{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T05:37:00Z","timestamp":1743053820965,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":52,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071612699"},{"type":"electronic","value":"9781071612705"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-1-0716-1270-5_25","type":"book-chapter","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T19:25:13Z","timestamp":1622661913000},"page":"405-421","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Methods for Studying Cardiac Energetics"],"prefix":"10.1007","author":[{"given":"Philippe","family":"Diolez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Deschodt-Arsac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Calmettes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Gouspillou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Arsac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Jais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Haissaguerre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"issue":"5\u20136","key":"25_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.bbabio.2006.03.008","volume":"1757","author":"FL Sheeran","year":"2006","unstructured":"Sheeran FL, Pepe S (2006) Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate. Biochim Biophys Acta 1757(5\u20136):543\u2013552","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"25_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1742-7843.2009.00534.x","volume":"106","author":"M Fink","year":"2010","unstructured":"Fink M, Noble D (2010) Pharmacodynamic effects in the cardiovascular system: the modeller\u2019s view. Basic Clin Pharmacol Toxicol 106(3):243\u2013249. Epub 2010\/05\/18. eng","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"3","key":"25_CR3","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nbt0302-243","volume":"20","author":"M Cascante","year":"2002","unstructured":"Cascante M, Boros LG, Comin-Anduix B, de Atauri P, Centelles JJ, Lee PW (2002) Metabolic control analysis in drug discovery and disease. Nat Biotechnol 20(3):243\u2013249. Epub 2002\/03\/05. eng","journal-title":"Nat Biotechnol"},{"issue":"Pt 2","key":"25_CR4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1042\/bj2860313","volume":"286","author":"DA Fell","year":"1992","unstructured":"Fell DA (1992) Metabolic control analysis: a survey of its theoretical and experimental development. Biochem J 286(Pt 2):313\u2013330","journal-title":"Biochem J"},{"issue":"1","key":"25_CR5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1432-1033.1974.tb03318.x","volume":"42","author":"R Heinrich","year":"1974","unstructured":"Heinrich R, Rapoport TA (1974) A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur J Biochem 42(1):89\u201395","journal-title":"Eur J Biochem"},{"key":"25_CR6","first-page":"65","volume":"27","author":"H Kacser","year":"1973","unstructured":"Kacser H, Burns JA (1973) The control of flux. Symp Soc Exp Biol 27:65\u2013104","journal-title":"Symp Soc Exp Biol"},{"issue":"2","key":"25_CR7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1042\/bst0230341","volume":"23","author":"H Kacser","year":"1995","unstructured":"Kacser H, Burns JA (1995) The control of flux. Biochem Soc Trans 23(2):341\u2013366","journal-title":"Biochem Soc Trans"},{"issue":"3","key":"25_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1006\/jtbi.1996.0174","volume":"182","author":"MD Brand","year":"1996","unstructured":"Brand MD (1996) Top down metabolic control analysis. J Theor Biol 182(3):351\u2013360. Epub 1996\/10\/07. eng","journal-title":"J Theor Biol"},{"issue":"2","key":"25_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1042\/bst0300025","volume":"30","author":"MD Brand","year":"2002","unstructured":"Brand MD, Curtis RK (2002) Simplifying metabolic complexity. Biochem Soc Trans 30(2):25\u201330. Epub 2002\/05\/25. eng","journal-title":"Biochem Soc Trans"},{"issue":"2","key":"25_CR10","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1432-1033.1990.tb15406.x","volume":"188","author":"GC Brown","year":"1990","unstructured":"Brown GC, Hafner RP, Brand MD (1990) A \u201ctop-down\u201d approach to the determination of control coefficients in