{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T23:29:17Z","timestamp":1750116557527,"version":"3.40.5"},"publisher-location":"New York, NY","reference-count":32,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071621882"},{"type":"electronic","value":"9781071621899"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-1-0716-2189-9_32","type":"book-chapter","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T13:06:06Z","timestamp":1658840766000},"page":"435-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis by Flow Cytometry of \u03b12-Macroglobulin and Nonimmune IgM-Binding to Plasmodium falciparum-Infected Erythrocytes"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-4927","authenticated-orcid":false,"given":"Lars","family":"Hviid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-0248","authenticated-orcid":false,"given":"Mary","family":"Lopez-Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"32_CR1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.4269\/ajtmh.1969.18.860","volume":"18","author":"LH Miller","year":"1969","unstructured":"Miller LH (1969) Distribution of mature trophozoites and schizonts of plasmodium falciparum in the organs of Aotus trivirgatus, the night monkey. Am J Trop Med Hyg 18:860\u2013865","journal-title":"Am J Trop Med Hyg"},{"key":"32_CR2","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/415673a","volume":"415","author":"LH Miller","year":"2002","unstructured":"Miller LH, Baruch DI, Marsh K, Doumbo OK (2002) The pathogenic basis of malaria. Nature 415:673\u2013679","journal-title":"Nature"},{"key":"32_CR3","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4269\/ajtmh.1988.38.289","volume":"38","author":"PH David","year":"1988","unstructured":"David PH, Handunnetti SM, Leech JH, Gamage P, Mendis KN (1988) Rosetting: a new cytoadherence property of malaria-infected erythrocytes. Am J Trop Med Hyg 38:289\u2013297","journal-title":"Am J Trop Med Hyg"},{"key":"32_CR4","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1084\/jem.169.5.1835","volume":"169","author":"R Udomsangpetch","year":"1989","unstructured":"Udomsangpetch R, Wahlin B, Carlson J, Berzins K, Torii M, Aikawa M, Perlmann P, Wahlgren M (1989) Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes. J Exp Med 169:1835\u20131840","journal-title":"J Exp Med"},{"key":"32_CR5","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1128\/iai.59.6.2135-2139.1991","volume":"59","author":"M Ho","year":"1991","unstructured":"Ho M, Davis TM, Silamut K, Bunnag D, White NJ (1991) Rosette formation of plasmodium falciparum-infected erythrocytes from patients with acute malaria. Infect Immun 59:2135\u20132139","journal-title":"Infect Immun"},{"key":"32_CR6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/0092-8674(95)90056-X","volume":"82","author":"JD Smith","year":"1995","unstructured":"Smith JD, Chitnis CE, Craig AG, Roberts DJ, Hudson-Taylor DE, Peterson DS, Pinches R, Newbold CI, Miller LH (1995) Switches in expression of plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell 82:101\u2013110","journal-title":"Cell"},{"key":"32_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/bs.apar.2015.02.004","volume":"88","author":"L Hviid","year":"2015","unstructured":"Hviid L, Jensen AT (2015) PfEMP1 - a parasite protein family of key importance in plasmodium falciparum malaria immunity and pathogenesis. Adv Parasitol 88:51\u201384","journal-title":"Adv Parasitol"},{"key":"32_CR8","doi-asserted-by":"publisher","first-page":"e1000933","DOI":"10.1371\/journal.pcbi.1000933","volume":"6","author":"TS Rask","year":"2010","unstructured":"Rask TS, Hansen DA, Theander TG, Gorm Pedersen A, Lavstsen T (2010) Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer. PLoS Comput Biol 6:e1000933","journal-title":"PLoS Comput Biol"},{"key":"32_CR9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0092-8674(95)90055-1","volume":"82","author":"XZ Su","year":"1995","unstructured":"Su XZ, Heatwole VM, Wertheimer SP, Guinet F, Herrfeldt JA, Peterson DS, Ravetch JA, Wellems TE (1995) The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes. Cell 82:89\u2013100","journal-title":"Cell"},{"key":"32_CR10","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/35091146","volume":"412","author":"KW Deitsch","year":"2001","unstructured":"Deitsch KW, Calderwood MS, Wellems TE (2001) Malaria. Cooperative silencing elements in var genes. Nature 412:875\u2013876","journal-title":"Nature"},{"key":"32_CR11","doi-asserted-by":"publisher","first-page":"692","DOI":"10.4269\/ajtmh.2002.66.692","volume":"66","author":"JA Rowe","year":"2002","unstructured":"Rowe