocognition in college-aged daily marijuana users. J Clin Exp Neuropsychol 36(4):379\u2013398. https:\/\/doi.org\/10.1080\/13803395.2014.893996","journal-title":"J Clin Exp Neuropsychol"},{"issue":"6","key":"396_CR7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1080\/13803395.2017.1385729","volume":"40","author":"MP Becker","year":"2018","unstructured":"Becker MP et al (2018) Longitudinal changes in cognition in young adult cannabis users. J Clin Exp Neuropsychol 40(6):529\u2013543. https:\/\/doi.org\/10.1080\/13803395.2017.1385729","journal-title":"J Clin Exp Neuropsychol"},{"issue":"5","key":"396_CR8","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/J.1369-1600.2011.00427.X","volume":"18","author":"G Bedi","year":"2013","unstructured":"Bedi G, Cooper ZD, Haney M (2013) Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers. Addict Biol 18(5):872\u2013881. https:\/\/doi.org\/10.1111\/J.1369-1600.2011.00427.X","journal-title":"Addict Biol"},{"key":"396_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2147\/SAR.S25869","volume":"4","author":"S Bhattacharyya","year":"2013","unstructured":"Bhattacharyya S, Schoeler T (2013) The effect of cannabis use on memory function: an update. Subst Abuse Rehabil 4:11. https:\/\/doi.org\/10.2147\/SAR.S25869","journal-title":"Subst Abuse Rehabil"},{"key":"396_CR10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/J.SCHRES.2017.06.042","volume":"193","author":"AW Bismark","year":"2018","unstructured":"Bismark AW et al (2018) Relationship between effortful motivation and neurocognition in schizophrenia. Schizophr Res 193:69\u201376. https:\/\/doi.org\/10.1016\/J.SCHRES.2017.06.042","journal-title":"Schizophr Res"},{"issue":"7629","key":"396_CR11","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature20153","volume":"539","author":"MAP Bloomfield","year":"2016","unstructured":"Bloomfield MAP et al (2016) The effects of \u03b49-tetrahydrocannabinol on the dopamine system. Nature 539(7629):369\u2013377. https:\/\/doi.org\/10.1038\/nature20153","journal-title":"Nature"},{"key":"396_CR12","doi-asserted-by":"publisher","unstructured":"Bosker WM et al (2013) Psychomotor function in chronic daily cannabis smokers during sustained abstinence. PLoS One 8(1). https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0053127","DOI":"10.1371\/JOURNAL.PONE.0053127"},{"key":"396_CR13","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/1471-244X-12-221","volume":"12","author":"JG Bramness","year":"2012","unstructured":"Bramness JG et al (2012) Amphetamine-induced psychosis \u2013 a separate diagnostic entity or primary psychosis triggered in the vulnerable? BMC Psychiatry 12:221. https:\/\/doi.org\/10.1186\/1471-244X-12-221","journal-title":"BMC Psychiatry"},{"issue":"1","key":"396_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/J.1476-5381.2010.00870.X","volume":"161","author":"JJ Burston","year":"2010","unstructured":"Burston JJ et al (2010) Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated \u03949-tetrahydrocannabinol exposure. Br J Pharmacol 161(1):103. https:\/\/doi.org\/10.1111\/J.1476-5381.2010.00870.X","journal-title":"Br J Pharmacol"},{"issue":"5\u20136","key":"396_CR15","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/FBP.0b013e3282ee7b7e","volume":"18","author":"YM Cha","year":"2007","unstructured":"Cha YM et al (2007) Sex differences in the effects of \u03949-tetrahydrocannabinol on spatial learning in adolescent and adult rats. Behav Pharmacol 18(5\u20136):563\u2013569. https:\/\/doi.org\/10.1097\/FBP.0b013e3282ee7b7e","journal-title":"Behav Pharmacol"},{"key":"396_CR16","doi-asserted-by":"publisher","unstructured":"Chambers RA, Krystal JH, Self DW (2001) A neurobiological basis for substance abuse comorbidity in schizophrenia. Biol Psychiatry:71\u201383. https:\/\/doi.org\/10.1016\/S0006-3223(01)01134-9","DOI":"10.1016\/S0006-3223(01)01134-9"},{"issue":"8","key":"396_CR17","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1038\/SJ.NPP.1300496","volume":"29","author":"DC D\u2019Souza","year":"2004","unstructured":"D\u2019Souza DC et al (2004) The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology 29(8):1558\u20131572. https:\/\/doi.org\/10.1038\/SJ.NPP.1300496","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"396_CR18","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.biopsych.2004.12.006","volume":"57","author":"DC D\u2019Souza","year":"2005","unstructured":"D\u2019Souza DC et al (2005) Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biol Psychiatry 57(6):594\u2013608. https:\/\/doi.org\/10.1016\/j.biopsych.2004.12.006","journal-title":"Biol Psychiatry"},{"issue":"4","key":"396_CR19","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/S00213-007-1042-2","volume":"198","author":"DC D\u2019Souza","year":"2008","unstructured":"D\u2019Souza DC et al (2008) Effects of haloperidol on the behavioral, subjective, cognitive, motor, and neuroendocrine effects of Delta-9-tetrahydrocannabinol in humans. Psychopharmacology (Berl) 198(4):587\u2013603. https:\/\/doi.org\/10.1007\/S00213-007-1042-2","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"396_CR20","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S2215-0366(19)30048-3","volume":"6","author":"M Di Forti","year":"2019","unstructured":"Di Forti M et al (2019) The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. Lancet Psychiatry 6(5):427\u2013436. https:\/\/doi.org\/10.1016\/S2215-0366(19)30048-3","journal-title":"Lancet Psychiatry"},{"issue":"1607","key":"396_CR21","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1098\/rstb.2011.0382","volume":"367","author":"V Di Marzo","year":"2012","unstructured":"Di Marzo V, De Petrocellis L (2012) Why do cannabinoid receptors have more than one endogenous ligand? Philos Trans R Soc B Biol Sci 367(1607):3216\u20133228. https:\/\/doi.org\/10.1098\/rstb.2011.0382","journal-title":"Philos Trans R Soc B Biol Sci"},{"issue":"2","key":"396_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00213-012-2908-5","volume":"226","author":"DM Dougherty","year":"2013","unstructured":"Dougherty DM et al (2013) Impulsivity, attention, memory, and decision-making among adolescent marijuana users. Psychopharmacology (Berl) 226(2):307\u2013319. https:\/\/doi.org\/10.1007\/s00213-012-2908-5","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"396_CR23","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/J.NEUBIOREV.2004.09.002","volume":"28","author":"PA Dudchenko","year":"2004","unstructured":"Dudchenko PA (2004) An overview of the tasks used to test working memory in rodents. Neurosci Biobehav Rev 28(7):699\u2013709. