{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:14:03Z","timestamp":1767183243440,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":26,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071632543"},{"type":"electronic","value":"9781071632550"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-1-0716-3255-0_2","type":"book-chapter","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T11:02:32Z","timestamp":1686913352000},"page":"13-26","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Akimba Proliferative Diabetic Retinopathy Model: Understanding Molecular Mechanism and Drug Screening for the Progression of Diabetic Retinopathy"],"prefix":"10.1007","author":[{"given":"Sai Bo Bo","family":"Tun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veluchamy Amutha","family":"Barathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,17]]},"reference":[{"key":"2_CR1","volume-title":"IDF diabetes atlas","author":"International Diabetes Federation (IDF)","year":"2021","unstructured":"International Diabetes Federation (IDF) (2021) IDF diabetes atlas, 10th edn. IDF, Brussels","edition":"10"},{"issue":"11","key":"2_CR2","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.2337\/diabetes.54.11.3119","volume":"54","author":"AK Cheung","year":"2005","unstructured":"Cheung AK, Fung MK, Lo AC, Lam TT, So KF, Chung SS, Chung SK (2005) Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db\/db mice. Diabetes 54(11):3119\u20133125. https:\/\/doi.org\/10.2337\/diabetes.54.11.3119","journal-title":"Diabetes"},{"issue":"2","key":"2_CR3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1159\/000266787","volume":"21","author":"E Midena","year":"1989","unstructured":"Midena E, Segato T, Radin S, di Giorgio G, Meneghini F, Piermarocchi S, Belloni AS (1989) Studies on the retina of the diabetic db\/db mouse. I. Endothelial cell-pericyte ratio. Ophthalmic Res 21(2):106\u2013111. https:\/\/doi.org\/10.1159\/000266787","journal-title":"Ophthalmic Res"},{"issue":"5","key":"2_CR4","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.2353\/ajpath.2010.090883","volume":"177","author":"EP Rakoczy","year":"2010","unstructured":"Rakoczy EP, Ali Rahman IS, Binz N, Li CR, Vagaja NN, de Pinho M, Lai CM (2010) Characterization of a mouse model of hyperglycemia and retinal neovascularization. Am J Pathol 177(5):2659\u20132670. https:\/\/doi.org\/10.2353\/ajpath.2010.090883","journal-title":"Am J Pathol"},{"key":"2_CR5","doi-asserted-by":"publisher","unstructured":"Chaurasia SS, Lim RR, Parikh BH, Wey YS, Tun BB, Wong TY, