{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:15:40Z","timestamp":1790612140769,"version":"4.1.0"},"publisher-location":"New York, NY","reference-count":30,"publisher":"Springer US","isbn-type":[{"value":"9781071619780","type":"print"},{"value":"9781071619797","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-1-0716-1979-7_15","type":"book-chapter","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T06:03:29Z","timestamp":1651644209000},"page":"233-246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Generation of Embryonic Origin-Specific Vascular Smooth Muscle Cells from Human Induced Pluripotent Stem Cells"],"prefix":"10.1007","author":[{"given":"Mengcheng","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"issue":"3","key":"15_CR1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1152\/physrev.00041.2003","volume":"84","author":"GK Owens","year":"2004","unstructured":"Owens GK, Kumar MS, Wamhoff BR (2004) Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84(3):767\u2013801. https:\/\/doi.org\/10.1152\/physrev.00041.2003","journal-title":"Physiol Rev"},{"issue":"3","key":"15_CR2","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1152\/physrev.2001.81.3.999","volume":"81","author":"BC Berk","year":"2001","unstructured":"Berk BC (2001) Vascular smooth muscle growth: autocrine growth mechanisms. Physiol Rev 81(3):999\u20131030. https:\/\/doi.org\/10.1152\/physrev.2001.81.3.999","journal-title":"Physiol Rev"},{"issue":"12","key":"15_CR3","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/s41569-019-0227-9","volume":"16","author":"GL Basatemur","year":"2019","unstructured":"Basatemur GL, Jorgensen HF, Clarke MCH, Bennett MR, Mallat Z (2019) Vascular smooth muscle cells in atherosclerosis. Nat Rev Cardiol 16(12):727\u2013744. https:\/\/doi.org\/10.1038\/s41569-019-0227-9","journal-title":"Nat Rev Cardiol"},{"issue":"6","key":"15_CR4","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1161\/ATVBAHA.107.141069","volume":"27","author":"MW Majesky","year":"2007","unstructured":"Majesky MW (2007) Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol 27(6):1248\u20131258. https:\/\/doi.org\/10.1161\/ATVBAHA.107.141069","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7200","key":"15_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature06969","volume":"454","author":"CL Cai","year":"2008","unstructured":"Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM (2008) A myocardial lineage derives from Tbx18 epicardial cells. Nature 454(7200):104\u2013108. https:\/\/doi.org\/10.1038\/nature06969","journal-title":"Nature"},{"issue":"7200","key":"15_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nature07060","volume":"454","author":"B Zhou","year":"2008","unstructured":"Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT (2008) Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 454(7200):109\u2013113. https:\/\/doi.org\/10.1038\/nature07060","journal-title":"Nature"},{"issue":"9","key":"15_CR7","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1161\/ATVBAHA.117.309599","volume":"37","author":"H Sawada","year":"2017","unstructured":"Sawada H, Rateri DL, Moorleghen JJ, Majesky MW, Daugherty A (2017) Smooth muscle cells derived from second heart field and cardiac neural crest reside in spatially distinct domains in the media of the ascending aorta. Arterioscler Thromb Vasc Biol 37(9):1722\u20131726. https:\/\/doi.org\/10.1161\/ATVBAHA.117.309599","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"15_CR8","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1242\/dev.127.8.1607","volume":"127","author":"X Jiang","year":"2000","unstructured":"Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM (2000) Fate of the mammalian cardiac neural crest. Development 127(8):1607\u20131616","journal-title":"Development"},{"issue":"6","key":"15_CR9","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1242\/dev.02269","volume":"133","author":"C Pouget","year":"2006","unstructured":"Pouget C, Gautier R, Teillet MA, Jaffredo T (2006) Somite-derived cells replace ventral aortic hemangioblasts and provide aortic smooth muscle cells of the trunk. Development 133(6):1013\u20131022. https:\/\/doi.org\/10.1242\/dev.02269","journal-title":"Development"},{"issue":"10","key":"15_CR10","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1242\/dev.020958","volume":"135","author":"P Wasteson","year":"2008","unstructured":"Wasteson P, Johansson BR, Jukkola T, Breuer S, Akyurek LM, Partanen J, Lindahl P (2008) Developmental origin of smooth muscle cells in the descending aorta in mice. Development 