{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T18:25:02Z","timestamp":1746815102778,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":65,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071604748"},{"type":"electronic","value":"9781071604755"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-1-0716-0475-5_14","type":"book-chapter","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T02:03:38Z","timestamp":1589335418000},"page":"191-204","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design of a Peptide-Carrier Vaccine Based on the Highly Immunogenic Fasciola hepatica Leucine Aminopeptidase"],"prefix":"10.1007","author":[{"given":"Cecilia","family":"Salazar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 F.","family":"Tort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"14_CR1","doi-asserted-by":"crossref","unstructured":"Bachmann MF, Rohrer UH, K\u00fcndig TM, B\u00fcrki K,\u00a0\u00a0Hengartner H,\u00a0Zinkernagel RM (1993) The influence of antigen organization on B cell responsiveness. Science 262(5138):1448\u20131451","DOI":"10.1126\/science.8248784"},{"key":"14_CR2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1084\/jem.179.2.425","volume":"179","author":"MP Cooke","year":"1994","unstructured":"Cooke MP, Heath AW, Shokat KM, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC (1994) Immunoglobulin signal transduction guides the specificity of B cell\u2013T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med 179:425\u2013438","journal-title":"J Exp Med"},{"key":"14_CR3","first-page":"1","volume":"319","author":"HJ Hinton","year":"2008","unstructured":"Hinton HJ, Jegerlehner A, Bachmann MF (2008) Pattern recognition by B cells: the role of antigen repetitiveness versus toll-like receptors. Curr Top Microbiol Immunol 319:1\u201315","journal-title":"Curr Top Microbiol Immunol"},{"issue":"23","key":"14_CR4","doi-asserted-by":"publisher","first-page":"10795","DOI":"10.1073\/pnas.91.23.10795","volume":"91","author":"JB Sun","year":"1994","unstructured":"Sun JB, Holmgren J, Czerkinsky C (1994) Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc Natl Acad Sci U S A 91(23):10795\u201310799","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"14_CR5","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/prot.20248","volume":"57","author":"DA Laplagne","year":"2004","unstructured":"Laplagne DA, Zylberman V, Ainciart N, Steward MW, Sciutto E, Fossati CA, Goldbaum FA (2004) Engineering of a polymeric bacterial protein as a scaffold for the multiple display of peptides. Proteins 57(4):820\u2013828","journal-title":"Proteins"},{"key":"14_CR6","doi-asserted-by":"crossref","unstructured":"Piacenza L, Acosta D, Basmadjian I,\u00a0Dalton JP, Carmona C (1999) Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep.\u00a0Infect Immun 67(4):1954\u201361.","DOI":"10.1128\/IAI.67.4.1954-1961.1999"},{"issue":"48","key":"14_CR7","doi-asserted-by":"publisher","first-page":"9057","DOI":"10.1016\/j.vaccine.2011.09.020","volume":"29","author":"G Maggioli","year":"2011","unstructured":"Maggioli G, Acosta D, Silveira F, Rossi S, Giacaman S, Basika T et al (2011) The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep. Vaccine 29(48):9057\u20139063","journal-title":"Vaccine"},{"issue":"1","key":"14_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.molbiopara.2007.11.011","volume":"158","author":"D Acosta","year":"2008","unstructured":"Acosta D, Cancela M, Piacenza L, Roche L, Carmona C, Tort JF (2008) Fasciola hepatica leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis. Mol Biochem Parasitol 158(1):52\u201364","journal-title":"Mol Biochem Parasitol"},{"issue":"5","key":"14_CR9","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.micinf.2005.12.006","volume":"8","author":"G Rosas","year":"2006","unstructured":"Rosas G, Fragoso G, Ainciart N, Esquivel-Guadarrama F, Santana A, Bobes RJ et al (2006) Brucella spp. lumazine synthase: a novel adjuvant and antigen delivery