{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:00:09Z","timestamp":1791356409211,"version":"4.3.1"},"publisher-location":"Berlin, Heidelberg","reference-count":203,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642405907","type":"print"},{"value":"9783642405914","type":"electronic"}],"license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/82_2013_351","type":"book-chapter","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T08:23:10Z","timestamp":1376468590000},"page":"1-34","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["From Amoeba to Macrophages: Exploring the Molecular Mechanisms of Legionella pneumophila Infection in Both Hosts"],"prefix":"10.1007","author":[{"given":"Pedro","family":"Escoll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Rolando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gomez-Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Buchrieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,8,15]]},"reference":[{"issue":"6","key":"351_CR1","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1128\/aem.62.6.2022-2028.1996","volume":"62","author":"Y Abu Kwaik","year":"1996","unstructured":"Abu Kwaik Y (1996) The phagosome containing Legionella pneumophila within the protozoan Hartmannella vermiformis is surrounded by the rough endoplasmic reticulum. Appl Environ Microbiol 62(6):2022\u20132028","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"351_CR2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1462-5822.2006.00785.x","volume":"9","author":"A Abu-Zant","year":"2007","unstructured":"Abu-Zant A, Jones S, Asare R, Suttles J, Price C, Graham J et al (2007) Anti-apoptotic signalling by the Dot\/Icm secretion system of L. pneumophila. Cell Microbiol 9(1):246\u2013264","journal-title":"Cell Microbiol"},{"issue":"1","key":"351_CR3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1128\/IAI.73.1.352-361.2005","volume":"73","author":"M Akamine","year":"2005","unstructured":"Akamine M, Higa F, Arakaki N, Kawakami K, Takeda K, Akira S et al (2005) Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila. Infect Immun 73(1):352\u2013361","journal-title":"Infect Immun"},{"key":"351_CR4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fmicb.2011.00023","volume":"2","author":"T Al-Quadan","year":"2011","unstructured":"Al-Quadan T, Kwaik YA (2011) Molecular characterization of exploitation of the polyubiquitination and farnesylation machineries of dictyostelium discoideum by the AnkB F-box effector of Legionella pneumophila. Front Microbiol 2:23","journal-title":"Front Microbiol"},{"issue":"6","key":"351_CR5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.tim.2012.03.005","volume":"20","author":"T Al-Quadan","year":"2012","unstructured":"Al-Quadan T, Price CT, Kwaik YA (2012) Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella. Trends Microbiol 20(6):299\u2013306","journal-title":"Trends Microbiol"},{"issue":"11","key":"351_CR6","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1128\/IAI.68.11.6431-6440.2000","volume":"68","author":"OA Alli","year":"2000","unstructured":"Alli OA, Gao LY, Pedersen LL, Zink S, Radulic M, Doric M et al (2000) Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophila. Infect Immun 68(11):6431\u20136440","journal-title":"Infect Immun"},{"issue":"5","key":"351_CR7","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1074\/jbc.M707704200","volume":"283","author":"M Alter-Koltunoff","year":"2008","unstructured":"Alter-Koltunoff M, Goren S, Nousbeck J, Feng CG, Sher A, Ozato K et al (2008) Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. J Biol Chem 283(5):2724\u20132733","journal-title":"J Biol Chem"},{"issue":"2","key":"351_CR8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1462-5822.2009.01401.x","volume":"12","author":"AO Amer","year":"2010","unstructured":"Amer AO (2010) Modulation of caspases and their non-apoptotic functions by Legionella pneumophila. Cell Microbiol 12(2):140\u2013147","journal-title":"Cell Microbiol"},{"issue":"5","key":"351_CR9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1600-0854.2010.01050.x","volume":"11","author":"K Arasaki","year":"2010","unstructured":"Arasaki K, Roy CR (2010) Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. Traffic 11(5):587\u2013600","journal-title":"Traffic"},{"issue":"12","key":"351_CR10","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1073\/pnas.0611030104","volume":"104","author":"S Banga","year":"2007","unstructured":"Banga S, Gao P, Shen X, Fiscus V, Zong W-X, Chen L et al (2007) Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc Natl Acad Sci U S A 104(12):5121\u20135126","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"351_CR11","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.4049\/jimmunol.181.10.7147","volume":"181","author":"IN Baranova","year":"2008","unstructured":"Baranova IN, Kurlander R, Bocharov AV, Vishnyakova TG, Chen Z, Remaley AT et al (2008) Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling. J Immunol 181(10):7147\u20137156","journal-title":"J Immunol"},{"issue":"1","key":"351_CR12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-2958.2005.04539.x","volume":"56","author":"JP Bardill","year":"2005","unstructured":"Bardill JP, Miller JL, Vogel JP (2005) IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion system. Mol Microbiol 56(1):90\u2013103","journal-title":"Mol Microbiol"},{"issue":"11","key":"351_CR13","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1111\/j.1462-5822.2009.01354.x","volume":"11","author":"S Bartfeld","year":"2009","unstructured":"Bartfeld S, Engels C, Bauer B, Aurass P, Flieger A, Br\u00fcggemann H et al (2009) Temporal resolution of two-tracked NF-kappaB activation by Legionella pneumophila. Cell Microbiol 11(11):1638\u20131651","journal-title":"Cell Microbiol"},{"issue":"4","key":"351_CR14","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1084\/jem.172.4.1201","volume":"172","author":"C Bellinger-Kawahara","year":"1990","unstructured":"Bellinger-Kawahara C, Horwitz MA (1990) Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes. J Exp Med 172(4):1201\u20131210","journal-title":"J Exp Med"},{"issue":"8","key":"351_CR15","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/JB.01798-07","volume":"190","author":"Y Belyi","year":"2008","unstructured":"Belyi Y, Tabakova I, Stahl M, Aktories K (2008) Lgt: a family of cytotoxic glucosyl transferases produced by Legionella pneumophila. J Bacteriol 190(8):3026\u20133035","journal-title":"J Bacteriol"},{"issue":"1","key":"351_CR16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2958.1993.tb01092.x","volume":"7","author":"KH Berger","year":"1993","unstructured":"Berger KH, Isberg RR (1993) Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol 7(1):7\u201319","journal-title":"Mol Microbiol"},{"issue":"4","key":"351_CR17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2958.1994.tb01317.x","volume":"14","author":"KH Berger","year":"1994","unstructured":"Berger KH, Merriam JJ, Isberg RR (1994) Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene. Mol Microbiol 14(4):809\u2013822","journal-title":"Mol Microbiol"},{"issue":"2","key":"351_CR18","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1128\/iai.64.2.668-673.1996","volume":"64","author":"JA Bozue","year":"1996","unstructured":"Bozue JA, Johnson W (1996) Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion. Infect Immun 64(2):668\u2013673","journal-title":"Infect Immun"},{"issue":"4","key":"351_CR19","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1365-2958.1994.tb01316.x","volume":"14","author":"BC Brand","year":"1994","unstructured":"Brand BC, Sadosky AB, Shuman HA (1994) The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages. Mol Microbiol 14(4):797\u2013808","journal-title":"Mol Microbiol"},{"issue":"3","key":"351_CR20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1462-5822.2009.01398.x","volume":"12","author":"AKC Brassinga","year":"2010","unstructured":"Brassinga AKC, Kinchen JM, Cupp ME, Day SR, Hoffman PS, Sifri CD (2010) Caenorhabditis is a metazoan host for Legionella. Cell Microbiol 12(3):343\u2013361","journal-title":"Cell Microbiol"},{"key":"351_CR202","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/978-1-62703-161-5_27","volume":"954","author":"AK Brassinga","year":"2013","unstructured":"Brassinga AK, Sifri CD (2013) The Caenorhabditis elegans model of Legionella infection. Methods Mol Biol 954:439\u2013461","journal-title":"Methods Mol Biol"},{"issue":"21","key":"351_CR21","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1001\/jama.1990.03440210074036","volume":"263","author":"RF Breiman","year":"1990","unstructured":"Breiman RF, Fields BS, Sanden GN, Volmer L, Meier A, Spika JS (1990) Association of shower use with legionnaires-disease\u2014possible role of amoebas. J Am Med Assoc 263(21):2924\u20132926","journal-title":"J Am Med Assoc"},{"issue":"8","key":"351_CR22","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1074\/jbc.M807505200","volume":"284","author":"E Brombacher","year":"2009","unstructured":"Brombacher E, Urwyler S, Ragaz C, Weber SS, Kami K, Overduin M et al (2009) Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila. J Biol Chem 284(8):4846\u20134856","journal-title":"J Biol Chem"},{"issue":"7","key":"351_CR23","doi-asserted-by":"crossref","first-page":"e1000508","DOI":"10.1371\/journal.ppat.1000508","volume":"5","author":"D Burstein","year":"2009","unstructured":"Burstein D, Zusman T, Degtyar E, Viner R, Segal G, Pupko T (2009) Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog 5(7):e1000508","journal-title":"PLoS Pathog"},{"issue":"7","key":"351_CR24","first-page":"M111","volume":"11","author":"F-X Campbell-Valois","year":"2012","unstructured":"Campbell-Valois F-X, Trost M, Chemali M, Dill BD, Laplante A, Duclos S et al (2012) Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Mol Cell Proteomics 11(7):M111.016378","journal-title":"Mol Cell Proteomics"},{"issue":"4","key":"351_CR25","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1365-2958.2005.04595.x","volume":"56","author":"EM Campodonico","year":"2005","unstructured":"Campodonico EM, Chesnel L, Roy CR (2005) A yeast genetic system for the identification and characterization of substrate proteins transferred into host cells by the Legionella pneumophila Dot\/Icm system. Mol Microbiol 56(4):918\u2013933","journal-title":"Mol Microbiol"},{"issue":"11","key":"351_CR26","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/ng1447","volume":"36","author":"C Cazalet","year":"2004","unstructured":"Cazalet C, Rusniok C, Br\u00fcggemann H, Zidane N, Magnier A, Ma L et al (2004) Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat Genet 36(11):1165\u20131173","journal-title":"Nat Genet"},{"issue":"4","key":"351_CR27","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20030088","volume":"198","author":"J Celli","year":"2003","unstructured":"Celli J, de Chastellier C, Franchini D-M, Pizarro-Cerda J, Moreno E, Gorvel J-P (2003) Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum. J Exp Med 198(4):545\u2013556","journal-title":"J Exp Med"},{"issue":"7","key":"351_CR28","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1128\/IAI.73.7.4272-4280.2005","volume":"73","author":"B Chang","year":"2005","unstructured":"Chang B, Kura F, Amemura-Maekawa J, Koizumi N, Watanabe H (2005) Identification of a novel adhesion molecule involved in the virulence of Legionella pneumophila. Infect Immun 73(7):4272\u20134280","journal-title":"Infect Immun"},{"issue":"7","key":"351_CR29","doi-asserted-by":"crossref","first-page":"e1000501","DOI":"10.1371\/journal.ppat.1000501","volume":"5","author":"X Charpentier","year":"2009","unstructured":"Charpentier X, Gabay JE, Reyes M, Zhu JW, Weiss A, Shuman HA (2009) Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathog 5(7):e1000501 (Roy CR, editor)","journal-title":"PLoS Pathog"},{"issue":"5838","key":"351_CR30","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1143991","volume":"317","author":"G Chen","year":"2007","unstructured":"Chen G, Zhuchenko O, Kuspa A (2007) Immune-like phagocyte activity in the social amoeba. Science 317(5838):678\u2013681","journal-title":"Science"},{"issue":"5662","key":"351_CR31","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.1094226","volume":"303","author":"J Chen","year":"2004","unstructured":"Chen J (2004) Legionella effectors that promote nonlytic release from protozoa. Science 303(5662):1358\u20131361","journal-title":"Science"},{"issue":"11","key":"351_CR32","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1128\/IAI.00150-09","volume":"77","author":"A Chong","year":"2009","unstructured":"Chong A, Lima CA, Allan DS, Nasrallah GK, Garduno RA (2009) The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization. Infect Immun 77(11):4724\u20134739","journal-title":"Infect Immun"},{"issue":"19","key":"351_CR33","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0960-9822(98)70444-0","volume":"8","author":"MM Chou","year":"1998","unstructured":"Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS et al (1998) Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol 8(19):1069\u20131077","journal-title":"Curr Biol"},{"issue":"6110","key":"351_CR34","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1126\/science.1227026","volume":"338","author":"A Choy","year":"2012","unstructured":"Choy A, Dancourt J, Mugo B, O\u2019Connor TJ, Isberg RR, Melia TJ et al (2012) The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science 338(6110):1072\u20131076","journal-title":"Science"},{"issue":"3\u20134","key":"351_CR35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10534-006-9057-4","volume":"20","author":"NP Cianciotto","year":"2007","unstructured":"Cianciotto NP (2007) Iron acquisition by Legionella pneumophila. Biometals. 20(3\u20134):323\u2013331","journal-title":"Biometals."},{"issue":"11","key":"351_CR36","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1073\/pnas.89.11.5188","volume":"89","author":"NP Cianciotto","year":"1992","unstructured":"Cianciotto NP, Fields BS (1992) Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages. Proc Natl Acad Sci U S A 89(11):5188\u20135191","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"351_CR37","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1128\/iai.62.8.3254-3261.1994","volume":"62","author":"JD Cirillo","year":"1994","unstructured":"Cirillo JD, Falkow S, Tompkins LS (1994) Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion. Infect Immun 62(8):3254\u20133261","journal-title":"Infect Immun"},{"issue":"Pt 6","key":"351_CR38","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1099\/00221287-146-6-1345","volume":"146","author":"SL Cirillo","year":"2000","unstructured":"Cirillo SL, Lum J, Cirillo JD (2000) Identification of novel loci involved in entry by Legionella pneumophila. Microbiology (Reading, Engl.) 146 (Pt 6):1345\u20131359","journal-title":"Microbiology (Reading, Engl.)"},{"issue":"Pt 6","key":"351_CR39","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1099\/00221287-148-6-1667","volume":"148","author":"SLG Cirillo","year":"2002","unstructured":"Cirillo SLG, Yan L, Littman M, Samrakandi MM, Cirillo JD (2002) Role of the Legionella pneumophila rtxA gene in amoebae. Microbiology (Reading, Engl.) 148(Pt 6):1667\u20131677","journal-title":"Microbiology (Reading, Engl.)"},{"issue":"2","key":"351_CR40","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/gb-2013-14-2-r11","volume":"14","author":"M Clarke","year":"2013","unstructured":"Clarke M, Lohan AJ, Liu B, Lagkouvardos I, Roy S, Zafar N et al (2013) Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome Biol 14(2):R11","journal-title":"Genome Biol"},{"issue":"2","key":"351_CR41","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1365-2958.2003.03400.x","volume":"48","author":"GM Conover","year":"2003","unstructured":"Conover GM, Derr\u00e9 I, Vogel JP, Isberg RR (2003) The Legionella pneumophila LidA protein: a translocated substrate of the Dot\/Icm system associated with maintenance of bacterial integrity. Mol Microbiol 48(2):305\u2013321","journal-title":"Mol Microbiol"},{"issue":"3","key":"351_CR42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.mib.2008.05.005","volume":"11","author":"P Cosson","year":"2008","unstructured":"Cosson P, Soldati T (2008) Eat, kill or die: when amoeba meets bacteria. Curr Opin Microbiol 11(3):271\u2013276","journal-title":"Curr Opin Microbiol"},{"issue":"6","key":"351_CR43","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/IAI.66.6.2905-2913.1998","volume":"66","author":"PY Coxon","year":"1998","unstructured":"Coxon PY, Summersgill JT, Ramirez JA, Miller RD (1998) Signal transduction during Legionella pneumophila entry into human monocytes. Infect Immun 66(6):2905\u20132913","journal-title":"Infect Immun"},{"issue":"9","key":"351_CR44","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1073\/pnas.1121286109","volume":"109","author":"EA Creasey","year":"2012","unstructured":"Creasey EA, Isberg RR (2012) The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc Natl Acad Sci U S A 109(9):3481\u20133486","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"351_CR45","doi-asserted-by":"crossref","first-page":"e1000117","DOI":"10.1371\/journal.ppat.1000117","volume":"4","author":"KS de Felipe","year":"2008","unstructured":"de Felipe KS, Glover RT, Charpentier X, Anderson OR, Reyes M, Pericone CD et al (2008) Legionella eukaryotic-like type IV substrates interfere with organelle trafficking. PLoS Pathog 4(8):e1000117","journal-title":"PLoS Pathog"},{"issue":"22","key":"351_CR46","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1128\/JB.187.22.7716-7726.2005","volume":"187","author":"KS de Felipe","year":"2005","unstructured":"de Felipe KS, Pampou S, Jovanovic OS, Pericone CD, Ye SF, Kalachikov S et al (2005) Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer. J Bacteriol 187(22):7716\u20137726","journal-title":"J Bacteriol"},{"issue":"8","key":"351_CR47","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1462-5822.2009.01328.x","volume":"11","author":"E Degtyar","year":"2009","unstructured":"Degtyar E, Zusman T, Ehrlich M, Segal G (2009) A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria. Cell Microbiol 11(8):1219\u20131235","journal-title":"Cell Microbiol"},{"issue":"5","key":"351_CR48","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1128\/IAI.72.5.3048-3053.2004","volume":"72","author":"I Derr\u00e9","year":"2004","unstructured":"Derr\u00e9 I, Isberg RR (2004) Legionella pneumophila replication vacuole formation involves rapid recruitment of proteins of the early secretory system. Infect Immun 72(5):3048\u20133053","journal-title":"Infect Immun"},{"issue":"1","key":"351_CR49","doi-asserted-by":"crossref","first-page":"e1002459","DOI":"10.1371\/journal.ppat.1002459","volume":"8","author":"P Dolezal","year":"2012","unstructured":"Dolezal P, Aili M, Tong J, Jiang J-H, Marobbio CM, Lee SF et al (2012) Legionella pneumophila secretes a mitochondrial