135(10):1823\u20131832. https:\/\/doi.org\/10.1242\/dev.020958","journal-title":"Development"},{"issue":"23","key":"15_CR11","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.1242\/dev.02141","volume":"132","author":"B Wilm","year":"2005","unstructured":"Wilm B, Ipenberg A, Hastie ND, Burch JB, Bader DM (2005) The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature. Development 132(23):5317\u20135328. https:\/\/doi.org\/10.1242\/dev.02141","journal-title":"Development"},{"issue":"3","key":"15_CR12","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1002\/hep.24119","volume":"53","author":"K Asahina","year":"2011","unstructured":"Asahina K, Zhou B, Pu WT, Tsukamoto H (2011) Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 53(3):983\u2013995. https:\/\/doi.org\/10.1002\/hep.24119","journal-title":"Hepatology"},{"issue":"43","key":"15_CR13","doi-asserted-by":"publisher","first-page":"16626","DOI":"10.1073\/pnas.0808649105","volume":"105","author":"J Que","year":"2008","unstructured":"Que J, Wilm B, Hasegawa H, Wang F, Bader D, Hogan BL (2008) Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc Natl Acad Sci U S A 105(43):16626\u201316630. https:\/\/doi.org\/10.1073\/pnas.0808649105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"15_CR14","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1172\/JCI123547","volume":"129","author":"EG MacFarlane","year":"2019","unstructured":"MacFarlane EG, Parker SJ, Shin JY, Kang BE, Ziegler SG, Creamer TJ, Bagirzadeh R, Bedja D, Chen Y, Calderon JF, Weissler K, Frischmeyer-Guerrerio PA, Lindsay ME, Habashi JP, Dietz HC (2019) Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome. J Clin Invest 129(2):659\u2013675. https:\/\/doi.org\/10.1172\/JCI123547","journal-title":"J Clin Invest"},{"issue":"1","key":"15_CR15","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1038\/s41467-018-06891-x","volume":"9","author":"L Dobnikar","year":"2018","unstructured":"Dobnikar L, Taylor AL, Chappell J, Oldach P, Harman JL, Oerton E, Dzierzak E, Bennett MR, Spivakov M, Jorgensen HF (2018) Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels. Nat Commun 9(1):4567. https:\/\/doi.org\/10.1038\/s41467-018-06891-x","journal-title":"Nat Commun"},{"issue":"4","key":"15_CR16","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1093\/cvr\/cvy005","volume":"114","author":"S Sinha","year":"2018","unstructured":"Sinha S, Santoro MM (2018) New models to study vascular mural cell embryonic origin: implications in vascular diseases. Cardiovasc Res 114(4):481\u2013491. https:\/\/doi.org\/10.1093\/cvr\/cvy005","journal-title":"Cardiovasc Res"},{"issue":"8","key":"15_CR17","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s00018-017-2730-7","volume":"75","author":"D Klein","year":"2018","unstructured":"Klein D (2018) iPSCs-based generation of vascular cells: reprogramming approaches and applications. Cell Mol Life Sci 75(8):1411\u20131433. https:\/\/doi.org\/10.1007\/s00018-017-2730-7","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"15_CR18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ydbio.2018.01.018","volume":"435","author":"U Roostalu","year":"2018","unstructured":"Roostalu U, Wong JK (2018) Arterial smooth muscle dynamics in development and repair. Dev Biol 435(2):109\u2013121. https:\/\/doi.org\/10.1016\/j.ydbio.2018.01.018","journal-title":"Dev Biol"},{"issue":"3","key":"15_CR19","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1152\/physrev.00036.2015","volume":"96","author":"E Matsa","year":"2016","unstructured":"Matsa E, Ahrens JH, Wu JC (2016) Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine. Physiol Rev 96(3):1093\u20131126. https:\/\/doi.org\/10.1152\/physrev.00036.2015","journal-title":"Physiol Rev"},{"issue":"1","key":"15_CR20","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1124\/pr.116.013003","volume":"72","author":"DT Paik","year":"2020","unstructured":"Paik DT, Chandy M, Wu JC (2020) Patient and disease-specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics. Pharmacol Rev 72(1):320\u2013342. https:\/\/doi.org\/10.1124\/pr.116.013003","journal-title":"Pharmacol Rev"},{"issue":"12","key":"15_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112291","volume":"9","author":"M Fukuta","year":"2014","unstructured":"Fukuta M, Nakai Y, Kirino K, Nakagawa M, Sekiguchi K, Nagata S, Matsumoto Y, Yamamoto T, Umeda K, Heike T, Okumura N, Koizumi N, Sato T, Nakahata T, Saito M, Otsuka T, Kinoshita S, Ueno M, Ikeya M, Toguchida J (2014) Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media. PLoS One 9(12):e112291. https:\/\/doi.org\/10.1371\/journal.pone.0112291","journal-title":"PLoS One"},{"issue":"4","key":"15_CR22","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.stemcr.2017.08.008","volume":"9","author":"JOS Hackland","year":"2017","unstructured":"Hackland JOS, Frith TJR, Thompson O, Marin Navarro A, Garcia-Castro MI, Unger C, Andrews PW (2017) Top-down inhibition of BMP signaling enables robust induction of hPSCs into neural crest in fully defined, xeno-free conditions. Stem Cell Reports 9(4):1043\u20131052. https:\/\/doi.org\/10.1016\/j.stemcr.2017.08.008","journal-title":"Stem Cell Reports"},{"issue":"2","key":"15_CR23","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.cell.2016.06.011","volume":"166","author":"KM Loh","year":"2016","unstructured":"Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL (2016) Mapping the pairwise choices leading from pluripotency to human bone, heart, and other mesoderm cell types. Cell 166(2):451\u2013467. https:\/\/doi.org\/10.1016\/j.cell.2016.06.011","journal-title":"Cell"},{"issue":"10","key":"15_CR24","doi-asserted-by":"publisher","first-page":"a013847","DOI":"10.1101\/cshperspect.a013847","volume":"3","author":"T Brade","year":"2013","unstructured":"Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL (2013) Embryonic heart progenitors and cardiogenesis. Cold Spring Harb Perspect Med 3(10):a013847. https:\/\/doi.org\/10.1101\/cshperspect.a013847","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"11","key":"15_CR25","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nrg1710","volume":"6","author":"M Buckingham","year":"2005","unstructured":"Buckingham M, Meilhac S, Zaffran S (2005) Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 6(11):826\u2013835. https:\/\/doi.org\/10.1038\/nrg1710","journal-title":"Nat Rev Genet"},{"key":"15_CR26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-3-7091-1883-2_4","volume-title":"Congenital heart diseases: the broken heart","author":"B Thattaliyath","year":"2016","unstructured":"Thattaliyath B, Hutson M (2016) Neural crest. In: Congenital heart diseases: the broken heart. Springer, Vienna, pp 41\u201353"},{"issue":"16","key":"15_CR27","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1242\/dev.128.16.3071","volume":"128","author":"CB Brown","year":"2001","unstructured":"Brown CB, Feiner L, Lu MM, Li J, Ma X, Webber AL, Jia L, Raper JA, Epstein JA (2001) PlexinA2 and semaphorin signaling during cardiac neural crest development. Development 128(16):3071\u20133080","journal-title":"Development"},{"issue":"6027","key":"15_CR28","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1192149","volume":"332","author":"TM Holm","year":"2011","unstructured":"Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, van Erp C, Lindsay ME, Kim D, Schoenhoff F, Cohn RD, Loeys BL, Thomas CJ, Patnaik S, Marugan JJ, Judge DP, Dietz HC (2011) Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science 332(6027):358\u2013361. https:\/\/doi.org\/10.1126\/science.1192149","journal-title":"Science"},{"issue":"6","key":"15_CR29","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.stemcr.2019.04.013","volume":"12","author":"J Zhang","year":"2019","unstructured":"Zhang J, McIntosh BE, Wang B, Brown ME, Probasco MD, Webster S, Duffin B, Zhou Y, Guo LW, Burlingham WJ, Kent C, Ferris M, Thomson JA (2019) A human pluripotent stem cell-based screen for smooth muscle cell differentiation and maturation identifies inhibitors of intimal hyperplasia. Stem Cell Reports 12(6):1269\u20131281. https:\/\/doi.org\/10.1016\/j.stemcr.2019.04.013","journal-title":"Stem Cell Reports"},{"issue":"8","key":"15_CR30","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/ncb3205","volume":"17","author":"C Patsch","year":"2015","unstructured":"Patsch C, Challet-Meylan L, Thoma EC, Urich E, Heckel T, O'Sullivan JF, Grainger SJ, Kapp FG, Sun L, Christensen K, Xia Y, Florido MH, He W, Pan W, Prummer M, Warren CR, Jakob-Roetne R, Certa U, Jagasia R, Freskgard PO, Adatto I, Kling D, Huang P, Zon LI, Chaikof EL, Gerszten RE, Graf M, Iacone R, Cowan CA (2015) Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol 17(8):994\u20131003. https:\/\/doi.org\/10.1038\/ncb3205","journal-title":"Nat Cell Biol"}],"container-title":["Methods in Molecular Biology","Stem Cell Assays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-1979-7_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T06:04:10Z","timestamp":1651644250000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-1979-7_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9781071619780","9781071619797"],"references-count":30,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-1979-7_15","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"5 May 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}