{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:35:23Z","timestamp":1792157723514,"version":"4.4.0"},"publisher-location":"New York, NY","reference-count":28,"publisher":"Springer US","isbn-type":[{"value":"9781071608593","type":"print"},{"value":"9781071608609","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-1-0716-0860-9_16","type":"book-chapter","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T08:02:57Z","timestamp":1598515377000},"page":"245-261","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Detection of Circulating Tumor Cells (CTCs) in Patients with Testicular Germ Cell Tumors"],"prefix":"10.1007","author":[{"given":"Paulina","family":"Nasta\u0142y","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"Honecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pantel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Riethdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"16_CR1","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1111\/j.1464-410X.2009.08854.x","volume":"104","author":"RP Manecksha","year":"2009","unstructured":"Manecksha RP, Fitzpatrick JM (2009) Epidemiology of testicular cancer. BJU Int 104:1329\u20131333","journal-title":"BJU Int"},{"key":"16_CR2","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/1097-0142(19870801)60:3+<464::AID-CNCR2820601506>3.0.CO;2-C","volume":"60","author":"PH Lange","year":"1987","unstructured":"Lange PH, Winfield HN (1987) Biological markers in urologic cancer. Cancer 60:464\u2013472","journal-title":"Cancer"},{"key":"16_CR3","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1200\/JCO.2009.26.4481","volume":"28","author":"TD Gilligan","year":"2010","unstructured":"Gilligan TD, Seidenfeld J, Basch EM, Einhorn LH, Fancher T, Smith DC, Stephenson AJ, Vaughn DJ, Cosby R, Hayes DF (2010) American Society of Clinical Oncology Clinical Practice Guideline on uses of serum tumor markers in adult males with germ cell tumors. J Clin Oncol 28:3388\u20133404","journal-title":"J Clin Oncol"},{"key":"16_CR4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3109\/02841868409136024","volume":"23","author":"B Norgaard-Pedersen","year":"1984","unstructured":"Norgaard-Pedersen B, Schultz HP, Arends J, Brincker H, Krag Jacobsen G, Lindelov B, Rorth M, Svennekjaer IL (1984) Tumour markers in testicular germ cell tumours. Five-year experience from the DATECA Study 1976-1980. Acta Radiol Oncol 23:287\u2013294","journal-title":"Acta Radiol Oncol"},{"key":"16_CR5","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1159\/000474288","volume":"24","author":"JN Kulkarni","year":"1993","unstructured":"Kulkarni JN, Kamat MR (1993) Value of tumor markers in nonseminomatous germ cell tumor of the testis. Eur Urol 24:166\u2013171","journal-title":"Eur Urol"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1309\/AJCPOE11KEYZCJHT","volume":"135","author":"MJ Murray","year":"2011","unstructured":"Murray MJ, Halsall DJ, Hook CE, Williams DM, Nicholson JC, Coleman N (2011) Identification of microRNAs From the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. Am J Clin Pathol 135:119\u2013125","journal-title":"Am J Clin Pathol"},{"key":"16_CR7","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.eururo.2012.02.037","volume":"61","author":"G Belge","year":"2012","unstructured":"Belge G, Dieckmann KP, Spiekermann M, Balks T, Bullerdiek J (2012) Serum levels of microRNAs miR-371-3: a novel class of serum biomarkers for testicular germ cell tumors? Eur Urol 61:1068\u20131069","journal-title":"Eur Urol"},{"key":"16_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.eururo.2016.07.029","volume":"71","author":"KP Dieckmann","year":"2017","unstructured":"Dieckmann KP, Radtke A, Spiekermann M, Balks T, Matthies C, Becker P, Ruf C, Oing C, Oechsle K, Bokemeyer C, Hammel J, Melchior S, Wosniok W, Belge G (2017) Serum levels of microRNA miR-371a-3p: a sensitive and specific new biomarker for germ cell tumours. Eur Urol 71:213\u2013220","journal-title":"Eur Urol"},{"key":"16_CR9","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.molonc.2013.08.002","volume":"7","author":"AJ Gillis","year":"2013","unstructured":"Gillis AJ, Rijlaarsdam MA, Eini R, Dorssers LC, Biermann K, Murray MJ, Nicholson JC, Coleman N, Dieckmann KP, Belge G, Bullerdiek J, Xu T, Bernard N, Looijenga LH (2013) Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle. Mol Oncol 7:1083\u20131092","journal-title":"Mol Oncol"},{"key":"16_CR10","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.ccell.2017.01.002","volume":"31","author":"A Bardelli","year":"2017","unstructured":"Bardelli A, Pantel K (2017) Liquid biopsies, what we do not know (yet). Cancer Cell 31:172\u2013179","journal-title":"Cancer Cell"},{"key":"16_CR11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00404-015-3879-7","volume":"293","author":"A Schramm","year":"2016","unstructured":"Schramm A, Friedl TW, Schochter F, Scholz C, de Gregorio N, Huober J, Rack B, Trapp E, Alunni-Fabbroni M, Muller V, Schneeweiss A, Pantel K, Meier-Stiegen F, Hartkopf A, Taran FA, Wallwiener D, Janni W, Fehm T (2016) Therapeutic intervention based on circulating tumor cell phenotype in metastatic breast cancer: concept of the DETECT study program. Arch Gynecol Obstet 293:271\u2013281","journal-title":"Arch Gynecol Obstet"},{"key":"16_CR12","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.ejca.2016.04.024","volume":"63","author":"M Ignatiadis","year":"2016","unstructured":"Ignatiadis M, Rack B, Rothe F, Riethdorf S, Decraene C, Bonnefoi H, Dittrich C, Messina C, Beauvois M, Trapp E, Goulioti T, Tryfonidis K, Pantel K, Repollet M, Janni W, Piccart M, Sotiriou C, Litiere S, Pierga JY (2016) Liquid biopsy-based clinical research in early breast cancer: the EORTC 90091-10093 Treat CTC trial. Eur J Cancer 63:97\u2013104","journal-title":"Eur J Cancer"},{"key":"16_CR13","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1056\/NEJMoa040766","volume":"351","author":"M Cristofanilli","year":"2004","unstructured":"Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW, Hayes DF (2004) Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351:781\u2013791","journal-title":"N Engl J Med"},{"key":"16_CR14","first-page":"93","volume":"4","author":"Y Fan","year":"1998","unstructured":"Fan Y, Einhorn L, Saxman S, Katz B, Abonour R, Cornetta K (1998) Detection of germ cell tumor cells in apheresis products using polymerase chain reaction. Clin Cancer Res 4:93\u201398","journal-title":"Clin Cancer Res"},{"key":"16_CR15","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/sj.bmt.1701416","volume":"22","author":"MO Hildebrandt","year":"1998","unstructured":"Hildebrandt MO, Blaser F, Beyer J, Siegert W, Mapara MY, Huhn D, Salama A (1998) Detection of tumor cells in peripheral blood samples from patients with germ cell tumors using immunocytochemical and reverse transcriptase-polymerase chain reaction techniques. Bone Marrow Transplant 22:771\u2013775","journal-title":"Bone Marrow Transplant"},{"key":"16_CR16","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1200\/JCO.2001.19.12.3029","volume":"19","author":"C Bokemeyer","year":"2001","unstructured":"Bokemeyer C, Gillis AJ, Pompe K, Mayer F, Metzner B, Schleucher N, Schleicher J, Pflugrad-Jauch G, Oosterhuis JW, Kanz L, Looijenga LH (2001) Clinical impact of germ cell tumor cells in apheresis products of patients receiving high-dose chemotherapy. J Clin Oncol 19:3029\u20133036","journal-title":"J Clin Oncol"},{"key":"16_CR17","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1046\/j.1442-2042.1999.00064.x","volume":"6","author":"T Yuasa","year":"1999","unstructured":"Yuasa T, Yoshiki T, Isono T, Tanaka T, Hayashida H, Okada Y (1999) Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. Int J Urol 6:286\u2013292","journal-title":"Int J Urol"},{"key":"16_CR18","first-page":"3170","volume":"60","author":"AL Hautkappe","year":"2000","unstructured":"Hautkappe AL, Lu M, Mueller H, Bex A, Harstrick A, Roggendorf M, Ruebben H (2000) Detection of germ-cell tumor cells in the peripheral blood by nested reverse transcription-polymerase chain reaction for alpha-fetoprotein-messenger RNA and beta human chorionic gonadotropin-messenger RNA. Cancer Res 60:3170\u20133174","journal-title":"Cancer