carrier protein during infection. PLoS Pathog 8(1):e1002459 (Roy CR, editor)","journal-title":"PLoS Pathog"},{"issue":"4","key":"351_CR50","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1371\/journal.ppat.0020034","volume":"2","author":"MS Dorer","year":"2006","unstructured":"Dorer MS, Kirton D, Bader JS, Isberg RR (2006) RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. PLoS Pathog 2(4):e34","journal-title":"PLoS Pathog"},{"issue":"1","key":"351_CR51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1128\/iai.51.1.31-36.1986","volume":"51","author":"JA Elliott","year":"1986","unstructured":"Elliott JA, Winn WC (1986) Treatment of alveolar macrophages with cytochalasin D inhibits uptake and subsequent growth of Legionella pneumophila. Infect Immun 51(1):31\u201336","journal-title":"Infect Immun"},{"issue":"9","key":"351_CR52","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1128\/IAI.00344-10","volume":"78","author":"AW Ensminger","year":"2010","unstructured":"Ensminger AW, Isberg RR (2010) E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates. Infect Immun 78(9):3905\u20133919","journal-title":"Infect Immun"},{"issue":"17","key":"351_CR53","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1093\/emboj\/18.17.4689","volume":"18","author":"T Eulgem","year":"1999","unstructured":"Eulgem T, Rushton PJ, Schmelzer E, Hahlbrock K, Somssich IE (1999) Early nuclear events in plant defence signalling: rapid gene activation by WRKY transcription factors. EMBO J 18(17):4689\u20134699","journal-title":"EMBO J"},{"issue":"7","key":"351_CR54","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1128\/JCM.36.7.1942-1947.1998","volume":"36","author":"M Fabbi","year":"1998","unstructured":"Fabbi M, Pastoris MC, Scanziani E, Magnino S, Di Matteo L (1998) Epidemiological and environmental investigations of Legionella pneumophila infection in cattle and case report of fatal pneumonia in a calf. J Clin Microbiol 36(7):1942\u20131947","journal-title":"J Clin Microbiol"},{"issue":"Pt 9","key":"351_CR55","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1099\/mic.0.27111-0","volume":"150","author":"M Fajardo","year":"2004","unstructured":"Fajardo M, Schleicher M, Noegel A, Bozzaro S, Killinger S, Heuner K et al (2004) Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum. Microbiology (Reading, Engl.) 150(Pt 9):2825\u20132835","journal-title":"Microbiology (Reading, Engl.)"},{"key":"351_CR56","doi-asserted-by":"crossref","unstructured":"Falc\u00f3 V, Fern\u00e1ndez de Sevilla T, Alegre J, Ferrer A, Mart\u00ednez V\u00e1zquez JM (1991) Legionella pneumophila. A cause of severe community-acquired pneumonia. Chest 100(4):1007\u20131011","DOI":"10.1378\/chest.100.4.1007"},{"issue":"3","key":"351_CR57","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1462-5822.2005.00633.x","volume":"8","author":"P Farbrother","year":"2006","unstructured":"Farbrother P, Wagner C, Na J, Tunggal B, Morio T, Urushihara H et al (2006) Dictyostelium transcriptional host cell response upon infection with Legionella. Cell Microbiol 8(3):438\u2013456","journal-title":"Cell Microbiol"},{"issue":"9","key":"351_CR58","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1128\/jcm.27.9.1961-1964.1989","volume":"27","author":"RC Fernandez","year":"1989","unstructured":"Fernandez RC, Lee SH, Haldane D, Sumarah R, Rozee KR (1989) Plaque assay for virulent Legionella pneumophila. J Clin Microbiol 27(9):1961\u20131964","journal-title":"J Clin Microbiol"},{"issue":"6","key":"351_CR59","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/iai.64.6.1968-1976.1996","volume":"64","author":"RC Fernandez","year":"1996","unstructured":"Fernandez RC, Logan SM, Lee SH, Hoffman PS (1996) Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence. Infect Immun 64(6):1968\u20131976","journal-title":"Infect Immun"},{"issue":"6","key":"351_CR60","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1128\/IAI.01382-05","volume":"74","author":"E Fernandez-Moreira","year":"2006","unstructured":"Fernandez-Moreira E, Helbig JH, Swanson MS (2006) Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes. Infect Immun 74(6):3285\u20133295","journal-title":"Infect Immun"},{"issue":"7","key":"351_CR61","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0966-842X(96)10041-X","volume":"4","author":"BS Fields","year":"1996","unstructured":"Fields BS (1996) The molecular ecology of Legionellae. Trends Microbiol 4(7):286\u2013290","journal-title":"Trends Microbiol"},{"issue":"3","key":"351_CR62","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1128\/iai.53.3.553-559.1986","volume":"53","author":"BS Fields","year":"1986","unstructured":"Fields BS, Barbaree JM, Shotts EB, Feeley JC, Morrill WE, Sanden GN et al (1986) Comparison of guinea pig and protozoan models for determining virulence of Legionella species. Infect Immun 53(3):553\u2013559","journal-title":"Infect Immun"},{"issue":"1","key":"351_CR63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1017\/S0022172400063877","volume":"90","author":"RB Fitzgeorge","year":"1983","unstructured":"Fitzgeorge RB, Baskerville A, Broster M, Hambleton P, Dennis PJ (1983) Aerosol infection of animals with strains of Legionella pneumophila of different virulence: comparison with intraperitoneal and intranasal routes of infection. J Hyg (Lond) 90(1):81\u201389","journal-title":"J Hyg (Lond)"},{"issue":"3","key":"351_CR64","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0021-9258(19)86105-7","volume":"255","author":"MD Flanagan","year":"1980","unstructured":"Flanagan MD, Lin S (1980) Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem 255(3):835\u2013838","journal-title":"J Biol Chem"},{"issue":"10","key":"351_CR65","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1128\/IAI.00557-12","volume":"80","author":"MF Fontana","year":"2012","unstructured":"Fontana MF, Shin S, Vance RE (2012) Activation of host MAP kinases by Legionella pneumophila secreted effectors that inhibit host protein translation. Infect Immun 80(10):3570\u20133575","journal-title":"Infect Immun"},{"issue":"11","key":"351_CR66","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","volume":"8","author":"M Forgac","year":"2007","unstructured":"Forgac M (2007) Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nat Rev Mol Cell Biol 8(11):917\u2013929","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9\u201310","key":"351_CR67","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1242\/dmm.003319","volume":"2","author":"L Francione","year":"2009","unstructured":"Francione L, Smith PK, Accari SL, Taylor PE, Bokko PB, Bozzaro S et al (2009) Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells. Dis Model Mech 2(9\u201310):479\u2013489","journal-title":"Dis Model Mech"},{"issue":"10","key":"351_CR68","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.bcp.2011.07.071","volume":"82","author":"LM Francione","year":"2011","unstructured":"Francione LM, Fisher PR (2011) Heteroplasmic mitochondrial disease in Dictyostelium discoideum. Biochem Pharmacol 82(10):1510\u20131520","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"351_CR69","doi-asserted-by":"crossref","first-page":"e1002546","DOI":"10.1371\/journal.ppat.1002546","volume":"8","author":"IS Franco","year":"2012","unstructured":"Franco IS, Shohdy N, Shuman HA (2012) The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking. PLoS Pathog 8(2):e1002546 (Stebbins CE, editor)","journal-title":"PLoS Pathog"},{"issue":"10","key":"351_CR70","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1111\/j.1462-5822.2009.01351.x","volume":"11","author":"IS Franco","year":"2009","unstructured":"Franco IS, Shuman HA, Charpentier X (2009) The perplexing functions and surprising origins of Legionella pneumophila type IV secretion effectors. Cell Microbiol 11(10):1435\u20131443","journal-title":"Cell Microbiol"},{"issue":"4","key":"351_CR71","first-page":"183","volume":"4","author":"H Fujio","year":"1992","unstructured":"Fujio H, Yoshida S, Miyamoto H, Mitsuyama M, Mizuguchi Y (1992) Investigation of the role of macrophages and endogenous interferon-gamma in natural resistance of mice against Legionella pneumophila infection. FEMS Microbiol Immunol 4(4):183\u2013191","journal-title":"FEMS Microbiol Immunol"},{"issue":"1","key":"351_CR72","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1128\/jb.162.1.85-91.1985","volume":"162","author":"JE Gabay","year":"1985","unstructured":"Gabay JE, Blake M, Niles WD, Horwitz MA (1985) Purification of Legionella pneumophila major outer membrane protein and demonstration that it is a porin. J Bacteriol 162(1):85\u201391","journal-title":"J Bacteriol"},{"issue":"11","key":"351_CR73","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1128\/iai.65.11.4738-4746.1997","volume":"65","author":"LY Gao","year":"1997","unstructured":"Gao LY, Harb OS, Abu Kwaik Y (1997) Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa. Infect Immun 65(11):4738\u20134746","journal-title":"Infect Immun"},{"issue":"1","key":"351_CR74","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1462-2920.2000.00076.x","volume":"2","author":"LY Gao","year":"2000","unstructured":"Gao LY, Kwaik YA (2000) The mechanism of killing and exiting the protozoan host Acanthamoeba polyphaga by Legionella pneumophila. Environ Microbiol 2(1):79\u201390","journal-title":"Environ Microbiol"},{"issue":"6","key":"351_CR75","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1006\/mpat.1998.0237","volume":"25","author":"LY Gao","year":"1998","unstructured":"Gao