{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T20:03:41Z","timestamp":1743537821319,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":22,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071608449"},{"type":"electronic","value":"9781071608456"}],"license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-1-0716-0845-6_9","type":"book-chapter","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T22:04:02Z","timestamp":1597701842000},"page":"85-96","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In Vivo Ear Sponge Lymphangiogenesis Assay"],"prefix":"10.1007","author":[{"given":"Racheal G.","family":"Akwii","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md S.","family":"Sajib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatema T.","family":"Zahra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanumantha R.","family":"Madala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalkunte S.","family":"Srivenugopal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantinos M.","family":"Mikelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/978-1-4939-7595-2_20","volume":"1731","author":"M Van de Velde","year":"2018","unstructured":"Van de Velde M, Garcia-Caballero M, Durre T et al (2018) Ear sponge assay: a method to investigate angiogenesis and lymphangiogenesis in mice. Methods Mol Biol 1731:223\u2013233. \nhttps:\/\/doi.org\/10.1007\/978-1-4939-7595-2_20","journal-title":"Methods Mol Biol"},{"issue":"4","key":"9_CR2","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","volume":"140","author":"T Tammela","year":"2010","unstructured":"Tammela T, Alitalo K (2010) Lymphangiogenesis: molecular mechanisms and future promise. Cell 140(4):460\u2013476. \nhttps:\/\/doi.org\/10.1016\/j.cell.2010.01.045","journal-title":"Cell"},{"issue":"5","key":"9_CR3","doi-asserted-by":"publisher","first-page":"R70","DOI":"10.1186\/bcr2638","volume":"12","author":"A Baker","year":"2010","unstructured":"Baker A, Kim H, Semple JL et al (2010) Experimental assessment of pro-lymphangiogenic growth factors in the treatment of post-surgical lymphedema following lymphadenectomy. Breast Cancer Res 12(5):R70. \nhttps:\/\/doi.org\/10.1186\/bcr2638","journal-title":"Breast Cancer Res"},{"key":"9_CR4","doi-asserted-by":"publisher","unstructured":"Geladari E, Dimopoulou G, Margellou E et al (2019) Coexistence of Hodgkin and non-Hodgkin lymphoma; composite lymphoma (CL) in a patient presenting with waxing and waning lymphadenopathy. Cardiovasc Hematol Disord Drug Targets. \nhttps:\/\/doi.org\/10.2174\/1871529x19666191014111118","DOI":"10.2174\/1871529x19666191014111118"},{"issue":"11","key":"9_CR5","first-page":"896","volume":"94","author":"HL Gaddey","year":"2016","unstructured":"Gaddey HL, Riegel AM (2016) Unexplained lymphadenopathy: evaluation and differential diagnosis. Am Fam Physician 94(11):896\u2013903","journal-title":"Am Fam Physician"},{"key":"9_CR6","doi-asserted-by":"publisher","unstructured":"Otsuka I (2019) Cutaneous metastasis after surgery, injury, lymphadenopathy, and peritonitis: possible mechanisms. Int J Mol Sci 20(13). \nhttps:\/\/doi.org\/10.3390\/ijms20133286","DOI":"10.3390\/ijms20133286"},{"issue":"586","key":"9_CR7","first-page":"2124","volume":"13","author":"M Depairon","year":"2017","unstructured":"Depairon M, Lessert C, Tomson D et al (2017) Primary lymphedema. Rev Med Suisse 13(586):2124\u20132128","journal-title":"Rev Med Suisse"},{"issue":"5-6","key":"9_CR8","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s10585-018-9899-5","volume":"35","author":"M Bernas","year":"2018","unstructured":"Bernas M, Thiadens SRJ, Smoot B et al (2018) Lymphedema following cancer therapy: overview and options. Clin Exp Metastasis 35(5-6):547\u2013551. \nhttps:\/\/doi.org\/10.1007\/s10585-018-9899-5","journal-title":"Clin Exp Metastasis"},{"key":"9_CR9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.11604\/pamj.2018.31.251.16166","volume":"31","author":"FZ Agharbi","year":"2018","unstructured":"Agharbi FZ (2018) Lymphedema complicated with verrucous papillomatosis. Pan Afr Med J 31:251. \nhttps:\/\/doi.org\/10.11604\/pamj.2018.31.251.16166","journal-title":"Pan Afr Med J"},{"issue":"23","key":"9_CR10","doi-asserted-by":"publisher","first-page":"8364","DOI":"10.1158\/1078-0432.Ccr-05-1238","volume":"11","author":"Z Gombos","year":"2005","unstructured":"Gombos Z, Xu X, Chu CS et al (2005) Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res 11(23):8364\u20138371. \nhttps:\/\/doi.org\/10.1158\/1078-0432.Ccr-05-1238","journal-title":"Clin Cancer Res"},{"issue":"5","key":"9_CR11","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1007\/s00428-006-0166-9","volume":"448","author":"P Liang","year":"2006","unstructured":"Liang P, Hong JW, Ubukata H et al (2006) Increased density and diameter of lymphatic microvessels correlate with lymph node metastasis in early stage invasive colorectal carcinoma. Virchows