{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:26:56Z","timestamp":1777426016250,"version":"3.51.4"},"publisher-location":"New York, NY","reference-count":22,"publisher":"Springer US","isbn-type":[{"value":"9781071618837","type":"print"},{"value":"9781071618844","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-1-0716-1884-4_25","type":"book-chapter","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T16:04:44Z","timestamp":1639670684000},"page":"481-502","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preclinical Assessment of the Immunogenicity of Experimental Leishmania Vaccines"],"prefix":"10.1007","author":[{"given":"Vivian Tamietti","family":"Martins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Sanchez","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Victoria","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron","family":"Christodoulides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Antonio Ferraz","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"25_CR1","unstructured":"World Health Organisation (2018). http:\/\/www.who.int\/topics\/leishmaniasis\/en\/. Accessed 30 Mar 2020"},{"issue":"9","key":"25_CR2","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/nrmicro981","volume":"2","author":"P Desjeux","year":"2004","unstructured":"Desjeux P (2004) Leishmaniasis. Nat Rev Microbiol 2(9):692. https:\/\/doi.org\/10.1038\/nrmicro981","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"25_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/00062752-200001000-00006","volume":"7","author":"MM Kane","year":"2000","unstructured":"Kane MM et al (2000) Leishmania parasites and their ploys to disrupt macrophage activation. Curr Opin Hematol 7(1):26\u201331. https:\/\/doi.org\/10.1097\/00062752-200001000-00006","journal-title":"Curr Opin Hematol"},{"issue":"7","key":"25_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.pt.2010.04.005","volume":"26","author":"AB Reis","year":"2010","unstructured":"Reis AB et al (2010) Immunity to Leishmania and the rational search for vaccines against canine leishmaniasis. Trends Parasitol 26(7):341\u2013349. https:\/\/doi.org\/10.1016\/j.pt.2010.04.005","journal-title":"Trends Parasitol"},{"key":"25_CR5","doi-asserted-by":"publisher","unstructured":"Martins VT et al (2017) A recombinant chimeric protein composed of human and mice-specific CD4(+) and CD8(+) T-cell epitopes protects against visceral leishmaniasis. Parasite Immunol 39(1). https:\/\/doi.org\/10.1111\/pim.12359","DOI":"10.1111\/pim.12359"},{"key":"25_CR6","doi-asserted-by":"crossref","unstructured":"Green SJ et al (1990) Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha. J Immunol 145(12):4290\u20134297","DOI":"10.4049\/jimmunol.145.12.4290"},{"issue":"Suppl","key":"25_CR7","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.1017\/S0031182000076678","volume":"112","author":"JM Blackwell","year":"1996","unstructured":"Blackwell JM (1996) Genetic susceptibility to leishmanial infections: studies in mice and man. Parasitology 112(Suppl):S67\u2013S74","journal-title":"Parasitology"},{"issue":"1","key":"25_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/sji.12557","volume":"86","author":"L Pirdel","year":"2017","unstructured":"Pirdel L et al (2017) A non-pathogenic recombinant Leishmania expressing Lipophosphoglycan 3 against experimental infection with Leishmania infantum. Scand J Immunol 86(1):15\u201322. https:\/\/doi.org\/10.1111\/sji.12557","journal-title":"Scand J Immunol"},{"issue":"1","key":"25_CR9","doi-asserted-by":"publisher","first-page":"163","DOI":"10.4049\/jimmunol.1700674","volume":"200","author":"A Banerjee","year":"2018","unstructured":"Banerjee A et al (2018) Live attenuated Leishmania donovani Centrin gene-deleted parasites induce IL-23-dependent IL-17-protective immune response against visceral Leishmaniasis in a murine model. J Immunol 200(1):163\u2013176. https:\/\/doi.org\/10.4049\/jimmunol.1700674","journal-title":"J Immunol"},{"issue":"1","key":"25_CR10","doi-asserted-by":"publisher","first-page":"e0004322","DOI":"10.1371\/journal.pntd.0004322","volume":"10","author":"JA Fiuza","year":"2016","unstructured":"Fiuza JA et al (2016) Intradermal immunization of Leishmania donovani Centrin Knock-out parasites in combination with salivary protein LJM19 from sand Fly vector induces a durable protective immune response in hamsters. PLoS Negl Trop Dis 10(1):e0004322. https:\/\/doi.org\/10.1371\/journal.pntd.0004322","journal-title":"PLoS Negl Trop Dis"},{"issue":"17","key":"25_CR11","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.vaccine.2018.03.027","volume":"36","author":"Keerti","year":"2018","unstructured":"Keerti et al (2018) Immunotherapeutic potential of Leishmania (Leishmania) donovani Th1 