LY, Stone BJ, Brieland JK, Abu Kwaik Y (1998) Different fates of Legionella pneumophila pmi and mil mutants within macrophages and alveolar epithelial cells. Microb Pathog 25(6):291\u2013306","journal-title":"Microb Pathog"},{"issue":"3","key":"351_CR76","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1128\/JB.180.3.505-513.1998","volume":"180","author":"RA Garduno","year":"1998","unstructured":"Garduno RA, Faulkner G, Trevors MA, Vats N, Hoffman PS (1998a) Immunolocalization of Hsp60 in Legionella pneumophila. J Bacteriol 180(3):505\u2013513","journal-title":"J Bacteriol"},{"issue":"5","key":"351_CR77","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1139\/w98-023","volume":"44","author":"RA Garduno","year":"1998","unstructured":"Garduno RA, Quinn FD, Hoffman PS (1998b) HeLa cells as a model to study the invasiveness and biology of Legionella pneumophila. Can J Microbiol 44(5):430\u2013440","journal-title":"Can J Microbiol"},{"issue":"33","key":"351_CR78","doi-asserted-by":"crossref","first-page":"13725","DOI":"10.1073\/pnas.0907200106","volume":"106","author":"J Ge","year":"2009","unstructured":"Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S et al (2009) A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors. Proc Natl Acad Sci U S A 106(33):13725\u201313730","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"351_CR79","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1139\/m94-137","volume":"40","author":"FC Gibson","year":"1994","unstructured":"Gibson FC, Tzianabos AO, Rodgers FG (1994) Adherence of Legionella pneumophila to U-937 cells, guinea-pig alveolar macrophages, and MRC-5 cells by a novel, complement-independent binding mechanism. Can J Microbiol 40(10):865\u2013872","journal-title":"Can J Microbiol"},{"issue":"1","key":"351_CR80","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1600-065X.2012.01096.x","volume":"246","author":"TD Gilmore","year":"2012","unstructured":"Gilmore TD, Wolenski FS (2012) NF-\u03baB: where did it come from and why? Immunol Rev 246(1):14\u201335","journal-title":"Immunol Rev"},{"issue":"Pt 2","key":"351_CR81","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1242\/jcs.00212","volume":"116","author":"R Girard","year":"2003","unstructured":"Girard R, Pedron T, Uematsu S, Balloy V, Chignard M, Akira S et al (2003) Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci 116(Pt 2):293\u2013302","journal-title":"J Cell Sci"},{"issue":"10","key":"351_CR82","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35096054","volume":"2","author":"J Gruenberg","year":"2001","unstructured":"Gruenberg J (2001) The endocytic pathway: a mosaic of domains. Nat Rev Mol Cell Biol 2(10):721\u2013730","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"351_CR83","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1248\/bpb.b11-00011","volume":"35","author":"T Harada","year":"2012","unstructured":"Harada T, Tanikawa T, Iwasaki Y, Yamada M, Imai Y, Miyake M (2012) Phagocytic entry of Legionella pneumophila into macrophages through phosphatidylinositol 3,4,5-trisphosphate-independent pathway. Biol Pharm Bull 35(9):1460\u20131468","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"351_CR84","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1128\/AEM.64.1.126-132.1998","volume":"64","author":"OS Harb","year":"1998","unstructured":"Harb OS, Venkataraman C, Haack BJ, Gao LY, Kwaik YA (1998) Heterogeneity in the attachment and uptake mechanisms of the Legionnaires\u2019 disease bacterium, Legionella pneumophila, by protozoan hosts. Appl Environ Microbiol 64(1):126\u2013132","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"351_CR203","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1128\/IAI.00510-12","volume":"80","author":"CR Harding","year":"2012","unstructured":"Harding CR, Schroeder GN, Reynolds S, Kosta A, Collins JW, Mousnier A, Frankel G (2012) Legionella pneumophila pathogenesis in the Galleria mellonella infection model. Infect Immun 80(8):2780\u20132790","journal-title":"Infect Immun"},{"issue":"3","key":"351_CR85","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/ars.2010.3684","volume":"15","author":"KT Hastings","year":"2011","unstructured":"Hastings KT, Cresswell P (2011) Disulfide reduction in the endocytic pathway: immunological functions of gamma-interferon-inducible lysosomal thiol reductase. Antioxid Redox Signal 15(3):657\u2013668","journal-title":"Antioxid Redox Signal"},{"issue":"10","key":"351_CR86","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.4049\/jimmunol.179.10.6981","volume":"179","author":"TR Hawn","year":"2007","unstructured":"Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A et al (2007) Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. J Immunol 179(10):6981\u20136987","journal-title":"J Immunol"},{"issue":"12","key":"351_CR87","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1086\/504525","volume":"193","author":"TR Hawn","year":"2006","unstructured":"Hawn TR, Smith KD, Aderem A, Skerrett SJ (2006) Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila. J Infect Dis 193(12):1693\u20131702","journal-title":"J Infect Dis"},{"issue":"5","key":"351_CR88","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1248\/bpb.31.861","volume":"31","author":"T Hayashi","year":"2008","unstructured":"Hayashi T, Miyake M, Fukui T, Sugaya N, Daimon T, Itoh S et al (2008) Exclusion of actin-binding protein p57\/coronin-1 from bacteria-containing phagosomes in macrophages infected with Legionella. Biol Pharm Bull 31(5):861\u2013865","journal-title":"Biol Pharm Bull"},{"issue":"2","key":"351_CR89","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1462-5822.2008.01249.x","volume":"11","author":"M Heidtman","year":"2009","unstructured":"Heidtman M, Chen EJ, Moy M-Y, Isberg RR (2009) Large-scale identification of Legionella pneumophila Dot\/Icm substrates that modulate host cell vesicle trafficking pathways. Cell Microbiol 11(2):230\u2013248","journal-title":"Cell Microbiol"},{"issue":"5","key":"351_CR90","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1128\/IAI.00805-10","volume":"79","author":"E Hervet","year":"2011","unstructured":"Hervet E, Charpentier X, Vianney A, Lazzaroni J-C, Gilbert C, Atlan D et al (2011) Protein kinase LegK2 is a type IV secretion system effector involved in endoplasmic reticulum recruitment and intracellular replication of Legionella pneumophila. Infect Immun 79(5):1936\u20131950","journal-title":"Infect Immun"},{"issue":"3","key":"351_CR91","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1365-2958.2001.02645.x","volume":"42","author":"H Hilbi","year":"2001","unstructured":"Hilbi H, Segal G, Shuman HA (2001) Icm\/dot-dependent upregulation of phagocytosis by Legionella pneumophila. Mol Microbiol 42(3):603\u2013617","journal-title":"Mol Microbiol"},{"issue":"7025","key":"351_CR92","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature03253","volume":"433","author":"K Hoebe","year":"2005","unstructured":"Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K et al (2005) CD36 is a sensor of diacylglycerides. Nature 433(7025):523\u2013527","journal-title":"Nature"},{"issue":"6","key":"351_CR93","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1084\/jem.158.6.2108","volume":"158","author":"MA Horwitz","year":"1983","unstructured":"Horwitz MA (1983a) The Legionnaires\u2019 disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J Exp Med 158(6):2108\u20132126","journal-title":"J Exp Med"},{"issue":"4","key":"351_CR94","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.158.4.1319","volume":"158","author":"MA Horwitz","year":"1983","unstructured":"Horwitz MA (1983b) Formation of a novel phagosome by the Legionnaires\u2019 disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med 158(4):1319\u20131331","journal-title":"J Exp Med"},{"issue":"1","key":"351_CR95","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0092-8674(84)90070-9","volume":"36","author":"MA Horwitz","year":"1984","unstructured":"Horwitz MA (1984) Phagocytosis of the Legionnaires\u2019 disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell 36(1):27\u201333","journal-title":"Cell"},{"issue":"6","key":"351_CR96","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1083\/jcb.99.6.1936","volume":"99","author":"MA Horwitz","year":"1984","unstructured":"Horwitz MA, Maxfield FR (1984) Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J Cell Biol 99(6):1936\u20131943","journal-title":"J Cell Biol"},{"issue":"34","key":"351_CR97","doi-asserted-by":"crossref","first-page":"13567","DOI":"10.1073\/pnas.1207903109","volume":"109","author":"F Hsu","year":"2012","unstructured":"Hsu F, Zhu W, Brennan L, Tao L, Luo Z-Q, Mao Y (2012) Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc Natl Acad Sci U S A 109(34):13567\u201313572","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"351_CR98","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-cellbio-100109-104034","volume":"26","author":"A Hubber","year":"2010","unstructured":"Hubber A, Roy CR (2010) Modulation of Host Cell Function by Legionella pneumophilaType IV Effectors. Annu Rev Cell Dev Biol 26(1):261\u2013283","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"12","key":"351_CR99","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1128\/iai.60.12.5212-5218.1992","volume":"60","author":"LK Husmann","year":"1992","unstructured":"Husmann LK, Johnson W (1992) Adherence of Legionella pneumophila to guinea pig peritoneal macrophages, J774 mouse macrophages, and undifferentiated U937 human monocytes: role of Fc and complement receptors. Infect Immun 60(12):5212\u20135218","journal-title":"Infect Immun"},{"issue":"7168","key":"351_CR100","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nature06336","volume":"450","author":"A Ingmundson","year":"2007","unstructured":"Ingmundson A, Delprato A, Lambright DG, Roy CR (2007) Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature 450(7168):365\u2013369","journal-title":"Nature"},{"issue":"1","key":"351_CR101","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrmicro1967","volume":"7","author":"RR Isberg","year":"2009","unstructured":"Isberg RR, O\u2019Connor TJ, Heidtman M (2009) The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat Rev Microbiol 7(1):13\u201324","journal-title":"Nat Rev Microbiol"},{"issue":"25","key":"351_CR102","doi-asserted-by":"crossref","first-page":"14657","DOI":"10.1074\/jbc.271.25.14657","volume":"271","author":"A Ito","year":"1996","unstructured":"Ito A, Mukaiyama A, Itoh Y, Nagase H, Thogersen IB, Enghild JJ et al (1996) Degradation of interleukin 1beta by matrix metalloproteinases. J Biol Chem 271(25):14657\u201314660","journal-title":"J Biol Chem"},{"issue":"45","key":"351_CR103","doi-asserted-by":"crossref","first-page":"34686","DOI":"10.1074\/jbc.M110.170746","volume":"285","author":"SS Ivanov","year":"2010","unstructured":"Ivanov SS, Charron G, Hang HC, Roy CR (2010) Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. J Biol Chem 285(45):34686\u201334698","journal-title":"J Biol Chem"},{"issue":"6652","key":"351_CR104","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/39622","volume":"389","author":"RS Jack","year":"1997","unstructured":"Jack RS, Fan X, Bernheiden M, Rune G, Ehlers M, Weber A et al (1997) Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection. Nature 389(6652):742\u2013745","journal-title":"Nature"},{"issue":"6","key":"351_CR105","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1462-5822.2012.01761.x","volume":"14","author":"T Jank","year":"2012","unstructured":"Jank T, B\u00f6hmer KE, Tzivelekidis T, Schwan C, Belyi Y, Aktories K (2012) Domain organization of Legionella effector SetA. Cell Microbiol 14(6):852\u2013868","journal-title":"Cell Microbiol"},{"issue":"12","key":"351_CR106","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/ncb883","volume":"4","author":"JC Kagan","year":"2002","unstructured":"Kagan JC, Roy CR (2002) Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nat Cell Biol 4(12):945\u2013954","journal-title":"Nat Cell Biol"},{"issue":"9","key":"351_CR107","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1084\/jem.20031706","volume":"199","author":"JC Kagan","year":"2004","unstructured":"Kagan JC, Stein M-P, Pypaert M, Roy CR (2004) Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. J Exp Med 199(9):1201\u20131211","journal-title":"J Exp Med"},{"issue":"8","key":"351_CR108","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1128\/IAI.69.8.5157-5161.2001","volume":"69","author":"N Khelef","year":"2001","unstructured":"Khelef N, Shuman HA, Maxfield FR (2001) Phagocytosis of wild-type Legionella pneumophila occurs through a wortmannin-insensitive pathway. Infect Immun 69(8):5157\u20135161","journal-title":"Infect Immun"},{"issue":"5","key":"351_CR109","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/eji.201242835","volume":"43","author":"AA Khweek","year":"2013","unstructured":"Khweek AA, Caution K, Akhter A, Abdulrahman BA, Tazi M, Hassan H et al (2013) A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy. Eur J Immunol 43(5):1333\u20131344","journal-title":"Eur J Immunol"},{"issue":"4","key":"351_CR110","doi-asserted-by":"crossref","first-page":"263","DOI":"10.7888\/juoeh.16.263","volume":"16","author":"H Kikuhara","year":"1994","unstructured":"Kikuhara H, Ogawa M, Miyamoto H, Nikaido Y, Yoshida S (1994) Intracellular multiplication of Legionella pneumophila in Tetrahymena thermophila. J UOEH 16(4):263\u2013275","journal-title":"J UOEH"},{"issue":"3","key":"351_CR111","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1128\/iai.59.3.758-763.1991","volume":"59","author":"CH King","year":"1991","unstructured":"King CH, Fields BS, Shotts EB, White EH (1991) Effects of cytochalasin D and methylamine on intracellular growth of Legionella pneumophila in amoebae and human monocyte-like cells. Infect Immun 59(3):758\u2013763","journal-title":"Infect Immun"},{"key":"351_CR112","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.cb.05.110189.002411","volume":"5","author":"S Kornfeld","year":"1989","unstructured":"Kornfeld S, Mellman I (1989) The biogenesis of lysosomes. Annu Rev Cell Biol 5:483\u2013525","journal-title":"Annu Rev Cell Biol"},{"issue":"6","key":"351_CR113","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/PL00008649","volume":"262","author":"R K\u00f6hler","year":"2000","unstructured":"K\u00f6hler R, Bubert A, Goebel W, Steinert M, Hacker J, Bubert B (2000) Expression and use of the green fluorescent protein as a reporter system in Legionella pneumophila. Mol Gen Genet 262(6):1060\u20131069","journal-title":"Mol Gen Genet"},{"issue":"4","key":"351_CR114","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1042\/BST0391039","volume":"39","author":"BC Krasity","year":"2011","unstructured":"Krasity BC, Troll JV, Weiss JP, McFall-Ngai MJ (2011) LBP\/BPI proteins and their relatives: conservation over evolution and roles in mutualism. Biochem Soc Trans 39(4):1039\u20131044","journal-title":"Biochem Soc Trans"},{"issue":"2","key":"351_CR115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1365-2672.1999.00667.x","volume":"86","author":"C Krinos","year":"1999","unstructured":"Krinos C, High AS, Rodgers FG (1999) Role of the 25\u00a0kDa major outer membrane protein of Legionella pneumophila in attachment to U-937 cells and its potential as a virulence factor for chick embryos. J Appl Microbiol 86(2):237\u2013244","journal-title":"J Appl Microbiol"},{"issue":"12","key":"351_CR116","doi-asserted-by":"crossref","first-page":"e1003082","DOI":"10.1371\/journal.ppat.1003082","volume":"8","author":"B Ku","year":"2012","unstructured":"Ku B, Lee K-H, Park WS, Yang C-S, Ge J, Lee S-G et al (2012) VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. PLoS Pathog 8(12):e1003082","journal-title":"PLoS Pathog"},{"issue":"6","key":"351_CR117","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/j.1365-2958.2008.06124.x","volume":"67","author":"T Kubori","year":"2008","unstructured":"Kubori T, Hyakutake A, Nagai H (2008) Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions. Mol Microbiol 67(6):1307\u20131319","journal-title":"Mol Microbiol"},{"issue":"49","key":"351_CR118","doi-asserted-by":"crossref","first-page":"18745","DOI":"10.1073\/pnas.0609012103","volume":"103","author":"RK Laguna","year":"2006","unstructured":"Laguna RK, Creasey EA, Li Z, Valtz N, Isberg RR (2006) A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death. Proc Natl Acad Sci U S A 103(49):18745\u201318750","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"351_CR119","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1365-2672.2009.04208.x","volume":"107","author":"HY Lau","year":"2009","unstructured":"Lau HY, Ashbolt NJ (2009) The role of biofilms and protozoa in Legionella pathogenesis: implications for drinking water. J Appl Microbiol 107(2):368\u2013378","journal-title":"J Appl Microbiol"},{"issue":"8","key":"351_CR120","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.4049\/jimmunol.173.8.5171","volume":"173","author":"CKF Li","year":"2004","unstructured":"Li CKF, Pender SLF, Pickard KM, Chance V, Holloway JA, Huett A et al (2004) Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. J. Immunol. 173(8):5171\u20135179","journal-title":"J. Immunol."},{"issue":"3","key":"351_CR121","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.chom.2009.08.005","volume":"6","author":"Z Li","year":"2009","unstructured":"Li Z, Dugan AS, Bloomfield G, Skelton J, Ivens A, Losick V et al (2009) The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe. 6(3):253\u2013267","journal-title":"Cell Host Microbe."