{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:43:50Z","timestamp":1793036630187,"version":"4.5.0"},"publisher-location":"New York, NY","reference-count":12,"publisher":"Springer US","isbn-type":[{"value":"9781071628980","type":"print"},{"value":"9781071628997","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-1-0716-2899-7_14","type":"book-chapter","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T20:00:04Z","timestamp":1677614404000},"page":"269-282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Concomitant Sequencing of Accessible Chromatin and Mitochondrial Genomes in Single Cells Using mtscATAC-Seq"],"prefix":"10.1007","author":[{"given":"Leif S.","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb A.","family":"Lareau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"14_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41576-020-0265-5","volume":"22","author":"AS Nam","year":"2021","unstructured":"Nam AS, Chaligne R, Landau DA (2021) Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics. Nat Rev Genet 22:3\u201318","journal-title":"Nat Rev Genet"},{"key":"14_CR2","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/nmeth.2688","volume":"10","author":"JD Buenrostro","year":"2013","unstructured":"Buenrostro JD, Giresi PG, Zaba LC et al (2013) Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat Methods 10:1213\u20131218","journal-title":"Nat Methods"},{"key":"14_CR3","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/nmeth.4396","volume":"14","author":"MR Corces","year":"2017","unstructured":"Corces MR, Trevino AE, Hamilton EG et al (2017) An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nat Methods 14:959\u2013962","journal-title":"Nat Methods"},{"key":"14_CR4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41587-020-0645-6","volume":"39","author":"CA Lareau","year":"2021","unstructured":"Lareau CA, Ludwig LS, Muus C et al (2021) Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Nat Biotechnol 39:451\u2013461","journal-title":"Nat Biotechnol"},{"key":"14_CR5","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1056\/NEJMoa2001265","volume":"383","author":"MA Walker","year":"2020","unstructured":"Walker MA, Lareau CA, Ludwig LS et al (2020) Purifying selection against pathogenic mitochondrial DNA in human T cells. N Engl J Med 383:1556\u20131563","journal-title":"N Engl J Med"},{"key":"14_CR6","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.cell.2019.01.022","volume":"176","author":"LS Ludwig","year":"2019","unstructured":"Ludwig LS, Lareau CA, Ulirsch JC et al (2019) Lineage tracing in humans enabled by mitochondrial mutations and single-cell genomics. Cell 176:1325\u20131339.e22","journal-title":"Cell"},{"key":"14_CR7","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1158\/2159-8290.CD-21-0276","volume":"11","author":"L Penter","year":"2021","unstructured":"Penter L, Gohil SH, Lareau C et al (2021) Longitudinal single-cell dynamics of chromatin accessibility and mitochondrial mutations in chronic lymphocytic leukemia mirror disease history. Cancer Discov 11:3048. https:\/\/doi.org\/10.1158\/2159-8290.CD-21-0276","journal-title":"Cancer Discov"},{"key":"14_CR8","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1182\/bloodadvances.2019001196","volume":"3","author":"CA Lareau","year":"2019","unstructured":"Lareau CA, Ludwig LS, Sankaran VG (2019) Longitudinal assessment of clonal mosaicism in human hematopoiesis via mitochondrial mutation tracking. Blood Adv 3:4161\u20134165","journal-title":"Blood Adv"},{"key":"14_CR9","doi-asserted-by":"crossref","unstructured":"Stuart T, Srivastava A, Madad S et al (2021) Multimodal single-cell chromatin analysis with Signac. Nat Methods (in press)","DOI":"10.1101\/2020.11.09.373613"},{"key":"14_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-21583-9","volume":"12","author":"R Fang","year":"2021","unstructured":"Fang R, Preissl S, Li Y et al (2021) Comprehensive analysis of single cell ATAC-seq data with SnapATAC. Nat Commun 12:1\u201315","journal-title":"Nat Commun"},{"key":"14_CR11","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/s41588-021-00790-6","volume":"53","author":"JM Granja","year":"2021","unstructured":"Granja JM, Corces MR, Pierce SE et al (2021) ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis. Nat Genet 53:403\u2013411","journal-title":"Nat Genet"},{"key":"14_CR12","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/s41587-021-00927-2","volume":"39","author":"EP Mimitou","year":"2021","unstructured":"Mimitou EP, Lareau CA, Chen KY et al (2021) Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells. Nat Biotechnol 39:1246. https:\/\/doi.org\/10.1038\/s41587-021-00927-2","journal-title":"Nat Biotechnol"}],"container-title":["Methods in Molecular Biology","Chromatin Accessibility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-2899-7_14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T20:00:25Z","timestamp":1677614425000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-2899-7_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9781071628980","9781071628997"],"references-count":12,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-2899-7_14","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"21 February 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}