{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:15:45Z","timestamp":1773288945851,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":9,"publisher":"Springer US","isbn-type":[{"value":"9781071625644","type":"print"},{"value":"9781071625651","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/978-1-0716-2565-1_4","type":"book-chapter","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T21:02:45Z","timestamp":1663707765000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantification of Plasma S-adenosylmethionine and S-adenosylhomocysteine Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry"],"prefix":"10.1007","author":[{"given":"Erland","family":"Arning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandi","family":"Wasek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodoro","family":"Bottiglieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1093\/jn\/135.11.2703","volume":"135","author":"YI Kim","year":"2005","unstructured":"Kim YI (2005) Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr 135:2703\u20132709","journal-title":"J Nutr"},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1139\/o79-007","volume":"57","author":"DR Hoffman","year":"1979","unstructured":"Hoffman DR, Cornatzer WE, Duerre JA (1979) Relationship between tissue levels of S-adenosylmethionine, S-adenosylhomocysteine and transmethylation reactions. Can J Biochem 57:56\u201365","journal-title":"Can J Biochem"},{"issue":"38","key":"4_CR3","doi-asserted-by":"publisher","first-page":"239318","DOI":"10.1074\/jbc.M002725200","volume":"275","author":"P Yi","year":"2000","unstructured":"Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ (2000) Parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275(38):239318\u2013239323","journal-title":"J Biol Chem"},{"key":"4_CR4","first-page":"47","volume":"198","author":"GL Cantoni","year":"1985","unstructured":"Cantoni GL (1985) The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine. Prog Clin Biol Res 198:47\u201365","journal-title":"Prog Clin Biol Res"},{"issue":"1","key":"4_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/ajmg.c.30293","volume":"157C","author":"SH Mudd","year":"2011","unstructured":"Mudd SH (2011) Hypermethioninemias of genetic and non-genetic origin: a review. Am J Med Genet C Semin Med Genet 157C(1):3\u201332","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10545-016-9972-7","volume":"40","author":"I Baric","year":"2017","unstructured":"Baric I, Staufner C, Augoustides-Savvopoulou P, Chien YH, Dobbelaere D, Grunert SC, Opladen T, Ramadza DP, Rakic B, Wedell A, Blom HJ (2017) Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders. J Inherit Metab Dis 40:5\u201320","journal-title":"J Inherit Metab Dis"},{"issue":"5","key":"4_CR7","doi-asserted-by":"publisher","first-page":"1151S","DOI":"10.1093\/ajcn\/76.5.1151S","volume":"76","author":"T Bottiglieri","year":"2002","unstructured":"Bottiglieri T (2002) S-Adenosyl-L-methionine (SAMe): from the bench to the bedside\u2013molecular basis of a pleiotropic molecule. Am J Clin Nutr 76(5):1151S\u20131157S","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"4_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.4254\/wjh.v12.i2.46","volume":"12","author":"M Noureddin","year":"2020","unstructured":"Noureddin M, Sander-Struckmeier S, Mato JM (2020) Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: a systematic review. World J Hepatol 12(2):46\u201363","journal-title":"World J Hepatol"},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12991-020-00298-z","volume":"19","author":"A Cuomo","year":"2020","unstructured":"Cuomo A, Beccarini Crescenzi B, Bolognesi S, Goracci A, Koukouna D, Rossi R, Fagiolini A (2020) S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review. Ann Gen Psychiatry 19:50","journal-title":"Ann Gen Psychiatry"}],"container-title":["Methods in Molecular Biology","Clinical Applications of Mass Spectrometry in Biomolecular Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-2565-1_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T21:04:16Z","timestamp":1663707856000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-2565-1_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9781071625644","9781071625651"],"references-count":9,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-2565-1_4","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"21 September 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}