{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:42:17Z","timestamp":1790199737211,"version":"4.1.0"},"publisher-location":"New York, NY","reference-count":33,"publisher":"Springer US","isbn-type":[{"value":"9781071631744","type":"print"},{"value":"9781071631751","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-1-0716-3175-1_31","type":"book-chapter","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T07:02:13Z","timestamp":1684479733000},"page":"481-486","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Overview of Laboratory Testing for ADAMTS13"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-1661","authenticated-orcid":false,"given":"Emmanuel J.","family":"Favaloro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8237-6743","authenticated-orcid":false,"given":"Leonardo","family":"Pasalic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,20]]},"reference":[{"issue":"1","key":"31_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1055\/s-0031-1300951","volume":"38","author":"K Chapman","year":"2012","unstructured":"Chapman K, Seldon M, Richards R (2012) Thrombotic microangiopathies, thrombotic thrombocytopenic purpura, and ADAMTS-13. Semin Thromb Hemost 38(1):47\u201354. https:\/\/doi.org\/10.1055\/s-0031-1300951","journal-title":"Semin Thromb Hemost"},{"issue":"1","key":"31_CR2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1055\/s-0030-1248726","volume":"36","author":"Z Zhou","year":"2010","unstructured":"Zhou Z, Nguyen TC, Guchhait P, Dong JF (2010) Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. Semin Thromb Hemost 36(1):71\u201381. https:\/\/doi.org\/10.1055\/s-0030-1248726","journal-title":"Semin Thromb Hemost"},{"key":"31_CR3","doi-asserted-by":"publisher","unstructured":"Woods AI, Paiva J, Dos Santos C, Alberto MF, S\u00e1nchez-Luceros A (2023) From the discovery of ADAMTS13 to current understanding of its role in health and disease. Semin Thromb Hemost 49(3):284\u2013294. https:\/\/doi.org\/10.1055\/s-0042-1758059.","DOI":"10.1055\/s-0042-1758059"},{"issue":"1","key":"31_CR4","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1055\/s-0031-1300950","volume":"38","author":"N Turner","year":"2012","unstructured":"Turner N, Nolasco L, Moake J (2012) Generation and breakdown of soluble ultralarge von Willebrand factor multimers. Semin Thromb Hemost 38(1):38\u201346. https:\/\/doi.org\/10.1055\/s-0031-1300950","journal-title":"Semin Thromb Hemost"},{"key":"31_CR5","doi-asserted-by":"publisher","unstructured":"Saadalla A, Seheult J, Pruthi RV, Chen D (2023) von Willebrand factor multimer analysis and classification: a comprehensive review and updates. Semin Thromb Hemost. https:\/\/doi.org\/10.1055\/s-0042-1757183. (in press)","DOI":"10.1055\/s-0042-1757183"},{"key":"31_CR6","doi-asserted-by":"publisher","first-page":"755","DOI":"10.2147\/JBM.S266791","volume":"12","author":"CK Colonne","year":"2021","unstructured":"Colonne CK, Reardon B, Curnow J, Favaloro EJ (2021) Why is misdiagnosis of von Willebrand disease still prevalent and how can we overcome it? A focus on clinical considerations and recommendations. J Blood Med 12:755\u2013768. https:\/\/doi.org\/10.2147\/JBM.S266791","journal-title":"J Blood Med"},{"issue":"1","key":"31_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1055\/s-0035-1564838","volume":"42","author":"C Tersteeg","year":"2016","unstructured":"Tersteeg C, Fijnheer R, Pasterkamp G, de Groot PG, Vanhoorelbeke K, de Maat S, Maas C (2016) Keeping von Willebrand factor under control: alternatives for ADAMTS13. Semin Thromb Hemost 42(1):9\u201317. https:\/\/doi.org\/10.1055\/s-0035-1564838","journal-title":"Semin Thromb Hemost"},{"issue":"1","key":"31_CR8","first-page":"55","volume":"9","author":"EJ Favaloro","year":"2021","unstructured":"Favaloro EJ, Henry BM, Lippi G (2021) VWF and ADAMTS13 in COVID-19 and beyond: a question of balance. EMJ Hematol 9(1):55\u201368","journal-title":"EMJ Hematol"},{"key":"31_CR9","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.thromres.2014.09.029","volume":"134","author":"EJ Favaloro","year":"2014","unstructured":"Favaloro EJ (2014) Evaluating the interaction of von Willebrand factor and ADAMTS13 \u2013 and perhaps also beyond ADAMTS13. Thromb Res 134:1167\u20131168. https:\/\/doi.org\/10.1016\/j.thromres.2014.09.029","journal-title":"Thromb Res"},{"issue":"3","key":"31_CR10","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3390\/healthcare10030557","volume":"10","author":"CK Colonne","year":"2022","unstructured":"Colonne CK, Favaloro EJ, Pasalic L (2022) The intriguing connections between von Willebrand factor, ADAMTS13 and cancer. Healthcare (Basel) 10(3):557. https:\/\/doi.org\/10.3390\/healthcare10030557","journal-title":"Healthcare (Basel)"},{"issue":"9","key":"31_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/jcdd8090115","volume":"8","author":"B