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2004.09.002","journal-title":"Neurosci Biobehav Rev"},{"issue":"9 Pt B","key":"396_CR24","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1016\/J.NEUBIOREV.2012.03.003","volume":"37","author":"PA Dudchenko","year":"2013","unstructured":"Dudchenko PA et al (2013) Animal models of working memory: a review of tasks that might be used in screening drug treatments for the memory impairments found in schizophrenia. Neurosci Biobehav Rev 37(9 Pt B):2111\u20132124. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2012.03.003","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"396_CR25","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/S002130050892","volume":"142","author":"H Ehrenreich","year":"1999","unstructured":"Ehrenreich H et al (1999) Specific attentional dysfunction in adults following early start of cannabis use. Psychopharmacology (Berl) 142(3):295\u2013301. https:\/\/doi.org\/10.1007\/S002130050892","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"396_CR26","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.biopsych.2016.01.004","volume":"79","author":"MA ElSohly","year":"2016","unstructured":"ElSohly MA et al (2016) Changes in cannabis potency over the last 2 decades (1995\u20132014): analysis of current data in the United States. Biol Psychiatry 79(7):613\u2013619. https:\/\/doi.org\/10.1016\/j.biopsych.2016.01.004","journal-title":"Biol Psychiatry"},{"issue":"6","key":"396_CR27","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.bpsc.2020.12.016","volume":"6","author":"MA ElSohly","year":"2021","unstructured":"ElSohly MA et al (2021) A comprehensive review of cannabis potency in the United States in the last decade. Biol Psychiatry Cogn Neurosci Neuroimaging 6(6):603\u2013606. https:\/\/doi.org\/10.1016\/j.bpsc.2020.12.016","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"issue":"3","key":"396_CR28","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/schbul\/sbz077","volume":"46","author":"L Ferraro","year":"2020","unstructured":"Ferraro L et al (2020) Premorbid adjustment and IQ in patients with first-episode psychosis: a multisite case-control study of their relationship with cannabis use. Schizophr Bull 46(3):517\u2013529. https:\/\/doi.org\/10.1093\/schbul\/sbz077","journal-title":"Schizophr Bull"},{"issue":"7","key":"396_CR29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1177\/0269881107084000","volume":"22","author":"J Fisk","year":"2008","unstructured":"Fisk J, Montgomery C (2008) Real-world memory and executive processes in cannabis users and non-users. J Psychopharmacol 22(7):727\u2013736. https:\/\/doi.org\/10.1177\/0269881107084000","journal-title":"J Psychopharmacol"},{"issue":"5","key":"396_CR30","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1111\/add.15253","volume":"116","author":"TP Freeman","year":"2021","unstructured":"Freeman TP et al (2021) Changes in delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) concentrations in cannabis over time: systematic review and meta-analysis. Addiction 116(5):1000\u20131010. https:\/\/doi.org\/10.1111\/add.15253","journal-title":"Addiction"},{"issue":"2","key":"396_CR31","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/J.NTT.2004.11.003","volume":"27","author":"PA Fried","year":"2005","unstructured":"Fried PA, Watkinson B, Gray R (2005) Neurocognitive consequences of marihuana \u2013 a comparison with pre-drug performance. Neurotoxicol Teratol 27(2):231\u2013239. https:\/\/doi.org\/10.1016\/J.NTT.2004.11.003","journal-title":"Neurotoxicol Teratol"},{"key":"396_CR32","doi-asserted-by":"publisher","unstructured":"Gold JM et al (2008) Reward processing in schizophrenia: a deficit in the representation of value. Schizophr Bull:835\u2013847. https:\/\/doi.org\/10.1093\/schbul\/sbn068","DOI":"10.1093\/schbul\/sbn068"},{"issue":"3","key":"396_CR33","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1093\/schbul\/23.3.437","volume":"23","author":"PS Goldman-Rakic","year":"1997","unstructured":"Goldman-Rakic PS, Selemon LD (1997) Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr Bull 23(3):437\u2013458. https:\/\/doi.org\/10.1093\/schbul\/23.3.437","journal-title":"Schizophr Bull"},{"issue":"1","key":"396_CR34","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1002\/mpr.1813","volume":"29","author":"M Gon\u00e7alves-Pinho","year":"2020","unstructured":"Gon\u00e7alves-Pinho M, Bragan\u00e7a M, Freitas A (2020) Psychotic disorders hospitalizations associated with cannabis abuse or dependence: a nationwide big data analysis. Int J Methods Psychiatr Res 29(1):2020\u20132021. https:\/\/doi.org\/10.1002\/mpr.1813","journal-title":"Int J Methods Psychiatr Res"},{"issue":"1\u20132","key":"396_CR35","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/J.DRUGALCDEP.2011.08.015","volume":"121","author":"JE Grant","year":"2012","unstructured":"Grant JE et al (2012) Neuropsychological deficits associated with cannabis use in young adults. Drug Alcohol Depend 