{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:33:30Z","timestamp":1782970410264,"version":"3.54.5"},"publisher-location":"New York, NY","reference-count":18,"publisher":"Springer US","isbn-type":[{"value":"9781071601747","type":"print"},{"value":"9781071601754","type":"electronic"}],"license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-1-0716-0175-4_7","type":"book-chapter","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T11:13:55Z","timestamp":1575285235000},"page":"77-90","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adeno-Associated Virus as Gene Delivery Vehicle into the Retina"],"prefix":"10.1007","author":[{"given":"Shuyun","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,1]]},"reference":[{"issue":"3685","key":"7_CR1","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1126\/science.149.3685.754","volume":"149","author":"RW Atchison","year":"1965","unstructured":"Atchison RW, Casto BC, Hammon WM (1965) Adenovirus-associated defective virus particles. Science 149(3685):754\u2013756","journal-title":"Science"},{"key":"7_CR2","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.coviro.2017.06.003","volume":"24","author":"S Pillay","year":"2017","unstructured":"Pillay S, Carette JE (2017) Host determinants of adeno-associated viral vector entry. Curr Opin Virol 24:124\u2013131. \nhttps:\/\/doi.org\/10.1016\/j.coviro.2017.06.003","journal-title":"Curr Opin Virol"},{"issue":"189","key":"7_CR3","doi-asserted-by":"publisher","first-page":"189ra176","DOI":"10.1126\/scitranslmed.3005708","volume":"5","author":"D Dalkara","year":"2013","unstructured":"Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV (2013) In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Sci Transl Med 5(189):189ra176. \nhttps:\/\/doi.org\/10.1126\/scitranslmed.3005708","journal-title":"Sci Transl Med"},{"issue":"2","key":"7_CR4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1089\/hum.2016.111","volume":"28","author":"PS Ramachandran","year":"2017","unstructured":"Ramachandran PS, Lee V, Wei Z, Song JY, Casal G, Cronin T, Willett K, Huckfeldt R, Morgan JI, Aleman TS, Maguire AM, Bennett J (2017) Evaluation of dose and safety of AAV7m8 and AAV8BP2 in the non-human primate retina. Hum Gene Ther 28(2):154\u2013167. \nhttps:\/\/doi.org\/10.1089\/hum.2016.111","journal-title":"Hum Gene Ther"},{"issue":"12","key":"7_CR5","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1038\/mt.2015.173","volume":"23","author":"D Grimm","year":"2015","unstructured":"Grimm D, Zolotukhin S (2015) E pluribus Unum: 50 years of research, millions of viruses, and one goal\u2014tailored acceleration of AAV evolution. Mol Ther 23(12):1819\u20131831. \nhttps:\/\/doi.org\/10.1038\/mt.2015.173","journal-title":"Mol Ther"},{"issue":"5","key":"7_CR6","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s11262-017-1502-7","volume":"53","author":"J Weinmann","year":"2017","unstructured":"Weinmann J, Grimm D (2017) Next-generation AAV vectors for clinical use: an ever-accelerating race. Virus Genes 53(5):707\u2013713. \nhttps:\/\/doi.org\/10.1007\/s11262-017-1502-7","journal-title":"Virus Genes"},{"key":"7_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.omtm.2017.11.007","volume":"8","author":"P Colella","year":"2018","unstructured":"Colella P, Ronzitti G, Mingozzi F (2018) Emerging issues in AAV-mediated in vivo gene therapy. Mol Ther Methods Clin Dev 8:87\u2013104. \nhttps:\/\/doi.org\/10.1016\/j.omtm.2017.11.007","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"15","key":"7_CR8","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.1128\/JVI.75.15.6969-6976.2001","volume":"75","author":"H Nakai","year":"2001","unstructured":"Nakai H, Yant SR, Storm TA, Fuess S, Meuse L, Kay MA (2001) Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo. J Virol 75(15):6969\u20136976. \nhttps:\/\/doi.org\/10.1128\/JVI.75.15.6969-6976.2001","journal-title":"J Virol"},{"issue":"1","key":"7_CR9","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ymthe.2006.03.008","volume":"14","author":"P Bell","year":"2006","unstructured":"Bell P, Moscioni AD, McCarter RJ, Wu D, Gao G, Hoang A, Sanmiguel JC, Sun X, Wivel NA, Raper SE, Furth EE, Batshaw ML, Wilson JM (2006) Analysis of tumors arising in male B6C3F1 mice with and without AAV vector delivery to liver. Mol Ther 14(1):34\u201344. \nhttps:\/\/doi.org\/10.1016\/j.ymthe.2006.03.008","journal-title":"Mol