Reardon","year":"2021","unstructured":"Reardon B, Pasalic L, Favaloro EJ (2021) The intriguing relationships of von Willebrand factor, ADAMTS13 and cardiac disease. J Cardiovasc Dev Dis 8(9):115. https:\/\/doi.org\/10.3390\/jcdd8090115","journal-title":"J Cardiovasc Dev Dis"},{"issue":"4","key":"31_CR12","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1055\/s-0041-1727282","volume":"47","author":"EJ Favaloro","year":"2021","unstructured":"Favaloro EJ, Henry BM, Lippi G (2021) Increased VWF and decreased ADAMTS13 in COVID-19: creating a milieu for (micro)thrombosis? Semin Thromb Hemost 47(4):400\u2013418. https:\/\/doi.org\/10.1055\/s-0041-1727282","journal-title":"Semin Thromb Hemost"},{"issue":"Suppl 1","key":"31_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/ijlh.13415","volume":"43","author":"BM Henry","year":"2021","unstructured":"Henry BM, Benoit SW, de Oliveira MHS, Lippi G, Favaloro EJ, Benoit JL (2021) ADAMTS13 activity to von Willebrand factor antigen ratio predicts acute kidney injury in patients with COVID-19: evidence of SARS-CoV-2 induced secondary thrombotic microangiopathy. Int J Lab Hematol 43(Suppl 1):129\u2013136. https:\/\/doi.org\/10.1111\/ijlh.13415","journal-title":"Int J Lab Hematol"},{"issue":"8","key":"31_CR14","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/ajh.26241","volume":"96","author":"EJ Favaloro","year":"2021","unstructured":"Favaloro EJ, Pasalic L, Henry B, Lippi G (2021) Laboratory testing for ADAMTS13: utility for TTP diagnosis\/exclusion and beyond. Am J Hematol 96(8):1049\u20131055. https:\/\/doi.org\/10.1002\/ajh.26241","journal-title":"Am J Hematol"},{"issue":"1","key":"31_CR15","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1055\/s-0030-1248727","volume":"36","author":"S Just","year":"2010","unstructured":"Just S (2010) Methodologies and clinical utility of ADAMTS-13 activity testing. Semin Thromb Hemost 36(1):82\u201390. https:\/\/doi.org\/10.1055\/s-0030-1248727","journal-title":"Semin Thromb Hemost"},{"issue":"4","key":"31_CR16","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1055\/s-0034-1376883","volume":"40","author":"P Kn\u00f6bl","year":"2014","unstructured":"Kn\u00f6bl P (2014) Inherited and acquired thrombotic thrombocytopenic purpura (TTP) in adults. Semin Thromb Hemost 40(4):493\u2013502. https:\/\/doi.org\/10.1055\/s-0034-1376883","journal-title":"Semin Thromb Hemost"},{"issue":"4","key":"31_CR17","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1055\/s-0034-1376152","volume":"40","author":"WA Hassenpflug","year":"2014","unstructured":"Hassenpflug WA, Budde U, Schneppenheim S, Schneppenheim R (2014) Inherited thrombotic thrombocytopenic purpura in children. Semin Thromb Hemost 40(4):487\u2013492. https:\/\/doi.org\/10.1055\/s-0034-1376152","journal-title":"Semin Thromb Hemost"},{"issue":"3","key":"31_CR18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1055\/s-0040-1708541","volume":"46","author":"R Blennerhassett","year":"2020","unstructured":"Blennerhassett R, Curnow J, Pasalic L (2020) Immune-mediated thrombotic thrombocytopenic purpura: a narrative review of diagnosis and treatment in adults. Semin Thromb Hemost 46(3):289\u2013301. https:\/\/doi.org\/10.1055\/s-0040-1708541","journal-title":"Semin Thromb Hemost"},{"issue":"1","key":"31_CR19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1055\/s-0033-1363165","volume":"40","author":"K Chapman","year":"2014","unstructured":"Chapman K, Yuen S (2014) Therapy for thrombotic thrombocytopenia purpura: past, present, and future. Semin Thromb Hemost 40(1):34\u201340. https:\/\/doi.org\/10.1055\/s-0033-1363165","journal-title":"Semin Thromb Hemost"},{"key":"31_CR20","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/978-1-4939-7196-1_30","volume":"1646","author":"EJ Favaloro","year":"2017","unstructured":"Favaloro EJ, Mohammed S, Patzke J (2017) Laboratory testing for von willebrand factor antigen (VWF:Ag). Methods Mol Biol 1646:403\u2013416. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_30","journal-title":"Methods Mol Biol"},{"key":"31_CR21","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/978-1-4939-7196-1_33","volume":"1646","author":"J Patzke","year":"2017","unstructured":"Patzke J, Favaloro EJ (2017) Laboratory testing for von Willebrand factor activity by glycoprotein ib binding assays (VWF:GPIb). Methods Mol Biol 1646:453\u2013460. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_33","journal-title":"Methods Mol Biol"},{"key":"31_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/978-1-4939-7196-1_32","volume":"1646","author":"S Mohammed","year":"2017","unstructured":"Mohammed S, Favaloro EJ (2017) Laboratory testing for von Willebrand factor ristocetin cofactor (VWF:RCo). Methods Mol Biol 1646:435\u2013451. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_32","journal-title":"Methods Mol Biol"},{"key":"31_CR23","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/978-1-4939-7196-1_31","volume":"1646","author":"EJ Favaloro","year":"2017","unstructured":"Favaloro EJ, Mohammed S (2017) Laboratory testing for von Willebrand factor collagen binding (VWF:CB). Methods Mol Biol 1646:417\u2013433. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_31","journal-title":"Methods Mol Biol"},{"key":"31_CR24","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/978-1-4939-7196-1_36","volume":"1646","author":"S Oliver","year":"2017","unstructured":"Oliver S, Lau KKE, Chapman K, Favaloro EJ (2017) Laboratory testing for von Willebrand factor multimers. Methods Mol Biol 1646:495\u2013511. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_36","journal-title":"Methods Mol Biol"},{"key":"31_CR25","doi-asserted-by":"publisher","unstructured":"Favaloro EJ, Mohammed S, Vong R, Pasalic L (2023) Laboratory testing for von Willebrand disease using a composite 3-test chemiluminescence-based von Willebrand factor assay panel. In: Hemostasis and thrombosis: methods and protocols. Springer, New York, pp 647\u2013667. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_43","DOI":"10.1007\/978-1-0716-3175-1_43"},{"key":"31_CR26","doi-asserted-by":"publisher","unstructured":"Seidizadeh O, Peyvandi F (2023) Laboratory testing for von Willebrand factor activity by a glycoprotein Ib binding assay (VWF:GPIbR): HemosIL von Willebrand factor ristocetin cofactor activity on ACL TOP. In: Hemostasis and thrombosis: methods and protocols. Springer, New York, pp 669\u2013677. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_44","DOI":"10.1007\/978-1-0716-3175-1_44"},{"key":"31_CR27","doi-asserted-by":"publisher","unstructured":"Moore GW (2023) ADAMTS13 activity: screening test protocol. In: Hemostasis and thrombosis: methods and protocols. Springer, New York, pp 523\u2013531. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_34","DOI":"10.1007\/978-1-0716-3175-1_34"},{"key":"31_CR28","doi-asserted-by":"publisher","unstructured":"Moore GW, Llusa M, Griffiths MM, Binder NB (2023) ADAMTS13 activity measurement by ELISA and fluorescence resonance energy transfer assay. In: Hemostasis and thrombosis: methods and protocols. Springer, New York, pp 533\u2013547. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_35","DOI":"10.1007\/978-1-0716-3175-1_35"},{"key":"31_CR29","doi-asserted-by":"publisher","unstructured":"Moore GW, Vetr H, Binder NB (2023) ADAMTS13 antibody and inhibitor assays. In: Hemostasis and thrombosis: methods and protocols. Springer, New York, pp 549\u2013565. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_36","DOI":"10.1007\/978-1-0716-3175-1_36"},{"key":"31_CR30","doi-asserted-by":"publisher","unstructured":"Favaloro EJ, Kent Chapman K, Mohammed S, Vong R, Pasalic L (2023) Automated and rapid ADAMTS13 testing using chemiluminescence: utility for identification or exclusion of TTP and beyond. In: Hemostasis and thrombosis: methods and protocols. Springer, New York, pp 487\u2013504. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_32","DOI":"10.1007\/978-1-0716-3175-1_32"},{"key":"31_CR31","doi-asserted-by":"publisher","unstructured":"Favaloro EJ, Kent Chapman K, Mohammed S, Vong R, Pasalic L (2023) Identification of ADAMTS13 inhibitors in acquired TTP. In: Hemostasis and thrombosis: methods and protocols. Springer, New York, pp 505\u2013521. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_33","DOI":"10.1007\/978-1-0716-3175-1_33"},{"issue":"2","key":"31_CR32","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/jth.15157","volume":"19","author":"EJ Favaloro","year":"2021","unstructured":"Favaloro EJ, Mohammed S, Chapman K et al (2021) A multicentre laboratory assessment of a new automated chemiluminescent assay for ADAMTS13 activity. J Thromb Haemost 19(2):417\u2013428. https:\/\/doi.org\/10.1111\/jth.15157","journal-title":"J Thromb Haemost"},{"key":"31_CR33","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/978-1-4939-7196-1_23","volume":"1646","author":"G Kershaw","year":"2017","unstructured":"Kershaw G (2017) Detection and measurement of factor inhibitors. Methods Mol Biol 1646:295\u2013304. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_23","journal-title":"Methods Mol Biol"}],"container-title":["Methods in Molecular Biology","Hemostasis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3175-1_31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T07:07:05Z","timestamp":1684480025000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3175-1_31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9781071631744","9781071631751"],"references-count":33,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_31","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"20 May 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}