121(1\u20132):159\u2013162. https:\/\/doi.org\/10.1016\/J.DRUGALCDEP.2011.08.015","journal-title":"Drug Alcohol Depend"},{"issue":"4","key":"396_CR36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.eurpsy.2004.09.013","volume":"20","author":"A Grech","year":"2005","unstructured":"Grech A et al (2005) Cannabis use and outcome of recent onset psychosis. Eur Psychiatry 20(4):349\u2013353. https:\/\/doi.org\/10.1016\/j.eurpsy.2004.09.013","journal-title":"Eur Psychiatry"},{"issue":"3","key":"396_CR37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1176\/ajp.2007.164.3.402","volume":"164","author":"AI Green","year":"2007","unstructured":"Green AI et al (2007) Schizophrenia and co-occurring substance use disorder. Am J Psychiatry 164(3):402\u2013408. https:\/\/doi.org\/10.1176\/ajp.2007.164.3.402","journal-title":"Am J Psychiatry"},{"issue":"3","key":"396_CR38","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1037\/a0026269","volume":"26","author":"SA Gruber","year":"2012","unstructured":"Gruber SA et al (2012) Age of onset of marijuana use and executive function. Psychol Addict Behav 26(3):496\u2013506. https:\/\/doi.org\/10.1037\/a0026269","journal-title":"Psychol Addict Behav"},{"key":"396_CR39","doi-asserted-by":"publisher","unstructured":"Hakak-Zargar B et al (2022) The utility of research domain criteria in diagnosis and management of dual disorders: a mini-review. Front Psych 13. https:\/\/doi.org\/10.3389\/FPSYT.2022.805163","DOI":"10.3389\/FPSYT.2022.805163"},{"key":"396_CR40","doi-asserted-by":"publisher","unstructured":"Hamidullah S et al (2020) Adolescent substance use and the brain: behavioral, cognitive and neuroimaging correlates. Front Hum Neurosci 14. https:\/\/doi.org\/10.3389\/fnhum.2020.00298","DOI":"10.3389\/fnhum.2020.00298"},{"issue":"11","key":"396_CR41","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.addbeh.2010.06.012","volume":"35","author":"KL Hanson","year":"2010","unstructured":"Hanson KL et al (2010) Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. Addict Behav 35(11):970\u2013976. https:\/\/doi.org\/10.1016\/j.addbeh.2010.06.012","journal-title":"Addict Behav"},{"key":"396_CR42","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0893-133X(01)00273-1","volume":"25","author":"CL Hart","year":"2001","unstructured":"Hart CL et al (2001) Effects of acute smoked marijuana on complex cognitive performance. Neuropsychopharmacology 25:757\u2013765. https:\/\/www.nature.com\/articles\/1395716. Accessed 12 Nov 2021","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"396_CR43","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1080\/09595230701247772","volume":"26","author":"MA Harvey","year":"2007","unstructured":"Harvey MA et al (2007) The relationship between non-acute adolescent cannabis use and cognition. Drug Alcohol Rev 26(3):309\u2013319. https:\/\/doi.org\/10.1080\/09595230701247772","journal-title":"Drug Alcohol Rev"},{"issue":"1","key":"396_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.100794","volume":"23","author":"A Hasbi","year":"2020","unstructured":"Hasbi A et al (2020) \u0394-tetrahydrocannabinol increases dopamine D1-D2 receptor heteromer and elicits phenotypic reprogramming in adult primate striatal neurons. iScience 23(1):100794. https:\/\/doi.org\/10.1016\/j.isci.2019.100794","journal-title":"iScience"},{"issue":"35","key":"396_CR45","doi-asserted-by":"publisher","first-page":"E7395","DOI":"10.1073\/pnas.1705643114","volume":"114","author":"TU Hauser","year":"2017","unstructured":"Hauser TU, Eldar E, Dolan RJ (2017) Separate mesocortical and mesolimbic pathways encode effort and reward learning signals. Proc Natl Acad Sci U S A 114(35):E7395\u2013E7404. https:\/\/doi.org\/10.1073\/pnas.1705643114","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"396_CR46","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1177\/0269881120965931","volume":"35","author":"CM Hernandez","year":"2021","unstructured":"Hernandez CM et al (2021) Effects of repeated adolescent exposure to cannabis smoke on cognitive outcomes in adulthood. J Psychopharmacol 35(7):848\u2013863. https:\/\/doi.org\/10.1177\/0269881120965931","journal-title":"J Psychopharmacol"},{"issue":"8","key":"396_CR47","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1007\/s00213-014-3463-z","volume":"231","author":"SR Hooper","year":"2014","unstructured":"Hooper SR, Woolley D, De Bellis MD (2014) Intellectual, neurocognitive, and academic achievement in abstinent adolescents with cannabis use disorder. Psychopharmacology (Berl) 231(8):1467\u20131477. https:\/\/doi.org\/10.1007\/s00213-014-3463-z","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"396_CR48","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/S00213-008-1440-0","volume":"204","author":"CC Hunault","year":"2009","unstructured":"Hunault CC et al (2009) Cognitive and psychomotor effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg delta-9-tetrahydrocannabinol (THC). Psychopharmacology (Berl) 204(1):85\u201394. https:\/\/doi.org\/10.1007\/S00213-008-1440-0","journal-title":"Psychopharmacology (Berl)"},{"key":"396_CR49","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.drugalcdep.2018.07.011","volume":"191","author":"GE Hunt","year":"2018","unstructured":"Hunt GE et al (2018) Prevalence of comorbid substance use in schizophrenia spectrum disorders in community and clinical settings, 1990\u20132017: systematic review and meta-analysis. Drug Alcohol Depend 191:234\u2013258. https:\/\/doi.org\/10.1016\/j.drugalcdep.2018.07.011","journal-title":"Drug Alcohol Depend"},{"issue":"16","key":"396_CR50","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1007\/s00213-015-3942-x","volume":"232","author":"C Irimia","year":"2015","unstructured":"Irimia C et al (2015) Persistent effects of chronic \u03949-THC