{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:34:09Z","timestamp":1792650849770,"version":"4.5.0"},"publisher-location":"New York, NY","reference-count":15,"publisher":"Springer US","isbn-type":[{"value":"9781071613108","type":"print"},{"value":"9781071613115","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-1-0716-1311-5_27","type":"book-chapter","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T22:02:44Z","timestamp":1619733764000},"page":"375-384","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Experimental Autoimmune Encephalomyelitis"],"prefix":"10.1007","author":[{"given":"Clara","family":"Ballerini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"issue":"1","key":"27_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1084\/jem.2021fta","volume":"202","author":"VL Van Epps","year":"2005","unstructured":"Van Epps VL (2005) Thomas River and the EAE model. J Exp Med 202(1):4. https:\/\/doi.org\/10.1084\/jem.2021fta","journal-title":"J Exp Med"},{"key":"27_CR2","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ejphar.2015.03.042","volume":"759","author":"C Procaccini","year":"2015","unstructured":"Procaccini C, De Rosa V, Pucino V et al (2015) Animal models of multiple sclerosis. Eur J Pharmacol 759:182\u2013191. https:\/\/doi.org\/10.1016\/j.ejphar.2015.03.042","journal-title":"Eur J Pharmacol"},{"key":"27_CR3","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","volume":"164","author":"CS Costantinescu","year":"2011","unstructured":"Costantinescu CS, Farooqi N, O\u2019Briejn K et al (2011) Experimental autoimmune encephalomyelitis (EAE) as a model of multiple sclerosis (MS). Br J Pharmacol 164:1079\u20131106. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01302.x","journal-title":"Br J Pharmacol"},{"key":"27_CR4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1146\/annurev.immunol.20.081701.141316","volume":"20","author":"VK Kuchroo","year":"2002","unstructured":"Kuchroo VK, Anderson AC, Waldner H et al (2002) T-cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning and regulating the autopathogenic T-cell repertoire. Annu Rev Immunol 20:101\u2013123. https:\/\/doi.org\/10.1146\/annurev.immunol.20.081701.141316","journal-title":"Annu Rev Immunol"},{"key":"27_CR5","doi-asserted-by":"publisher","first-page":"7104","DOI":"10.4049\/jimmunol.169.12.7104","volume":"169","author":"B Gran","year":"2002","unstructured":"Gran B, Zhang GX, Yu S et al (2002) IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system demyelination. J Immunol 169:7104\u20137110. https:\/\/doi.org\/10.4049\/jimmunol.169.12.7104","journal-title":"J Immunol"},{"key":"27_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1084\/jem.20041257","volume":"201","author":"CL Langrish","year":"2005","unstructured":"Langrish CL, Chen Y, Blumenschein WM et al (2005) IL-23 drives a pathogenic T- cell population that induces autoimmune inflammation. J Exp Med 201:233\u2013240. https:\/\/doi.org\/10.1084\/jem.20041257","journal-title":"J Exp Med"},{"key":"27_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1084\/jem.111.1.119","volume":"111","author":"PY Paterson","year":"1960","unstructured":"Paterson PY (1960) Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J Exp Med 111:119\u2013135. https:\/\/doi.org\/10.1084\/jem.111.1.119","journal-title":"J Exp Med"},{"key":"27_CR8","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/978-1-60327-931-4_11","volume":"549","author":"R Furlan","year":"2009","unstructured":"Furlan R, Cuomo C, Martino G (2009) Animal models of multiple sclerosis. Methods Mol Biol 549:157\u2013173","journal-title":"Methods Mol Biol"},{"key":"27_CR9","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/jnr.24224","volume":"96","author":"I Bjielobaba","year":"2018","unstructured":"Bjielobaba I, Begovic-Kupresanin V, Pekovic S et al (2018) Animal models of multiple sclerosis: focus on experimental autoimmune encephalomyelitis. J Neurosci Res 96:1021\u20131042. https:\/\/doi.org\/10.1002\/jnr.24224","journal-title":"J Neurosci Res"},{"key":"27_CR10","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.4049\/jimmunol.130.3.1024","volume":"130","author":"RB Fritz","year":"1983","unstructured":"Fritz RB, Chou CH, McFarlin DE (1983) Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein. J Immunol 130:1024\u20131026","journal-title":"J Immunol"},{"key":"27_CR11","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.4049\/jimmunol.153.10.4349","volume":"153","author":"S Amor","year":"1994","unstructured":"Amor S, Groome N, Linington C et al (1994) Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB\/H mice. J Immunol 153:4349\u20134356","journal-title":"J Immunol"},{"key":"27_CR12","doi-asserted-by":"publisher","first-page":"462","DOI":"10.4049\/jimmunol.171.1.462","volume":"17","author":"AR Oliver","year":"2003","unstructured":"Oliver AR, Lyon GM, Ruddle NH (2003) Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL\/6 mice. J Immunol 17:462\u2013468. https:\/\/doi.org\/10.4049\/jimmunol.171.1.462","journal-title":"J Immunol"},{"key":"27_CR13","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/ng0795-313","volume":"10","author":"M Sundvall","year":"1995","unstructured":"Sundvall M, Jirholt J, Yang HT et al (1995) Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat Genet 10:313\u2013317. https:\/\/doi.org\/10.1038\/ng0795-313","journal-title":"Nat Genet"},{"key":"27_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.msard.2011.09.002","volume":"1","author":"M Kipp","year":"2012","unstructured":"Kipp M, van der Star B, Vogel DYS et al (2012) Experimental in vivo and in vitro models of multiple sclerosis: EAE and beyond. Mult Scler Relat Disord 1:15\u201328. https:\/\/doi.org\/10.1016\/j.msard.2011.09.002","journal-title":"Mult Scler Relat Disord"},{"key":"27_CR15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jneuroim.2005.04.020","volume":"175","author":"F Giuliani","year":"2005","unstructured":"Giuliani F, Fu SA, Metz LM et al (2005) Effective combination of minocycline and interferon beta in a model of multiple sclerosis. J Neuroimmunol 175:83\u201391. https:\/\/doi.org\/10.1016\/j.jneuroim.2005.04.020","journal-title":"J Neuroimmunol"}],"container-title":["Methods in Molecular Biology","T-Helper Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-1311-5_27","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T01:04:44Z","timestamp":1698973484000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-1311-5_27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9781071613108","9781071613115"],"references-count":15,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-1311-5_27","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"30 April 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}