system to effectively induce oral immunity. Microbes Infect 8(5):1277\u20131286","journal-title":"Microbes Infect"},{"issue":"4","key":"14_CR10","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1128\/IAI.71.4.2272-2275.2003","volume":"71","author":"SF Lee","year":"2003","unstructured":"Lee SF, Halperin SA, Salloum DF, MacMillan A, Morris A (2003) Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein. Infect Immun 71(4):2272\u20132275","journal-title":"Infect Immun"},{"issue":"3","key":"14_CR11","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3390\/vaccines2030515","volume":"2","author":"W Li","year":"2014","unstructured":"Li W, Joshi M, Singhania S, Ramsey K, Murthy A (2014) Peptide vaccine: progress and challenges. Vaccine 2(3):515\u2013536","journal-title":"Vaccine"},{"issue":"3","key":"14_CR12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2165\/00063030-200721030-00002","volume":"21","author":"JM Gershoni","year":"2007","unstructured":"Gershoni JM, Roitburd-Berman A, Siman-Tov DD, Freund NT, Weiss Y (2007) Epitope mapping: the first step in developing epitope-based vaccines. BioDrugs 21(3):145\u2013156","journal-title":"BioDrugs"},{"issue":"12","key":"14_CR13","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nchem.2396","volume":"7","author":"LH Jones","year":"2015","unstructured":"Jones LH (2015) Recent advances in the molecular design of synthetic vaccines. Nat Chem 7(12):952\u2013960","journal-title":"Nat Chem"},{"key":"14_CR14","doi-asserted-by":"crossref","unstructured":"Blythe MJ, Flower DR (2005) Benchmarking B cell epitope prediction: underperformance of existing methods. Protein Sci 14(1):246\u2013248","DOI":"10.1110\/ps.041059505"},{"issue":"4","key":"14_CR15","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.4049\/jimmunol.152.4.1861","volume":"152","author":"JL Sexton","year":"1994","unstructured":"Sexton JL, Wilce MC, Colin T, Wijffels GL, Salvatore L, Feil S et al (1994) Vaccination of sheep against Fasciola hepatica with glutathione S-transferase. Identification and mapping of antibody epitopes on a three-dimensional model of the antigen. J Immunol 152(4):1861\u20131872","journal-title":"J Immunol"},{"issue":"8","key":"14_CR16","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1128\/IAI.00442-06","volume":"74","author":"D Torres","year":"2006","unstructured":"Torres D, Espino AM (2006) Mapping of B-cell epitopes on a novel 11.5-kilodalton Fasciola hepatica-Schistosoma mansoni cross-reactive antigen belonging to a member of the F. hepatica saposin-like protein family. Infect Immun 74(8):4932\u20134938","journal-title":"Infect Immun"},{"issue":"8","key":"14_CR17","doi-asserted-by":"publisher","first-page":"e105323","DOI":"10.1371\/journal.pone.0105323","volume":"9","author":"J Rojas-Caraballo","year":"2014","unstructured":"Rojas-Caraballo J, L\u00f3pez-Ab\u00e1n J, P\u00e9rez Del Villar L, Vizca\u00edno C, Vicente B, Fern\u00e1ndez-Soto P et al (2014) In vitro and in vivo studies for assessing the immune response and protection-inducing ability conferred by Fasciola hepatica-derived synthetic peptides containing B- and T-cell epitopes. PLoS One 9(8):e105323","journal-title":"PLoS One"},{"issue":"1","key":"14_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00436-013-3650-6","volume":"113","author":"A Villa-Mancera","year":"2014","unstructured":"Villa-Mancera A, Reynoso-Palomar A, Utrera-Quintana F, Carre\u00f3n-Luna L (2014) Cathepsin L1 mimotopes with adjuvant Quil a induces a Th1\/Th2 immune response and confers significant protection against Fasciola hepatica infection in goats. Parasitol Res 113(1):243\u2013250","journal-title":"Parasitol Res"},{"issue":"1","key":"14_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1017\/S0022149X1000026X","volume":"85","author":"A Villa-Mancera","year":"2011","unstructured":"Villa-Mancera A, Quiroz-Romero H, Correa D, Alonso RA (2011) Proteolytic activity in Fasciola hepatica is reduced by the administration of