{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:23:38Z","timestamp":1790774618883,"version":"4.1.0"},"publisher-location":"Cham","reference-count":55,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319295541","type":"print"},{"value":"9783319295565","type":"electronic"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/82_2015_5020","type":"book-chapter","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T10:23:30Z","timestamp":1453890210000},"page":"131-148","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Many Facets of Lipooligosaccharide as a Virulence Factor for Histophilus somni"],"prefix":"10.1007","author":[{"given":"Thomas J.","family":"Inzana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"5020_CR1","first-page":"167","volume":"7","author":"C Alexander","year":"2001","unstructured":"Alexander C, Rietschel ET (2001) Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 7:167\u2013202","journal-title":"J Endotoxin Res"},{"key":"5020_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fcimb.2012.00019","volume":"2","author":"MA Apicella","year":"2012","unstructured":"Apicella MA (2012) Nontypeable Haemophilus influenzae: the role of N-acetyl-5-neuraminic acid in biology. Front Cell Infect Microbiol 2:19","journal-title":"Front Cell Infect Microbiol"},{"key":"5020_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1128\/9781555817671.ch14","volume-title":"The innate imune response to infection","author":"GM Barton","year":"2004","unstructured":"Barton GM, Pasare C, Medzhitov R (2004) Toll-Like Receptors and Control of Adaptive Immunity. In: Kaufmann SHE, Medzhitov R, Gordon S (eds) The innate imune response to infection. ASM Press, Washington, D.C., pp 271\u2013285"},{"key":"5020_CR4","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1574-695X.2002.tb00633.x","volume":"34","author":"AW Berrington","year":"2002","unstructured":"Berrington AW, Tan YC, Srikhanta Y, Kuipers B, van der Ley P, Peak IR, Jennings MP (2002) Phase variation in meningococcal lipooligosaccharide biosynthesis genes. FEMS Immunol Med Microbiol 34:267\u2013275","journal-title":"FEMS Immunol Med Microbiol"},{"key":"5020_CR5","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1128\/IAI.01168-12","volume":"81","author":"SE Clark","year":"2013","unstructured":"Clark SE, Weiser JN (2013) Microbial modulation of host immunity with the small molecule phosphorylcholine. Infect Immun 81:392\u2013401","journal-title":"Infect Immun"},{"key":"5020_CR6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/JCM.22.2.192-198.1985","volume":"22","author":"LB Corbeil","year":"1985","unstructured":"Corbeil LB, Blau K, Prieur DJ, Ward ACS (1985) Serum susceptibility of Haemophilus somnus from bovine clinical cases and carriers. J Clin Microbiol 22:192\u2013198","journal-title":"J Clin Microbiol"},{"key":"5020_CR7","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1046\/j.1432-1327.1998.2530507.x","volume":"253","author":"AD Cox","year":"1998","unstructured":"Cox AD, Howard MD, Brisson J-R, Van Der Zwan M, Thibault P, Perry MB, Inzana TJ (1998) Structural analysis of the phase-variable lipooligosaccharide from Haemophilus somnus strain 738. Eur J Biochem 253:507\u2013516","journal-title":"Eur J Biochem"},{"key":"5020_CR8","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.1046\/j.1432-1033.2002.03090.x","volume":"269","author":"AD Cox","year":"2002","unstructured":"Cox AD, Hood DW, Martin A, Makepeace KM, Deadman ME, Li J, Brisson JR, Moxon ER, Richards JC (2002) Identification and structural characterization of a sialylated lacto-N-neotetraose structure in the lipopolysaccharide of Haemophilus influenzae. Eur J Biochem 269:4009\u20134019","journal-title":"Eur