{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:16:45Z","timestamp":1790821005321,"version":"4.1.0"},"publisher-location":"New York, NY","reference-count":28,"publisher":"Springer US","isbn-type":[{"value":"9781071631744","type":"print"},{"value":"9781071631751","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-1-0716-3175-1_33","type":"book-chapter","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T07:02:13Z","timestamp":1684479733000},"page":"505-521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of ADAMTS13 Inhibitors in Acquired TTP"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-1661","authenticated-orcid":false,"given":"Emmanuel J.","family":"Favaloro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Vong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8237-6743","authenticated-orcid":false,"given":"Leonardo","family":"Pasalic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,20]]},"reference":[{"key":"33_CR1","doi-asserted-by":"publisher","first-page":"17020","DOI":"10.1038\/nrdp.2017.20","volume":"3","author":"JA Kremer Hovinga","year":"2017","unstructured":"Kremer Hovinga JA, Coppo P, L\u00e4mmle B, Moake JL, Miyata T, Vanhoorelbeke K (2017) Thrombotic thrombocytopenic purpura. Nat Rev Dis Primers 3:17020. https:\/\/doi.org\/10.1038\/nrdp.2017.20","journal-title":"Nat Rev Dis Primers"},{"key":"33_CR2","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1111\/jth.13764","volume":"15","author":"M Saha","year":"2017","unstructured":"Saha M, McDaniel JK, Zheng XL (2017) Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics. J Thromb Haemost 15:1889\u20131900. https:\/\/doi.org\/10.1111\/jth.13764","journal-title":"J Thromb Haemost"},{"key":"33_CR3","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/jth.13571","volume":"15","author":"Scully M, Cataland S, Coppo P, et al, for the International Working Group for Thrombotic Thrombocytopenic Purpura","year":"2017","unstructured":"Scully M, Cataland S, Coppo P, et al, for the International Working Group for Thrombotic Thrombocytopenic Purpura (2017) Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. J Thromb Haemost 15:312\u2013322. https:\/\/doi.org\/10.1111\/jth.13571","journal-title":"J Thromb Haemost"},{"key":"33_CR4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1055\/s-0040-1708541","volume":"46","author":"R Blennerhassett","year":"2020","unstructured":"Blennerhassett R, Curnow J, Pasalic L (2020) Immune-mediated thrombotic thrombocytopenic purpura: a narrative review of diagnosis and treatment in adults. Semin Thromb Hemost 46:289\u2013301. https:\/\/doi.org\/10.1055\/s-0040-1708541","journal-title":"Semin Thromb Hemost"},{"key":"33_CR5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1365-2141.2012.09167.x","volume":"158","author":"M Scully","year":"2012","unstructured":"Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F, Cheung B, Machin SJ (2012) Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol 158:323\u2013335. https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09167.x","journal-title":"Br J Haematol"},{"key":"33_CR6","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1182\/blood-2018-02-791533","volume":"132","author":"C Masias","year":"2018","unstructured":"Masias C, Cataland SR (2018) The role of ADAMTS13 testing in the diagnosis and management of thrombotic microangiopathies and thrombosis. Blood 132:903\u2013910. https:\/\/doi.org\/10.1182\/blood-2018-02-791533","journal-title":"Blood"},{"key":"33_CR7","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1002\/ajh.26241","volume":"96","author":"EJ Favaloro","year":"2021","unstructured":"Favaloro EJ, Pasalic L, Henry B, Lippi G (2021) Laboratory testing for ADAMTS13: utility for TTP diagnosis\/exclusion and beyond. Am J Hematol 96:1049\u20131055. https:\/\/doi.org\/10.1002\/ajh.26241","journal-title":"Am J Hematol"},{"issue":"1","key":"33_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1055\/s-0033-1363165","volume":"40","author":"K Chapman","year":"2014","unstructured":"Chapman K, Yuen S (2014) Therapy for thrombotic thrombocytopenia purpura: past, present, and future. Semin Thromb Hemost 40(1):34\u201340. https:\/\/doi.org\/10.1055\/s-0033-1363165","journal-title":"Semin Thromb Hemost"},{"key":"33_CR9","doi-asserted-by":"publisher","unstructured":"Moore GW, Vetr H, Binder NB (2023) ADAMTS13 antibody and inhibitor assays. In: Favaloro EJ, Gosselin RC (eds) Hemostasis and thrombosis: methods and protocols. Methods in molecular biology. Springer, New York, pp 549\u2013565. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_36","DOI":"10.1007\/978-1-0716-3175-1_36"},{"issue":"12","key":"33_CR10","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1182\/blood-2003-12-4165","volume":"103","author":"C Klaus","year":"2004","unstructured":"Klaus C, Plaimauer B, Studt JD, Dorner F, L\u00e4mmle B, Mannucci PM, Scheiflinger F (2004) Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura. Blood 103(12):4514\u20134519. https:\/\/doi.org\/10.1182\/blood-2003-12-4165","journal-title":"Blood"},{"key":"33_CR11","doi-asserted-by":"publisher","unstructured":"Moore GW (2023) ADAMTS13 activity measurement by ELISA and fluorescence resonance energy transfer assay. In: Hemostasis and thrombosis: methods and protocols. Springer, New York, pp 533\u2013547. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_35","DOI":"10.1007\/978-1-0716-3175-1_35"},{"key":"33_CR12","doi-asserted-by":"publisher","unstructured":"Favaloro EJ, Kent Chapman C, Mohammed S, Vong R, Pasalic L (2023) Automated and rapid ADAMTS13 testing using chemiluminescence: utility for identification or exclusion of TTP and beyond. In: Favaloro EJ, Gosselin RC (eds) Hemostasis and thrombosis: methods and protocols. Methods in molecular biology. Springer, New York, pp 487\u2013504. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_32","DOI":"10.1007\/978-1-0716-3175-1_32"},{"issue":"2","key":"33_CR13","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/jth.15157","volume":"19","author":"EJ Favaloro","year":"2021","unstructured":"Favaloro EJ, Mohammed S, Chapman K, Swanepoel P, Zebeljan D, Sefhore O, Malan E, Clifford J, Yuen A, Donikian D, Kondo M, Duncan E, Abraham S, Beggs J, Chatrapati R, Perel J, Coleman R, Klose N, Hsu D, Motum P, Wee Tan C, Brighton T, Pasalic L (2021 Feb) A multicentre laboratory assessment of a new automated chemiluminescent assay for ADAMTS13 activity. J Thromb Haemost 19(2):417\u2013428. https:\/\/doi.org\/10.1111\/jth.15157","journal-title":"J Thromb Haemost"},{"key":"33_CR14","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/978-1-4939-7196-1_23","volume":"1646","author":"G Kershaw","year":"2017","unstructured":"Kershaw G (2017) Detection and measurement of factor inhibitors. Methods Mol Biol 1646:295\u2013304. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_23","journal-title":"Methods Mol Biol"},{"key":"33_CR15","first-page":"H21","volume-title":"5th","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute (2008) Collection, transport, and processing of blood specimens for testing plasma-based coagulation assays and molecular Hemostasis assays; approved guideline. In: Document CLSI (ed) 5th. Clinical and Laboratory Standards Institute, Wayne, PA, pp H21\u2013HA5"},{"key":"33_CR16","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1055\/s-0032-1315961","volume":"38","author":"G Lippi","year":"2012","unstructured":"Lippi G, Salvagno GL, Montagnana M, Lima-Oliveira G, Guidi GC, Favaloro EJ (2012) Quality standards for sample collection in coagulation testing. Semin Thromb Hemost 38:565\u2013575. https:\/\/doi.org\/10.1055\/s-0032-1315961","journal-title":"Semin Thromb Hemost"},{"key":"33_CR17","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1055\/s-0032-1319768","volume":"38","author":"DM Adcock Funk","year":"2012","unstructured":"Adcock Funk DM, Lippi G, Favaloro EJ (2012) Quality standards for sample processing, transportation, and storage in Hemostasis testing. Semin Thromb Hemost 38:576\u2013585. https:\/\/doi.org\/10.1055\/s-0032-1319768","journal-title":"Semin Thromb Hemost"},{"key":"33_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/ijlh.12004","volume":"35","author":"I Mackie","year":"2013","unstructured":"Mackie I, Cooper P, Lawrie A, Kitchen S, Gray E, Laffan M, British Committee for Standards in Haematology (2013) Guidelines on the laboratory aspects of assays used in haemostasis and thrombosis. Int J Lab Hematol 35:1\u201313. https:\/\/doi.org\/10.1111\/ijlh.12004","journal-title":"Int J Lab Hematol"},{"issue":"3","key":"33_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/bjh.16776","volume":"191","author":"Baker P, Platton S, Gibson C, Gray E, Jennings I, Murphy P, Laffan M, British Society for Haematology, Haemostasis and Thrombosis Task Force","year":"2020","unstructured":"Baker P, Platton S, Gibson C, Gray E, Jennings I, Murphy P, Laffan M, British Society for Haematology, Haemostasis and Thrombosis Task Force (2020) Guidelines on the laboratory aspects of assays used in haemostasis and thrombosis. Br J Haematol 191(3):347\u2013362. https:\/\/doi.org\/10.1111\/bjh.16776","journal-title":"Br J Haematol"},{"key":"33_CR20","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/ijlh.13295","volume":"42","author":"I Mackie","year":"2020","unstructured":"Mackie I, Mancini I, Muia J, Kremer Hovinga J, Nair S, Machin S, Baker R (2020) International Council for Standardization in haematology (ICSH) recommendations for laboratory measurement of ADAMTS13. Int J Lab Hematol 42:685\u2013696","journal-title":"Int J Lab Hematol"},{"key":"33_CR21","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1111\/jth.12881","volume":"13","author":"AR Hubbard","year":"2015","unstructured":"Hubbard AR, Heath AB, Kremer Hovinga JA, Subcommittee on von Willebrand Factor (2015) Establishment of the WHO 1st international standard ADAMTS13, plasma (12\/252): communication from the SSC of the ISTH. J Thromb Haemost 13:1151\u20131153. https:\/\/doi.org\/10.1111\/jth.12881","journal-title":"J Thromb Haemost"},{"key":"33_CR22","doi-asserted-by":"publisher","unstructured":"Favaloro EJ, Mohammed S, Vong R, Pasalic L (2023) Laboratory testing for von Willebrand disease using a composite rapid 3-test chemiluminescence-based von Willebrand factor assay panel. In: Favaloro EJ, Gosselin RC (eds) Hemostasis and thrombosis: methods and protocols. Methods in molecular biology. Springer, New York, pp 647\u2013667. https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_43","DOI":"10.1007\/978-1-0716-3175-1_43"},{"key":"33_CR23","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/978-1-4939-7196-1_30","volume":"1646","author":"EJ Favaloro","year":"2017","unstructured":"Favaloro EJ, Mohammed S, Patzke J (2017) Laboratory testing for von Willebrand factor antigen (VWF:ag). Methods Mol Biol 1646:403\u2013416. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_30","journal-title":"Methods Mol Biol"},{"key":"33_CR24","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/978-1-4939-7196-1_31","volume":"1646","author":"EJ Favaloro","year":"2017","unstructured":"Favaloro EJ, Mohammed S (2017) Laboratory testing for von Willebrand factor collagen binding (VWF:CB). Methods Mol Biol 1646:417\u2013433. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_31","journal-title":"Methods Mol Biol"},{"key":"33_CR25","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/978-1-4939-7196-1_32","volume":"1646","author":"S Mohammed","year":"2017","unstructured":"Mohammed S, Favaloro EJ (2017) Laboratory testing for von Willebrand factor Ristocetin cofactor (VWF:RCo). Methods Mol Biol 1646:435\u2013451. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_32","journal-title":"Methods Mol Biol"},{"key":"33_CR26","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/978-1-4939-7196-1_33","volume":"1646","author":"J Patzke","year":"2017","unstructured":"Patzke J, Favaloro EJ (2017) Laboratory testing for von Willebrand factor activity by glycoprotein Ib binding assays (VWF:GPIb). Methods Mol Biol 1646:453\u2013460. https:\/\/doi.org\/10.1007\/978-1-4939-7196-1_33","journal-title":"Methods Mol Biol"},{"issue":"1","key":"33_CR27","first-page":"55","volume":"9","author":"EJ Favaloro","year":"2021","unstructured":"Favaloro EJ, Henry BM, Lippi G (2021) VWF and ADAMTS13 in COVID-19 and beyond: a question of balance. EMJ Hematol 9(1):55\u201368","journal-title":"EMJ Hematol"},{"issue":"4","key":"33_CR28","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1055\/s-0041-1727282","volume":"47","author":"EJ Favaloro","year":"2021","unstructured":"Favaloro EJ, Henry BM, Lippi G (2021) Increased VWF and decreased ADAMTS13 in COVID-19: creating a milieu for (micro)thrombosis? Semin Thromb Hemost 47(4):400\u2013418. https:\/\/doi.org\/10.1055\/s-0041-1727282","journal-title":"Semin Thromb Hemost"}],"container-title":["Methods in Molecular Biology","Hemostasis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3175-1_33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T07:06:49Z","timestamp":1684480009000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3175-1_33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9781071631744","9781071631751"],"references-count":28,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3175-1_33","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"20 May 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}