cathepsin L mimotopes. J Helminthol 85(1):51\u201355","journal-title":"J Helminthol"},{"issue":"1","key":"14_CR20","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.tvjl.2012.03.003","volume":"194","author":"A Villa-Mancera","year":"2012","unstructured":"Villa-Mancera A, M\u00e9ndez-Mendoza M (2012) Protection and antibody isotype responses against Fasciola hepatica with specific antibody to pIII-displayed peptide mimotopes of cathepsin L1 in sheep. Vet J 194(1):108\u2013112","journal-title":"Vet J"},{"key":"14_CR21","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1017\/S003118200800471X","volume":"135","author":"A Villa-Mancera","year":"2008","unstructured":"Villa-Mancera A, Quiroz-Romero H, Correa D, Ibarra F, Reyes-P\u00e9rez M, Reyes-Vivas H et al (2008) Induction of immunity in sheep to Fasciola hepatica with mimotopes of cathepsin L selected from a phage display library. Parasitology 135:1437\u20131445","journal-title":"Parasitology"},{"issue":"5","key":"14_CR22","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0020-7519(99)00017-X","volume":"29","author":"JBWJ Cornelissen","year":"1999","unstructured":"Cornelissen JBWJ, Gaasenbeek CPH, Boersma W, Borgsteede FHM, Van Milligen FJ (1999) Use of a pre-selected epitope of cathepsin-L1in a highly specific peptide-based immunoassay for the diagnosis of Fasciola hepatica infections in cattle. Int J Parasitol 29(5):685\u2013696","journal-title":"Int J Parasitol"},{"key":"14_CR23","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.vaccine.2018.01.020","volume":"36","author":"L Garza-cuartero","year":"2018","unstructured":"Garza-cuartero L, Geurden T, Mahan SM, Hardham JM, Dalton JP, Mulcahy G (2018) Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica -infected and \/ or vaccinated cattle and identification of protective linear B-cell epitopes. Vaccine 36:958\u2013968","journal-title":"Vaccine"},{"issue":"1","key":"14_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1017\/S0022149X14000686","volume":"90","author":"K Hern\u00e1ndez-Guzm\u00e1n","year":"2016","unstructured":"Hern\u00e1ndez-Guzm\u00e1n K, Sahag\u00fan-Ruiz A, Vallecillo AJ, Cruz-Mendoza I, Quiroz-Romero H (2016) Construction and evaluation of a chimeric protein made from Fasciola hepatica leucine aminopeptidase and cathepsin L1. J Helminthol 90(1):7\u201313","journal-title":"J Helminthol"},{"key":"14_CR25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.vetpar.2015.01.004","volume":"208","author":"V Molina-Hern\u00e1ndez","year":"2015","unstructured":"Molina-Hern\u00e1ndez V, Mulcahy G, P\u00e9rez J, Mart\u00ednez-Moreno \u00c1, Donnelly S, O\u2019Neill SM et al (2015) Fasciola hepatica vaccine: we may not be there yet but we\u2019re on the right road. Vet Parasitol 208:101\u2013111","journal-title":"Vet Parasitol"},{"issue":"7","key":"14_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0002269","volume":"7","author":"I Corvo","year":"2013","unstructured":"Corvo I, O\u2019Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L et al (2013) Dissecting the active site of the Collagenolytic Cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis 7(7):1\u201311","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"14_CR27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.molbiopara.2009.04.005","volume":"167","author":"I Corvo","year":"2009","unstructured":"Corvo I, Cancela M, Cappetta M, Pi-Denis N, Tort JF, Roche L (2009) The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen. Mol Biochem Parasitol 167(1):41\u201347","journal-title":"Mol Biochem Parasitol"},{"issue":"4","key":"14_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001012","volume":"5","author":"MW Robinson","year":"2011","unstructured":"Robinson MW, Corvo I, Jones PM, George AM, Padula MP, To J et al (2011) Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica. PLoS Negl Trop Dis 5(4):e1012","journal-title":"PLoS Negl Trop