metabolic control theory. Eur J Biochem 188(2):321\u2013325. Epub 1990\/03\/10. eng","journal-title":"Eur J Biochem"},{"key":"25_CR11","doi-asserted-by":"crossref","unstructured":"Dufour S, Rousse N, Canioni P, Diolez P (1996) Top-down control analysis of temperature effect on oxidative phosphorylation. Biochem J 314(Pt 3):743-751","DOI":"10.1042\/bj3140743"},{"issue":"2","key":"25_CR12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1432-1033.1990.tb15405.x","volume":"188","author":"RP Hafner","year":"1990","unstructured":"Hafner RP, Brown GC, Brand MD (1990) Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the 'top-down' approach of metabolic control theory. Eur J Biochem 188(2):313\u2013319. Epub 1990\/03\/10. eng","journal-title":"Eur J Biochem"},{"issue":"1","key":"25_CR13","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1152\/ajpregu.00189.2006","volume":"293","author":"P Diolez","year":"2007","unstructured":"Diolez P, Deschodt-Arsac V, Raffard G, Simon C, Santos PD, Thiaudiere E et al (2007) Modular regulation analysis of heart contraction: application to in situ demonstration of a direct mitochondrial activation by calcium in beating heart. Am J Physiol Regul Integr Comp Physiol 293(1):R13\u2013RR9","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1-2","key":"25_CR14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1023\/A:1020377829518","volume":"29","author":"P Diolez","year":"2002","unstructured":"Diolez P, Raffard G, Simon C, Leducq N, Dos SP, Canioni P (2002) Mitochondria do not control heart bioenergetics. Mol Biol Rep 29(1-2):193\u2013196. Epub 2002\/09\/21. eng","journal-title":"Mol Biol Rep"},{"issue":"6","key":"25_CR15","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/BF02111654","volume":"27","author":"MJ Kushmerick","year":"1995","unstructured":"Kushmerick MJ (1995) Skeletal muscle: a paradigm for testing principles of bioenergetics. J Bioenerg Biomembr 27(6):555\u2013569","journal-title":"J Bioenerg Biomembr"},{"issue":"10","key":"25_CR16","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1006\/jmcc.2002.2082","volume":"34","author":"RS Balaban","year":"2002","unstructured":"Balaban RS (2002) Cardiac energy metabolism homeostasis: role of cytosolic calcium. J Mol Cell Cardiol 34(10):1259\u20131271","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"25_CR17","doi-asserted-by":"publisher","first-page":"C285","DOI":"10.1152\/ajpcell.00129.2002","volume":"284","author":"RS Balaban","year":"2003","unstructured":"Balaban RS, Bose S, French SA, Territo PR (2003) Role of calcium in metabolic signaling between cardiac sarcoplasmic reticulum and mitochondria in vitro. Am J Physiol Cell Physiol 284(2):C285\u2013C293","journal-title":"Am J Physiol Cell Physiol"},{"key":"25_CR18","first-page":"101","volume-title":"BTK2000: animating the cellular map","author":"P Diolez","year":"2000","unstructured":"Diolez P, Simon C, Leducq N, Canioni P, Dos Santos P (2000) Top down analysis of heart bioenergetics. In: Hofmeyr J-HS, Rohwer M, Snoep JL (eds) BTK2000: animating the cellular map. Stellebosch University Press, Stellenbosch, pp 101\u2013106"},{"key":"25_CR19","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1196\/annals.1380.013","volume":"1080","author":"RS Balaban","year":"2006","unstructured":"Balaban RS (2006) Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach. Ann N Y Acad Sci 1080:140\u2013153. Epub 2006\/11\/30. eng","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"25_CR20","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1212\/WNL.42.6.1203","volume":"42","author":"D Bendahan","year":"1992","unstructured":"Bendahan D, Desnuelle C, Vanuxem D, Confort-Gouny S, Figarella-Branger D, Pellissier JF et al (1992) 31P NMR spectroscopy and ergometer exercise test as evidence for muscle oxidative performance improvement with coenzyme Q in mitochondrial myopathies. Neurology 42(6):1203\u20131208","journal-title":"Neurology"},{"issue":"1","key":"25_CR21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/nbm.1940060111","volume":"6","author":"GJ Kemp","year":"1993","unstructured":"Kemp GJ, Taylor DJ, Radda GK (1993) Control of phosphocreatine resynthesis during recovery from exercise in human