Arch 448(5):570\u2013575. \nhttps:\/\/doi.org\/10.1007\/s00428-006-0166-9","journal-title":"Virchows Arch"},{"issue":"3","key":"9_CR12","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/modpathol.3800546","volume":"19","author":"AA Roma","year":"2006","unstructured":"Roma AA, Magi-Galluzzi C, Kral MA et al (2006) Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma. Mod Pathol 19(3):392\u2013398. \nhttps:\/\/doi.org\/10.1038\/modpathol.3800546","journal-title":"Mod Pathol"},{"key":"9_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/aja.1000030205","volume":"3","author":"FR Sabin","year":"1904","unstructured":"Sabin FR (1904) On the development of the superficial lymphatics in the skin of the pig. Am J Anat 3:183\u2013195","journal-title":"Am J Anat"},{"issue":"1","key":"9_CR14","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1046\/j.1087-0024.2000.00001.x","volume":"5","author":"M Skobe","year":"2000","unstructured":"Skobe M, Detmar M (2000) Structure, function, and molecular control of the skin lymphatic system. J Investig Dermatol Symp Proc 5(1):14\u201319. \nhttps:\/\/doi.org\/10.1046\/j.1087-0024.2000.00001.x","journal-title":"J Investig Dermatol Symp Proc"},{"key":"9_CR15","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/978-1-4939-8712-2_17","volume":"1846","author":"WW Kilarski","year":"2018","unstructured":"Kilarski WW, Guc E, Swartz MA (2018) Dorsal ear skin window for Intravital imaging and functional analysis of Lymphangiogenesis. Methods Mol Biol 1846:261\u2013277. \nhttps:\/\/doi.org\/10.1007\/978-1-4939-8712-2_17","journal-title":"Methods Mol Biol"},{"issue":"7","key":"9_CR16","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/s0092-8674(00)81812-7","volume":"87","author":"S Davis","year":"1996","unstructured":"Davis S, Aldrich TH, Jones PF et al (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87(7):1161\u20131169. \nhttps:\/\/doi.org\/10.1016\/s0092-8674(00)81812-7","journal-title":"Cell"},{"issue":"3","key":"9_CR17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S1534-5807(02)00217-4","volume":"3","author":"NW Gale","year":"2002","unstructured":"Gale NW, Thurston G, Hackett SF et al (2002) Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell 3(3):411\u2013423","journal-title":"Dev Cell"},{"issue":"5","key":"9_CR18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3390\/cells8050471","volume":"8","author":"RG Akwii","year":"2019","unstructured":"Akwii RG, Sajib MS, Zahra FT et al (2019) Role of Angiopoietin-2 in vascular physiology and pathophysiology. Cell 8(5):471. \nhttps:\/\/doi.org\/10.3390\/cells8050471","journal-title":"Cell"},{"issue":"1","key":"9_CR19","doi-asserted-by":"publisher","first-page":"H215","DOI":"10.1152\/ajpheart.00895.2011","volume":"302","author":"ZX Yan","year":"2012","unstructured":"Yan ZX, Jiang ZH, Liu NF (2012) Angiopoietin-2 promotes inflammatory lymphangiogenesis and its effect can be blocked by the specific inhibitor L1-10. Am J Physiol Heart Circ Physiol 302(1):H215\u2013H223. \nhttps:\/\/doi.org\/10.1152\/ajpheart.00895.2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"9_CR20","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ydbio.2008.04.024","volume":"319","author":"M Dellinger","year":"2008","unstructured":"Dellinger M, Hunter R, Bernas M et al (2008) Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev Biol 319(2):309\u2013320. \nhttps:\/\/doi.org\/10.1016\/j.ydbio.2008.04.024","journal-title":"Dev Biol"},{"key":"9_CR21","doi-asserted-by":"publisher","first-page":"41494","DOI":"10.1038\/srep41494","volume":"7","author":"M Garcia-Caballero","year":"2017","unstructured":"Garcia-Caballero M, Van de Velde M, Blacher S et al (2017) Modeling pre-metastatic lymphvascular niche in the mouse ear sponge assay. Sci Rep 7:41494. \nhttps:\/\/doi.org\/10.1038\/srep41494","journal-title":"Sci Rep"},{"issue":"1","key":"9_CR22","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1038\/s41467-018-07514-1","volume":"9","author":"T Durre","year":"2018","unstructured":"Durre T, Morfoisse F, Erpicum C et al (2018) uPARAP\/Endo180 receptor is a gatekeeper of VEGFR-2\/VEGFR-3 heterodimerisation during pathological lymphangiogenesis. Nat Commun 9(1):5178. \nhttps:\/\/doi.org\/10.1038\/s41467-018-07514-1","journal-title":"Nat Commun"}],"container-title":["Methods in Molecular Biology","Wound Regeneration"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-0845-6_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T22:10:37Z","timestamp":1597702237000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-0716-0845-6_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"ISBN":["9781071608449","9781071608456"],"references-count":22,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-0845-6_9","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2020,8,18]]},"assertion":[{"value":"18 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}