Dis"},{"issue":"23","key":"14_CR29","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1016\/j.vaccine.2004.12.007","volume":"23","author":"N Reszka","year":"2005","unstructured":"Reszka N, Cornelissen JBWJ, Harmsen MM, Bie\u0144kowska-Szewczyk K, De Bree J, Boersma WJ et al (2005) Fasciola hepatica procathepsin L3 protein expressed by a baculovirus recombinant can partly protect rats against fasciolosis. Vaccine 23(23):2987\u20132993","journal-title":"Vaccine"},{"key":"14_CR30","doi-asserted-by":"crossref","unstructured":"Harmsen MM, Cornelissen JBWJ, Buijs HECM, Boersma WJA, Jeurissen SHM, Van Milligen FJ (2004) Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide. Int J Parasitol 34(6):675\u2013682","DOI":"10.1016\/j.ijpara.2003.12.011"},{"key":"14_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/6760830","volume":"2016","author":"L Potocnakova","year":"2016","unstructured":"Potocnakova L, Bhide M, Pulzova LB (2016) An introduction to B-cell epitope mapping and in Silico epitope prediction. J Immunol Res 2016:1\u201311","journal-title":"J Immunol Res"},{"issue":"W1","key":"14_CR32","doi-asserted-by":"publisher","first-page":"W24","DOI":"10.1093\/nar\/gkx346","volume":"45","author":"MC Jespersen","year":"2017","unstructured":"Jespersen MC, Peters B, Nielsen M, Marcatili P (2017) BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes. Nucleic Acids Res 45(W1):W24\u2013W29","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"14_CR33","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","volume":"276","author":"AS Kolaskar","year":"1990","unstructured":"Kolaskar AS, Tongaonkar PC (1990) A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett 276(1\u20132):172\u2013174","journal-title":"FEBS Lett"},{"issue":"4","key":"14_CR34","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/BF01195768","volume":"72","author":"PA Karplus","year":"1985","unstructured":"Karplus PA, Schulz GE (1985) Prediction of chain flexibility in proteins. Naturwissenschaften 72(4):212\u2013213","journal-title":"Naturwissenschaften"},{"issue":"3","key":"14_CR35","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1128\/jvi.55.3.836-839.1985","volume":"55","author":"EA Emini","year":"1985","unstructured":"Emini EA, Hughes JV, Perlow DS, Boger J (1985) Induction of hepatitis a virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol 55(3):836\u2013839","journal-title":"J Virol"},{"key":"14_CR36","first-page":"45","volume":"47","author":"PY Chou","year":"1978","unstructured":"Chou PY, Fasman GD (1978) Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol 47:45\u2013148","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"issue":"19","key":"14_CR37","doi-asserted-by":"publisher","first-page":"5425","DOI":"10.1021\/bi00367a013","volume":"25","author":"JMR Parker","year":"1986","unstructured":"Parker JMR, Guo D, Hodges RS (1986) New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites. Biochemistry 25(19):5425\u20135432","journal-title":"Biochemistry"},{"key":"14_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/978-1-4939-6406-2_17","volume":"1484","author":"Y El-Manzalawy","year":"2017","unstructured":"El-Manzalawy Y, Dobbs D, Honavar VG (2017) In Silico prediction of linear B-cell epitopes on proteins. Methods Mol Biol 1484:255\u2013264","journal-title":"Methods Mol Biol"},{"issue":"3","key":"14_CR39","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00726-006-0485-9","volume":"33","author":"J Chen","year":"2007","unstructured":"Chen J, Liu H, Yang J, Chou K-C (2007) Prediction of linear B-cell epitopes using amino acid pair antigenicity scale. Amino Acids 33(3):423\u2013428","journal-title":"Amino Acids"},{"key":"14_CR40","doi-asserted-by":"crossref","unstructured":"El-Manzalawy Y, Dobbs D,\u00a0Honavar V (2008) Predicting linear B-cell epitopes using string kernels. J Mol Recognit 21(4):243\u2013255","DOI":"10.1002\/jmr.893"},{"key":"14_CR41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1142\/9781848162648_0011","volume":"7","author":"Y