JA, Shafi J, Kai OK, Marsh K, Raza A (2002) Nonimmune IgM, but not I(g)G binds to the surface of plasmodium falciparum-infected erythrocytes and correlates with rosetting and severe malaria. Am J Trop Med Hyg 66:692\u2013699","journal-title":"Am J Trop Med Hyg"},{"key":"32_CR12","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1128\/IAI.71.8.4767-4771.2003","volume":"71","author":"AM Creasey","year":"2003","unstructured":"Creasey AM, Staalsoe T, Raza A, Arnot DE, Rowe JA (2003) Nonspecific immunoglobulin M binding and chondroitin sulfate a binding are linked phenotypes of plasmodium falciparum isolates implicated in malaria during pregnancy. Infect Immun 71:4767\u20134771","journal-title":"Infect Immun"},{"key":"32_CR13","doi-asserted-by":"publisher","first-page":"13795","DOI":"10.1073\/pnas.0601519103","volume":"103","author":"N Rasti","year":"2006","unstructured":"Rasti N, Namusoke F, Chene A, Chen Q, Staalsoe T, Klinkert MQ, Mirembe F, Kironde F, Wahlgren M (2006) Nonimmune immunoglobulin binding and multiple adhesion characterize plasmodium falciparum-infected erythrocytes of placental origin. Proc Natl Acad Sci U S A 103:13795\u201313800","journal-title":"Proc Natl Acad Sci U S A"},{"key":"32_CR14","doi-asserted-by":"publisher","first-page":"3972","DOI":"10.1128\/IAI.00337-15","volume":"83","author":"A Jeppesen","year":"2015","unstructured":"Jeppesen A, Ditlev SB, Soroka V, Stevenson L, Turner L, Dzikowski R, Hviid L, Barfod L (2015) Multiple plasmodium falciparum erythrocyte membrane protein 1 variants per genome can bind IgM via Iis fc fragment Fc\u03bc. Infect Immun 83:3972\u20133981","journal-title":"Infect Immun"},{"key":"32_CR15","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/cmi.12403","volume":"17","author":"L Stevenson","year":"2015","unstructured":"Stevenson L, Huda P, Jeppesen A, Laursen E, Rowe JA, Craig A, Streicher W, Barfod L, Hviid L (2015) Investigating the function of fc-specific binding of IgM to plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting. Cell Microbiol 17:819\u2013831","journal-title":"Cell Microbiol"},{"key":"32_CR16","doi-asserted-by":"publisher","first-page":"6050","DOI":"10.1038\/s41598-019-42585-0","volume":"9","author":"MDP Quintana","year":"2019","unstructured":"Quintana MDP, Ecklu-Mensah G, Tcherniuk SO, Ditlev SB, Oleinikov AV, Hviid L, Lopez-Perez M (2019) Comprehensive analysis of fc-mediated IgM binding to the plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones. Sci Rep 9:6050","journal-title":"Sci Rep"},{"key":"32_CR17","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1186\/s12936-020-03438-8","volume":"19","author":"M Lopez-Perez","year":"2020","unstructured":"Lopez-Perez M, van der Puije W, Castberg FC, Ofori MF, Hviid L (2020) Binding of human serum proteins to plasmodium falciparum-infected erythrocytes and its association with malaria clinical presentation. Malar J 19:362","journal-title":"Malar J"},{"key":"32_CR18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.pt.2015.09.007","volume":"32","author":"RJ Pleass","year":"2016","unstructured":"Pleass RJ, Moore SC, Stevenson L, Hviid L (2016) Immunoglobulin M: restrainer of inflammation and mediator of immune evasion by plasmodium falciparum malaria. Trends Parasitol 32:108\u2013119","journal-title":"Trends Parasitol"},{"key":"32_CR19","doi-asserted-by":"publisher","first-page":"12485","DOI":"10.1073\/pnas.1103708108","volume":"108","author":"L Barfod","year":"2011","unstructured":"Barfod L, Dalgaard MB, Pleman ST, Ofori MF, Pleass RJ, Hviid L (2011) Evasion of immunity to plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1. Proc Natl Acad Sci U S A 108:12485\u201312490","journal-title":"Proc Natl Acad Sci U S A"},{"key":"32_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005022","volume":"11","author":"L Stevenson","year":"2015","unstructured":"Stevenson L, Laursen E, Cowan GJ, Bandoh B, Barfod L, Cavanagh DR, Andersen GR, Hviid L (2015) alpha2-macroglobulin can crosslink multiple plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) molecules and may facilitate adhesion of parasitized erythrocytes. PLoS Pathog 11:e1005022","journal-title":"PLoS Pathog"},{"key":"32_CR21","doi-asserted-by":"publisher","first-page":"418","DOI":"10.2307\/3280287","volume":"65","author":"C Lambros","year":"1979","unstructured":"Lambros C, Vanderberg JP (1979) Synchronization of plasmodium falciparum erythrocytic stages in culture. J Parasitol 65:418\u2013420","journal-title":"J Parasitol"},{"key":"32_CR22","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1152\/physrev.2001.81.2.495","volume":"81","author":"K