},{"issue":"8","key":"351_CR122","doi-asserted-by":"crossref","first-page":"E707","DOI":"10.1073\/pnas.1215278110","volume":"110","author":"Z Lifshitz","year":"2013","unstructured":"Lifshitz Z, Burstein D, Peeri M, Zusman T, Schwartz K, Shuman HA et al (2013) Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal. Proc. Natl. Acad. Sci. U.S.A. 110(8):E707\u2013E715","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"10","key":"351_CR123","first-page":"1171","volume":"9","author":"KL Lightfield","year":"2008","unstructured":"Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA et al (2008) Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Publ Group 9(10):1171\u20131178","journal-title":"Nat Publ Group"},{"issue":"9","key":"351_CR124","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/j.1462-5822.2008.01180.x","volume":"10","author":"M Liu","year":"2008","unstructured":"Liu M, Conover GM, Isberg RR (2008) Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor \u03b1-stimulated macrophages. Cell Microbiol 10(9):1906\u20131923","journal-title":"Cell Microbiol"},{"issue":"2","key":"351_CR125","first-page":"11","volume":"12","author":"M Liu","year":"2012","unstructured":"Liu M, Haenssler E, Uehara T, Losick VP, Park JT, Isberg RR (2012) The Legionella pneumophila EnhC Protein Interferes with immunostimulatory muramyl peptide production to evade innate immunity. Cell Host Microbe 12(2):11","journal-title":"Cell Host Microbe"},{"issue":"2","key":"351_CR126","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/IAI.01278-06","volume":"75","author":"Y Liu","year":"2007","unstructured":"Liu Y, Luo Z-Q (2007) The Legionella pneumophila effector SidJ is required for efficient recruitment of endoplasmic reticulum proteins to the bacterial phagosome. Infect Immun 75(2):592\u2013603","journal-title":"Infect Immun"},{"issue":"9","key":"351_CR127","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1462-5822.2010.01467.x","volume":"12","author":"M Lomma","year":"2010","unstructured":"Lomma M, Dervins-Ravault D, Rolando M, Nora T, Newton HJ, Sansom FM et al (2010) The Legionella pneumophila F-box protein Lpp 2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication. Cell Microbiol 12(9):1272\u20131291","journal-title":"Cell Microbiol"},{"issue":"8","key":"351_CR128","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1462-5822.2010.01452.x","volume":"12","author":"VP Losick","year":"2010","unstructured":"Losick VP, Haenssler E, Moy M-Y, Isberg RR (2010) LnaB: a Legionella pneumophila activator of NF-kappa B. Cell Microbiol 12(8):1083\u20131097","journal-title":"Cell Microbiol"},{"issue":"9","key":"351_CR129","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1084\/jem.20060766","volume":"203","author":"VP Losick","year":"2006","unstructured":"Losick VP, Isberg RR (2006) NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. J Exp Med 203(9):2177\u20132189","journal-title":"J Exp Med"},{"issue":"7","key":"351_CR130","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1462-5822.2005.00528.x","volume":"7","author":"H Lu","year":"2005","unstructured":"Lu H, Clarke M (2005) Dynamic properties of Legionella-containing phagosomes in Dictyostelium amoebae. Cell Microbiol 7(7):995\u20131007","journal-title":"Cell Microbiol"},{"issue":"3","key":"351_CR131","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.0304916101","volume":"101","author":"Z-Q Luo","year":"2004","unstructured":"Luo Z-Q, Isberg RR (2004) Multiple substrates of the Legionella pneumophila Dot\/Icm system identified by interbacterial protein transfer. Proc Natl Acad Sci U S A 101(3):841\u2013846","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"351_CR132","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.devcel.2006.05.013","volume":"11","author":"MP Machner","year":"2006","unstructured":"Machner MP, Isberg RR (2006) Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell 11(1):47\u201356","journal-title":"Dev Cell"},{"issue":"10","key":"351_CR133","doi-asserted-by":"crossref","first-page":"e48018","DOI":"10.1371\/journal.pone.0048018","volume":"7","author":"R McDonald","year":"2012","unstructured":"McDonald R, Schreier HJ, Watts JEM (2012) Phylogenetic analysis of microbial communities in different regions of the gastrointestinal tract in Panaque nigrolineatus, a wood-eating fish. PLoS ONE 7(10):e48018 (Ravel J, editor)","journal-title":"PLoS ONE"},{"issue":"1","key":"351_CR134","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/iai.60.1.296-301.1992","volume":"60","author":"JF Moffat","year":"1992","unstructured":"Moffat JF, Tompkins LS (1992) A quantitative model of intracellular growth of Legionella pneumophila in Acanthamoeba castellanii. Infect Immun 60(1):296\u2013301","journal-title":"Infect Immun"},{"issue":"1","key":"351_CR135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1128\/AEM.71.1.20-28.2005","volume":"71","author":"M Molmeret","year":"2005","unstructured":"Molmeret M, Horn M, Wagner M, Santic M, Abu Kwaik Y (2005) Amoebae as training grounds for intracellular bacterial pathogens. Appl Environ Microbiol 71(1):20\u201328","journal-title":"Appl Environ Microbiol"},{"issue":"9","key":"351_CR136","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb1463","volume":"8","author":"T Murata","year":"2006","unstructured":"Murata T, Delprato A, Ingmundson A, Toomre DK, Lambright DG, Roy CR (2006) The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor. Nat Cell Biol 8(9):971\u2013977","journal-title":"Nat Cell Biol"},{"issue":"5555","key":"351_CR137","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.1067025","volume":"295","author":"H Nagai","year":"2002","unstructured":"Nagai H, Kagan JC, Zhu X, Kahn RA, Roy CR (2002) A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science 295(5555):679\u2013682","journal-title":"Science"},{"key":"351_CR138","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fmicb.2011.00136","volume":"2","author":"H Nagai","year":"2011","unstructured":"Nagai H, Kubori T (2011) Type IVB secretion systems of legionella and other gram-negative bacteria. Front Microbiol 2:136","journal-title":"Front Microbiol"},{"issue":"1","key":"351_CR139","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0021-9258(18)54107-7","volume":"268","author":"H Nakanishi","year":"1993","unstructured":"Nakanishi H, Brewer KA, Exton JH (1993) Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 268(1):13\u201316","journal-title":"J Biol Chem"},{"issue":"6041","key":"351_CR140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.1207193","volume":"333","author":"MR Neunuebel","year":"2011","unstructured":"Neunuebel MR, Chen Y, Gaspar AH, Backlund PS, Yergey A, Machner MP (2011) De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science 333(6041):453\u2013456","journal-title":"Science"},{"issue":"2","key":"351_CR141","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/iai.50.2.449-452.1985","volume":"50","author":"AL Newsome","year":"1985","unstructured":"Newsome AL, Baker RL, Miller RD, Arnold RR (1985) Interactions between Naegleria fowleri and Legionella pneumophila. Infect Immun 50(2):449\u2013452","journal-title":"Infect Immun"},{"issue":"7","key":"351_CR142","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1128\/IAI.00209-08","volume":"76","author":"HJ Newton","year":"2008","unstructured":"Newton HJ, Sansom FM, Dao J, Cazalet C, Bruggemann H, Albert-Weissenberger C et al (2008) Significant role for ladC in initiation of Legionella pneumophila infection. Infect Immun 76(7):3075\u20133085","journal-title":"Infect Immun"},{"issue":"1","key":"351_CR143","doi-asserted-by":"crossref","first-page":"e1000278","DOI":"10.1371\/journal.ppat.1000278","volume":"5","author":"S Ninio","year":"2009","unstructured":"Ninio S, Celli J, Roy CR (2009) A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot\/Icm-modified vacuoles. PLoS Pathog 5(1):e1000278","journal-title":"PLoS Pathog"},{"issue":"6","key":"351_CR144","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2217\/fmb.09.47","volume":"4","author":"T Nora","year":"2009","unstructured":"Nora T, Lomma M, Gomez-Valero L, Buchrieser C (2009) Molecular mimicry: an important virulence strategy employed by Legionella pneumophila to subvert host functions. Future Microbiol 4(6):691\u2013701","journal-title":"Future Microbiol"},{"issue":"5883","key":"351_CR145","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1126\/science.1158160","volume":"320","author":"X Pan","year":"2008","unstructured":"Pan X, L\u00fchrmann A, Satoh A, Laskowski-Arce MA, Roy CR (2008) Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science 320(5883):1651\u20131654","journal-title":"Science"},{"issue":"5","key":"351_CR146","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1084\/jem.166.5.1377","volume":"166","author":"NR Payne","year":"1987","unstructured":"Payne NR, Horwitz MA (1987) Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors. J Exp Med 166(5):1377\u20131389","journal-title":"J Exp Med"},{"issue":"Pt 23","key":"351_CR147","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1242\/jcs.072124","volume":"123","author":"B Peracino","year":"2010","unstructured":"Peracino B, Balest A, Bozzaro S (2010) Phosphoinositides differentially regulate bacterial uptake and Nramp1-induced resistance to Legionella infection in Dictyostelium. J Cell Sci 123(Pt 23):4039\u20134051","journal-title":"J Cell Sci"},{"issue":"1","key":"351_CR148","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0854.2005.00356.x","volume":"7","author":"B Peracino","year":"2006","unstructured":"Peracino B, Wagner C, Balest A, Balbo A, Pergolizzi B, Noegel AA et al (2006) Function and mechanism of action of Dictyostelium Nramp1 (Slc11a1) in bacterial infection. Traffic 7(1):22\u201338","journal-title":"Traffic"},{"issue":"12","key":"351_CR149","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.4049\/jimmunol.1003784","volume":"187","author":"MSF Pereira","year":"2011","unstructured":"Pereira MSF, Morgantetti GF, Massis LM, Horta CV, Hori JI, Zamboni DS (2011) Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo. J Immunol 187(12):6447\u20136455","journal-title":"J Immunol"},{"issue":"10","key":"351_CR150","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1111\/j.1462-5822.2012.01828.x","volume":"14","author":"A Prashar","year":"2012","unstructured":"Prashar A, Bhatia S, Tabatabaeiyazdi Z, Duncan C, Gardu\u00f1o RA, Tang P et al (2012) Mechanism of invasion of lung epithelial cells by filamentous Legionella pneumophila. Cell Microbiol 14(10):1632\u20131655","journal-title":"Cell Microbiol"},{"issue":"5","key":"351_CR151","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1128\/IAI.01450-09","volume":"78","author":"CTD Price","year":"2010","unstructured":"Price CTD, Al-Khodor S, Al-Quadan T, Abu Kwaik Y (2010a) Indispensable role for the eukaryotic-like ankyrin domains of the ankyrin B effector of Legionella pneumophila within