Ther"},{"issue":"5","key":"7_CR10","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1089\/hum.2012.112","volume":"24","author":"L Zhong","year":"2013","unstructured":"Zhong L, Malani N, Li M, Brady T, Xie J, Bell P, Li S, Jones H, Wilson JM, Flotte TR, Bushman FD, Gao G (2013) Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction. Hum Gene Ther 24(5):520\u2013525. \nhttps:\/\/doi.org\/10.1089\/hum.2012.112","journal-title":"Hum Gene Ther"},{"issue":"10","key":"7_CR11","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/ng.3389","volume":"47","author":"JC Nault","year":"2015","unstructured":"Nault JC, Datta S, Imbeaud S, Franconi A, Mallet M, Couchy G, Letouze E, Pilati C, Verret B, Blanc JF, Balabaud C, Calderaro J, Laurent A, Letexier M, Bioulac-Sage P, Calvo F, Zucman-Rossi J (2015) Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet 47(10):1187\u20131193. \nhttps:\/\/doi.org\/10.1038\/ng.3389","journal-title":"Nat Genet"},{"issue":"1","key":"7_CR12","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/mt.2009.258","volume":"18","author":"B Dong","year":"2010","unstructured":"Dong B, Nakai H, Xiao W (2010) Characterization of genome integrity for oversized recombinant AAV vector. Mol Ther 18(1):87\u201392. \nhttps:\/\/doi.org\/10.1038\/mt.2009.258","journal-title":"Mol Ther"},{"key":"7_CR13","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/02648725.2007.10648098","volume":"24","author":"A Ghosh","year":"2007","unstructured":"Ghosh A, Duan D (2007) Expanding adeno-associated viral vector capacity: a tale of two vectors. Biotechnol Genet Eng Rev 24:165\u2013177","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"2","key":"7_CR14","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.ymthe.2017.11.019","volume":"26","author":"A Maddalena","year":"2018","unstructured":"Maddalena A, Tornabene P, Tiberi P, Minopoli R, Manfredi A, Mutarelli M, Rossi S, Simonelli F, Naggert JK, Cacchiarelli D, Auricchio A (2018) Triple vectors expand AAV transfer capacity in the retina. Mol Ther 26(2):524\u2013541. \nhttps:\/\/doi.org\/10.1016\/j.ymthe.2017.11.019","journal-title":"Mol Ther"},{"issue":"4","key":"7_CR15","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/gt.2009.157","volume":"17","author":"E Ayuso","year":"2010","unstructured":"Ayuso E, Mingozzi F, Montane J, Leon X, Anguela XM, Haurigot V, Edmonson SA, Africa L, Zhou S, High KA, Bosch F, Wright JF (2010) High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency. Gene Ther 17(4):503\u2013510. \nhttps:\/\/doi.org\/10.1038\/gt.2009.157","journal-title":"Gene Ther"},{"issue":"10","key":"7_CR16","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1089\/hum.2010.055","volume":"21","author":"M Lock","year":"2010","unstructured":"Lock M, Alvira M, Vandenberghe LH, Samanta A, Toelen J, Debyser Z, Wilson JM (2010) Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale. Hum Gene Ther 21(10):1259\u20131271. \nhttps:\/\/doi.org\/10.1089\/hum.2010.055","journal-title":"Hum Gene Ther"},{"issue":"1","key":"7_CR17","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ymthe.2005.02.021","volume":"12","author":"JF Wright","year":"2005","unstructured":"Wright JF, Le T, Prado J, Bahr-Davidson J, Smith PH, Zhen Z, Sommer JM, Pierce GF, Qu G (2005) Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation. Mol Ther 12(1):171\u2013178. \nhttps:\/\/doi.org\/10.1016\/j.ymthe.2005.02.021","journal-title":"Mol Ther"},{"key":"7_CR18","doi-asserted-by":"publisher","first-page":"16019","DOI":"10.1038\/mtm.2016.19","volume":"5","author":"S D\u2019Costa","year":"2016","unstructured":"D\u2019Costa S, Blouin V, Broucque F, Penaud-Budloo M, Francois A, Perez IC, Le Bec C, Moullier P, Snyder RO, Ayuso E (2016) Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR. Mol Ther Methods Clin Dev 5:16019. \nhttps:\/\/doi.org\/10.1038\/mtm.2016.19","journal-title":"Mol Ther Methods Clin Dev"}],"container-title":["Methods in Molecular Biology","Retinal Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-0175-4_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T11:33:49Z","timestamp":1575286429000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-0716-0175-4_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,1]]},"ISBN":["9781071601747","9781071601754"],"references-count":18,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-0175-4_7","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,1]]},"assertion":[{"value":"1 December 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}