skeletal muscle. NMR Biomed 6(1):66\u201372","journal-title":"NMR Biomed"},{"issue":"5","key":"25_CR22","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/nbm.1940060504","volume":"6","author":"GJ Kemp","year":"1993","unstructured":"Kemp GJ, Taylor DJ, Thompson CH, Hands LJ, Rajagopalan B, Styles P et al (1993) Quantitative analysis by 31P magnetic resonance spectroscopy of abnormal mitochondrial oxidation in skeletal muscle during recovery from exercise. NMR Biomed 6(5):302\u2013310","journal-title":"NMR Biomed"},{"issue":"3","key":"25_CR23","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1042\/BJ20090395","volume":"423","author":"B Korzeniewski","year":"2009","unstructured":"Korzeniewski B, Deschodt-Arsac V, Calmettes G, Gouspillou G, Franconi JM, Diolez P (2009) Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart. Biochem J 423(3):421\u2013428. Epub 2009\/08\/19. eng","journal-title":"Biochem J"},{"issue":"2","key":"25_CR24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1042\/BJ20080162","volume":"413","author":"B Korzeniewski","year":"2008","unstructured":"Korzeniewski B, Deschodt-Arsac V, Calmettes G, Franconi JM, Diolez P (2008) Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply. Biochem J 413(2):343\u2013347. Epub 2008\/04\/02. eng","journal-title":"Biochem J"},{"issue":"3","key":"25_CR25","doi-asserted-by":"publisher","first-page":"R786","DOI":"10.1152\/ajpregu.00184.2010","volume":"299","author":"V Deschodt-Arsac","year":"2010","unstructured":"Deschodt-Arsac V, Calmettes G, Raffard G, Massot P, Franconi JM, Pollesello P et al (2010) Absence of mitochondrial activation during levosimendan inotropic action in perfused paced guinea pig hearts as demonstrated by modular control analysis. Am J Physiol Regul Integr Comp Physiol 299(3):R786\u2013R792. Pubmed Central PMCID: 3.1. Epub 2010\/07\/02. eng","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"25_CR26","doi-asserted-by":"publisher","first-page":"R1891","DOI":"10.1152\/ajpregu.90548.2008","volume":"295","author":"G Calmettes","year":"2008","unstructured":"Calmettes G, Deschodt-Arsac V, Thiaudiere E, Muller B, Diolez P (2008) Modular control analysis of effects of chronic hypoxia on mouse heart. Am J Physiol Regul Integr Comp Physiol 295(6):R1891\u2013R1897. Epub 2008\/10\/04. eng","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"25_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009306","volume":"5","author":"G Calmettes","year":"2010","unstructured":"Calmettes G, Deschodt-Arsac V, Gouspillou G, Miraux S, Muller B, Franconi J-M et al (2010) Improved energy supply regulation in chronic hypoxic mouse counteracts hypoxia-induced altered cardiac energetics. PLoS One 5(2):e9306","journal-title":"PLoS One"},{"issue":"2","key":"25_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.bpc.2005.04.001","volume":"116","author":"B Korzeniewski","year":"2005","unstructured":"Korzeniewski B, Noma A, Matsuoka S (2005) Regulation of oxidative phosphorylation in intact mammalian heart in vivo. Biophys Chem 116(2):145\u2013157","journal-title":"Biophys Chem"},{"issue":"1-2","key":"25_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0005-2728(00)00054-2","volume":"1457","author":"NI Kavanagh","year":"2000","unstructured":"Kavanagh NI, Ainscow EK, Brand MD (2000) Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria. Biochim Biophys Acta 1457(1-2):57\u201370","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"25_CR30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1042\/bj2450217","volume":"245","author":"JD Johnston","year":"1987","unstructured":"Johnston JD, Brand MD (1987) Stimulation of the respiration rate of rat liver mitochondria by sub-micromolar concentrations of extramitochondrial Ca2+. Biochem J 245(1):217\u2013222. Pubmed Central PMCID: 1148102. Epub 1987\/07\/01. eng","journal-title":"Biochem J"},{"issue":"Pt 1","key":"25_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1042\/bj3200329","volume":"320","author":"V Mildaziene","year":"1996","unstructured":"Mildaziene V, Baniene R, Nauciene Z, Marcinkeviciute A, Morkuniene R, Borutaite V et al (1996) Ca2+ stimulates both the respiratory and phosphorylation subsystems in rat heart mitochondria. Biochem