J Biochem"},{"key":"5020_CR9","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0008-6215(03)00113-7","volume":"338","author":"AD Cox","year":"2003","unstructured":"Cox AD, Howard MD, Inzana TJ (2003) Structural analysis of the lipooligosaccharide from the commensal Haemophilus somnus strain 1P. Carbohydr Res 338:1223\u20131228","journal-title":"Carbohydr Res"},{"key":"5020_CR10","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1128\/JB.155.2.831-838.1983","volume":"155","author":"RP Darveau","year":"1983","unstructured":"Darveau RP, Hancock RE (1983) Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains. J Bacteriol 155:831\u2013838","journal-title":"J Bacteriol"},{"key":"5020_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.micpath.2009.08.001","volume":"47","author":"SF Elswaifi","year":"2009","unstructured":"Elswaifi SF, St Michael F, Sreenivas A, Cox A, Carman GM, Inzana TJ (2009) Molecular characterization of phosphorylcholine expression on the lipooligosaccharide of Histophilus somni. Microb Pathog 47:223\u2013230","journal-title":"Microb Pathog"},{"key":"5020_CR12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1297-9716-43-49","volume":"43","author":"SF Elswaifi","year":"2012","unstructured":"Elswaifi SF, Scarratt WK, Inzana TJ (2012) The role of lipooligosaccharide phosphorylcholine in colonization and pathogenesis of Histophilus somni in cattle. Vet Res 43:49","journal-title":"Vet Res"},{"key":"5020_CR13","doi-asserted-by":"publisher","first-page":"40024","DOI":"10.1074\/jbc.M602314200","volume":"281","author":"KL Fox","year":"2006","unstructured":"Fox KL, Cox AD, Gilbert M, Wakarchuk WW, Li J, Makepeace K, Richards JC, Moxon ER, Hood DW (2006) Identification of a bifunctional lipopolysaccharide sialyltransferase in Haemophilus influenzae: incorporation of disialic acid. J Biol Chem 281:40024\u201340032","journal-title":"J Biol Chem"},{"key":"5020_CR14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1432-1033.1969.tb00601.x","volume":"9","author":"C Galanos","year":"1969","unstructured":"Galanos C, L\u00fcderitz O, Westphal O (1969) A new method for the extraction of R lipopolysaccharides. Eur J Biochem 9:245\u2013249","journal-title":"Eur J Biochem"},{"key":"5020_CR15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/030098588702400309","volume":"24","author":"RP Gogolewski","year":"1987","unstructured":"Gogolewski RP, Leathers CW, Liggitt HD, Corbeil LB (1987) Experimental Haemophilus somnus pneumonia in calves and immunoperoxidase localization of bacteria. Vet Pathol 24:250\u2013256","journal-title":"Vet Pathol"},{"key":"5020_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1365-2958.1996.tb02498.x","volume":"20","author":"NJ High","year":"1996","unstructured":"High NJ, Jennings MP, Moxon ER (1996) Tandem repeats of the tetramer 5\u2019-CAAT-3\u2019 present in lic2A are required for phase variation but not lipopolysaccharide biosynthesis in Haemophilus influenzae. Mol Microbiol 20:165\u2013174","journal-title":"Mol Microbiol"},{"key":"5020_CR17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1128\/jb.166.3.699-705.1986","volume":"166","author":"PJ Hitchcock","year":"1986","unstructured":"Hitchcock PJ, Leive L, M\u00e4lel\u00e4 PH, Rietschel ET, Strittmatter W, Morrison DC (1986) Lipopolysaccharide nomenclature-past, present, and future. J Bacteriol 166:699\u2013705","journal-title":"J Bacteriol"},{"key":"5020_CR18","first-page":"305","volume-title":"Endotoxin in health and disease","author":"O Holst","year":"1999","unstructured":"Holst O (1999) Chemical structure of the core region of lipopolysaccharides. In: Brade H (ed) Endotoxin in health and disease. Marcel Dekker, New