{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:30:55Z","timestamp":1790854255672,"version":"4.1.0"},"publisher-location":"Boston, MA","reference-count":114,"publisher":"Springer US","isbn-type":[{"value":"9780387754338","type":"print"},{"value":"9780387754345","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007]]},"DOI":"10.1007\/978-0-387-75434-5_5","type":"book-chapter","created":{"date-parts":[[2008,1,4]],"date-time":"2008-01-04T05:34:00Z","timestamp":1199424840000},"page":"51-67","source":"Crossref","is-referenced-by-count":73,"title":["Intermittent Hypoxia and Cognitive Function: Implications from Chronic Animal Models"],"prefix":"10.1007","author":[{"given":"Barry W.","family":"Row","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5_CR1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1212\/WNL.42.4.733","volume":"42","author":"RL Albin","year":"1992","unstructured":"Albin RL, and Greenamyre JT. Alternative excitotoxic hypotheses. Neurology42:733-738, 1992.","journal-title":"Neurology"},{"key":"5_CR2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1183\/09031936.04.00127603","volume":"24","author":"M Alchanatis","year":"2004","unstructured":"Alchanatis M, Deligiorgis N, Zias N, Amfilochiou A, Gotsis E, Karakatsani A, and Papadimitriou A. Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study. Eur Respir J24:980-986, 2004.","journal-title":"Eur Respir J"},{"key":"5_CR3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0149-7634(99)00044-5","volume":"24","author":"SL Andersen","year":"2000","unstructured":"Andersen SL, and Teicher MH. Sex differences in dopamine receptors and their relevance to ADHD. Neurosci Biobehav Rev24:137-141, 2000.","journal-title":"Neurosci Biobehav Rev"},{"key":"5_CR4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1744-9081-1-2","volume":"1","author":"AF Arnsten","year":"2005","unstructured":"Arnsten AF, and Dudley AG. Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder. Behav Brain Funct 1: 2, 2005.","journal-title":"Behav Brain Funct"},{"key":"5_CR5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1037\/0033-2909.121.1.65","volume":"121","author":"RA Barkley","year":"1997","unstructured":"Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull121:65-94, 1997.","journal-title":"Psychol Bull"},{"key":"5_CR6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.sleep.2004.08.004","volume":"5","author":"DJ Bartlett","year":"2004","unstructured":"Bartlett DJ, Rae C, Thompson CH, Byth K, Joffe DA, Enright T, and Grunstein RR. Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea. Sleep Med5:593-596, 2004.","journal-title":"Sleep Med"},{"key":"5_CR7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1542\/peds.2004-0227","volume":"114","author":"JL Bass","year":"2004","unstructured":"Bass JL, Corwin M, Gozal D, Moore C, Nishida H, Parker S, Schonwald A, Wilker RE, Stehle S, and Kinane TB. The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence. Pediatrics114:805-816, 2004.","journal-title":"Pediatrics"},{"key":"5_CR8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0091-3057(99)00168-9","volume":"64","author":"JB Becker","year":"1999","unstructured":"Becker JB. Gender differences in dopaminergic function in striatum and nucleus accumbens. Pharmacol Biochem Behav64:803-812, 1999.","journal-title":"Pharmacol Biochem Behav"},{"key":"5_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2869.2002.00289.x","volume":"11","author":"DW Beebe","year":"2002","unstructured":"Beebe DW, and Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res11:1-16, 2002.","journal-title":"J Sleep Res"},{"key":"5_CR10","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1017\/S135561770410708X","volume":"10","author":"DW Beebe","year":"2004","unstructured":"Beebe DW, Wells CT, Jeffries J, Chini B, Kalra M, and Amin R. Neuropsychological effects of pediatric obstructive sleep apnea. J Int Neuropsychol Soc10:962-975, 2004.","journal-title":"J Int Neuropsychol Soc"},{"key":"5_CR11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1569-9048(02)00038-1","volume":"131","author":"M Behan","year":"2002","unstructured":"Behan M, Zabka AG, and Mitchell GS. Age and gender effects on serotonin-dependent plasticity in respiratory motor control. Respir Physiol Neurobiol131:65-77, 2002.","journal-title":"Respir Physiol Neurobiol"},{"key":"5_CR12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/070674370200601S03","volume":"1: S","author":"J Biederman","year":"2002","unstructured":"Biederman J, and Faraone SV. Current concepts on the neurobiology of Attention-Deficit\/Hyperactivity Disorder. J Atten Disord6 Suppl 1: S7-16, 2002.","journal-title":"J Atten Disord 6 Suppl"},{"key":"5_CR13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0022-3999(02)00436-1","volume":"53","author":"DL Bliwise","year":"2002","unstructured":"Bliwise DL. Sleep apnea, APOE4 and Alzheimer\u2019s disease 20 years and counting? J Psychosom Res53:539-546, 2002.","journal-title":"J Psychosom Res"},{"key":"5_CR14","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.122.4.1162","volume":"122","author":"GE Carpagnano","year":"2002","unstructured":"Carpagnano GE, Kharitonov SA, Resta O, Foschino-Barbaro MP, Gramiccioni E, and Barnes PJ. Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest122:1162-1167, 2002.","journal-title":"Chest"},{"key":"5_CR15","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1152\/jappl.2001.90.6.2476","volume":"90","author":"TL Clanton","year":"2001","unstructured":"Clanton TL, and Klawitter PF. Invited review: Adaptive responses of skeletal muscle to intermittent hypoxia: the known and the unknown. J Appl Physiol90:2476-2487, 2001.","journal-title":"J Appl Physiol"},{"key":"5_CR16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/sleep\/23.3.1d","volume":"23","author":"A Decary","year":"2000","unstructured":"Decary A, Rouleau I, and Montplaisir J. Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test battery. Sleep23:369-381, 2000.","journal-title":"Sleep"},{"key":"5_CR17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0306-4522(02)00805-9","volume":"117","author":"MJ Decker","year":"2003","unstructured":"Decker MJ, Hue GE, Caudle WM, Miller GW, Keating GL, and Rye DB. Episodic neonatal hypoxia evokes executive dysfunction and regionally specific alterations in markers of dopamine signaling. Neuroscience117:417-425, 2003.","journal-title":"Neuroscience"},{"key":"5_CR18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/sleep\/28.2.169","volume":"28","author":"MJ Decker","year":"2005","unstructured":"Decker MJ, Jones KA, Solomon IG, Keating GL, and Rye DB. Reduced extracellular dopamine and increased responsiveness to novelty: neurochemical and behavioral sequelae of intermittent hypoxia. Sleep28:169-176, 2005.","journal-title":"Sleep"},{"key":"5_CR19","doi-asserted-by":"crossref","unstructured":"Douglas RM, Miyasaka N, Takahashi K, Latuszek-Barrantes A, Haddad GG, and Hetherington HP. Chronic Intermittent but not Constant Hypoxia Decreases NAA\/Cr Ratios in Neonatal Mouse Hippocampus and Thalamus. Am J Physiol Regul Integr Comp Physiol2006.","DOI":"10.1152\/ajpregu.00404.2006"},{"key":"5_CR20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0095-5108(18)30162-3","volume":"24","author":"AJ Plessis du","year":"1997","unstructured":"du Plessis AJ, and Johnston MV. Hypoxic-ischemic brain injury in the newborn. Cellular mechanisms and potential strategies for neuroprotection. Clin Perinatol24:627-654, 1997.","journal-title":"Clin Perinatol"},{"key":"5_CR21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mam.2004.09.004","volume":"26","author":"AJ Duncan","year":"2005","unstructured":"Duncan AJ, and Heales SJ. Nitric oxide and neurological disorders. Mol Aspects Med 26:67-96, 2005.","journal-title":"Mol Aspects Med"},{"key":"5_CR22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/mrdd.10079","volume":"9","author":"S Durston","year":"2003","unstructured":"Durston S. A review of the biological bases of ADHD: what have we learned from imaging studies? Ment Retard Dev Disabil Res Rev9:184-195, 2003.","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"5_CR23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0006-3223(98)00240-6","volume":"44","author":"SV Faraone","year":"1998","unstructured":"Faraone SV, and Biederman J. Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry44:951-958, 1998.","journal-title":"Biol Psychiatry"},{"key":"5_CR24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1152\/jn.1998.79.1.95","volume":"79","author":"R Fern","year":"1998","unstructured":"Fern R, Davis P, Waxman SG, and Ransom BR. Axon conduction and survival in CNS white matter during energy deprivation: a developmental study. J Neurophysiol79:95-105, 1998.","journal-title":"J Neurophysiol"},{"key":"5_CR25","first-page":"926","volume":"51","author":"JH Ficker","year":"1997","unstructured":"Ficker JH, Feistel H, Moller C, Merkl M, Dertinger S, Siegfried W, and Hahn EG. [Changes in regional CNS perfusion in obstructive sleep apnea syndrome: initial SPECT studies with injected nocturnal 99mTc-HMPAO]. Pneumologie51:926-930, 1997.","journal-title":"Pneumologie"},{"key":"5_CR26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.pediatrneurol.2004.06.010","volume":"31","author":"Y Frank","year":"2004","unstructured":"Frank Y, Pergolizzi RG, and Perilla MJ. Dopamine D4 receptor gene and attention deficit hyperactivity disorder. Pediatr Neurol31:345-348, 2004.","journal-title":"Pediatr Neurol"},{"key":"5_CR27","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.nbd.2003.08.004","volume":"14","author":"A Goldbart","year":"2003","unstructured":"Goldbart A, Cheng ZJ, Brittian KR, and Gozal D. Intermittent hypoxia induces timedependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat. Neurobiol Dis14:440-446, 2003.","journal-title":"Neurobiol Dis"},{"key":"5_CR28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuroscience.2003.08.054","volume":"122","author":"A Goldbart","year":"2003","unstructured":"Goldbart A, Row BW, Kheirandish L, Schurr A, Gozal E, Guo SZ, Payne RS, Cheng Z, Brittian KR, and Gozal D. Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlates. Neuroscience122:585-590, 2003.","journal-title":"Neuroscience"},{"key":"5_CR29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.brainres.2006.03.046","volume":"1090","author":"AD Goldbart","year":"2006","unstructured":"Goldbart AD, Row BW, Kheirandish-Gozal L, Cheng Y, Brittian KR, and Gozal D. High fat\/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia. Brain Res1090:190-196, 2006.","journal-title":"Brain Res"},{"key":"5_CR30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jpeds.2004.05.039","volume":"145","author":"DJ Gottlieb","year":"2004","unstructured":"Gottlieb DJ, Chase C, Vezina RM, Heeren TC, Corwin MJ, Auerbach SH, Weese-Mayer DE, and Lesko SM. Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children. J Pediatr145:458-464, 2004.","journal-title":"J Pediatr"},{"key":"5_CR31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1055\/s-2001-12790","volume":"5","author":"D Gozal","year":"2001","unstructured":"Gozal D. Morbidity of obstructive sleep apnea in children: facts and theory. Sleep Breath5:35-42, 2001.","journal-title":"Sleep Breath"},{"key":"5_CR32","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1523\/JNEUROSCI.21-07-02442.2001","volume":"21","author":"D Gozal","year":"2001","unstructured":"Gozal D, Daniel JM, and Dohanich GP. Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. J Neurosci21:2442-2450., 2001.","journal-title":"J Neurosci"},{"key":"5_CR33","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1542\/peds.107.6.1394","volume":"107","author":"D Gozal","year":"2001","unstructured":"Gozal D, and Pope DW, Jr. Snoring during early childhood and academic performance at ages thirteen to fourteen years. Pediatrics107:1394-1399, 2001.","journal-title":"Pediatrics"},{"key":"5_CR34","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1046\/j.1460-9568.2003.02947.x","volume":"18","author":"D Gozal","year":"2003","unstructured":"Gozal D, Row BW, Gozal E, Kheirandish L, Neville JJ, Brittian KR, Sachleben LR, Jr., and Guo SZ. Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis. Eur J Neurosci18:2335-2342, 2003.","journal-title":"Eur J Neurosci"},{"key":"5_CR35","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1046\/j.1471-4159.2003.01973.x","volume":"86","author":"D Gozal","year":"2003","unstructured":"Gozal D, Row BW, Kheirandish L, Liu R, Guo SZ, Qiang F, and Brittian KR. Increased susceptibility to intermittent hypoxia in aging rats: changes in proteasomal activity, neuronal apoptosis and spatial function. J Neurochem86:1545-1552, 2003.","journal-title":"J Neurochem"},{"key":"5_CR36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1471-4159.2002.01134.x","volume":"83","author":"E Gozal","year":"2002","unstructured":"Gozal E, Gozal D, Pierce WM, Thongboonkerd V, Scherzer JA, Sachleben LR, Jr., Brittian KR, Guo SZ, Cai J, and Klein JB. Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia. J Neurochem83:331-345, 2002.","journal-title":"J Neurochem"},{"key":"5_CR37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0304-3940(01)01853-5","volume":"305","author":"E Gozal","year":"2001","unstructured":"Gozal E, Row BW, Schurr A, and Gozal D. Developmental differences in cortical and hippocampal vulnerability to intermittent hypoxia in the rat. Neurosci Lett305:197-201, 2001.","journal-title":"Neurosci Lett"},{"key":"5_CR38","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/j.1469-8749.1993.tb11578.x","volume":"35","author":"PH Gray","year":"1993","unstructured":"Gray PH, Tudehope DI, Masel JP, Burns YR, Mohay HA, O\u2019Callaghan MJ, and Williams GM. Perinatal hypoxic-ischaemic brain injury: prediction of outcome. Dev Med Child Neurol35:965-973, 1993.","journal-title":"Dev Med Child Neurol"},{"key":"5_CR39","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1152\/jappl.2001.91.3.1245","volume":"91","author":"XQ Gu","year":"2001","unstructured":"Gu XQ, and Haddad GG. Decreased neuronal excitability in hippocampal neurons of mice exposed to cyclic hypoxia. J Appl Physiol91:1245-1250, 2001.","journal-title":"J Appl Physiol"},{"key":"5_CR40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.smrv.2005.10.002","volume":"10","author":"AC Halbower","year":"2006","unstructured":"Halbower AC, and Mahone EM. Neuropsychological morbidity linked to childhood sleep-disordered breathing. Sleep Med Rev10:97-107, 2006.","journal-title":"Sleep Med Rev"},{"key":"5_CR41","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","volume":"97","author":"B Halliwell","year":"2006","unstructured":"Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem 97:1634-1658, 2006.","journal-title":"J Neurochem"},{"key":"5_CR42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02815202","volume":"28","author":"JA Joseph","year":"1996","unstructured":"Joseph JA, Denisova N, Villalobos-Molina R, Erat S, and Strain J. Oxidative stress and age-related neuronal deficits. Mol Chem Neuropathol28:35-40, 1996.","journal-title":"Mol Chem Neuropathol"},{"key":"5_CR43","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1001\/jama.285.22.2888","volume":"285","author":"H Kadotani","year":"2001","unstructured":"Kadotani H, Kadotani T, Young T, Peppard PE, Finn L, Colrain IM, Murphy GM, Jr., and Mignot E. Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults. Jama285:2888-2890, 2001.","journal-title":"Jama"},{"key":"5_CR44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0021-9681(85)90138-9","volume":"38","author":"A Kales","year":"1985","unstructured":"Kales A, Caldwell AB, Cadieux RJ, Vela-Bueno A, Ruch LG, and Mayes SD. Severe obstructive sleep apnea\u2013II: Associated psychopathology and psychosocial consequences. J Chronic Dis38:427-434, 1985.","journal-title":"J Chronic Dis"},{"key":"5_CR45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/jnnp.71.3.334","volume":"71","author":"M Kamba","year":"2001","unstructured":"Kamba M, Inoue Y, Higami S, Suto Y, Ogawa T, and Chen W. Cerebral metabolic impairment in patients with obstructive sleep apnoea: an independent association of obstructive sleep apnoea with white matter change. J Neurol Neurosurg Psychiatry 71:334-339, 2001.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5_CR46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1164\/ajrccm.156.1.9611063","volume":"156","author":"M Kamba","year":"1997","unstructured":"Kamba M, Suto Y, Ohta Y, Inoue Y, and Matsuda E. Cerebral metabolism in sleep apnea. Evaluation by magnetic resonance spectroscopy. Am J Respir Crit Care Med 156:296-298, 1997.","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR47","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1152\/ajpregu.00535.2005","volume":"290","author":"A Kanaan","year":"2006","unstructured":"Kanaan A, Farahani R, Douglas RM, Lamanna JC, and Haddad GG. Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination. Am J Physiol Regul Integr Comp Physiol290: R1105-1114, 2006.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"5_CR48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ana.10262","volume":"52","author":"G Kempermann","year":"2002","unstructured":"Kempermann G, Gast D, and Gage FH. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol52:135-143, 2002.","journal-title":"Ann Neurol"},{"key":"5_CR49","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1203\/01.pdr.0000176915.19287.e2","volume":"58","author":"L Kheirandish","year":"2005","unstructured":"Kheirandish L, Gozal D, Pequignot JM, Pequignot J, and Row BW. Intermittent Hypoxia during Development Induces Long-Term Alterations in Spatial Working Memory, Monoamines, and Dendritic Branching in Rat Frontal Cortex. Pediatr Res 58:594-599, 2005.","journal-title":"Pediatr Res"},{"key":"5_CR50","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/sleep\/28.11.1412","volume":"28","author":"L Kheirandish","year":"2005","unstructured":"Kheirandish L, Row BW, Li RC, Brittian KR, and Gozal D. Apolipoprotein Edeficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits. Sleep28:1412-1417, 2005.","journal-title":"Sleep"},{"key":"5_CR51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1053\/smrv.2002.0261","volume":"7","author":"L Lavie","year":"2003","unstructured":"Lavie L. Obstructive sleep apnoea syndrome\u2013an oxidative stress disorder. Sleep Med Rev7:35-51, 2003.","journal-title":"Sleep Med Rev"},{"key":"5_CR52","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1152\/ajpregu.00124.2004","volume":"287","author":"JM Li","year":"2004","unstructured":"Li JM, and Shah AM. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol287: R1014-1030, 2004.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"5_CR53","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0031-9384(96)00149-7","volume":"60","author":"R Li","year":"1996","unstructured":"Li R, Bao G, el-Mallakh RS, and Fletcher EC. Effects of chronic episodic hypoxia on monoamine metabolism and motor activity. Physiol Behav60:1071-1076, 1996.","journal-title":"Physiol Behav"},{"key":"5_CR54","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1164\/rccm.200211-1264OC","volume":"168","author":"RC Li","year":"2003","unstructured":"Li RC, Row BW, Gozal E, Kheirandish L, Fan Q, Brittian KR, Guo SZ, Sachleben LR, Jr., and Gozal D. Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the rat. Am J Respir Crit Care Med168:469-475, 2003.","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR55","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.nbd.2004.05.006","volume":"17","author":"RC Li","year":"2004","unstructured":"Li RC, Row BW, Kheirandish L, Brittian KR, Gozal E, Guo SZ, Sachleben LR, Jr., and Gozal D. Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the rat. Neurobiol Dis17:44-53, 2004.","journal-title":"Neurobiol Dis"},{"key":"5_CR56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/exnr.2001.7732","volume":"171","author":"LF Lue","year":"2001","unstructured":"Lue LF, Walker DG, Brachova L, Beach TG, Rogers J, Schmidt AM, Stern DM, and Yan SD. Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer\u2019s disease: identification of a cellular activation mechanism. Exp Neurol171:29-45, 2001.","journal-title":"Exp Neurol"},{"key":"5_CR57","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1164\/rccm.200201-050OC","volume":"166","author":"PM Macey","year":"2002","unstructured":"Macey PM, Henderson LA, Macey KE, Alger JR, Frysinger RC, Woo MA, Harper RK, Yan-Go FL, and Harper RM. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med166:1382-1387, 2002.","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR58","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0197-4580(02)00004-0","volume":"23","author":"JA Markham","year":"2002","unstructured":"Markham JA, and Juraska JM. Aging and sex influence the anatomy of the rat anterior cingulate cortex. Neurobiol Aging23:579-588, 2002.","journal-title":"Neurobiol Aging"},{"key":"5_CR59","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.regpep.2004.05.010","volume":"123","author":"Y Masuo","year":"2004","unstructured":"Masuo Y, Morita M, Oka S, and Ishido M. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain. Regul Pept123:225-234, 2004.","journal-title":"Regul Pept"},{"key":"5_CR60","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1152\/japplphysiol.00405.2002","volume":"93","author":"M McGuire","year":"2002","unstructured":"McGuire M, Zhang Y, White DP, and Ling L. Effect of hypoxic episode number and severity on ventilatory long-term facilitation in awake rats. J Appl Physiol93:2155-2161, 2002.","journal-title":"J Appl Physiol"},{"key":"5_CR61","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.bcp.2005.05.019","volume":"70","author":"M McKinney","year":"2005","unstructured":"McKinney M, and Jacksonville MC. Brain cholinergic vulnerability: relevance to behavior and disease. Biochem Pharmacol70:1115-1124, 2005.","journal-title":"Biochem Pharmacol"},{"key":"5_CR62","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0166-4328(93)90134-C","volume":"57","author":"AH Mohammed","year":"1993","unstructured":"Mohammed AH, Henriksson BG, Soderstrom S, Ebendal T, Olsson T, and Seckl JR. Environmental influences on the central nervous system and their implications for the aging rat. Behav Brain Res57:183-191, 1993.","journal-title":"Behav Brain Res"},{"key":"5_CR63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-0-387-34817-9_8","volume":"588","author":"MJ Morrell","year":"2006","unstructured":"Morrell MJ, and Twigg G. Neural consequences of sleep disordered breathing: the role of intermittent hypoxia. Adv Exp Med Biol588:75-88, 2006.","journal-title":"Adv Exp Med Biol"},{"key":"5_CR64","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.freeradbiomed.2005.08.044","volume":"40","author":"R Muralikrishna Adibhatla","year":"2006","unstructured":"Muralikrishna Adibhatla R, and Hatcher JF. Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic Biol Med40:376-387, 2006.","journal-title":"Free Radic Biol Med"},{"key":"5_CR65","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1076\/jcen.26.1.43.23929","volume":"26","author":"S Naismith","year":"2004","unstructured":"Naismith S, Winter V, Gotsopoulos H, Hickie I, and Cistulli P. Neurobehavioral functioning in obstructive sleep apnea: differential effects of sleep quality, hypoxemia and subjective sleepiness. J Clin Exp Neuropsychol26:43-54, 2004.","journal-title":"J Clin Exp Neuropsychol"},{"key":"5_CR66","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1152\/jappl.2001.90.4.1593","volume":"90","author":"JA Neubauer","year":"2001","unstructured":"Neubauer JA. Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol90:1593-1599, 2001.","journal-title":"J Appl Physiol"},{"key":"5_CR67","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/sleep\/29.12.1521","volume":"29","author":"M Nowak","year":"2006","unstructured":"Nowak M, Kornhuber J, and Meyrer R. Daytime impairment and neurodegeneration in OSAS. Sleep29:1521-1530, 2006.","journal-title":"Sleep"},{"key":"5_CR68","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0306-4522(94)90176-7","volume":"59","author":"C Nyakas","year":"1994","unstructured":"Nyakas C, Buwalda B, Kramers RJ, Traber J, and Luiten PG. Postnatal development of hippocampal and neocortical cholinergic and serotonergic innervation in rat: effects of nitrite-induced prenatal hypoxia and nimodipine treatment. Neuroscience 59:541-559, 1994.","journal-title":"Neuroscience"},{"key":"5_CR69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(96)00007-X","volume":"49","author":"C Nyakas","year":"1996","unstructured":"Nyakas C, Buwalda B, and Luiten PG. Hypoxia and brain development. Prog Neurobiol49:1-51, 1996.","journal-title":"Prog Neurobiol"},{"key":"5_CR70","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1460-9568.1991.tb00077.x","volume":"3","author":"C Nyakas","year":"1991","unstructured":"Nyakas C, Markel E, Schuurman T, and Luiten PG. Impaired Learning and Abnormal Open-field Behaviours of Rats After Early Postnatal Anoxia and the Beneficial Effect of the Calcium Antagonist Nimodipine. Eur J Neurosci3:168-174, 1991.","journal-title":"Eur J Neurosci"},{"key":"5_CR71","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2869.2004.00395.x","volume":"13","author":"LM O\u2019Brien","year":"2004","unstructured":"O\u2019Brien LM, Mervis CB, Holbrook CR, Bruner JL, Smith NH, McNally N, McClimment MC, and Gozal D. Neurobehavioral correlates of sleep-disordered breathing in children. J Sleep Res13:165-172, 2004.","journal-title":"J Sleep Res"},{"key":"5_CR72","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/rccm.200406-738OC","volume":"171","author":"FJ O\u2019Donoghue","year":"2005","unstructured":"O\u2019Donoghue FJ, Briellmann RS, Rochford PD, Abbott DF, Pell GS, Chan CH, Tarquinio N, Jackson GD, and Pierce RJ. Cerebral structural changes in severe obstructive sleep apnea. Am J Respir Crit Care Med171:1185-1190, 2005.","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR73","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1212\/01.wnl.0000173055.75950.bf","volume":"65","author":"R O\u2019Hara","year":"2005","unstructured":"O\u2019Hara R, Schroder CM, Kraemer HC, Kryla N, Cao C, Miller E, Schatzberg AF, Yesavage JA, and Murphy GM, Jr. Nocturnal sleep apnea\/hypopnea is associated with lower memory performance in APOE epsilon4 carriers. Neurology65:642-644, 2005.","journal-title":"Neurology"},{"key":"5_CR74","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/sj.cdd.4401172","volume":"10","author":"M Ozaki","year":"2003","unstructured":"Ozaki M, Haga S, Zhang HQ, Irani K, and Suzuki S. Inhibition of hypoxia\/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1. Cell Death Differ10:508-515, 2003.","journal-title":"Cell Death Differ"},{"key":"5_CR75","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1164\/rccm.200509-1478OE","volume":"173","author":"AI Pack","year":"2006","unstructured":"Pack AI. Advances in Sleep-disordered Breathing. Am J Respir Crit Care Med 173:7-15, 2006.","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR76","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1569-9048(03)00044-2","volume":"135","author":"LJ Palmer","year":"2003","unstructured":"Palmer LJ and Redline S. Genomic approaches to understanding obstructive sleep apnea. Respir Physiol Neurobiol 135:187-205, 2003.","journal-title":"Respir Physiol Neurobiol"},{"key":"5_CR77","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/sleep\/6.3.179","volume":"6","author":"M Partinen","year":"1983","unstructured":"Partinen M, Kaprio J, Koskenvuo M, Putkonen P, and Langinvainio H. Genetic and environmental determination of human sleep. Sleep 6:179-185, 1983.","journal-title":"Sleep"},{"key":"5_CR78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/15.suppl_6.S1","volume":"15","author":"M Partinen","year":"1992","unstructured":"Partinen M and Telakivi T. Epidemiology of obstructive sleep apnea syndrome. Sleep 15: S1-4, 1992.","journal-title":"Sleep"},{"key":"5_CR79","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.brainres.2004.09.045","volume":"1029","author":"RS Payne","year":"2004","unstructured":"Payne RS, Goldbart A, Gozal D, and Schurr A. Effect of intermittent hypoxia on longterm potentiation in rat hippocampal slices. Brain Res 1029:195-199, 2004.","journal-title":"Brain Res"},{"key":"5_CR80","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/15270290260131920","volume":"3","author":"NR Prabhakar","year":"2002","unstructured":"Prabhakar NR and Kline DD. Ventilatory changes during intermittent hypoxia: importance of pattern and duration. High Alt Med Biol 3:195-204, 2002.","journal-title":"High Alt Med Biol"},{"key":"5_CR81","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1152\/japplphysiol.00695.2005","volume":"99","author":"NM Punjabi","year":"2005","unstructured":"Punjabi NM and Polotsky VY. Disorders of glucose metabolism in sleep apnea. J Appl Physiol 99:1998-2007, 2005.","journal-title":"J Appl Physiol"},{"key":"5_CR82","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1152\/ajpregu.00851.2005","volume":"290","author":"SR Reeves","year":"2006","unstructured":"Reeves SR, Mitchell GS, and Gozal D. Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats. Am J Physiol Regul Integr Comp Physiol 290: R1664-1671, 2006.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"5_CR83","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/sleep\/18.5.382","volume":"18","author":"T Roehrs","year":"1995","unstructured":"Roehrs T, Merrion M, Pedrosi B, Stepanski E, Zorick F, and Roth T. Neuropsychological function in obstructive sleep apnea syndrome (OSAS) compared to chronic obstructive pulmonary disease (COPD). Sleep 18:382-388, 1995.","journal-title":"Sleep"},{"key":"5_CR84","first-page":"165","volume":"28","author":"BW Row","year":"2005","unstructured":"Row BW. Intermittent hypoxia and behavior: is dopamine to blame? Sleep 28:165-167, 2005.","journal-title":"Sleep"},{"key":"5_CR85","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0304-3940(02)01459-3","volume":"339","author":"BW Row","year":"2003","unstructured":"Row BW, Goldbart A, Gozal E, and Gozal D. Spatial pre-training attenuates hippocampal impairments in rats exposed to intermittent hypoxia. Neurosci Lett 339:67-71, 2003.","journal-title":"Neurosci Lett"},{"key":"5_CR86","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bbr.2006.11.028","volume":"177","author":"BW Row","year":"2007","unstructured":"Row BW, Kheirandish L, Cheng Y, Rowell PP, and Gozal D. Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep. Behav Brain Res 177:308-314, 2007.","journal-title":"Behav Brain Res"},{"key":"5_CR87","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1471-4159.2004.02352.x","volume":"89","author":"BW Row","year":"2004","unstructured":"Row BW, Kheirandish L, Li RC, Guo SZ, Brittian KR, Hardy M, Bazan NG, and Gozal D. Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficits. J Neurochem 89:189-196, 2004.","journal-title":"J Neurochem"},{"key":"5_CR88","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1203\/00006450-200209000-00024","volume":"52","author":"BW Row","year":"2002","unstructured":"Row BW, Kheirandish L, Neville JJ, and Gozal D. Impaired spatial learning and hyperactivity in developing rats exposed to intermittent hypoxia. Pediatr Res 52:449-453, 2002.","journal-title":"Pediatr Res"},{"key":"5_CR89","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1164\/rccm.200209-1050OC","volume":"167","author":"BW Row","year":"2003","unstructured":"Row BW, Liu R, Xu W, Kheirandish L, and Gozal D. Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. Am J Respir Crit Care Med 167:1548-1553, 2003.","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR90","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.brainres.2006.03.053","volume":"1089","author":"E Rybnikova","year":"2006","unstructured":"Rybnikova E, Sitnik N, Gluschenko T, Tjulkova E, and Samoilov MO. The preconditioning modified neuronal expression of apoptosis-related proteins of Bcl-2 superfamily following severe hypobaric hypoxia in rats. Brain Res 1089:195-202, 2006.","journal-title":"Brain Res"},{"key":"5_CR91","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/sleep\/29.2.152","volume":"29","author":"B Sanfilippo-Cohn","year":"2006","unstructured":"Sanfilippo-Cohn B, Lai S, Zhan G, Fenik P, Pratico D, Mazza E, and Veasey SC. Sex differences in susceptibility to oxidative injury and sleepiness from intermittent hypoxia. Sleep 29:152-159, 2006.","journal-title":"Sleep"},{"key":"5_CR92","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1523\/JNEUROSCI.18-04-01613.1998","volume":"18","author":"JK Seamans","year":"1998","unstructured":"Seamans JK, Floresco SB, and Phillips AG. D1 receptor modulation of hippocampalprefrontal cortical circuits integrating spatial memory with executive functions in the rat. J Neurosci 18:1613-1621, 1998.","journal-title":"J Neurosci"},{"key":"5_CR93","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0166-4328(02)00366-2","volume":"141","author":"Z Simonova","year":"2003","unstructured":"Simonova Z, Sterbova K, Brozek G, Komarek V, and Sykova E. Postnatal hypobaric hypoxia in rats impairs water maze learning and the morphology of neurones and macroglia in cortex and hippocampus. Behav Brain Res 141:195-205, 2003.","journal-title":"Behav Brain Res"},{"key":"5_CR94","first-page":"528","volume":"275","author":"DA Snowdon","year":"1996","unstructured":"Snowdon DA, Kemper SJ, Mortimer JA, Greiner LH, Wekstein DR, and Markesbery WR. Linguistic ability in early life and cognitive function and Alzheimer\u2019s disease in late life. Findings from the Nun Study. Jama 275:528-532, 1996.","journal-title":"Findings from the Nun Study. Jama"},{"key":"5_CR95","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S1474-4422(02)00103-5","volume":"1","author":"S Taheri","year":"2002","unstructured":"Taheri S and Mignot E. The genetics of sleep disorders. Lancet Neurol 1:242-250, 2002.","journal-title":"Lancet Neurol"},{"key":"5_CR96","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1152\/japplphysiol.01225.2004","volume":"98","author":"RJ Thomas","year":"2005","unstructured":"Thomas RJ, Rosen BR, Stern CE, Weiss JW, and Kwong KK. Functional imaging of working memory in obstructive sleep-disordered breathing. J Appl Physiol 98:2226-2234, 2005.","journal-title":"J Appl Physiol"},{"key":"5_CR97","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0166-4328(97)00142-3","volume":"93","author":"M Torasdotter","year":"1998","unstructured":"Torasdotter M, Metsis M, Henriksson BG, Winblad B, and Mohammed AH. Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus. Behav Brain Res 93:83-90, 1998.","journal-title":"Behav Brain Res"},{"key":"5_CR98","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-3806(97)00036-9","volume":"100","author":"J Towfighi","year":"1997","unstructured":"Towfighi J, Mauger D, Vannucci RC, and Vannucci SJ. Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. Brain Res Dev Brain Res 100:149-160, 1997.","journal-title":"Brain Res Dev Brain Res"},{"key":"5_CR99","first-page":"159","volume":"8","author":"UI Tuor","year":"1996","unstructured":"Tuor UI, Del Bigio MR, and Chumas PD. Brain damage due to cerebral hypoxia\/ischemia in the neonate: pathology and pharmacological modification. Cerebrovasc Brain Metab Rev 8:159-193, 1996.","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"5_CR100","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1749-6632.1997.tb48634.x","volume":"835","author":"RC Vannucci","year":"1997","unstructured":"Vannucci RC and Vannucci SJ. A model of perinatal hypoxic-ischemic brain damage. Ann N Y Acad Sci 835:234-249, 1997.","journal-title":"Ann N Y Acad Sci"},{"key":"5_CR101","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/sleep\/27.2.194","volume":"27","author":"SC Veasey","year":"2004","unstructured":"Veasey SC, Davis CW, Fenik P, Zhan G, Hsu YJ, Pratico D, and Gow A. Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions. Sleep 27:194-201, 2004.","journal-title":"Sleep"},{"key":"5_CR102","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1164\/rccm.200403-261OC","volume":"170","author":"SC Veasey","year":"2004","unstructured":"Veasey SC, Zhan G, Fenik P, and Pratico D. Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve output. Am J Respir Crit Care Med 170:665-672, 2004.","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR103","first-page":"685","volume":"27","author":"E Verstraeten","year":"2004","unstructured":"Verstraeten E, Cluydts R, Pevernagie D, and Hoffmann G. Executive function in sleep apnea: controlling for attentional capacity in assessing executive attention. Sleep 27:685-693, 2004.","journal-title":"Sleep"},{"key":"5_CR104","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.smrv.2005.01.006","volume":"9","author":"AN Vgontzas","year":"2005","unstructured":"Vgontzas AN, Bixler EO, and Chrousos GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 9:211-224, 2005.","journal-title":"Sleep Med Rev"},{"key":"5_CR105","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.neubiorev.2003.08.006","volume":"27","author":"D Viggiano","year":"2003","unstructured":"Viggiano D, Ruocco LA, and Sadile AG. Dopamine phenotype and behaviour in animal models: in relation to attention deficit hyperactivity disorder. Neurosci Biobehav Rev 27:623-637, 2003.","journal-title":"Neurosci Biobehav Rev"},{"key":"5_CR106","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1155\/NP.2004.97","volume":"11","author":"D Viggiano","year":"2004","unstructured":"Viggiano D, Vallone D, and Sadile A. Dysfunctions in dopamine systems and ADHD: evidence from animals and modeling. Neural Plast 11:97-114, 2004.","journal-title":"Neural Plast"},{"key":"5_CR107","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/dmrr.233","volume":"17","author":"H Vlassara","year":"2001","unstructured":"Vlassara H. The AGE-receptor in the pathogenesis of diabetic complications. Diabetes Metab Res Rev 17:436-443, 2001.","journal-title":"Diabetes Metab Res Rev"},{"key":"5_CR108","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.brainres.2006.03.060","volume":"1090","author":"Q Wang","year":"2006","unstructured":"Wang Q, Tompkins KD, Simonyi A, Korthuis RJ, Sun AY, and Sun GY. Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res 1090:182-189, 2006.","journal-title":"Brain Res"},{"key":"5_CR109","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuroscience.2005.09.028","volume":"139","author":"GV Williams","year":"2006","unstructured":"Williams GV and Castner SA. Under the curve: critical issues for elucidating D1 receptor function in working memory. Neuroscience 139:263-276, 2006.","journal-title":"Neuroscience"},{"key":"5_CR110","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1096\/fj.04-3218fje","volume":"19","author":"KC Wood","year":"2005","unstructured":"Wood KC, Hebbel RP, and Granger DN. Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice. Faseb J 19:989-991, 2005.","journal-title":"Faseb J"},{"key":"5_CR111","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuroscience.2004.03.055","volume":"126","author":"W Xu","year":"2004","unstructured":"Xu W, Chi L, Row BW, Xu R, Ke Y, Xu B, Luo C, Kheirandish L, Gozal D, and Liu R. Increased oxidative stress is associated with chronic intermittent hypoxiamediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea. Neuroscience 126:313-323, 2004.","journal-title":"Neuroscience"},{"key":"5_CR112","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/7449","volume":"5","author":"D Young","year":"1999","unstructured":"Young D, Lawlor PA, Leone P, Dragunow M, and During MJ. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med 5:448-453, 1999.","journal-title":"Nat Med"},{"key":"5_CR113","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1164\/rccm.200411-1564OC","volume":"171","author":"G Zhan","year":"2005","unstructured":"Zhan G, Fenik P, Pratico D, and Veasey SC. Inducible Nitric Oxide Synthase in Longterm Intermittent Hypoxia: Hypersomnolence and Brain Injury. Am J Respir Crit Care Med 171:1414-1420, 2005.","journal-title":"Am J Respir Crit Care Med"},{"key":"5_CR114","doi-asserted-by":"crossref","unstructured":"Zhan G, Serrano F, Fenik P, Hsu R, Kong L, Pratico D, Klann E, and Veasey SC. NADPH Oxidase Mediates Hypersomnolence and Brain Oxidative Injury in a Murine Model of Sleep Apnea. Am J Respir Crit Care Med, 2005.","DOI":"10.1164\/rccm.200504-581OC"}],"container-title":["Advances in Experimental Medicine and Biology","Hypoxia and the Circulation"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-0-387-75434-5_5.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T23:50:58Z","timestamp":1619653858000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-0-387-75434-5_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"ISBN":["9780387754338","9780387754345"],"references-count":114,"URL":"https:\/\/doi.org\/10.1007\/978-0-387-75434-5_5","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2007]]}}}