exposure on motor impulsivity in rats. Psychopharmacology (Berl) 232(16):3033\u20133043. https:\/\/doi.org\/10.1007\/s00213-015-3942-x","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"396_CR51","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s00213-005-0298-7","volume":"185","author":"G Jager","year":"2006","unstructured":"Jager G et al (2006) Long-term effects of frequent cannabis use on working memory and attention: an fMRI study. Psychopharmacology (Berl) 185(3):358\u2013368. https:\/\/doi.org\/10.1007\/s00213-005-0298-7","journal-title":"Psychopharmacology (Berl)"},{"key":"396_CR52","doi-asserted-by":"publisher","unstructured":"Jenkins BW, Khokhar JY (2021) Cannabis use and mental illness: understanding circuit dysfunction through preclinical models. Front Psych 12. https:\/\/doi.org\/10.3389\/fpsyt.2021.597725","DOI":"10.3389\/fpsyt.2021.597725"},{"key":"396_CR53","doi-asserted-by":"publisher","unstructured":"Jenkins BW et al (2022) Cannabis vapor exposure alters neural circuit oscillatory activity in a neurodevelopmental model of schizophrenia: exploring the differential impact of cannabis constituents. Schizophr Bull Open 3(1). https:\/\/doi.org\/10.1093\/schizbullopen\/sgab052","DOI":"10.1093\/schizbullopen\/sgab052"},{"issue":"5","key":"396_CR54","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.pnpbp.2007.03.006","volume":"31","author":"MC Jockers-Scher\u00fcbl","year":"2007","unstructured":"Jockers-Scher\u00fcbl MC et al (2007) Cannabis induces different cognitive changes in schizophrenic patients and in healthy controls. Prog Neuropsychopharmacol Biol Psychiatry 31(5):1054\u20131063. https:\/\/doi.org\/10.1016\/j.pnpbp.2007.03.006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3\u20134","key":"396_CR55","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00213-004-1885-8","volume":"176","author":"G Kanayama","year":"2004","unstructured":"Kanayama G et al (2004) Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology (Berl) 176(3\u20134):239\u2013247. https:\/\/doi.org\/10.1007\/s00213-004-1885-8","journal-title":"Psychopharmacology (Berl)"},{"key":"396_CR56","doi-asserted-by":"publisher","unstructured":"Karhson DS, Hardan AY, Parker KJ (2016) Endocannabinoid signaling in social functioning: an RDoC perspective. Transl Psychiatry 6(9). https:\/\/doi.org\/10.1038\/TP.2016.169","DOI":"10.1038\/TP.2016.169"},{"issue":"9","key":"396_CR57","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1176\/appi.ajp.2019.18101217","volume":"176","author":"KS Kendler","year":"2019","unstructured":"Kendler KS et al (2019) Prediction of onset of substance-induced psychotic disorder and its progression to schizophrenia in a Swedish National Sample. Am J Psychiatry 176(9):711\u2013719. https:\/\/doi.org\/10.1176\/appi.ajp.2019.18101217","journal-title":"Am J Psychiatry"},{"issue":"1","key":"396_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-017-0071-9","volume":"8","author":"JP Kesby","year":"2018","unstructured":"Kesby JP et al (2018) Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience. Transl Psychiatry 8(1):1\u201312. https:\/\/doi.org\/10.1038\/s41398-017-0071-9","journal-title":"Transl Psychiatry"},{"key":"396_CR59","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.schres.2017.04.016","volume":"194","author":"JY Khokhar","year":"2018","unstructured":"Khokhar JY et al (2018) The link between schizophrenia and substance use disorder: a unifying hypothesis. Schizophr Res 194:78\u201385. https:\/\/doi.org\/10.1016\/j.schres.2017.04.016","journal-title":"Schizophr Res"},{"key":"396_CR60","doi-asserted-by":"publisher","first-page":"114347","DOI":"10.1016\/j.psychres.2021.114347","volume":"308","author":"AE Kirkland","year":"2022","unstructured":"Kirkland AE et al (2022) A scoping review of the use of cannabidiol in psychiatric disorders. Psychiatry Res 308:114347. https:\/\/doi.org\/10.1016\/j.psychres.2021.114347","journal-title":"Psychiatry Res"},{"key":"396_CR61","doi-asserted-by":"publisher","unstructured":"Koob GF, Volkow ND (2016) Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry:760\u2013773. https:\/\/doi.org\/10.1016\/S2215-0366(16)00104-8","DOI":"10.1016\/S2215-0366(16)00104-8"},{"issue":"3\u20134","key":"396_CR62","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1300\/J374v03n03_05","volume":"3","author":"S Leonard","year":"2007","unstructured":"Leonard S, Mexal S, Freedman R (2007) Smoking, genetics and schizophrenia: evidence for self medication. J Dual Diagn 3(3\u20134):43\u201359. https:\/\/doi.org\/10.1300\/J374v03n03_05","journal-title":"J Dual Diagn"},{"issue":"3","key":"396_CR63","doi-asserted-by":"publisher","first-page":"e94","DOI":"10.1038\/tp.2012.15","volume":"2","author":"FM Leweke","year":"2012","unstructured":"Leweke FM et al (2012) Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry 2(3):e94. https:\/\/doi.org\/10.1038\/tp.2012.15","journal-title":"Transl Psychiatry"},{"issue":"4","key":"396_CR64","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1017\/S1355617712000276","volume":"18","author":"KM Lisdahl","year":"2012","unstructured":"Lisdahl KM, Price JS (2012) Increased marijuana use and gender predict poorer cognitive functioning in adolescents and emerging adults. J Int Neuropsychol Soc 18(4):678\u2013688. https:\/\/doi.org\/10.1017\/S1355617712000276","journal-title":"J Int Neuropsychol Soc"},{"issue":"1","key":"396_CR65","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1176\/appi.ajp.2021.21010073","volume":"179","author":"O Livne","year":"2022","unstructured":"Livne O et al (2022) Association of cannabis use-related predictor variables and self-reported psychotic disorders: U.S. adults, 2001-2002 and 2012-2013. Am J Psychiatry 179(1):36\u201345. https:\/\/doi.org\/10.1176\/appi.ajp.2021.21010073","journal-title":"Am J