{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T14:39:21Z","timestamp":1743086361201,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":33,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071631546"},{"type":"electronic","value":"9781071631553"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-1-0716-3155-3_16","type":"book-chapter","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T19:03:09Z","timestamp":1680807789000},"page":"225-238","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Candida Antifungal Resistance Using Animal Infection Models"],"prefix":"10.1007","author":[{"given":"David R.","family":"Andes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeniel E.","family":"Nett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"16_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1128\/CMR.00029-06","volume":"20","author":"MA Pfaller","year":"2007","unstructured":"Pfaller MA, Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20:133\u2013163","journal-title":"Clin Microbiol Rev"},{"key":"16_CR2","doi-asserted-by":"crossref","unstructured":"Pappas PG, Kauffman CA, Andes DR et al (2016) Clinical practice guideline for the management of candidiasis: 2016 update by the infectious diseases society of America. Clin Infect Dis 62:e1\u2013e50","DOI":"10.1093\/cid\/civ933"},{"key":"16_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004668","volume":"11","author":"E Shor","year":"2015","unstructured":"Shor E, Perlin DS (2015) Coping with stress and the emergence of multidrug resistance in fungi. PLoS Pathog 11:e1004668","journal-title":"PLoS Pathog"},{"key":"16_CR4","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.2217\/fmb.13.101","volume":"8","author":"HT Taff","year":"2013","unstructured":"Taff HT, Mitchell KF, Edward JA et al (2013) Mechanisms of Candida biofilm drug resistance. Future Microbiol 8:1325\u20131337","journal-title":"Future Microbiol"},{"key":"16_CR5","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1128\/JB.183.18.5385-5394.2001","volume":"183","author":"J Chandra","year":"2001","unstructured":"Chandra J, Kuhn DM, Mukherjee PK et al (2001) Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance. J Bacteriol 183:5385\u20135394","journal-title":"J Bacteriol"},{"key":"16_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1128\/CMR.17.2.255-267.2004","volume":"17","author":"EM Kojic","year":"2004","unstructured":"Kojic EM, Darouiche RO (2004) Candida infections of medical devices. Clin Microbiol Rev 17:255\u2013267","journal-title":"Clin Microbiol Rev"},{"key":"16_CR7","doi-asserted-by":"publisher","first-page":"6390","DOI":"10.1016\/j.bmc.2016.11.008","volume":"24","author":"M Zhao","year":"2016","unstructured":"Zhao M, Lepak AJ, Andes DR (2016) Animal models in the pharmacokinetic\/pharmacodynamic evaluation of antimicrobial agents. Bioorg Med Chem 24:6390\u20136400","journal-title":"Bioorg Med Chem"},{"key":"16_CR8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1086\/430952","volume":"192","author":"B Spellberg","year":"2005","unstructured":"Spellberg B, Ibrahim AS, Edwards JE Jr et al (2005) Mice with disseminated candidiasis die of progressive sepsis. J Infect Dis 192:336\u2013343","journal-title":"J Infect Dis"},{"key":"16_CR9","doi-asserted-by":"crossref","unstructured":"Zhao M, Lepak AJ, Vanscoy B et al (2018) In vivo pharmacokinetics and pharmacodynamics of APX001 against Candida spp. in a neutropenic disseminated candidiasis mouse model. Antimicrob Agents Chemother 62","DOI":"10.1128\/AAC.02542-17"},{"key":"16_CR10","doi-asserted-by":"crossref","unstructured":"Lepak AJ, Zhao M, Vanscoy B et al (2018) Pharmacodynamics of a long-acting echinocandin, CD101, in a neutropenic invasive-candidiasis murine model using an extended-interval dosing design. Antimicrob Agents Chemother 62","DOI":"10.1128\/AAC.02154-17"},{"key":"16_CR11","doi-asserted-by":"crossref","unstructured":"Lepak AJ, Zhao M, Berkow EL et al (2017) Pharmacodynamic optimization for treatment of invasive Candida auris infection. Antimicrob Agents Chemother 