{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T19:55:21Z","timestamp":1743105321133,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":27,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071626740"},{"type":"electronic","value":"9781071626757"}],"license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-1-0716-2675-7_4","type":"book-chapter","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T08:18:38Z","timestamp":1664007518000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oxidative and Nitrosative Stress Detection in Human Sperm Using Fluorescent Probes"],"prefix":"10.1007","author":[{"given":"Sara","family":"Escada-Rebelo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Ramalho-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1365-2605.1993.tb01148.x","volume":"16","author":"E de Lamirande","year":"1993","unstructured":"de Lamirande E, Gagnon C (1993) A positive role for the superoxide anion in triggering hyperactivation and capacitation of human spermatozoa. Int J Androl 16:21\u201325","journal-title":"Int J Androl"},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/j.1365-2605.1993.tb01189.x","volume":"16","author":"E de Lamirande","year":"1993","unstructured":"de Lamirande E, Eiley D, Gagnon C (1993) Inverse relationship between the induction of human sperm capacitation and spontaneous acrosome reaction by various biological fluids and the superoxide scavenging capacity of these fluids. Int J Androl 16:258\u2013266","journal-title":"Int J Androl"},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0891-5849(96)00379-6","volume":"22","author":"P Leclerc","year":"1997","unstructured":"Leclerc P, De Lamirande E, Gagnon C (1997) Regulation of protein-tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivatives. Free Radic Biol Med 22:643\u2013656","journal-title":"Free Radic Biol Med"},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1089\/ars.2010.3186","volume":"14","author":"RJ Aitken","year":"2011","unstructured":"Aitken RJ, Curry BJ (2011) Redox regulation of human sperm function: from the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line. Antioxid Redox Signal 14:367\u2013381","journal-title":"Antioxid Redox Signal"},{"key":"4_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5534\/wjmh.2014.32.1.1","volume":"32","author":"A Agarwal","year":"2014","unstructured":"Agarwal A, Virk G, Ong C, du Plessis SS (2014) Effect of oxidative stress on male reproduction. World J Mens Health 32:1","journal-title":"World J Mens Health"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1093\/humrep\/14.11.2801","volume":"14","author":"RK Sharma","year":"1999","unstructured":"Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ, Agarwal A (1999) The reactive oxygen species - total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Hum Reprod 14:2801\u20132807","journal-title":"Hum Reprod"},{"key":"4_CR7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1095\/biolreprod41.1.183","volume":"41","author":"RJ Aitken","year":"1989","unstructured":"Aitken RJ, Clarkson JS, Fishel S (1989) Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod 41:183\u2013197","journal-title":"Biol Reprod"},{"key":"4_CR8","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0002-9378(11)80017-7","volume":"164","author":"RJ Aitken","year":"1991","unstructured":"Aitken RJ, Irvine DS, Wu FC (1991) Prospective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol 164:542\u2013551","journal-title":"Am J Obstet Gynecol"},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/molehr\/4.11.1053","volume":"4","author":"K Whittington","year":"1998","unstructured":"Whittington K, Ford WCL (1998) The effect of incubation periods under 95% oxygen on the stimulated acrosome reaction and motility of human spermatozoa. Mol Hum Reprod 4:1053\u20131057","journal-title":"Mol Hum Reprod"},{"key":"4_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.mce.2003.10.068","volume":"216","author":"MA Baker","year":"2004","unstructured":"Baker MA, Aitken RJ (2004) The importance of redox regulated pathways in sperm cell biology. Mol Cell Endocrinol 216:47\u201354","journal-title":"Mol Cell Endocrinol"},{"key":"4_CR11","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s10815-017-0912-8","volume":"34","author":"J Gosalvez","year":"2017","unstructured":"Gosalvez J, Tvrda E, Agarwal A (2017) Free radical and superoxide reactivity detection in semen quality assessment: past, present, and future. J Assist Reprod Genet 34:697\u2013707","journal-title":"J Assist Reprod Genet"},{"key":"4_CR12","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1210\/jc.2005-2711","volume":"91","author":"GN De Iuliis","year":"2006","unstructured":"De Iuliis GN, Wingate JK, Koppers AJ, McLaughlin EA, Aitken RJ (2006) Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa. J Clin Endocrinol Metab 91:1968\u20131975","journal-title":"J Clin Endocrinol Metab"},{"key":"4_CR13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0027-5107(03)00101-5","volume":"529","author":"DE Sawyer","year":"2003","unstructured":"Sawyer DE, Mercer BG, Wiklendt AM, Aitken RJ (2003) Quantitative analysis of gene-specific DNA damage in human spermatozoa. Mutat Res 529:21\u201334","journal-title":"Mutat Res"},{"key":"4_CR14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S0015-0282(16)43999-3","volume":"31","author":"R Jones","year":"1979","unstructured":"Jones R, Mann T, Sherins R (1979) Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxides, and protective action of seminal plasma. Fertil Steril 31:531\u2013537","journal-title":"Fertil Steril"},{"key":"4_CR15","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1530\/jrf.0.0810459","volume":"81","author":"RJ Aitken","year":"1987","unstructured":"Aitken RJ, Clarkson JS (1987) Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil 81:459\u2013469","journal-title":"J Reprod Fertil"},{"key":"4_CR16","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/j.1939-4640.1987.tb00973.x","volume":"8","author":"JG Alvarez","year":"1987","unstructured":"Alvarez JG, Touchstone JC, Blasco L, Storey BT (1987) Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. Superoxide dismutase as major enzyme protectant against oxygen toxicity. J Androl 8:338\u2013348","journal-title":"J Androl"},{"key":"4_CR17","unstructured":"Agarwal A, Cocuzza M, Abdelrazik H, Sharma RK (2008) Oxidative stress measurement in patients with male or female factor infertility. In: Popov I, Lewin G (eds) Handbook of chemiluminescent methods in oxidative stress assessment, Transworld Research Network, Kerala, India, pp 195\u2013218"},{"key":"4_CR18","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1111\/bph.12675","volume":"172","author":"B Buzadzic","year":"2015","unstructured":"Buzadzic B, Vucetic M, Jankovic A, Stancic A, Korac A, Korac B et al (2015) New insights into male (in)fertility: the importance of NO. Br J Pharmacol 172:1455\u20131467","journal-title":"Br J Pharmacol"},{"key":"4_CR19","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/biof.1535","volume":"46","author":"V Otasevic","year":"2020","unstructured":"Otasevic V, Stancic A, Korac A, Jankovic A, Korac B (2020) Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology. Biofactors 46:206\u2013219","journal-title":"Biofactors"},{"key":"4_CR20","doi-asserted-by":"publisher","first-page":"465","DOI":"10.4103\/aja.aja_132_19","volume":"22","author":"S Escada-Rebelo","year":"2020","unstructured":"Escada-Rebelo S, Mora FG, Sousa AP, Almeida-Santos T, Paiva A, Ramalho-Santos J (2020) Fluorescent probes for the detection of reactive oxygen species in human spermatozoa. Asian J Androl 22:465\u2013471","journal-title":"Asian J Androl"},{"key":"4_CR21","doi-asserted-by":"publisher","first-page":"15038","DOI":"10.1073\/pnas.0601945103","volume":"103","author":"KM Robinson","year":"2006","unstructured":"Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM et al (2006) Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A 103:15038\u201315043","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4_CR22","doi-asserted-by":"publisher","first-page":"9638","DOI":"10.1021\/ja802355u","volume":"130","author":"BC Dickinson","year":"2008","unstructured":"Dickinson BC, Chang CJ (2008) A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells. J Am Chem Soc 130:9638\u20139639","journal-title":"J Am Chem Soc"},{"key":"4_CR23","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1210\/jc.2007-2616","volume":"93","author":"AJ Koppers","year":"2008","unstructured":"Koppers AJ, De Iuliis GN, Finnie JM, McLaughlin EA, Aitken RJ (2008) Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa. J Clin Endocrinol Metab 93:3199\u20133207","journal-title":"J Clin Endocrinol Metab"},{"key":"4_CR24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1095\/biolreprod.113.109157","volume":"89","author":"JE Gray","year":"2013","unstructured":"Gray JE, Starmer J, Lin VS, Dickinson BC, Magnuson T (2013) Mitochondrial hydrogen peroxide and defective cholesterol efflux prevent in vitro fertilization by cryopreserved inbred mouse sperm. Biol Reprod 89:17","journal-title":"Biol Reprod"},{"key":"4_CR25","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1439-0272.2009.01005.x","volume":"42","author":"C Roessner","year":"2010","unstructured":"Roessner C, Paasch U, Glander HJ, Grunewald S (2010) Activity of nitric oxide synthase in mature and immature human spermatozoa. Andrologia 42:132\u2013137","journal-title":"Andrologia"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.fertnstert.2011.07.1091","volume":"96","author":"A Amaral","year":"2011","unstructured":"Amaral A, Paiva C, Baptista M, Sousa AP, Ramalho-Santos J (2011) Exogenous glucose improves long-standing human sperm motility, viability, and mitochondrial function. Fertil Steril 96:848\u2013850","journal-title":"Fertil Steril"},{"key":"4_CR27","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1530\/REP-13-0644","volume":"147","author":"M Marques","year":"2014","unstructured":"Marques M, Sousa AP, Paiva A, Almeida-Santos T, Ramalho-Santos J (2014) Low amounts of mitochondrial reactive oxygen species define human sperm quality. Reproduction 147:817\u2013824","journal-title":"Reproduction"}],"container-title":["Methods in Molecular Biology","Histochemistry of Single Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-2675-7_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T08:22:55Z","timestamp":1664007775000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-2675-7_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,25]]},"ISBN":["9781071626740","9781071626757"],"references-count":27,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-2675-7_4","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2022,9,25]]},"assertion":[{"value":"25 September 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}