El-Manzalawy","year":"2008","unstructured":"El-Manzalawy Y, Dobbs D, Honavar V (2008) Predicting flexible length linear B-cell epitopes. Comput Syst Bioinformatics Conf 7:121\u2013132","journal-title":"Comput Syst Bioinformatics Conf"},{"issue":"3","key":"14_CR42","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/protein\/gzn075","volume":"22","author":"MJ Sweredoski","year":"2009","unstructured":"Sweredoski MJ, Baldi P (2009) COBEpro: a novel system for predicting continuous B-cell epitopes. Protein Eng Des Sel 22(3):113\u2013120","journal-title":"Protein Eng Des Sel"},{"issue":"5","key":"14_CR43","first-page":"1","volume":"8","author":"H Singh","year":"2013","unstructured":"Singh H, Ansari HR, Raghava GPS (2013) Improved method for linear B-cell epitope prediction using Antigen\u2019s primary sequence. PLoS One 8(5):1\u20138","journal-title":"PLoS One"},{"issue":"9","key":"14_CR44","first-page":"5","volume":"7","author":"B Yao","year":"2012","unstructured":"Yao B, Zhang L, Liang S, Zhang C (2012) SVMTriP: a method to predict antigenic epitopes using support vector machine to integrate tri-peptide similarity and propensity. PLoS One 7(9):5\u20139","journal-title":"PLoS One"},{"issue":"1","key":"14_CR45","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/prot.21078","volume":"65","author":"S Saha","year":"2006","unstructured":"Saha S, Raghava GPS (2006) Prediction of continuous B-cell epitopes in an antigen using recurrent neural network. Proteins 65(1):40\u201348","journal-title":"Proteins"},{"issue":"1","key":"14_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nmeth.3213","volume":"12","author":"J Yang","year":"2014","unstructured":"Yang J, Yan R, Roy A, Xu D, Poisson J, Zhang Y (2014) The I-TASSER suite: protein structure and function prediction. Nat Methods 12(1):7\u20138","journal-title":"Nat Methods"},{"issue":"4","key":"14_CR47","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nprot.2010.5","volume":"5","author":"A Roy","year":"2010","unstructured":"Roy A, Kucukural A, Zhang Y (2010) I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc 5(4):725\u2013738","journal-title":"Nat Protoc"},{"key":"14_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-9-1","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y (2008) I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 9:1\u20138","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"14_CR49","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","volume":"234","author":"A Sali","year":"1993","unstructured":"Sali A, Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234(3):779\u2013815","journal-title":"J Mol Biol"},{"key":"14_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6807-9-51","volume":"9","author":"B Petersen","year":"2009","unstructured":"Petersen B, Petersen TN, Andersen P, Nielsen M, Lundegaard C (2009) A generic method for assignment of reliability scores applied to solvent accessibility predictions. BMC Struct Biol 9:1\u201310","journal-title":"BMC Struct Biol"},{"issue":"15","key":"14_CR51","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"N Guex","year":"1997","unstructured":"Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18(15):2714\u20132723","journal-title":"Electrophoresis"},{"issue":"5016","key":"14_CR52","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1126\/science.1853201","volume":"253","author":"JU Bowie","year":"1991","unstructured":"Bowie JU, Luthy R, Eisenberg D (1991) A method to identify protein sequences that fold into a known three-dimensional structure. Science 253(5016):164\u2013170","journal-title":"Science"},{"issue":"6364","key":"14_CR53","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/356083a0","volume":"356","author":"R Luthy","year":"1992","unstructured":"Luthy R, Bowie JU, Eisenberg D (1992) Assessment of protein models with three-dimensional profiles. Nature 356(6364):83\u201385","journal-title":"Nature"},{"key":"14_CR54","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/pro.5560020916","volume":"2","author":"C