York, pp 305\u2013330"},{"key":"5020_CR19","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1128\/JCM.38.12.4412-4419.2000","volume":"38","author":"MD Howard","year":"2000","unstructured":"Howard MD, Cox AD, Weiser JN, Schurig GG, Inzana TJ (2000) Antigenic diversity of Haemophilus somnus lipooligosaccharide: phase-variable accessibility of the phosphorylcholine epitope. J Clin Microbiol 38:4412\u20134419","journal-title":"J Clin Microbiol"},{"key":"5020_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.vetmic.2011.02.054","volume":"153","author":"MD Howard","year":"2011","unstructured":"Howard MD, Willis L, Wakarchuk W, St Michael F, Cox A, Horne WT, Hontecillas R, Bassaganya-Riera J, Lorenz E, Inzana TJ (2011) Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling. Vet Microbiol 153:163\u2013172","journal-title":"Vet Microbiol"},{"key":"5020_CR21","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/(SICI)1522-2683(19990301)20:3<462::AID-ELPS462>3.0.CO;2-N","volume":"20","author":"TJ Inzana","year":"1999","unstructured":"Inzana TJ, Apicella MA (1999) Use of a bilayer stacking gel to improve resolution of lipopolysaccharides and lipooligosaccharides in polyacrylamide gels. Electrophoresis 20:462\u2013465","journal-title":"Electrophoresis"},{"key":"5020_CR22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2460\/ajvr.1992.53.02.175","volume":"53","author":"TJ Inzana","year":"1992","unstructured":"Inzana TJ, Todd J (1992) Immune response of cattle to an Haemophilus somnus lipid A-protein conjugate vaccine and efficacy in a mouse model. Am J Vet Res 53:175\u2013179","journal-title":"Am J Vet Res"},{"key":"5020_CR23","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1128\/IAI.48.2.324-330.1985","volume":"48","author":"TJ Inzana","year":"1985","unstructured":"Inzana TJ, Seifert WE Jr, Williams RP (1985) Composition and antigenic activity of the oligosaccharide moiety of Haemophilus influenzae type b lipooligosaccharide. Infect Immun 48:324\u2013330","journal-title":"Infect Immun"},{"key":"5020_CR24","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1128\/IAI.56.11.2830-2837.1988","volume":"56","author":"TJ Inzana","year":"1988","unstructured":"Inzana TJ, Iritani B, Gogolewski RP, Kania SA, Corbeil LB (1988) Purification and characterization of lipooligosaccharides from four strains of \u201cHaemophilus somnus\u201d. Infect Immun 56:2830\u20132837","journal-title":"Infect Immun"},{"key":"5020_CR25","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1128\/IAI.60.7.2943-2951.1992","volume":"60","author":"TJ Inzana","year":"1992","unstructured":"Inzana TJ, Gogolewski RP, Corbeil LB (1992) Phenotypic phase variation in Haemophilus somnus lipooligosaccharide during bovine pneumonia and after in vitro passage. Infect Immun 60:2943\u20132951","journal-title":"Infect Immun"},{"key":"5020_CR26","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1128\/IAI.65.11.4675-4681.1997","volume":"65","author":"TJ Inzana","year":"1997","unstructured":"Inzana TJ, Hensley J, McQuiston J, Lesse AJ, Campagnari AA, Boyle SM, Apicella MA (1997) Phase variation and conservation of lipooligosaccharide epitopes in Haemophilus somnus. Infect Immun 65:4675\u20134681","journal-title":"Infect Immun"},{"key":"5020_CR27","doi-asserted-by":"publisher","first-page":"4870","DOI":"10.1128\/IAI.70.9.4870-4879.2002","volume":"70","author":"TJ Inzana","year":"2002","unstructured":"Inzana TJ, Glindemann G, Cox AD, Wakarchuk W, Howard MD (2002) Incorporation of N-acetylneuraminic acid into Haemophilus somnus lipooligosaccharide (LOS): enhancement of resistance to serum and reduction of LOS antibody binding. Infect Immun 70:4870\u20134879","journal-title":"Infect