J 320(Pt 1):329\u2013334. Pubmed Central PMCID: 1217935. Epub 1996\/11\/15. eng","journal-title":"Biochem J"},{"issue":"1","key":"25_CR32","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.biocel.2012.07.007","volume":"45","author":"V Deschodt-Arsac","year":"2013","unstructured":"Deschodt-Arsac V, Calmettes G, Gouspillou G, Chapolard M, Raffard G, Rouland R et al (2013) Non-invasive integrative analysis of contraction energetics in intact beating heart. Int J Biochem Cell Biol 45(1):4\u201310","journal-title":"Int J Biochem Cell Biol"},{"issue":"4","key":"25_CR33","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0143-4160(92)90012-H","volume":"13","author":"ST Wu","year":"1992","unstructured":"Wu ST, Kojima S, Parmley WW, Wikman-Coffelt J (1992) Relationship between cytosolic calcium and oxygen consumption in isolated rat hearts. Cell Calcium 13(4):235\u2013247","journal-title":"Cell Calcium"},{"issue":"5","key":"25_CR34","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1254\/jphs.CPJ06009X","volume":"100","author":"M Endoh","year":"2006","unstructured":"Endoh M (2006) Signal transduction and Ca2+ signaling in intact myocardium. J Pharmacol Sci 100(5):525\u2013537. Epub 2006\/06\/27. eng","journal-title":"J Pharmacol Sci"},{"key":"25_CR35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ijcard.2019.09.005","volume":"297","author":"D Farmakis","year":"2019","unstructured":"Farmakis D, Agostoni P, Baholli L, Bautin A, Comin-Colet J, Crespo-Leiro MG et al (2019) A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus. Int J Cardiol 297:83\u201390","journal-title":"Int J Cardiol"},{"issue":"4","key":"25_CR36","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1157\/13087053","volume":"59","author":"JF Delgado","year":"2006","unstructured":"Delgado JF (2006) Levosimendan in acute heart failure: past, present and future. Rev Esp Cardiol 59(4):309\u2013312","journal-title":"Rev Esp Cardiol"},{"issue":"1","key":"25_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1527-3466.2005.tb00158.x","volume":"23","author":"Z Papp","year":"2005","unstructured":"Papp Z, Csapo K, Pollesello P, Haikala H, Edes I (2005) Pharmacological mechanisms contributing to the clinical efficacy of levosimendan. Cardiovasc Drug Rev 23(1):71\u201398","journal-title":"Cardiovasc Drug Rev"},{"issue":"46","key":"25_CR38","doi-asserted-by":"publisher","first-page":"28584","DOI":"10.1016\/S0021-9258(19)61945-9","volume":"269","author":"P Pollesello","year":"1994","unstructured":"Pollesello P, Ovaska M, Kaivola J, Tilgmann C, Lundstrom K, Kalkkinen N et al (1994) Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study. J Biol Chem 269(46):28584\u201328590","journal-title":"J Biol Chem"},{"issue":"1-2","key":"25_CR39","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1023\/B:MCBI.0000049141.37823.19","volume":"266","author":"T Sorsa","year":"2004","unstructured":"Sorsa T, Pollesello P, Solaro RJ (2004) The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c. Mol Cell Biochem 266(1-2):87\u2013107","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"25_CR40","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1161\/01.RES.77.1.107","volume":"77","author":"I Edes","year":"1995","unstructured":"Edes I, Kiss E, Kitada Y, Powers FM, Papp JG, Kranias EG et al (1995) Effects of Levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in Guinea pig heart. Circ Res 77(1):107\u2013113","journal-title":"Circ Res"},{"issue":"Suppl 1","key":"25_CR41","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1097\/00005344-199506261-00003","volume":"26","author":"H Haikala","year":"1995","unstructured":"Haikala H, Linden IB (1995) Mechanisms of action of calcium-sensitizing drugs. J Cardiovasc Pharmacol 26(Suppl 1):S10\u2013S19","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"25_CR42","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/01.fjc.0000175454.69116.9","volume":"46","author":"S Szilagyi","year":"2005","unstructured":"Szilagyi S, Pollesello P, Levijoki J, Haikala H, Bak I, Tosaki A et al (2005) Two inotropes with different mechanisms of action: contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone. J Cardiovasc Pharmacol 46(3):369\u2013376. Epub 