{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:52:21Z","timestamp":1792641141433,"version":"4.5.0"},"publisher-location":"New York, NY","reference-count":15,"publisher":"Springer US","isbn-type":[{"value":"9781071615928","type":"print"},{"value":"9781071615935","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/978-1-0716-1593-5_20","type":"book-chapter","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T19:27:13Z","timestamp":1627673233000},"page":"313-329","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Multiplexed Imaging Mass Spectrometry of Histological Staining, N-Glycan and Extracellular Matrix from One Tissue Section: A Tool for Fibrosis Research"],"prefix":"10.1007","author":[{"given":"Cassandra L.","family":"Clift","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Drake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggi M.","family":"Angel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"20_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dmm.004077","volume":"4","author":"TR Cox","year":"2011","unstructured":"Cox TR, Erler JT (2011) Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. Dis Model Mech 4:165\u2013178. https:\/\/doi.org\/10.1242\/dmm.004077","journal-title":"Dis Model Mech"},{"issue":"1","key":"20_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1755-1536-5-15","volume":"5","author":"D Fan","year":"2012","unstructured":"Fan D, Takawale A, Lee J, Kassiri Z (2012) Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenes Tissue Repair 5(1):15. https:\/\/doi.org\/10.1186\/1755-1536-5-15","journal-title":"Fibrogenes Tissue Repair"},{"key":"20_CR3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.matbio.2018.02.020","volume":"71-72","author":"M Walraven","year":"2018","unstructured":"Walraven M, Hinz B (2018) Therapeutic approaches to control tissue repair and fibrosis: extracellular matrix as a game changer. Matrix Biol 71-72:205\u2013224. https:\/\/doi.org\/10.1016\/j.matbio.2018.02.020","journal-title":"Matrix Biol"},{"issue":"7","key":"20_CR4","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.bbapap.2016.10.014","volume":"1865","author":"K Schwamborn","year":"2017","unstructured":"Schwamborn K, Kriegsmann M, Weichert W (2017) MALDI imaging mass spectrometry \u2014 from bench to bedside. Biochim Biophys Acta Proteins Proteom 1865(7):776\u2013783. https:\/\/doi.org\/10.1016\/j.bbapap.2016.10.014","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"key":"20_CR5","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.1021\/acs.jproteome.8b00323","volume":"17","author":"CA West","year":"2018","unstructured":"West CA, Wang M, Herrera H et al (2018) N-linked glycan branching and fucosylation are increased directly in Hcc tissue as determined through in situ glycan imaging. J Proteome Res 17:3454\u20133462. https:\/\/doi.org\/10.1021\/acs.jproteome.8b00323","journal-title":"J Proteome Res"},{"key":"20_CR6","first-page":"59","volume-title":"MALDI mass spectrometry imaging of N-linked glycans in tissues","author":"RR Drake","year":"2018","unstructured":"Drake RR, West CA, Mehta AS, Angel PM (2018) MALDI mass spectrometry imaging of N-linked glycans in tissues. Springer, Singapore, pp 59\u201376"},{"key":"20_CR7","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.3390\/biom5042554","volume":"5","author":"T Powers","year":"2015","unstructured":"Powers T, Holst S, Wuhrer M et al (2015) Two-dimensional N-glycan distribution mapping of hepatocellular carcinoma tissues by MALDI-imaging mass spectrometry. Biomol Ther 5:2554\u20132572. https:\/\/doi.org\/10.3390\/biom5042554","journal-title":"Biomol Ther"},{"key":"20_CR8","doi-asserted-by":"publisher","first-page":"9799","DOI":"10.1021\/ac402108x","volume":"85","author":"TW Powers","year":"2013","unstructured":"Powers TW, Jones EE, Betesh LR et al (2013) Matrix assisted laser desorption ionization imaging mass spectrometry workflow for spatial profiling analysis of N-linked glycan expression in tissues. Anal Chem 85:9799\u20139806. https:\/\/doi.org\/10.1021\/ac402108x","journal-title":"Anal Chem"},{"key":"20_CR9","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/7651_2017_81","volume":"1788","author":"PM Angel","year":"2018","unstructured":"Angel PM, Mehta A, Norris-Caneda K, Drake RR (2018) MALDI imaging mass spectrometry of N-glycans and tryptic peptides from the same formalin-fixed, paraffin-embedded tissue section. Methods Mol Biol 1788:225\u2013241. https:\/\/doi.org\/10.1007\/7651_2017_81","journal-title":"Methods Mol Biol"},{"key":"20_CR10","first-page":"240","volume":"25","author":"PM Angel","year":"2016","unstructured":"Angel PM, Bayoumi AS, Hinton RB et al (2016) MALDI-IMS as a lipidomic approach to heart valve research. J Heart Valve Dis 25:240\u2013252","journal-title":"J Heart Valve Dis"},{"issue":"1","key":"20_CR11","doi-asserted-by":"publisher","first-page":"e1800014","DOI":"10.1002\/prca.201800014","volume":"13","author":"DA Scott","year":"2019","unstructured":"Scott DA, Casadonte R, Cardinali B et al (2019) Increases in tumor N-glycan polylactosamines associated with advanced HER2-positive and triple-negative breast Cancer tissues. Proteomics Clin Appl 13(1):e1800014. https:\/\/doi.org\/10.1002\/prca.201800014","journal-title":"Proteomics Clin Appl"},{"issue":"9","key":"20_CR12","doi-asserted-by":"publisher","first-page":"e106255","DOI":"10.1371\/journal.pone.0106255","volume":"9","author":"TW Powers","year":"2014","unstructured":"Powers TW, Neely BA, Shao Y et al (2014) MALDI imaging mass spectrometry profiling of N-glycans in formalin-fixed paraffin embedded clinical tissue blocks and tissue microarrays. PLoS One 9(9):e106255. https:\/\/doi.org\/10.1371\/journal.pone.0106255","journal-title":"PLoS One"},{"key":"20_CR13","doi-asserted-by":"publisher","unstructured":"Angel, PM (Corresponding author), Comte-Walters, Ball, LE, Talbot, K, Mehta AS, Drake RR (2018) Mapping extracellular matrix proteins in formalin-Fixed, paraffin-embedded tissues by MALDI imaging mass spectrometry.J Proteome Res 17:635\u2013646. https:\/\/doi.org\/10.1021\/acs.jproteome.7b00713","DOI":"10.1021\/acs.jproteome.7b00713"},{"key":"20_CR14","doi-asserted-by":"publisher","unstructured":"Angel, PM (Corresponding author), Bruner E, Bethard JR, Clift CL, Ball LE, Drake RR, Feghali-Bostwick C (2019) Extracellular matrix alterations in low grade lung adenocarcinoma compared to normal lung tissue by imaging mass spectrometry. J Mass Spect 55(4):e4450. https:\/\/doi.org\/10.1002\/jms.4450","DOI":"10.1002\/jms.4450"},{"key":"20_CR15","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1021\/pr7008252","volume":"7","author":"A Ceroni","year":"2008","unstructured":"Ceroni A, Maass K, Geyer H et al (2008) GlycoWorkbench: a tool for the computer-assisted annotation of mass spectra of glycans. J Proteome Res 7:1650\u20131659. https:\/\/doi.org\/10.1021\/pr7008252","journal-title":"J Proteome Res"}],"container-title":["Methods in Molecular Biology","Multiplexed Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-1593-5_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T13:07:02Z","timestamp":1631106422000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-1593-5_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9781071615928","9781071615935"],"references-count":15,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-1593-5_20","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"31 July 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}