Psychiatry"},{"issue":"6","key":"396_CR66","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.bpsc.2020.07.016","volume":"6","author":"HC Lu","year":"2021","unstructured":"Lu HC, Mackie K (2021) Review of the endocannabinoid system. Biol Psychiatry Cogn Neurosci Neuroimaging 6(6):607\u2013615. https:\/\/doi.org\/10.1016\/j.bpsc.2020.07.016","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"issue":"7","key":"396_CR67","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1017\/S0033291704002260","volume":"34","author":"MJ Lyons","year":"2004","unstructured":"Lyons MJ et al (2004) Neuropsychological consequences of regular marijuana use: a twin study. Psychol Med 34(7):1239\u20131250. https:\/\/doi.org\/10.1017\/S0033291704002260","journal-title":"Psychol Med"},{"issue":"1","key":"396_CR68","doi-asserted-by":"publisher","first-page":"35","DOI":"10.5498\/WJP.V5.I1.35","volume":"5","author":"F Manzella","year":"2015","unstructured":"Manzella F, Maloney SE, Taylor GT (2015) Smoking in schizophrenic patients: a critique of the self-medication hypothesis. World J Psychiatry 5(1):35. https:\/\/doi.org\/10.5498\/WJP.V5.I1.35","journal-title":"World J Psychiatry"},{"issue":"5","key":"396_CR69","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1093\/SCHBUL\/SBW003","volume":"42","author":"A Marconi","year":"2016","unstructured":"Marconi A et al (2016) Meta-analysis of the association between the level of cannabis use and risk of psychosis. Schizophr Bull 42(5):1262\u20131269. https:\/\/doi.org\/10.1093\/SCHBUL\/SBW003","journal-title":"Schizophr Bull"},{"issue":"3","key":"396_CR70","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/oxfordjournals.schbul.a006887","volume":"27","author":"TM Maynard","year":"2001","unstructured":"Maynard TM et al (2001) Neural development, cell-cell signaling, and the \u201cTwo-Hit\u201d hypothesis of schizophrenia. Schizophr Bull 27(3):457\u2013476. https:\/\/doi.org\/10.1093\/oxfordjournals.schbul.a006887","journal-title":"Schizophr Bull"},{"issue":"3","key":"396_CR71","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.tins.2018.12.004","volume":"42","author":"RA McCutcheon","year":"2019","unstructured":"McCutcheon RA, Abi-Dargham A, Howes OD (2019) Schizophrenia, dopamine and the striatum: from biology to symptoms. Trends Neurosci 42(3):205\u2013220. https:\/\/doi.org\/10.1016\/j.tins.2018.12.004","journal-title":"Trends Neurosci"},{"key":"396_CR72","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.drugalcdep.2016.10.022","volume":"169","author":"R McKetin","year":"2016","unstructured":"McKetin R et al (2016) A longitudinal examination of the relationship between cannabis use and cognitive function in mid-life adults. Drug Alcohol Depend 169:134\u2013140. https:\/\/doi.org\/10.1016\/j.drugalcdep.2016.10.022","journal-title":"Drug Alcohol Depend"},{"issue":"5","key":"396_CR73","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1017\/S1355617707071032","volume":"13","author":"KL Medina","year":"2007","unstructured":"Medina KL et al (2007) Neuropsychological functioning in adolescent marijuana users: subtle deficits detectable after a month of abstinence. J Int Neuropsychol Soc 13(5):807. https:\/\/doi.org\/10.1017\/S1355617707071032","journal-title":"J Int Neuropsychol Soc"},{"issue":"5","key":"396_CR74","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1111\/j.1556-4029.2010.01441.x","volume":"55","author":"Z Mehmedic","year":"2010","unstructured":"Mehmedic Z et al (2010) Potency trends of \u03949-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008*. J Forensic Sci 55(5):1209\u20131217. https:\/\/doi.org\/10.1111\/j.1556-4029.2010.01441.x","journal-title":"J Forensic Sci"},{"issue":"2","key":"396_CR75","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41386-020-00876-5","volume":"46","author":"CA Mielnik","year":"2021","unstructured":"Mielnik CA et al (2021) A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology 46(2):413\u2013422. https:\/\/doi.org\/10.1038\/s41386-020-00876-5","journal-title":"Neuropsychopharmacology"},{"key":"396_CR76","doi-asserted-by":"publisher","unstructured":"Minichino A et al (2019) Measuring disturbance of the endocannabinoid system in psychosis: a systematic review and meta-analysis. JAMA Psychiat:914\u2013923. https:\/\/doi.org\/10.1001\/jamapsychiatry.2019.0970","DOI":"10.1001\/jamapsychiatry.2019.0970"},{"issue":"5","key":"396_CR77","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1192\/bjp.bp.112.121178","volume":"202","author":"CJA Morgan","year":"2013","unstructured":"Morgan CJA et al (2013) Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. Br J Psychiatry 202(5):381\u2013382. https:\/\/doi.org\/10.1192\/bjp.bp.112.121178","journal-title":"Br J Psychiatry"},{"issue":"7","key":"396_CR78","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/S00210-014-0984-2","volume":"387","author":"D Muhl","year":"2014","unstructured":"Muhl D et al (2014) Increased CB2 mRNA and anandamide in human blood after cessation of cannabis abuse. Naunyn Schmiedebergs Arch Pharmacol 387(7):691\u2013695. https:\/\/doi.org\/10.1007\/S00210-014-0984-2","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"396_CR79","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1089\/can.2017.0034","volume":"2","author":"M Murphy","year":"2017","unstructured":"Murphy M et al (2017) Chronic adolescent \u0394 9 -tetrahydrocannabinol treatment of male mice leads to long-term cognitive and behavioral dysfunction, which are prevented by concurrent cannabidiol treatment. Cannabis Cannabinoid Res 2(1):235\u2013246. https:\/\/doi.org\/10.1089\/can.2017.0034","journal-title":"Cannabis Cannabinoid Res"},{"issue":"8","key":"396_CR80","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1001\/jamapsychiatry.2020.0339","volume":"77","author":"RM