{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T11:28:29Z","timestamp":1747913309723,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":8,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071622889"},{"type":"electronic","value":"9781071622896"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-1-0716-2289-6_10","type":"book-chapter","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T18:03:01Z","timestamp":1655920981000},"page":"175-190","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Dynamic, In Vitro BBB Model to Study the Effects of Varying Levels of Shear Stress"],"prefix":"10.1007","author":[{"given":"Gemma","family":"Molins Guti\u00e9rrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Martorell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio G.","family":"Salazar-Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Balcells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"10_CR1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s10545-013-9608-0","volume":"36","author":"NJ Abbott","year":"2013","unstructured":"Abbott NJ (2013) Blood-brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis 36:437\u2013449. https:\/\/doi.org\/10.1007\/s10545-013-9608-0","journal-title":"J Inherit Metab Dis"},{"issue":"7","key":"10_CR2","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1177\/0271678X16672482","volume":"37","author":"F Garcia-Polite","year":"2017","unstructured":"Garcia-Polite F, Martorell J, Del Rey-Puech P et al (2017) Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium. J Cereb Blood Flow Metab 37(7):2614\u20132625. https:\/\/doi.org\/10.1177\/0271678X16672482","journal-title":"J Cereb Blood Flow Metab"},{"key":"10_CR3","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1046\/j.1469-7580.2002.00064.x","volume":"200","author":"NJ Abbott","year":"2002","unstructured":"Abbott NJ (2002) Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat 200:629\u2013638. https:\/\/doi.org\/10.1046\/j.1469-7580.2002.00064.x","journal-title":"J Anat"},{"key":"10_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1371\/journal.pone.0061855","volume":"8","author":"J Singer","year":"2013","unstructured":"Singer J, Trollor JN, Crawford J et al (2013) The association between pulse wave velocity and cognitive function: the Sydney memory and ageing study. PLoS One 8:4\u20139. https:\/\/doi.org\/10.1371\/journal.pone.0061855","journal-title":"PLoS One"},{"key":"10_CR5","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.bbamem.2008.10.022","volume":"1788","author":"N Weiss","year":"2009","unstructured":"Weiss N, Miller F, Cazaubon S et al (2009) The blood-brain barrier in brain homeostasis and neurological diseases. Biochim Biophys Acta Biomembr 1788:842\u2013857. https:\/\/doi.org\/10.1016\/j.bbamem.2008.10.022","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10_CR6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1211\/jpp.58.3.0001","volume":"58","author":"JA Nicolazzo","year":"2006","unstructured":"Nicolazzo JA, Charman SA, Charman WN (2006) Methods to assess drug permeability across the blood-brain barrier. J Pharm Pharmacol 58:281\u2013293. https:\/\/doi.org\/10.1211\/jpp.58.3.0001","journal-title":"J Pharm Pharmacol"},{"key":"10_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.ejpb.2014.03.012","volume":"87","author":"J Bicker","year":"2014","unstructured":"Bicker J, Alves G, Fortuna A et al (2014) Blood\u2013brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review. Eur J Pharm Biopharm 87:409\u2013432. https:\/\/doi.org\/10.1016\/j.ejpb.2014.03.012","journal-title":"Eur J Pharm Biopharm"},{"key":"10_CR8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2202-12-40","volume":"12","author":"L Cucullo","year":"2011","unstructured":"Cucullo L, Hossain M, Puvenna V et al (2011) The role of shear stress in blood-brain barrier endothelial physiology. BMC Neurosci 12:40. https:\/\/doi.org\/10.1186\/1471-2202-12-40","journal-title":"BMC Neurosci"}],"container-title":["Methods in Molecular Biology","The Blood-Brain Barrier"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-2289-6_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T18:04:18Z","timestamp":1655921058000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-2289-6_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9781071622889","9781071622896"],"references-count":8,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-2289-6_10","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"23 June 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}