61","DOI":"10.1128\/AAC.00791-17"},{"key":"16_CR12","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.mib.2006.06.007","volume":"9","author":"J Nett","year":"2006","unstructured":"Nett J, Andes D (2006) Candida albicans biofilm development, modeling a host-pathogen interaction. Curr Opin Microbiol 9:340\u2013345","journal-title":"Curr Opin Microbiol"},{"key":"16_CR13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1023\/A:1006851418963","volume":"139","author":"H Nikawa","year":"1997","unstructured":"Nikawa H, Nishimura H, Hamada T et al (1997) Effects of dietary sugars and, saliva and serum on Candida bioflim formation on acrylic surfaces. Mycopathologia 139:87\u201391","journal-title":"Mycopathologia"},{"key":"16_CR14","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.cub.2008.06.034","volume":"18","author":"CJ Nobile","year":"2008","unstructured":"Nobile CJ, Schneider HA, Nett JE et al (2008) Complementary adhesin function in C. albicans biofilm formation. Curr Biol 18:1017\u20131024","journal-title":"Curr Biol"},{"key":"16_CR15","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1128\/AAC.01397-07","volume":"52","author":"P Uppuluri","year":"2008","unstructured":"Uppuluri P, Nett J, Heitman J et al (2008) Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrob Agents Chemother 52:1127\u20131132","journal-title":"Antimicrob Agents Chemother"},{"key":"16_CR16","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1086\/651200","volume":"202","author":"JE Nett","year":"2010","unstructured":"Nett JE, Sanchez H, Cain MT et al (2010) Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan. J Infect Dis 202:171\u2013175","journal-title":"J Infect Dis"},{"key":"16_CR17","doi-asserted-by":"publisher","first-page":"6023","DOI":"10.1128\/IAI.72.10.6023-6031.2004","volume":"72","author":"D Andes","year":"2004","unstructured":"Andes D, Nett J, Oschel P et al (2004) Development and characterization of an in vivo central venous catheter Candida albicans biofilm model. Infect Immun 72:6023\u20136031","journal-title":"Infect Immun"},{"key":"16_CR18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1086\/599838","volume":"200","author":"JE Nett","year":"2009","unstructured":"Nett JE, Lepak AJ, Marchillo K et al (2009) Time course global gene expression analysis of an in vivo Candida biofilm. J Infect Dis 200:307\u2013313","journal-title":"J Infect Dis"},{"key":"16_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1080\/00362178485380251","volume":"22","author":"J Ahrens","year":"1984","unstructured":"Ahrens J, Graybill JR, Craven PC et al (1984) Treatment of experimental murine candidiasis with liposome-associated amphotericin B. Sabouraudia 22:163\u2013166","journal-title":"Sabouraudia"},{"key":"16_CR20","doi-asserted-by":"publisher","first-page":"4911","DOI":"10.1128\/AAC.48.12.4911-4914.2004","volume":"48","author":"DM Maccallum","year":"2004","unstructured":"Maccallum DM, Odds FC (2004) Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection. Antimicrob Agents Chemother 48:4911\u20134914","journal-title":"Antimicrob Agents Chemother"},{"key":"16_CR21","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1093\/jac\/dkx422","volume":"73","author":"NP Wiederhold","year":"2018","unstructured":"Wiederhold NP, Najvar LK, Jaramillo R et al (2018) Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata. J Antimicrob Chemother 73:448\u2013451","journal-title":"J Antimicrob Chemother"},{"key":"16_CR22","doi-asserted-by":"crossref","unstructured":"Wiederhold NP, Najvar LK, Jaramillo R et al (2020) The novel Arylamidine T-2307 demonstrates in vitro and in vivo activity against Candida auris. Antimicrob Agents Chemother 64","DOI":"10.1128\/AAC.02198-19"},{"key":"16_CR23","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1086\/517522","volume":"195","author":"J Nett","year":"2007","unstructured":"Nett J, Lincoln L, Marchillo K et al (2007) Beta \u22121,3 glucan as a test for central venous catheter biofilm infection. J Infect Dis 195:1705\u20131712","journal-title":"J Infect Dis"},{"key":"16_CR24","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1128\/AAC.43.9.2116","volume":"43","author":"D