Murray","year":"2020","unstructured":"Murray RM, Hall W (2020) Will legalization and commercialization of cannabis use increase the incidence and prevalence of psychosis? JAMA Psychiat 77(8):777. https:\/\/doi.org\/10.1001\/jamapsychiatry.2020.0339","journal-title":"JAMA Psychiat"},{"issue":"1","key":"396_CR81","doi-asserted-by":"publisher","first-page":"20155","DOI":"10.4088\/JCP.12m07822","volume":"74","author":"JA Niemi-Pyntt\u00e4ri","year":"2013","unstructured":"Niemi-Pyntt\u00e4ri JA et al (2013) Substance-induced psychoses converting into schizophrenia: a register-based study of 18,478 Finnish inpatient cases. J Clin Psychiatry 74(1):20155. https:\/\/doi.org\/10.4088\/JCP.12m07822","journal-title":"J Clin Psychiatry"},{"issue":"1\u20132","key":"396_CR82","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0165-5728(02)00113-3","volume":"127","author":"L Nong","year":"2002","unstructured":"Nong L et al (2002) Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. J Neuroimmunol 127(1\u20132):169\u2013176. https:\/\/doi.org\/10.1016\/S0165-5728(02)00113-3","journal-title":"J Neuroimmunol"},{"issue":"4","key":"396_CR83","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0006-3223(93)90288-O","volume":"33","author":"AL Nordstr\u00f6m","year":"1993","unstructured":"Nordstr\u00f6m AL et al (1993) Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients. Biol Psychiatry 33(4):227\u2013235. https:\/\/doi.org\/10.1016\/0006-3223(93)90288-O","journal-title":"Biol Psychiatry"},{"key":"396_CR84","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/FPSYT.2013.00035\/BIBTEX","volume":"4","author":"G Orellana","year":"2013","unstructured":"Orellana G, Slachevsky A (2013) Executive functioning in schizophrenia. Front Psych 4:35. https:\/\/doi.org\/10.3389\/FPSYT.2013.00035\/BIBTEX","journal-title":"Front Psych"},{"issue":"7","key":"396_CR85","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1038\/npp.2017.40","volume":"42","author":"AL Osborne","year":"2017","unstructured":"Osborne AL et al (2017) Improved social interaction, recognition and working memory with cannabidiol treatment in a prenatal infection (poly I:C) rat model. Neuropsychopharmacology 42(7):1447\u20131457. https:\/\/doi.org\/10.1038\/npp.2017.40","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"396_CR86","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/s41593-018-0206-1","volume":"21","author":"JA Pasman","year":"2018","unstructured":"Pasman JA et al (2018) GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci 21(9):1161\u20131170. https:\/\/doi.org\/10.1038\/s41593-018-0206-1","journal-title":"Nat Neurosci"},{"key":"396_CR87","doi-asserted-by":"publisher","unstructured":"Peres FF et al (2018) Cannabidiol administered during peri-adolescence prevents behavioral abnormalities in an animal model of schizophrenia. Front Pharmacol 9(AUG). https:\/\/doi.org\/10.3389\/fphar.2018.00901","DOI":"10.3389\/fphar.2018.00901"},{"issue":"7","key":"396_CR88","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1001\/jama.275.7.521","volume":"275","author":"HG Pope","year":"1996","unstructured":"Pope HG, Yurgelun-Todd D (1996) The residual cognitive effects of heavy marijuana use in college students. JAMA 275(7):521\u2013527. https:\/\/doi.org\/10.1001\/jama.275.7.521","journal-title":"JAMA"},{"issue":"2\u20133","key":"396_CR89","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.psychres.2012.11.019","volume":"206","author":"RA Rabin","year":"2013","unstructured":"Rabin RA et al (2013) Effects of cannabis use status on cognitive function, in males with schizophrenia. Psychiatry Res 206(2\u20133):158\u2013165. https:\/\/doi.org\/10.1016\/j.psychres.2012.11.019","journal-title":"Psychiatry Res"},{"issue":"3","key":"396_CR90","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1177\/0269881108092393","volume":"23","author":"JG Ramaekers","year":"2009","unstructured":"Ramaekers JG et al (2009) Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. J Psychopharmacol 23(3):266\u2013277. https:\/\/doi.org\/10.1177\/0269881108092393","journal-title":"J Psychopharmacol"},{"issue":"4","key":"396_CR91","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1037\/A0033661","volume":"21","author":"D Ramesh","year":"2013","unstructured":"Ramesh D, Haney M, Cooper ZD (2013) Marijuana\u2019s dose-dependent effects in daily marijuana smokers. Exp Clin Psychopharmacol 21(4):287\u2013293. https:\/\/doi.org\/10.1037\/A0033661","journal-title":"Exp Clin Psychopharmacol"},{"issue":"18","key":"396_CR92","doi-asserted-by":"publisher","first-page":"5160","DOI":"10.1523\/JNEUROSCI.3387-15.2016","volume":"36","author":"J Renard","year":"2016","unstructured":"Renard J et al (2016) Cannabidiol counteracts amphetamine-induced neuronal and behavioral sensitization of the mesolimbic dopamine pathway through a novel mTOR\/p70S6 kinase signaling pathway. J Neurosci 36(18):5160\u20135169. https:\/\/doi.org\/10.1523\/JNEUROSCI.3387-15.2016","journal-title":"J Neurosci"},{"key":"396_CR93","doi-asserted-by":"publisher","unstructured":"Renard J et al (2017) Adolescent THC exposure causes enduring prefrontal cortical disruption of GABAergic inhibition and dysregulation of sub-cortical dopamine function. Sci Rep 7(1). https:\/\/doi.org\/10.1038\/S41598-017-11645-8","DOI":"10.1038\/S41598-017-11645-8"},{"key":"396_CR94","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.neubiorev.2017.05.025","volume":"80","author":"K R\u00f8mer Thomsen","year":"2017","unstructured":"R\u00f8mer Thomsen K, Callesen MB, Feldstein Ewing SW (2017) Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior. Neurosci Biobehav Rev 80:156\u2013158. https:\/\/doi.org\/10.1016\/j.neubiorev.2017.05.025","journal-title":"Neurosci Biobehav Rev"},{"issue":"11","key":"396_CR95","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1038\/sj.npp.1301664","volume":"33","author":"T Rubino","year":"2008","unstructured":"Rubino T et al (2008) Chronic \u03949-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates. Neuropsychopharmacology 33(11):2760\u20132771. https:\/\/doi.org\/10.1038\/sj.npp.1301664","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"396_CR96","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/hipo.20554","volume":"19","author":"T Rubino","year":"2009","unstructured":"Rubino T et al (2009) Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. Hippocampus 19(8):763\u2013772. https:\/\/doi.org\/10.1002\/hipo.20554","journal-title":"Hippocampus"},{"issue":"1","key":"396_CR97","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1017\/S0033291715001646","volume":"46","author":"T Schoeler","year":"2016","unstructured":"Schoeler T et al (2016) The effects of cannabis on memory function in users with and without a psychotic disorder: findings from a combined meta-analysis. Psychol Med 46(1):177\u2013188. https:\/\/doi.org\/10.1017\/S0033291715001646","journal-title":"Psychol Med"},{"issue":"6\u20137","key":"396_CR98","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1080\/J.1440-1614.2006.01840.X","volume":"40","author":"D Schofield","year":"2006","unstructured":"Schofield D et al (2006) Reasons for cannabis use in psychosis. Aust N Z J Psychiatry 40(6\u20137):570\u2013574. https:\/\/doi.org\/10.1080\/J.1440-1614.2006.01840.X","journal-title":"Aust N Z J Psychiatry"},{"key":"396_CR99","doi-asserted-by":"publisher","unstructured":"Scott JC et al (2018) Association of cannabis with cognitive functioning in adolescents and young adults a systematic review and meta-analysis. JAMA Psychiat:585\u2013595. https:\/\/doi.org\/10.1001\/jamapsychiatry.2018.0335","DOI":"10.1001\/jamapsychiatry.2018.0335"},{"issue":"10","key":"396_CR100","doi-asserted-by":"publisher","first-page":"e920","DOI":"10.1038\/TP.2016.195","volume":"6","author":"P Seeman","year":"2016","unstructured":"Seeman P (2016) Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose. Transl Psychiatry 6(10):e920. https:\/\/doi.org\/10.1038\/TP.2016.195","journal-title":"Transl Psychiatry"},{"issue":"3","key":"396_CR101","doi-asserted-by":"publisher","first-page":"187","DOI":"10.4103\/0019-5545.86796","volume":"53","author":"A Shrivastava","year":"2011","unstructured":"Shrivastava A, Tsuang M, Johnston M (2011) Cannabis use and cognitive dysfunction. Indian J Psychiatry 53(3):187. https:\/\/doi.org\/10.4103\/0019-5545.86796","journal-title":"Indian J Psychiatry"},{"issue":"1","key":"396_CR102","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1080\/15504263.2019.1674991","volume":"16","author":"L Sideli","year":"2020","unstructured":"Sideli L et al (2020) Cannabis use and the risk for psychosis and affective disorders. J Dual Diagn 16(1):22\u201342. https:\/\/doi.org\/10.1080\/15504263.2019.1674991","journal-title":"J Dual Diagn"},{"issue":"1","key":"396_CR103","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2174\/1874473710801010081","volume":"1","author":"N Solowij","year":"2008","unstructured":"Solowij N, Battisti R (2008) The chronic effects of cannabis on memory in humans: a review. Curr Drug Abuse Rev 1(1):81\u201398. https:\/\/doi.org\/10.2174\/1874473710801010081","journal-title":"Curr Drug Abuse Rev"},{"issue":"4","key":"396_CR104","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","volume":"24","author":"LP Spear","year":"2000","unstructured":"Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24(4):417\u2013463. https:\/\/doi.org\/10.1016\/S0149-7634(00)00014-2","journal-title":"Neurosci Biobehav Rev"},{"key":"396_CR105","doi-asserted-by":"publisher","unstructured":"Stark T et al (2020) Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment. Biochem Pharmacol 177. https:\/\/doi.org\/10.1016\/j.bcp.2020.114004","DOI":"10.1016\/j.bcp.2020.114004"},{"key":"396_CR106","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105938","volume":"174","author":"T Stark","year":"2021","unstructured":"Stark T, Di Martino S, Drago F, Wotjak CT et al (2021) Phytocannabinoids and schizophrenia: focus on adolescence as a critical window of enhanced vulnerability and opportunity for treatment. Pharmacol Res 174:105938. https:\/\/doi.org\/10.1016\/j.phrs.2021.105938","journal-title":"Pharmacol Res"},{"key":"396_CR107","doi-asserted-by":"publisher","unstructured":"Strauss GP, Waltz JA, Gold JM (2014) A review of reward processing and motivational impairment in schizophrenia. Schizophr Bull:107\u2013116. https:\/\/doi.org\/10.1093\/schbul\/sbt197","DOI":"10.1093\/schbul\/sbt197"},{"issue":"1","key":"396_CR108","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00213-020-05684-9","volume":"238","author":"SJ Stringfield","year":"2021","unstructured":"Stringfield SJ, Torregrossa MM (2021) Intravenous self-administration of delta-9-THC in adolescent rats produces long-lasting alterations in behavior and receptor protein expression. Psychopharmacology (Berl) 238(1):305\u2013319. https:\/\/doi.org\/10.1007\/s00213-020-05684-9","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"396_CR109","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/S41386-018-0282-7","volume":"44","author":"HJ Szkudlarek","year":"2019","unstructured":"Szkudlarek HJ et al (2019) \u0394-9-tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors. Neuropsychopharmacology 44(4):817. https:\/\/doi.org\/10.1038\/S41386-018-0282-7","journal-title":"Neuropsychopharmacology"},{"key":"396_CR110","doi-asserted-by":"publisher","first-page":"110029","DOI":"10.1016\/j.pnpbp.2020.110029","volume":"104","author":"HJ Szkudlarek","year":"2021","unstructured":"Szkudlarek HJ et al (2021) THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways. Prog Neuropsychopharmacol Biol Psychiatry 