{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:53:24Z","timestamp":1772916804094,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":11,"publisher":"Springer US","isbn-type":[{"value":"9781071622124","type":"print"},{"value":"9781071622131","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-1-0716-2213-1_8","type":"book-chapter","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T14:04:26Z","timestamp":1647439466000},"page":"73-82","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cell-Based Imaging Assay for Detection of Phospholipidosis"],"prefix":"10.1007","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaizhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"issue":"1","key":"8_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1515\/hsz-2019-0270","volume":"401","author":"B Breiden","year":"2019","unstructured":"Breiden B, Sandhoff K (2019) Emerging mechanisms of drug-induced phospholipidosis. Biol Chem 401(1):31\u201346. https:\/\/doi.org\/10.1515\/hsz-2019-0270","journal-title":"Biol Chem"},{"issue":"34","key":"8_CR2","doi-asserted-by":"publisher","first-page":"5394","DOI":"10.3748\/wjg.v11.i34.5394","volume":"11","author":"H Oikawa","year":"2005","unstructured":"Oikawa H, Maesawa C, Sato R, Oikawa K, Yamada H, Oriso S, Ono S, Yashima-Abo A, Kotani K, Suzuki K, Masuda T (2005) Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: a case report. World J Gastroenterol 11(34):5394\u20135397","journal-title":"World J Gastroenterol"},{"issue":"4","key":"8_CR3","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3181\/00379727-212-44019","volume":"212","author":"MJ Reasor","year":"1996","unstructured":"Reasor MJ, Kacew S (1996) An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity. Proc Soc Exp Biol Med 212(4):297\u2013304","journal-title":"Proc Soc Exp Biol Med"},{"issue":"1","key":"8_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0041-008X(89)90055-0","volume":"97","author":"Z Ruben","year":"1989","unstructured":"Ruben Z, Dodd DC, Rorig KJ, Anderson SN (1989) Disobutamide: a model agent for investigating intracellular drug storage. Toxicol Appl Pharmacol 97(1):57\u201371","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"8_CR5","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/ki.1980.175","volume":"18","author":"GJ Kaloyanides","year":"1980","unstructured":"Kaloyanides GJ, Pastoriza-Munoz E (1980) Aminoglycoside nephrotoxicity. Kidney Int 18(5):571\u2013582","journal-title":"Kidney Int"},{"issue":"3","key":"8_CR6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1023\/a:1024778329320","volume":"19","author":"A Casartelli","year":"2003","unstructured":"Casartelli A, Bonato M, Cristofori P, Crivellente F, Dal Negro G, Masotto I, Mutinelli C, Valko K, Bonfante V (2003) A cell-based approach for the early assessment of the phospholipidogenic potential in pharmaceutical research and drug development. Cell Biol Toxicol 19(3):161\u2013176. https:\/\/doi.org\/10.1023\/a:1024778329320","journal-title":"Cell Biol Toxicol"},{"issue":"12","key":"8_CR7","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1016\/s0006-2952(01)00823-1","volume":"62","author":"RJ Gum","year":"2001","unstructured":"Gum RJ, Hickman D, Fagerland JA, Heindel MA, Gagne GD, Schmidt JM, Michaelides MR, Davidsen SK, Ulrich RG (2001) Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1). Biochem Pharmacol 62(12):1661\u20131673. https:\/\/doi.org\/10.1016\/s0006-2952(01)00823-1","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"8_CR8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1093\/toxsci\/kfm157","volume":"99","author":"P Nioi","year":"2007","unstructured":"Nioi P, Perry BK, Wang EJ, Gu YZ, Snyder RD (2007) In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci 99(1):162\u2013173. https:\/\/doi.org\/10.1093\/toxsci\/kfm157","journal-title":"Toxicol Sci"},{"issue":"12","key":"8_CR9","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.1007\/s00204-019-02593-5","volume":"93","author":"S Li","year":"2019","unstructured":"Li S, Xia M (2019) Review of high-content screening applications in toxicology. Arch Toxicol 93(12):3387\u20133396. https:\/\/doi.org\/10.1007\/s00204-019-02593-5","journal-title":"Arch Toxicol"},{"issue":"1","key":"8_CR10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1177\/1087057113502851","volume":"19","author":"SA Shahane","year":"2014","unstructured":"Shahane SA, Huang R, Gerhold D, Baxa U, Austin CP, Xia M (2014) Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. J Biomol Screen 19(1):66\u201376. https:\/\/doi.org\/10.1177\/1087057113502851","journal-title":"J Biomol Screen"},{"issue":"12","key":"8_CR11","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1007\/s00204-017-1995-9","volume":"91","author":"S Slavov","year":"2017","unstructured":"Slavov S, Stoyanova-Slavova I, Li S, Zhao J, Huang R, Xia M, Beger R (2017) Why are most phospholipidosis inducers also hERG blockers? Arch Toxicol 91(12):3885\u20133895. https:\/\/doi.org\/10.1007\/s00204-017-1995-9","journal-title":"Arch Toxicol"}],"container-title":["Methods in Molecular Biology","High-Throughput Screening Assays in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-2213-1_8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T14:04:43Z","timestamp":1647439483000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-2213-1_8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9781071622124","9781071622131"],"references-count":11,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-2213-1_8","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"17 March 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}