stimulatory proteins against experimental visceral leishmaniasis. Vaccine 36(17):2293\u20132299. https:\/\/doi.org\/10.1016\/j.vaccine.2018.03.027","journal-title":"Vaccine"},{"issue":"12","key":"25_CR12","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/pim.12287","volume":"37","author":"DP Lage","year":"2015","unstructured":"Lage DP et al (2015) Prophylactic properties of a Leishmania-specific hypothetical protein in a murine model of visceral leishmaniasis. Parasite Immunol 37(12):646\u2013656. https:\/\/doi.org\/10.1111\/pim.12287","journal-title":"Parasite Immunol"},{"key":"25_CR13","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.molimm.2018.12.025","volume":"106","author":"PAF Ribeiro","year":"2019","unstructured":"Ribeiro PAF et al (2019) Immunogenicity and protective efficacy of a new Leishmania hypothetical protein applied as a DNA vaccine or in a recombinant form against Leishmania infantum infection. Mol Immunol 106:108\u2013118. https:\/\/doi.org\/10.1016\/j.molimm.2018.12.025","journal-title":"Mol Immunol"},{"key":"25_CR14","doi-asserted-by":"publisher","unstructured":"Moafi M et al (2019) Leishmania vaccines entered in clinical trials: a review of literature. Int J Prev Med 10:95. https:\/\/doi.org\/10.4103\/ijpvm.IJPVM_116_18","DOI":"10.4103\/ijpvm.IJPVM_116_18"},{"issue":"27","key":"25_CR15","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1016\/j.vaccine.2019.04.092","volume":"37","author":"S Ratnapriya","year":"2019","unstructured":"Ratnapriya S et al (2019) Visceral leishmaniasis: an overview of vaccine adjuvants and their applications. Vaccine 37(27):3505\u20133519. https:\/\/doi.org\/10.1016\/j.vaccine.2019.04.092","journal-title":"Vaccine"},{"key":"25_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jim.2015.03.017","volume":"422","author":"K Jain","year":"2015","unstructured":"Jain K et al (2015) Vaccines for visceral leishmaniasis: a review. J Immunol Methods 422:1\u201312. https:\/\/doi.org\/10.1016\/j.jim.2015.03.017","journal-title":"J Immunol Methods"},{"key":"25_CR17","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.molimm.2016.06.014","volume":"76","author":"MC Duarte","year":"2016","unstructured":"Duarte MC et al (2016) A vaccine combining two Leishmania braziliensis proteins offers heterologous protection against Leishmania infantum infection. Mol Immunol 76:70\u201379. https:\/\/doi.org\/10.1016\/j.molimm.2016.06.014","journal-title":"Mol Immunol"},{"key":"25_CR18","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fcimb.2018.00112","volume":"8","author":"E Garde","year":"2018","unstructured":"Garde E et al (2018) Analysis of the antigenic and prophylactic properties of the Leishmania translation initiation factors eIF2 and eIF2B in natural and experimental Leishmaniasis. Front Cell Infect Microbiol 8:112. https:\/\/doi.org\/10.3389\/fcimb.2018.00112","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"25_CR19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3390\/vaccines8020289","volume":"8","author":"DP Lage","year":"2020","unstructured":"Lage DP et al (2020) Liposomal formulation of ChimeraT, a multiple T-cell epitope-containing recombinant protein, is a candidate vaccine for human visceral Leishmaniasis. Vaccines (Basel) 8(2):289. https:\/\/doi.org\/10.3390\/vaccines8020289","journal-title":"Vaccines (Basel)"},{"key":"25_CR20","unstructured":"https:\/\/animal.research.uiowa.edu\/iacuc-guidelines-anesthesia. AGAo"},{"key":"25_CR21","doi-asserted-by":"publisher","first-page":"e53936","DOI":"10.3791\/53936","volume":"110","author":"SR Amend","year":"2016","unstructured":"Amend SR et al (2016) Murine hind limb long bone dissection and bone marrow isolation. J Vis Exp 110:e53936. https:\/\/doi.org\/10.3791\/53936","journal-title":"J Vis Exp"},{"issue":"6","key":"25_CR22","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1645\/ge-2566.1","volume":"96","author":"SM Lei","year":"2010","unstructured":"Lei SM et al (2010) Population changes in Leishmania chagasi promastigote developmental stages due to serial passage. J Parasitol 96(6):1134\u20131138. https:\/\/doi.org\/10.1645\/ge-2566.1","journal-title":"J Parasitol"}],"container-title":["Methods in Molecular Biology","Vaccine Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-1884-4_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T21:54:02Z","timestamp":1674078842000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-1884-4_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,17]]},"ISBN":["9781071618837","9781071618844"],"references-count":22,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-1884-4_25","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,17]]},"assertion":[{"value":"17 December 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}