Colovos","year":"1993","unstructured":"Colovos C, Yeates T (1993) Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci 2:1511\u20131519","journal-title":"Protein Sci"},{"issue":"1","key":"14_CR55","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1006\/jmbi.1996.0628","volume":"264","author":"J Pontius","year":"1996","unstructured":"Pontius J, Richelle J, Wodak SJ (1996) Deviations from standard atomic volumes as a quality measure for protein crystal structures. J Mol Biol 264(1):121\u2013136","journal-title":"J Mol Biol"},{"issue":"2","key":"14_CR56","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"RA Laskowski","year":"1993","unstructured":"Laskowski RA, MacArthur MW, Moss DS, Thornton JM (1993) PROCHECK: a program to check the stereochemical quality of protein structures. J Appl Crystallogr 26(2):283\u2013291","journal-title":"J Appl Crystallogr"},{"key":"14_CR57","doi-asserted-by":"crossref","unstructured":"Hooft RW, Vriend G, Sander C, Abola EE (1996) Errors in protein structures. Nature 381, 272\u00a0","DOI":"10.1038\/381272a0"},{"issue":"8","key":"14_CR58","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1107\/S2059798317008920","volume":"73","author":"SD Lam","year":"2017","unstructured":"Lam SD, Das S, Sillitoe I, Orengo C (2017) An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences. Acta Crystallogr D Struct Biol 73(8):628\u2013640","journal-title":"Acta Crystallogr D Struct Biol"},{"issue":"3\u20134","key":"14_CR59","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1006\/biol.2001.0308","volume":"29","author":"MHV Van Regenmortel","year":"2001","unstructured":"Van Regenmortel MHV (2001) Antigenicity and immunogenicity of synthetic peptides. Biologicals 29(3\u20134):209\u2013213","journal-title":"Biologicals"},{"key":"14_CR60","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1017\/S0033583500000998","volume":"3","author":"F Celada","year":"1972","unstructured":"Celada F, Strom R (1972) Antibody-induced conformational changes in proteins. Q Rev Biophys 3:395\u2013425","journal-title":"Q Rev Biophys"},{"key":"14_CR61","doi-asserted-by":"crossref","unstructured":"Fiser A (2010) Template-based protein structure modeling. Methods Mol Biol 673:73\u201394","DOI":"10.1007\/978-1-60761-842-3_6"},{"key":"14_CR62","doi-asserted-by":"crossref","unstructured":"Michael SK, Martin CJ, Henrik N, Kamilla KJ, Vanessa IJ, Casper KS, Morten OAS, Ole W, Morten N, Bent P, Paolo M (2019) NetSurfP\u20102.0: Improved prediction of protein structural features by integrated deep learning. Proteins: Structure, Function, and Bioinformatics 87(6):520\u2013527","DOI":"10.1002\/prot.25674"},{"key":"14_CR63","doi-asserted-by":"crossref","unstructured":"Waterhouse AM, Procter JB,Martin DMA, Clamp M, Barton GJ (2009) Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Bioinformatics 25(9):1189\u20131191","DOI":"10.1093\/bioinformatics\/btp033"},{"key":"14_CR64","doi-asserted-by":"crossref","unstructured":"G. E. Crooks, Hon G,\u00a0Chandonia JM,\u00a0Brenner SE (2004) WebLogo: A Sequence Logo Generator. Genome Research 14 (6):1188\u20131190","DOI":"10.1101\/gr.849004"},{"key":"14_CR65","doi-asserted-by":"crossref","unstructured":"Schneider TD, Stephens RM (1990) Sequence logos: a new way to display consensus sequences. Nucleic Acids Research 18 (20):6097\u20136100","DOI":"10.1093\/nar\/18.20.6097"}],"container-title":["Methods in Molecular Biology","Fasciola hepatica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-0475-5_14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:21:02Z","timestamp":1696119662000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-0475-5_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9781071604748","9781071604755"],"references-count":65,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-0475-5_14","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"14 May 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}