Kirk","year":"2001","unstructured":"Kirk K (2001) Membrane transport in the malaria-infected erythrocyte. Physiol Rev 81:495\u2013537","journal-title":"Physiol Rev"},{"key":"32_CR23","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/(SICI)1097-0320(19990401)35:4<329::AID-CYTO5>3.0.CO;2-Y","volume":"35","author":"T Staalsoe","year":"1999","unstructured":"Staalsoe T, Giha HA, Dodoo D, Theander TG, Hviid L (1999) Detection of antibodies to variant antigens on plasmodium falciparum-infected erythrocytes by flow cytometry. Cytometry 35:329\u2013336","journal-title":"Cytometry"},{"key":"32_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jim.2011.01.015","volume":"367","author":"BT Grimberg","year":"2011","unstructured":"Grimberg BT (2011) Methodology and application of flow cytometry for investigation of human malaria parasites. J Immunol Methods 367:1\u201316","journal-title":"J Immunol Methods"},{"key":"32_CR25","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0014-4894(86)90032-9","volume":"62","author":"AE Bianco","year":"1986","unstructured":"Bianco AE, Battye FL, Brown GV (1986) Plasmodium falciparum: rapid quantification of parasitemia in fixed malaria cultures by flow cytometry. Exp Parasitol 62:275\u2013282","journal-title":"Exp Parasitol"},{"key":"32_CR26","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.exppara.2008.10.008","volume":"121","author":"S Izumiyama","year":"2009","unstructured":"Izumiyama S, Omura M, Takasaki T, Ohmae H, Asahi H (2009) Plasmodium falciparum: development and validation of a measure of intraerythrocytic growth using SYBR green I in a flow cytometer. Exp Parasitol 121:144\u2013150","journal-title":"Exp Parasitol"},{"key":"32_CR27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/cyto.a.20380","volume":"71","author":"Q Li","year":"2007","unstructured":"Li Q, Gerena L, Xie L, Zhang J, Kyle D, Milhous W (2007) Development and validation of flow cytometric measurement for parasitemia in cultures of P. falciparum vitally stained with YOYO-1. Cytometry A 71:297\u2013307","journal-title":"Cytometry A"},{"key":"32_CR28","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1046\/j.1365-2958.2003.03784.x","volume":"50","author":"N Kriek","year":"2003","unstructured":"Kriek N, Tilley L, Horrocks P, Pinches R, Elford BC, Ferguson DJ, Lingelbach K, Newbold CI (2003) Characterization of the pathway for transport of the cytoadherence-mediating protein, PfEMP1, to the host cell surface in malaria parasite-infected erythrocytes. Mol Microbiol 50:1215\u20131227","journal-title":"Mol Microbiol"},{"key":"32_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045658","volume":"7","author":"KA Quadt","year":"2012","unstructured":"Quadt KA, Barfod L, Andersen D, Bruun J, Gyan B, Hassenkam T, Ofori MF, Hviid L (2012) The density of knobs on plasmodium falciparum-infected erythrocytes depends on developmental age and varies among isolates. PLoS One 7:e45658","journal-title":"PLoS One"},{"key":"32_CR30","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/s42003-019-0429-z","volume":"2","author":"CP Sanchez","year":"2019","unstructured":"Sanchez CP, Karathanasis C, Sanchez R, Cyrklaff M, Jager J, Buchholz B, Schwarz US, Heilemann M, Lanzer M (2019) Single-molecule imaging and quantification of the immune-variant adhesin VAR2CSA on knobs of plasmodium falciparum-infected erythrocytes. Commun Biol 2:172","journal-title":"Commun Biol"},{"key":"32_CR31","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/0035-9203(84)90221-9","volume":"78","author":"AR Dluzewski","year":"1984","unstructured":"Dluzewski AR, Ling IT, Rangachari K, Bates PA, Wilson RJ (1984) A simple method for isolating viable mature parasites of plasmodium falciparum from cultures. Trans R Soc Trop Med Hyg 78:622\u2013624","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"32_CR32","first-page":"7","volume":"4","author":"AC Uhlemann","year":"2000","unstructured":"Uhlemann AC, Staalsoe T, Klinkert MQ, Hviid L (2000) Analysis of plasmodium falciparum-infected red blood cells. MACS & More 4:7\u20138","journal-title":"MACS & More"}],"container-title":["Methods in Molecular Biology","Malaria Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-2189-9_32","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T13:08:56Z","timestamp":1658840936000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-2189-9_32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9781071621882","9781071621899"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-2189-9_32","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"27 July 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}