{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:44:52Z","timestamp":1772660692464,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":10,"publisher":"Springer US","isbn-type":[{"value":"9781071609385","type":"print"},{"value":"9781071609392","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-1-0716-0939-2_21","type":"book-chapter","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T22:03:31Z","timestamp":1597874611000},"page":"215-224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Invasion of Gingival Epithelial Cells by Porphyromonas gingivalis"],"prefix":"10.1007","author":[{"given":"Hiroki","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Amano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"issue":"4","key":"21_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003326","volume":"9","author":"H Takeuchi","year":"2013","unstructured":"Takeuchi H, Hirano T, Whitmore SE et al (2013) The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-\u03baB RelA\/p65. PLoS Pathog 9(4):e1003326","journal-title":"PLoS Pathog"},{"issue":"5698","key":"21_CR2","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1126\/science.1103966","volume":"306","author":"I Nakagawa","year":"2004","unstructured":"Nakagawa I, Amano A, Mizushima N et al (2004) Autophagy defends cells against invading group A Streptococcus. Science 306(5698):1037\u20131040","journal-title":"Science"},{"issue":"11","key":"21_CR3","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.1128\/IAI.00841-09","volume":"77","author":"N Furuta","year":"2009","unstructured":"Furuta N, Takeuchi H, Amano A (2009) Entry of Porphyromonas gingivalis outer membrane vesicles into epithelial cells causes cellular functional impairment. Infect Immun 77(11):4761\u20134770","journal-title":"Infect Immun"},{"issue":"2","key":"21_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1247\/csf.30.81","volume":"30","author":"K Tsuda","year":"2005","unstructured":"Tsuda K, Amano A, Umebayashi K et al (2005) Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle. Cell Struct Funct 30(2):81\u201391","journal-title":"Cell Struct Funct"},{"issue":"10","key":"21_CR5","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.1128\/IAI.00009-09","volume":"77","author":"N Furuta","year":"2009","unstructured":"Furuta N, Tsuda K, Omori H et al (2009) Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartments. Infect Immun 77(10):4187\u20134196","journal-title":"Infect Immun"},{"issue":"4","key":"21_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1177\/154405910208100403","volume":"81","author":"S Murakami","year":"2002","unstructured":"Murakami S, Yoshimura N, Koide H et al (2002) Activation of adenosine-receptor-enhanced iNOS mRNA expression by gingival epithelial cells. J Dent Res 81(4):236\u2013240","journal-title":"J Dent Res"},{"issue":"40","key":"21_CR7","doi-asserted-by":"publisher","first-page":"23619","DOI":"10.1074\/jbc.270.40.23619","volume":"270","author":"K Nakayama","year":"1995","unstructured":"Nakayama K, Kadowaki T, Okamoto K et al (1995) Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence. J Biol Chem 270(40):23619\u201323626","journal-title":"J Biol Chem"},{"issue":"33","key":"21_CR8","doi-asserted-by":"publisher","first-page":"21225","DOI":"10.1074\/jbc.273.33.21225","volume":"273","author":"K Okamoto","year":"1998","unstructured":"Okamoto K, Nakayama K, Kadowaki T et al (1998) Involvement of a lysine-specific cysteine proteinase in hemoglobin adsorption and heme accumulation by Porphyromonas gingivalis. J Biol Chem 273(33):21225\u201321231","journal-title":"J Biol Chem"},{"issue":"11","key":"21_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008124","volume":"15","author":"H Takeuchi","year":"2019","unstructured":"Takeuchi H, Sasaki N, Yamaga S et al (2019) Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1. PLoS Pathog 15(11):e1008124","journal-title":"PLoS Pathog"},{"issue":"6","key":"21_CR10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/jre.12059","volume":"48","author":"CE Moffatt-Jauregui","year":"2013","unstructured":"Moffatt-Jauregui CE, Robinson B, de Moya AV et al (2013) Establishment and characterization of a telomerase immortalized human gingival epithelial cell line. J Periodontal Res 48(6):713\u2013721","journal-title":"J Periodontal Res"}],"container-title":["Methods in Molecular Biology","Periodontal Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-0939-2_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T20:50:59Z","timestamp":1616964659000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-1-0716-0939-2_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,20]]},"ISBN":["9781071609385","9781071609392"],"references-count":10,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-0939-2_21","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,20]]},"assertion":[{"value":"20 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}