Immun"},{"key":"5020_CR28","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.vetmic.2012.07.008","volume":"161","author":"TJ Inzana","year":"2012","unstructured":"Inzana TJ, Balyan R, Howard MD (2012) Decoration of Histophilus somni lipooligosaccharide with N-acetyl-5-neuraminic acid enhances bacterial binding of complement factor H and resistance to killing by serum and polymorphonuclear leukocytes. Vet Microbiol 161:113\u2013121","journal-title":"Vet Microbiol"},{"key":"5020_CR29","unstructured":"Johnson KG (1993) Isolation and purification of lipopolysaccharides. In: BeMiller JNaRLW (ed) Methods in Carbohydrate Chemistry. Vol IX. Wiley, New York, pp 3\u201310"},{"key":"5020_CR30","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1128\/IAI.01177-06","volume":"75","author":"CJ Kuckleburg","year":"2007","unstructured":"Kuckleburg CJ, Elswaifi SF, Inzana TJ, Czuprynski CJ (2007) Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. Infect Immun 75:1045\u20131049","journal-title":"Infect Immun"},{"key":"5020_CR31","first-page":"203","volume":"4","author":"G Levinson","year":"1987","unstructured":"Levinson G, Gutman GA (1987) Slipped-strand mispairing: a major mechanism for DNA sequence evolution. Mol Biol Evol 4:203\u2013221","journal-title":"Mol Biol Evol"},{"key":"5020_CR32","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1046\/j.1365-2958.2000.01707.x","volume":"35","author":"E Lysenko","year":"2000","unstructured":"Lysenko E, Richards JC, Cox AD, Stewart A, Martin A, Kapoor M, Weiser JN (2000) The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae affects binding and sensitivity to C-reactive protein-mediated killing. Mol Microbiol 35:234\u2013245","journal-title":"Mol Microbiol"},{"key":"5020_CR33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1084\/jem.168.1.107","volume":"168","author":"RE Mandrell","year":"1988","unstructured":"Mandrell RE, Griffiss JM, Macher BA (1988) Lipooligosaccharides (LOS) of Neisseria gonorrhoeae and Neisseria meningitidis have components that are immunologically similar to precursors of human blood group antigens. J Exp Med 168:107\u2013126","journal-title":"J Exp Med"},{"key":"5020_CR34","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/0923-2508(91)90086-P","volume":"142","author":"DJ Maskell","year":"1991","unstructured":"Maskell DJ, Szabo MJ, Butler PD, Williams AE, Moxon ER (1991) Phase variation of lipopolysaccharide in Haemophilus influenzae. Res Microbiol 142:719\u2013724","journal-title":"Res Microbiol"},{"key":"5020_CR35","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1006\/mpat.1999.0351","volume":"28","author":"JH McQuiston","year":"2000","unstructured":"McQuiston JH, McQuiston JR, Cox AD, Wu Y, Boyle SM, Inzana TJ (2000) Characterization of a DNA region containing 5\u2019-CAAT-3\u2019 DNA sequences involved in lipooligosaccharide biosynthesis in Haemophilus somnus. Microb Pathogen 28:301\u2013312","journal-title":"Microb Pathogen"},{"key":"5020_CR36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1574-695X.1996.tb00127.x","volume":"16","author":"AP Moran","year":"1996","unstructured":"Moran AP, Prendergast MM, Appelmelk BJ (1996) Molecular mimicry of host structures by bacterial lipopolysaccharides and its contribution to disease. FEMS Immunol Med Microbiol 16:105\u2013115","journal-title":"FEMS Immunol Med Microbiol"},{"key":"5020_CR37","doi-asserted-by":"publisher","first-page":"5340","DOI":"10.1128\/IAI.72.9.5340-5348.2004","volume":"72","author":"NJ Phillips","year":"2004","unstructured":"Phillips NJ, Schilling B, McLendon MK, Apicella MA, Gibson BW (2004) Novel modification of lipid A of Francisella tularensis. Infect Immun 72:5340\u20135348","journal-title":"Infect