{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:32:24Z","timestamp":1780511544025,"version":"3.54.1"},"publisher-location":"New York, NY","reference-count":23,"publisher":"Springer US","isbn-type":[{"value":"9781071610152","type":"print"},{"value":"9781071610169","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-1-0716-1016-9_7","type":"book-chapter","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T09:19:23Z","timestamp":1618305563000},"page":"69-81","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hemolytic Tests Exploring Factor H Functional Activities"],"prefix":"10.1007","author":[{"given":"Melchior","family":"Chabannes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shambhuprasad K.","family":"Togarsimalemath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Agn\u00e8s","family":"Dragon-Durey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"7_CR1","first-page":"262","volume":"6","author":"NS Merle","year":"2015","unstructured":"Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT (2015) Complement system part I - molecular mechanisms of activation and regulation. Front Immunol 6:262","journal-title":"Front Immunol"},{"key":"7_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/sj.ki.5001612","volume":"70","author":"THJ Goodship","year":"2006","unstructured":"Goodship THJ (2006) Factor H genotype-phenotype correlations: lessons from aHUS, MPGN II, and AMD. Kidney Int 70:12\u201313","journal-title":"Kidney Int"},{"key":"7_CR3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.molimm.2004.02.005","volume":"41","author":"S Rodr\u00edguez de C\u00f3rdoba","year":"2004","unstructured":"Rodr\u00edguez de C\u00f3rdoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, S\u00e1nchez-Corral P (2004) The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol 41:355\u2013367","journal-title":"Mol Immunol"},{"key":"7_CR4","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/ni.1755","volume":"10","author":"J Wu","year":"2009","unstructured":"Wu J, Wu Y-Q, Ricklin D, Janssen BJC, Lambris JD, Gros P (2009) Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat Immunol 10:728\u2013733","journal-title":"Nat Immunol"},{"key":"7_CR5","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.molimm.2010.03.007","volume":"47","author":"A Bhattacharjee","year":"2010","unstructured":"Bhattacharjee A, Lehtinen MJ, Kajander T, Goldman A, Jokiranta TS (2010) Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d. Mol Immunol 47:1686\u20131691","journal-title":"Mol Immunol"},{"key":"7_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nsmb.2018","volume":"18","author":"HP Morgan","year":"2011","unstructured":"Morgan HP, Schmidt CQ, Guariento M et al (2011) Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol 18:463\u2013470","journal-title":"Nat Struct Mol Biol"},{"key":"7_CR7","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.4049\/jimmunol.157.12.5422","volume":"157","author":"TK Blackmore","year":"1996","unstructured":"Blackmore TK, Sadlon TA, Ward HM, Lublin DM, Gordon DL (1996) Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H. J Immunol 157:5422\u20135427","journal-title":"J Immunol"},{"key":"7_CR8","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.4049\/jimmunol.160.7.3342","volume":"160","author":"TK Blackmore","year":"1998","unstructured":"Blackmore TK, Hellwage J, Sadlon TA, Higgs N, Zipfel PF, Ward HM, Gordon DL (1998) Identification of the second heparin-binding domain in human complement factor H. J Immunol 160:3342\u20133348","journal-title":"J Immunol"},{"key":"7_CR9","doi-asserted-by":"publisher","first-page":"6935","DOI":"10.4049\/jimmunol.169.12.6935","volume":"169","author":"J Hellwage","year":"2002","unstructured":"Hellwage J, Jokiranta TS, Friese MA, Wolk TU, Kampen E, Zipfel PF, Meri S (2002) Complement C3b\/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H. J Immunol 169:6935\u20136944","journal-title":"J Immunol"},{"key":"7_CR10","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3389\/fimmu.2014.00126","volume":"5","author":"SJ Perkins","year":"2014","unstructured":"Perkins SJ, Fung KW, Khan S (2014) Molecular interactions between complement factor H and its heparin and Heparan sulfate ligands. Front Immunol 5:126","journal-title":"Front Immunol"},{"key":"7_CR11","first-page":"257","volume":"6","author":"NS Merle","year":"2015","unstructured":"Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT (2015) Complement system part II: role in immunity. Front Immunol 6:257","journal-title":"Front Immunol"},{"key":"7_CR12","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.4049\/jimmunol.1201751","volume":"190","author":"SJ Clark","year":"2013","unstructured":"Clark SJ, Ridge LA, Herbert AP et al (2013) Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. J Immunol 190:2049\u20132057","journal-title":"J Immunol"},{"key":"7_CR13","doi-asserted-by":"publisher","first-page":"13757","DOI":"10.1073\/pnas.1121309109","volume":"109","author":"PX Shaw","year":"2012","unstructured":"Shaw PX, Zhang L, Zhang M et al (2012) Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci U S A 109:13757\u201313762","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7_CR14","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrneph.2016.99","volume":"12","author":"M-AD Durey","year":"2016","unstructured":"Durey M-AD, Sinha A, Togarsimalemath SK, Bagga A (2016) Anti-complement-factor H-associated glomerulopathies. Nat Rev Nephrol 12:563\u2013578","journal-title":"Nat Rev Nephrol"},{"key":"7_CR15","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1110189","volume":"308","author":"AO Edwards","year":"2005","unstructured":"Edwards AO, Ritter R, Abel KJ, Manning A, Panhuysen C, Farrer LA (2005) Complement factor H polymorphism and age-related macular degeneration. Science 308:421\u2013424","journal-title":"Science"},{"key":"7_CR16","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.1182\/blood-2008-01-133702","volume":"112","author":"V Fr\u00e9meaux-Bacchi","year":"2008","unstructured":"Fr\u00e9meaux-Bacchi V, Miller EC, Liszewski MK et al (2008) Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood 112:4948\u20134952","journal-title":"Blood"},{"key":"7_CR17","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.kint.2016.10.005","volume":"91","author":"THJ Goodship","year":"2017","unstructured":"Goodship THJ, Cook HT, Fakhouri F et al (2017) Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a \u201ckidney disease: improving global outcomes\u201d (KDIGO) controversies conference. Kidney Int 91:539\u2013551","journal-title":"Kidney Int"},{"key":"7_CR18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1126\/science.1110359","volume":"308","author":"JL Haines","year":"2005","unstructured":"Haines JL, Hauser MA, Schmidt S et al (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308:419\u2013421","journal-title":"Science"},{"key":"7_CR19","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1109557","volume":"308","author":"RJ Klein","year":"2005","unstructured":"Klein RJ, Zeiss C, Chew EY et al (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308:385\u2013389","journal-title":"Science"},{"key":"7_CR20","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1182\/blood-2011-10-383281","volume":"119","author":"LT Roumenina","year":"2012","unstructured":"Roumenina LT, Frimat M, Miller EC et al (2012) A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. Blood 119:4182\u20134191","journal-title":"Blood"},{"key":"7_CR21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4049\/jimmunol.122.1.75","volume":"122","author":"MD Kazatchkine","year":"1979","unstructured":"Kazatchkine MD, Fearon DT, Austen KF (1979) Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b. J Immunol 122:75\u201381","journal-title":"J Immunol"},{"key":"7_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.molimm.2004.01.003","volume":"41","author":"P S\u00e1nchez-Corral","year":"2004","unstructured":"S\u00e1nchez-Corral P, Gonz\u00e1lez-Rubio C, Rodr\u00edguez de C\u00f3rdoba S, L\u00f3pez-Trascasa M (2004) Functional analysis in serum from atypical hemolytic uremic syndrome patients reveals impaired protection of host cells associated with mutations in factor H. Mol Immunol 41:81\u201384","journal-title":"Mol Immunol"},{"key":"7_CR23","doi-asserted-by":"publisher","first-page":"3528","DOI":"10.4049\/jimmunol.1200679","volume":"189","author":"C Blanc","year":"2012","unstructured":"Blanc C, Roumenina LT, Ashraf Y et al (2012) Overall neutralization of complement factor H by autoantibodies in the acute phase of the autoimmune form of atypical hemolytic uremic syndrome. J Immunol 189:3528\u20133537","journal-title":"J Immunol"}],"container-title":["Methods in Molecular Biology","The Complement System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-1016-9_7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:56:47Z","timestamp":1698886607000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-1016-9_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9781071610152","9781071610169"],"references-count":23,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-1016-9_7","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"14 April 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}