macrophages and amoebae. Infect Immun 78(5):2079\u20132088","journal-title":"Infect Immun"},{"issue":"8","key":"351_CR152","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.20100771","volume":"207","author":"CTD Price","year":"2010","unstructured":"Price CTD, Al-Quadan T, Santic M, Jones SC, Abu Kwaik Y (2010b) Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila. J Exp Med 207(8):1713\u20131726","journal-title":"J Exp Med"},{"issue":"6062","key":"351_CR153","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1212868","volume":"334","author":"CTD Price","year":"2011","unstructured":"Price CTD, Al-Quadan T, Santic M, Rosenshine I, Abu Kwaik Y (2011) Host proteasomal degradation generates amino acids essential for intracellular bacterial growth. Science 334(6062):1553\u20131557","journal-title":"Science"},{"issue":"12","key":"351_CR154","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1111\/j.1462-5822.2008.01219.x","volume":"10","author":"C Ragaz","year":"2008","unstructured":"Ragaz C, Pietsch H, Urwyler S, Tiaden A, Weber SS, Hilbi H (2008) The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole. Cell Microbiol 10(12):2416\u20132433","journal-title":"Cell Microbiol"},{"issue":"2","key":"351_CR155","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1699-0463.1989.tb00763.x","volume":"97","author":"C Rechnitzer","year":"1989","unstructured":"Rechnitzer C, Blom J (1989) Engulfment of the Philadelphia strain of Legionella pneumophila within pseudopod coils in human phagocytes. Comparison with other Legionella strains and species. APMIS 97(2):105\u2013114","journal-title":"APMIS"},{"issue":"4","key":"351_CR156","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4161\/viru.24290","volume":"4","author":"AM Richards","year":"2013","unstructured":"Richards AM, Dwingelo Von JE, Price CT, Abu Kwaik Y (2013) Cellular microbiology and molecular ecology of Legionella-amoeba interaction. Virulence 4(4):307\u2013314","journal-title":"Virulence"},{"issue":"10","key":"351_CR157","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0966-842X(98)01343-2","volume":"6","author":"MG Rittig","year":"1998","unstructured":"Rittig MG, Burmester GR, Krause A (1998) Coiling phagocytosis: when the zipper jams, the cup is deformed. Trends Microbiol 6(10):384\u2013388","journal-title":"Trends Microbiol"},{"issue":"5","key":"351_CR158","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1462-5822.2005.00666.x","volume":"8","author":"CG Robinson","year":"2006","unstructured":"Robinson CG, Roy CR (2006) Attachment and fusion of endoplasmic reticulum with vacuoles containing Legionella pneumophila. Cell Microbiol 8(5):793\u2013805","journal-title":"Cell Microbiol"},{"issue":"7","key":"351_CR159","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1139\/m93-103","volume":"39","author":"FG Rodgers","year":"1993","unstructured":"Rodgers FG, Gibson FC (1993) Opsonin-independent adherence and intracellular development of Legionella pneumophila within U-937 cells. Can J Microbiol 39(7):718\u2013722","journal-title":"Can J Microbiol"},{"issue":"12","key":"351_CR160","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1074\/jbc.M312741200","volume":"279","author":"C Roisin-Bouffay","year":"2004","unstructured":"Roisin-Bouffay C, Luciani M-F, Klein G, Levraud J-P, Adam M, Golstein P (2004) Developmental cell death in dictyostelium does not require paracaspase. J Biol Chem 279(12):11489\u201311494","journal-title":"J Biol Chem"},{"issue":"3","key":"351_CR161","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2217\/fmb.12.9","volume":"7","author":"M Rolando","year":"2012","unstructured":"Rolando M, Buchrieser C (2012) Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol 7(3):369\u2013381","journal-title":"Future Microbiol"},{"issue":"2","key":"351_CR162","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nri1775","volume":"6","author":"CR Roy","year":"2006","unstructured":"Roy CR, Salcedo SP, Gorvel J-PE (2006) Pathogen-endoplasmic-reticulum interactions: in through the out door. Nat Rev Immunol 6(2):136\u2013147","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"351_CR163","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/embor.2010.97","volume":"11","author":"S Schoebel","year":"2010","unstructured":"Schoebel S, Blankenfeldt W, Goody RS, Itzen A (2010) High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep 11(8):598\u2013604","journal-title":"EMBO Rep"},{"issue":"3","key":"351_CR164","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/molbev\/msq309","volume":"28","author":"A Seb\u00e9-Pedr\u00f3s","year":"2011","unstructured":"Seb\u00e9-Pedr\u00f3s A, de Mendoza A, Lang BF, Degnan BM, Ruiz-Trillo I (2011) Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki. Mol Biol Evol 28(3):1241\u20131254","journal-title":"Mol Biol Evol"},{"issue":"2","key":"351_CR165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1574-6968.2010.01976.x","volume":"307","author":"EM Seeger","year":"2010","unstructured":"Seeger EM, Thuma M, Fernandez-Moreira E, Jacobs E, Schmitz M, Helbig JH (2010) Lipopolysaccharide of Legionella pneumophila shed in a liquid culture as a nonvesicular fraction arrests phagosome maturation in amoeba and monocytic host cells. FEMS Microbiol Lett 307(2):113\u2013119","journal-title":"FEMS Microbiol Lett"},{"issue":"5","key":"351_CR166","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1128\/IAI.67.5.2117-2124.1999","volume":"67","author":"G Segal","year":"1999","unstructured":"Segal G, Shuman HA (1999) Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages. Infect Immun 67(5):2117\u20132124","journal-title":"Infect Immun"},{"issue":"7","key":"351_CR167","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ijmm.2009.03.006","volume":"299","author":"O Shevchuk","year":"2009","unstructured":"Shevchuk O, Batzilla C, H\u00e4gele S, Kusch H, Engelmann S, Hecker M et al (2009) Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium. Int J Med Microbiol 299(7):489\u2013508","journal-title":"Int J Med Microbiol"},{"key":"351_CR168","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/B978-0-12-394318-7.00003-6","volume":"79","author":"S Shin","year":"2012","unstructured":"Shin S (2012) Innate Immunity to Intracellular Pathogens: Lessons Learned from Legionella pneumophila. Adv Appl Microbiol 79:43\u201371","journal-title":"Adv Appl Microbiol"},{"issue":"11","key":"351_CR169","doi-asserted-by":"crossref","first-page":"e1000220","DOI":"10.1371\/journal.ppat.1000220","volume":"4","author":"S Shin","year":"2008","unstructured":"Shin S, Case CL, Archer KA, Nogueira CV, Kobayashi KS, Flavell RA et al (2008) Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS Pathog 4(11):e1000220","journal-title":"PLoS Pathog"},{"issue":"13","key":"351_CR170","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1073\/pnas.0501315102","volume":"102","author":"N Shohdy","year":"2005","unstructured":"Shohdy N, Efe JA, Emr SD, Shuman HA (2005) Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking. Proc Natl Acad Sci U S A 102(13):4866\u20134871","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"351_CR171","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1128\/IAI.68.5.2939-2947.2000","volume":"68","author":"JM Solomon","year":"2000","unstructured":"Solomon JM, Rupper A, Cardelli JA, Isberg RR (2000) Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions. Infect Immun 68(5):2939\u20132947","journal-title":"Infect Immun"},{"issue":"4","key":"351_CR172","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1128\/IAI.66.4.1768-1775.1998","volume":"66","author":"BJ Stone","year":"1998","unstructured":"Stone BJ, Abu Kwaik Y (1998) Expression of multiple pili by Legionella pneumophila: identification and characterization of a type IV pilin gene and its role in adherence to mammalian and protozoan cells. Infect Immun 66(4):1768\u20131775","journal-title":"Infect Immun"},{"key":"351_CR173","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.mi.47.100193.003025","volume":"47","author":"MS Strom","year":"1993","unstructured":"Strom MS, Lory S (1993) Structure-function and biogenesis of the type IV pili. Annu Rev Microbiol 47:565\u2013596","journal-title":"Annu Rev Microbiol"},{"issue":"5147","key":"351_CR174","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.8303277","volume":"263","author":"S Sturgill-Koszycki","year":"1994","unstructured":"Sturgill-Koszycki S, Schlesinger PH, Chakraborty P, Haddix PL, Collins HL, Fok AK et al (1994) Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263(5147):678\u2013681","journal-title":"Science"},{"issue":"9","key":"351_CR175","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.192.9.1261","volume":"192","author":"S Sturgill-Koszycki","year":"2000","unstructured":"Sturgill-Koszycki S, Swanson MS (2000) Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles. J Exp Med 192(9):1261\u20131272","journal-title":"J Exp Med"},{"issue":"4","key":"351_CR176","doi-asserted-by":"crossref","first-page":"e62972","DOI":"10.1371\/journal.pone.0062972","volume":"8","author":"EW Sun","year":"2013","unstructured":"Sun EW, Wagner ML, Maize A, Kemler D, Garland-Kuntz E, Xu L et al (2013) Legionella pneumophila infection of Drosophila S2 cells induces only minor changes in mitochondrial dynamics. PLoS ONE 8(4):e62972","journal-title":"PLoS ONE"},{"key":"351_CR177","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev.micro.54.1.567","volume":"54","author":"MS Swanson","year":"2000","unstructured":"Swanson MS, Hammer BK (2000) Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages. Annu Rev Microbiol 54:567\u2013613","journal-title":"Annu Rev Microbiol"},{"issue":"10","key":"351_CR178","doi-asserted-by":"crossref","first-page":"e3324","DOI":"10.1371\/journal.pone.0003324","volume":"3","author":"SD Tachado","year":"2008","unstructured":"Tachado SD, Samrakandi MM, Cirillo JD (2008) Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase. PLoS ONE 3(10):e3324","journal-title":"PLoS ONE"},{"key":"351_CR179","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","volume":"21","author":"K Takeda","year":"2003","unstructured":"Takeda K, Kaisho T, Akira S (2003) Toll-like receptors. Annu Rev Immunol 21:335\u2013376","journal-title":"Annu Rev Immunol"},{"issue":"52","key":"351_CR180","doi-asserted-by":"crossref","first-page":"21212","DOI":"10.1073\/pnas.1114023109","volume":"108","author":"Y Tan","year":"2011","unstructured":"Tan Y, Arnold RJ, Luo Z-Q (2011) Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination. Proc Natl Acad Sci U S A 108(52):21212\u201321217","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7357","key":"351_CR181","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature10307","volume":"475","author":"Y Tan","year":"2011","unstructured":"Tan Y, Luo Z-Q (2011) Legionella pneumophila SidD is a deAMPylase that modifies Rab1. Nature 475(7357):506\u2013509","journal-title":"Nature"},{"issue":"3","key":"351_CR182","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1189\/jlb.0212053","volume":"92","author":"EP Thi","year":"2012","unstructured":"Thi EP, Reiner NE (2012) Phosphatidylinositol 3-kinases and their roles in phagosome maturation. J Leukoc Biol 92(3):553\u2013566","journal-title":"J Leukoc Biol"},{"issue":"6372","key":"351_CR183","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","volume":"356","author":"NA Thornberry","year":"1992","unstructured":"Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ et al (1992) A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356(6372):768\u2013774","journal-title":"Nature"},{"issue":"Pt 24","key":"351_CR184","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1242\/jcs.114.24.4637","volume":"114","author":"LG Tilney","year":"2001","unstructured":"Tilney LG, Harb OS, Connelly PS, Robinson CG, Roy CR (2001) How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. J Cell Sci 114(Pt 24):4637\u20134650","journal-title":"J Cell Sci"},{"issue":"3","key":"351_CR185","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1083\/jcb.144.3.413","volume":"144","author":"F Uberall","year":"1999","unstructured":"Uberall F, Hellbert K, Kampfer S, Maly K, Villunger A, Spitaler M et al (1999) Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton. J Cell Biol 144(3):413\u2013425","journal-title":"J Cell Biol"},{"issue":"2","key":"351_CR186","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4161\/cib.7713","volume":"2","author":"S Urwyler","year":"2009","unstructured":"Urwyler S, Brombacher E, Hilbi H (2009a) Endosomal and secretory markers of the Legionella-containing vacuole. Commun Integr Biol 2(2):107\u2013109","journal-title":"Commun Integr Biol"},{"issue":"1","key":"351_CR187","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0854.2008.00851.x","volume":"10","author":"S Urwyler","year":"2009","unstructured":"Urwyler S, Nyfeler Y, Ragaz C, Lee H, Mueller LN, Aebersold R et al (2009b) Proteome analysis of Legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPases. Traffic 10(1):76\u201387","journal-title":"Traffic"},{"issue":"2","key":"351_CR188","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1574-6968.2010.01951.x","volume":"306","author":"L Vandersmissen","year":"2010","unstructured":"Vandersmissen L, De Buck E, Saels V, Coil DA, Ann\u00e9 J (2010) A Legionella pneumophilacollagen-like protein encoded by a gene with a variable number of tandem repeats is involved in the adherence and invasion of host cells. FEMS Microbiol Lett 306(2):168\u2013176","journal-title":"FEMS Microbiol Lett"},{"issue":"6","key":"351_CR189","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1128\/IAI.02060-05","volume":"74","author":"SM VanRheenen","year":"2006","unstructured":"VanRheenen SM, Luo Z-Q, O\u2019Connor T, Isberg RR (2006) Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun 74(6):3597\u20133606","journal-title":"Infect Immun"},{"issue":"4","key":"351_CR190","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1084\/jem.186.4.537","volume":"186","author":"C Venkataraman","year":"1997","unstructured":"Venkataraman C, Haack BJ, Bondada S, Abu Kwaik Y (1997) Identification of a Gal\/GalNAc lectin in the protozoan Hartmannella vermiformis as a potential receptor for attachment and invasion by the Legionnaires\u2019 disease bacterium. J Exp Med 186(4):537\u2013547","journal-title":"J Exp Med"},{"issue":"Pt 3","key":"351_CR191","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1042\/bj20020691","volume":"366","author":"OV Vieira","year":"2002","unstructured":"Vieira OV, Botelho RJ, Grinstein S (2002) Phagosome maturation: aging gracefully. Biochem J 366(Pt 3):689\u2013704","journal-title":"Biochem J"},{"issue":"10","key":"351_CR192","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.4049\/jimmunol.180.10.6808","volume":"180","author":"M Vinzing","year":"2008","unstructured":"Vinzing M, Eitel J, Lippmann J, Hocke AC, Zahlten J, Slevogt H et al (2008) NAIP and Ipaf control Legionella pneumophila replication in human cells. J Immunol 180(10):6808\u20136815","journal-title":"J Immunol"},{"issue":"2","key":"351_CR193","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.dci.2008.08.008","volume":"33","author":"Y Watanabe","year":"2009","unstructured":"Watanabe Y, Tateno H, Nakamura-Tsuruta S, Kominami J, Hirabayashi J, Nakamura O et al (2009) The function of rhamnose-binding lectin in innate immunity by restricted binding to Gb3. Dev Comp Immunol 33(2):187\u2013197","journal-title":"Dev Comp Immunol"},{"issue":"5","key":"351_CR194","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1371\/journal.ppat.0020046","volume":"2","author":"SS Weber","year":"2006","unstructured":"Weber SS, Ragaz C, Reus K, Nyfeler Y, Hilbi H (2006) Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. PLoS Pathog 2(5):e46","journal-title":"PLoS Pathog"},{"issue":"3","key":"351_CR195","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1128\/IAI.72.3.1512-1518.2004","volume":"72","author":"CT Welsh","year":"2004","unstructured":"Welsh CT, Summersgill JT, Miller RD (2004) Increases in c-Jun N-terminal kinase\/stress-activated protein kinase and p38 activity in monocyte-derived macrophages following the uptake of Legionella pneumophila. Infect Immun 72(3):1512\u20131518","journal-title":"Infect Immun"},{"issue":"3","key":"351_CR196","doi-asserted-by":"crossref","first-page":"e1000822","DOI":"10.1371\/journal.ppat.1000822","volume":"6","author":"L Xu","year":"2010","unstructured":"Xu L, Shen X, Bryan A, Banga S, Swanson MS, Luo Z-Q (2010) Inhibition of host vacuolar H\u00a0+\u00a0-ATPase activity by a Legionella pneumophila effector. PLoS Pathog 6(3):e1000822","journal-title":"PLoS Pathog"},{"issue":"7","key":"351_CR197","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1091\/mbc.e04-11-0989","volume":"16","author":"M Yan","year":"2005","unstructured":"Yan M, Collins RF, Grinstein S, Trimble WS (2005) Coronin-1 function is required for phagosome formation. Mol Biol Cell 16(7):3077\u20133087","journal-title":"Mol Biol Cell"},{"issue":"3","key":"351_CR198","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ni1305","volume":"7","author":"DS Zamboni","year":"2006","unstructured":"Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE et al (2006) The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol 7(3):318\u2013325","journal-title":"Nat Immunol"},{"issue":"5","key":"351_CR199","doi-asserted-by":"crossref","first-page":"e5706","DOI":"10.1371\/journal.pone.0005706","volume":"4","author":"C Zhang","year":"2009","unstructured":"Zhang C, Kuspa A (2009) Transcriptional down-regulation and rRNA cleavage in Dictyostelium discoideum mitochondria during Legionella pneumophila infection. PLoS ONE 4(5):e5706","journal-title":"PLoS ONE"},{"issue":"7366","key":"351_CR200","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature10510","volume":"477","author":"Y Zhao","year":"2011","unstructured":"Zhao Y, Yang J, Shi J, Gong Y-N, Lu Q, Xu H et al (2011) The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477(7366):596\u2013600","journal-title":"Nature"},{"issue":"3","key":"351_CR201","doi-asserted-by":"crossref","first-page":"e17638","DOI":"10.1371\/journal.pone.0017638","volume":"6","author":"W Zhu","year":"2011","unstructured":"Zhu W, Banga S, Tan Y, Zheng C, Stephenson R, Gately J et al (2011) Comprehensive identification of protein substrates of the Dot\/Icm type IV transporter of Legionella pneumophila. PLoS ONE 6(3):e17638","journal-title":"PLoS ONE"}],"container-title":["Current Topics in Microbiology and Immunology","Molecular Mechanisms in Legionella Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/82_2013_351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T12:06:51Z","timestamp":1674130011000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/82_2013_351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9783642405907","9783642405914"],"references-count":203,"URL":"https:\/\/doi.org\/10.1007\/82_2013_351","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"15 August 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}