Res"},{"key":"16_CR19","doi-asserted-by":"publisher","first-page":"3830","DOI":"10.1158\/1078-0432.CCR-13-2819","volume":"20","author":"P Nastaly","year":"2014","unstructured":"Nastaly P, Ruf C, Becker P, Bednarz-Knoll N, Stoupiec M, Kavsur R, Isbarn H, Matthies C, Wagner W, Hoppner D, Fisch M, Bokemeyer C, Ahyai S, Honecker F, Riethdorf S, Pantel K (2014) Circulating tumor cells in patients with testicular germ cell tumors. Clin Cancer Res 20:3830\u20133841","journal-title":"Clin Cancer Res"},{"key":"16_CR20","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.addr.2018.01.011","volume":"125","author":"S Riethdorf","year":"2018","unstructured":"Riethdorf S, O\u2019Flaherty L, Hille C, Pantel K (2018) Clinical applications of the CellSearch platform in cancer patients. Adv Drug Deliv Rev 125:102\u2013121","journal-title":"Adv Drug Deliv Rev"},{"key":"16_CR21","first-page":"1211","volume":"84","author":"Y Mizuno","year":"1993","unstructured":"Mizuno Y, Gotoh A, Kamidono S, Kitazawa S (1993) Establishment and characterization of a new human testicular germ cell tumor cell line (TCam-2). Nihon Hinyokika Gakkai Zasshi 84:1211\u20131218","journal-title":"Nihon Hinyokika Gakkai Zasshi"},{"key":"16_CR22","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/ijc.2910300506","volume":"30","author":"PW Andrews","year":"1982","unstructured":"Andrews PW (1982) Human embryonal carcinoma cells in culture do not synthesize fibronectin until they differentiate. Int J Cancer 30:567\u2013571","journal-title":"Int J Cancer"},{"key":"16_CR23","first-page":"220","volume":"68","author":"I Damjanov","year":"1993","unstructured":"Damjanov I, Horvat B, Gibas Z (1993) Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT. Lab Investig 68:220\u2013232","journal-title":"Lab Investig"},{"key":"16_CR24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0012-1606(84)90316-6","volume":"103","author":"PW Andrews","year":"1984","unstructured":"Andrews PW (1984) Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev Biol 103:285\u2013293","journal-title":"Dev Biol"},{"key":"16_CR25","first-page":"147","volume":"50","author":"PW Andrews","year":"1984","unstructured":"Andrews PW, Damjanov I, Simon D, Banting GS, Carlin C, Dracopoli NC, Fogh J (1984) Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Lab Investig 50:147\u2013162","journal-title":"Lab Investig"},{"key":"16_CR26","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1034\/j.1600-0463.2003.11101201.x","volume":"111","author":"LH Looijenga","year":"2003","unstructured":"Looijenga LH, Zafarana G, Grygalewicz B, Summersgill B, Debiec-Rychter M, Veltman J, Schoenmakers EF, Rodriguez S, Jafer O, Clark J, van Kessel AG, Shipley J, van Gurp RJ, Gillis AJ, Oosterhuis JW (2003) Role of gain of 12p in germ cell tumour development. APMIS 111:161\u2013171. Discussion 172\u2013173","journal-title":"APMIS"},{"key":"16_CR27","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/978-1-4939-2990-0_18","volume":"1347","author":"F Coumans","year":"2015","unstructured":"Coumans F, Terstappen L (2015) Detection and characterization of circulating tumor cells by the CellSearch approach. Methods Mol Biol 1347:263\u2013278","journal-title":"Methods Mol Biol"},{"key":"16_CR28","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1002\/1873-3468.12662","volume":"591","author":"C Alix-Panabieres","year":"2017","unstructured":"Alix-Panabieres C, Pantel K (2017) Characterization of single circulating tumor cells. FEBS Lett 591:2241\u20132250","journal-title":"FEBS Lett"}],"container-title":["Methods in Molecular Biology","Testicular Germ Cell Tumors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-0860-9_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T19:07:23Z","timestamp":1630091243000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-0860-9_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"ISBN":["9781071608593","9781071608609"],"references-count":28,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-0860-9_16","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"28 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}