2005\/08\/24. eng","journal-title":"J Cardiovasc Pharmacol"},{"key":"25_CR43","first-page":"9731467","volume":"2019","author":"J Pan","year":"2019","unstructured":"Pan J, Yang YM, Zhu JY, Lu YQ (2019) Multiorgan drug action of Levosimendan in critical illnesses. Biomed Res Int 2019:9731467","journal-title":"Biomed Res Int"},{"key":"25_CR44","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.yjmcc.2016.02.003","volume":"92","author":"SE Pineda-Sanabria","year":"2016","unstructured":"Pineda-Sanabria SE, Robertson IM, Sun YB, Irving M, Sykes BD (2016) Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog. J Mol Cell Cardiol 92:174\u2013184","journal-title":"J Mol Cell Cardiol"},{"issue":"5","key":"25_CR45","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1042\/BST0381319","volume":"38","author":"V Deschodt-Arsac","year":"2010","unstructured":"Deschodt-Arsac V, Calmettes G, Gouspillou G, Rouland R, Thiaudiere E, Miraux S et al (2010) System analysis of the effect of various drugs on cardiac contraction energetics. Biochem Soc Trans 38(5):1319\u20131321. Pubmed Central PMCID: 3.4. Epub 2010\/09\/25. eng","journal-title":"Biochem Soc Trans"},{"issue":"4","key":"25_CR46","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1007\/BF00789302","volume":"91","author":"PS Pagel","year":"1996","unstructured":"Pagel PS, Hettrick DA, Warltier DC (1996) Comparison of the effects of levosimendan, pimobendan, and milrinone on canine left ventricular-arterial coupling and mechanical efficiency. Basic Res Cardiol 91(4):296\u2013307","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"25_CR47","doi-asserted-by":"publisher","first-page":"e20709","DOI":"10.1371\/journal.pone.0020709","volume":"6","author":"G Gouspillou","year":"2011","unstructured":"Gouspillou G, Rouland R, Calmettes G, Deschodt-Arsac V, Franconi JM, Bourdel-Marchasson I et al (2011) Accurate determination of the oxidative phosphorylation affinity for ADP in isolated mitochondria. PLoS One 6(6):e20709","journal-title":"PLoS One"},{"issue":"3","key":"25_CR48","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/nbm.1588","volume":"24","author":"W Lefrancois","year":"2011","unstructured":"Lefrancois W, Miraux S, Calmettes G, Pourtau L, Franconi JM, Diolez P et al (2011) A fast black-blood sequence for four-dimensional cardiac manganese-enhanced MRI in mouse. NMR Biomed 24(3):291\u2013298","journal-title":"NMR Biomed"},{"issue":"4","key":"25_CR49","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1097\/00005344-200404000-00011","volume":"43","author":"P Kaheinen","year":"2004","unstructured":"Kaheinen P, Pollesello P, Levijoki J, Haikala H (2004) Effects of levosimendan and milrinone on oxygen consumption in isolated Guinea-pig heart. J Cardiovasc Pharmacol 43(4):555\u2013561","journal-title":"J Cardiovasc Pharmacol"},{"key":"25_CR50","volume-title":"Bioenergetics","author":"DG Nicholls","year":"2013","unstructured":"Nicholls DG, Ferguson SJ (2013) Bioenergetics, 4th edn. Academic Press, London","edition":"4"},{"issue":"Pt 2","key":"25_CR51","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1242\/jeb.200.2.193","volume":"200","author":"MD Brand","year":"1997","unstructured":"Brand MD (1997) Regulation analysis of energy metabolism. J Exp Biol 200(Pt 2):193\u2013202","journal-title":"J Exp Biol"},{"key":"25_CR52","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0303-2647(98)00040-9","volume":"49","author":"EK Ainscow","year":"1999","unstructured":"Ainscow EK, Brand MD (1999) Quantifying elasticity analysis: how external effectors cause changes to metabolic systems. Biosystems 49:151\u2013159","journal-title":"Biosystems"}],"container-title":["Methods in Molecular Biology","Mitochondrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-1270-5_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T14:05:27Z","timestamp":1635343527000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-1270-5_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9781071612699","9781071612705"],"references-count":52,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-1270-5_25","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"3 June 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}