Immun"},{"key":"5020_CR38","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.meegid.2008.11.006","volume":"9","author":"PM Power","year":"2009","unstructured":"Power PM, Sweetman WA, Gallacher NJ, Woodhall MR, Kumar GA, Moxon ER, Hood DW (2009) Simple sequence repeats in Haemophilus influenzae. Infect Genet Evol 9:216\u2013228","journal-title":"Infect Genet Evol"},{"key":"5020_CR39","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev.bi.59.070190.001021","volume":"59","author":"CRH Raetz","year":"1990","unstructured":"Raetz CRH (1990) Biochemistry of endotoxins. Annu Rev Biochem 59:129\u2013170","journal-title":"Annu Rev Biochem"},{"key":"5020_CR40","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1146\/annurev.biochem.71.110601.135414","volume":"71","author":"CR Raetz","year":"2002","unstructured":"Raetz CR, Whitfield C (2002) Lipopolysaccharide endotoxins. Annu Rev Biochem 71:635\u2013700","journal-title":"Annu Rev Biochem"},{"key":"5020_CR41","unstructured":"Rietschel ET, Wollenweber H-W, Brade H, Z\u00e4hringer U, Linder B, Seydel U, Bradaczek H, Giesbrecht P (1984) Structure and conformation of th lipid A component of lipopolysaccharides. In: Rietschel ET (ed) Chemistry of endotoxin. Handbook of endotoxin, vol 1. Elsevier Science Publishers, New York, pp 187\u2013220"},{"key":"5020_CR42","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/1471-2180-11-186","volume":"11","author":"I Sandal","year":"2011","unstructured":"Sandal I, Inzana TJ, Molinaro A, De Castro C, Shao JQ, Apicella MA, Cox AD, St Michael F, Berg G (2011) Identification, structure, and characterization of an exopolysaccharide produced by Histophilus somni during biofilm formation. BMC Microbiol 11:186","journal-title":"BMC Microbiol"},{"key":"5020_CR43","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1186\/1471-2164-12-570","volume":"12","author":"S Siddaramappa","year":"2011","unstructured":"Siddaramappa S, Challacombe JF, Duncan AJ, Gillaspy AF, Carson M, Gipson J, Orvis J, Zaitshik J, Barnes G, Bruce D, Chertkov O, Detter JC, Han CS, Tapia R, Thompson LS, Dyer DW, Inzana TJ (2011) Horizontal gene transfer in Histophilus somni and its role in the evolution of pathogenic strain 2336, as determined by comparative genomic analyses. BMC Genom 12:570","journal-title":"BMC Genom"},{"key":"5020_CR44","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.carres.2003.10.032","volume":"339","author":"F St Michael","year":"2004","unstructured":"St Michael F, Howard MD, Li J, Duncan AJ, Inzana TJ, Cox AD (2004) Structural analysis of the lipooligosaccharide from the commensal Haemophilus somnus genome strain 129Pt. Carbohydr Res 339:529\u2013535","journal-title":"Carbohydr Res"},{"key":"5020_CR45","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.carres.2004.12.029","volume":"340","author":"F St Michael","year":"2005","unstructured":"St Michael F, Li J, Howard MD, Duncan AJ, Inzana TJ, Cox AD (2005) Structural analysis of the oligosaccharide of Histophilus somni (Haemophilus somnus) strain 2336 and identification of several lipooligosaccharide biosynthesis gene homologues. Carbohydr Res 340:665\u2013672","journal-title":"Carbohydr Res"},{"key":"5020_CR46","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.carres.2005.11.021","volume":"341","author":"F St Michael","year":"2006","unstructured":"St Michael F, Inzana TJ, Cox AD (2006) Structural analysis of the lipooligosaccharide-derived oligosaccharide of Histophilus somni (Haemophilus somnus) strain 8025. Carbohydr Res 341:281\u2013284","journal-title":"Carbohydr Res"},{"key":"5020_CR47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1046\/j.1365-2958.2000.01952.x","volume":"37","author":"WE