104:110029. https:\/\/doi.org\/10.1016\/j.pnpbp.2020.110029","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"5","key":"396_CR111","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/J.ADDBEH.2014.01.019","volume":"39","author":"AD Thames","year":"2014","unstructured":"Thames AD, Arbid N, Sayegh P (2014) Cannabis use and neurocognitive functioning in a non-clinical sample of users. Addict Behav 39(5):994\u2013999. https:\/\/doi.org\/10.1016\/J.ADDBEH.2014.01.019","journal-title":"Addict Behav"},{"issue":"2","key":"396_CR112","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/S00213-014-3667-2","volume":"232","author":"EL Theunissen","year":"2015","unstructured":"Theunissen EL et al (2015) Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans. Psychopharmacology (Berl) 232(2):343\u2013353. https:\/\/doi.org\/10.1007\/S00213-014-3667-2","journal-title":"Psychopharmacology (Berl)"},{"key":"396_CR113","doi-asserted-by":"publisher","unstructured":"Thorpe HHA et al (2020) Adolescent neurodevelopment and substance use: receptor expression and behavioral consequences. Pharmacol Ther. https:\/\/doi.org\/10.1016\/j.pharmthera.2019.107431","DOI":"10.1016\/j.pharmthera.2019.107431"},{"key":"396_CR114","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-3-319-45541-9_3","volume-title":"Progress in the chemistry of organic natural products","author":"SE Turner","year":"2017","unstructured":"Turner SE et al (2017) Molecular pharmacology of phytocannabinoids. In: Progress in the chemistry of organic natural products. Springer, Cham, pp 61\u2013101. https:\/\/doi.org\/10.1007\/978-3-319-45541-9_3"},{"issue":"5","key":"396_CR115","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/mp.2016.252","volume":"23","author":"J Vaucher","year":"2018","unstructured":"Vaucher J et al (2018) Cannabis use and risk of schizophrenia: a Mendelian randomization study. Mol Psychiatry 23(5):1287\u20131292. https:\/\/doi.org\/10.1038\/mp.2016.252","journal-title":"Mol Psychiatry"},{"key":"396_CR116","doi-asserted-by":"publisher","unstructured":"Volkow ND (2009) Substance use disorders in schizophrenia \u2013 clinical implications of comorbidity. Schizophr Bull:469\u2013472. https:\/\/doi.org\/10.1093\/schbul\/sbp016","DOI":"10.1093\/schbul\/sbp016"},{"key":"396_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108288","volume":"179","author":"HV Weimar","year":"2020","unstructured":"Weimar HV et al (2020) Long-term effects of maternal cannabis vapor exposure on emotional reactivity, social behavior, and behavioral flexibility in offspring. Neuropharmacology 179:108288. https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108288","journal-title":"Neuropharmacology"},{"issue":"11","key":"396_CR118","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1177\/0269881109105900","volume":"24","author":"KA Wesnes","year":"2010","unstructured":"Wesnes KA et al (2010) Nabilone produces marked impairments to cognitive function and changes in subjective state in healthy volunteers. J Psychopharmacol 24(11):1659\u20131669. https:\/\/doi.org\/10.1177\/0269881109105900","journal-title":"J Psychopharmacol"},{"issue":"1","key":"396_CR119","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.drugalcdep.2004.04.009","volume":"76","author":"CT Whitlow","year":"2004","unstructured":"Whitlow CT et al (2004) Long-term heavy marijuana users make costly decisions on a gambling task. Drug Alcohol Depend 76(1):107\u2013111. https:\/\/doi.org\/10.1016\/j.drugalcdep.2004.04.009","journal-title":"Drug Alcohol Depend"},{"issue":"Pt B","key":"396_CR120","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/J.NEUBIOREV.2016.10.029","volume":"76","author":"JW Young","year":"2017","unstructured":"Young JW et al (2017) Research domain criteria versus DSM V: how does this debate affect attempts to model corticostriatal dysfunction in animals? Neurosci Biobehav Rev 76(Pt B):301\u2013316. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2016.10.029","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"396_CR121","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/schbul\/sbq079","volume":"38","author":"M Yucel","year":"2012","unstructured":"Yucel M et al (2012) The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample. Schizophr Bull 38(2):316\u2013330. https:\/\/doi.org\/10.1093\/schbul\/sbq079","journal-title":"Schizophr Bull"},{"key":"396_CR122","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.nbd.2013.10.028","volume":"63","author":"E Zamberletti","year":"2014","unstructured":"Zamberletti E et al (2014) Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats. Neurobiol Dis 63:35\u201347. https:\/\/doi.org\/10.1016\/j.nbd.2013.10.028","journal-title":"Neurobiol Dis"},{"key":"396_CR123","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.phrs.2016.07.008","volume":"111","author":"E Zamberletti","year":"2016","unstructured":"Zamberletti E et al (2016) Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats. Pharmacol Res 111:459\u2013470. https:\/\/doi.org\/10.1016\/j.phrs.2016.07.008","journal-title":"Pharmacol Res"}],"container-title":["Current Topics in Behavioral Neurosciences","Cognitive Functioning in Schizophrenia: Leveraging the RDoC Framework"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/7854_2022_396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T01:41:34Z","timestamp":1676684494000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/7854_2022_396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031264405","9783031264412"],"references-count":123,"URL":"https:\/\/doi.org\/10.1007\/7854_2022_396","relation":{},"ISSN":["1866-3370","1866-3389"],"issn-type":[{"value":"1866-3370","type":"print"},{"value":"1866-3389","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"2 November 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}