Andes","year":"1999","unstructured":"Andes D, Van Ogtrop M (1999) Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis infection model. Antimicrob Agents Chemother 43:2116\u20132120","journal-title":"Antimicrob Agents Chemother"},{"key":"16_CR25","doi-asserted-by":"publisher","first-page":"3497","DOI":"10.1128\/AAC.00478-08","volume":"52","author":"DR Andes","year":"2008","unstructured":"Andes DR, Diekema DJ, Pfaller MA et al (2008) In vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. glabrata in a neutropenic murine candidiasis model. Antimicrob Agents Chemother 52:3497\u20133503","journal-title":"Antimicrob Agents Chemother"},{"key":"16_CR26","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1128\/EC.5.4.613-619.2006","volume":"5","author":"DA Hogan","year":"2006","unstructured":"Hogan DA (2006) Talking to themselves: autoregulation and quorum sensing in fungi. Eukaryot Cell 5:613\u2013619","journal-title":"Eukaryot Cell"},{"key":"16_CR27","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1128\/AAC.00601-06","volume":"51","author":"WW Hope","year":"2007","unstructured":"Hope WW, Drusano GL, Moore CB et al (2007) Effect of neutropenia and treatment delay on the response to antifungal agents in experimental disseminated candidiasis. Antimicrob Agents Chemother 51:285\u2013295","journal-title":"Antimicrob Agents Chemother"},{"issue":"Pt 8","key":"16_CR28","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1099\/00221287-146-8-1881","volume":"146","author":"FC Odds","year":"2000","unstructured":"Odds FC, Van Nuffel L, Gow NA (2000) Survival in experimental Candida albicans infections depends on inoculum growth conditions as well as animal host. Microbiology 146(Pt 8):1881\u20131889","journal-title":"Microbiology"},{"key":"16_CR29","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/j.1365-2958.2012.08210.x","volume":"86","author":"C Sasse","year":"2012","unstructured":"Sasse C, Dunkel N, Schafer T et al (2012) The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans. Mol Microbiol 86:539","journal-title":"Mol Microbiol"},{"key":"16_CR30","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1128\/JB.183.10.2971-2978.2001","volume":"183","author":"LE Cowen","year":"2001","unstructured":"Cowen LE, Kohn LM, Anderson JB (2001) Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans. J Bacteriol 183:2971\u20132978","journal-title":"J Bacteriol"},{"key":"16_CR31","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4161\/viru.3.1.18886","volume":"3","author":"R Ben-Ami","year":"2012","unstructured":"Ben-Ami R, Kontoyiannis DP (2012) Resistance to echinocandins comes at a cost: the impact of FKS1 hotspot mutations on Candida albicans fitness and virulence. Virulence 3:95\u201397","journal-title":"Virulence"},{"key":"16_CR32","doi-asserted-by":"publisher","first-page":"5875","DOI":"10.1128\/AAC.01102-12","volume":"56","author":"A Lepak","year":"2012","unstructured":"Lepak A, Castanheira M, Diekema D et al (2012) Optimizing Echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations. Antimicrob Agents Chemother 56:5875\u20135882","journal-title":"Antimicrob Agents Chemother"},{"key":"16_CR33","doi-asserted-by":"publisher","first-page":"5642","DOI":"10.1128\/AAC.01354-13","volume":"57","author":"AJ Lepak","year":"2013","unstructured":"Lepak AJ, Marchillo K, Vanhecker J et al (2013) Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model. Antimicrob Agents Chemother 57:5642\u20135648","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Methods in Molecular Biology","Antifungal Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3155-3_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T19:04:04Z","timestamp":1680807844000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3155-3_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9781071631546","9781071631553"],"references-count":33,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3155-3_16","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"7 April 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}