Swords","year":"2000","unstructured":"Swords WE, Buscher BA, Ver Steeg Ii K, Preston A, Nichols WA, Weiser JN, Gibson BW, Apicella MA (2000) Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor. Mol Microbiol 37:13\u201327","journal-title":"Mol Microbiol"},{"key":"5020_CR48","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1128\/IAI.69.3.1650-1660.2001","volume":"69","author":"MJ Sylte","year":"2001","unstructured":"Sylte MJ, Corbeil LB, Inzana TJ, Czuprynski CJ (2001) Haemophilus somnus induces apoptosis in bovine endothelial cells in vitro. Infect Immun 69:1650\u20131660","journal-title":"Infect Immun"},{"key":"5020_CR49","doi-asserted-by":"publisher","first-page":"4616","DOI":"10.1074\/jbc.M808209200","volume":"284","author":"CM Tsai","year":"2009","unstructured":"Tsai CM, Jankowska-Stephens E, Mizanur RM, Cipollo JF (2009) The fine structure of Neisseria meningitidis lipooligosaccharide from the M986 strain and three of its variants. J Biol Chem 284:4616\u20134625","journal-title":"J Biol Chem"},{"key":"5020_CR50","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S0966-842X(02)02361-2","volume":"10","author":"E Vimr","year":"2002","unstructured":"Vimr E, Lichtensteiger C (2002) To sialylate, or not to sialylate: that is the question. Trends Microbiol 10:254\u2013257","journal-title":"Trends Microbiol"},{"key":"5020_CR51","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1046\/j.1365-2958.2000.01925.x","volume":"36","author":"E Vimr","year":"2000","unstructured":"Vimr E, Lichtensteiger C, Steenbergen S (2000) Sialic acid metabolism\u2019s dual function in Haemophilus influenzae. Mol Microbiol 36:1113\u20131123","journal-title":"Mol Microbiol"},{"key":"5020_CR52","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1128\/IAI.65.3.943-950.1997","volume":"65","author":"JN Weiser","year":"1997","unstructured":"Weiser JN, Shchepetov M, Chong ST (1997) Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae. Infect Immun 65:943\u2013950","journal-title":"Infect Immun"},{"key":"5020_CR53","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1084\/jem.187.4.631","volume":"187","author":"JN Weiser","year":"1998","unstructured":"Weiser JN, Pan N, McGowan KL, Musher D, Martin A, Richards J (1998) Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein. J Exp Med 187:631\u2013640","journal-title":"J Exp Med"},{"key":"5020_CR54","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0065-2911(08)60099-5","volume":"35","author":"C Whitfield","year":"1993","unstructured":"Whitfield C, Valvano MA (1993) Biosynthesis and expression of cell-surface polysaccharides in gram-negative bacteria. Adv Microb Physiol 35:135\u2013246","journal-title":"Adv Microb Physiol"},{"key":"5020_CR55","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1128\/IAI.68.1.310-319.2000","volume":"68","author":"Y Wu","year":"2000","unstructured":"Wu Y, McQuiston JH, Cox A, Pack TD, Inzana TJ (2000) Molecular cloning and mutagenesis of a DNA locus involved in lipooligosaccharide biosynthesis in Haemophilus somnus. Infect Immun 68:310\u2013319","journal-title":"Infect Immun"}],"container-title":["Current Topics in Microbiology and Immunology","Histophilus somni"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/82_2015_5020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:13:50Z","timestamp":1718324030000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/82_2015_5020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9783319295541","9783319295565"],"references-count":55,"URL":"https:\/\/doi.org\/10.1007\/82_2015_5020","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"28 January 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}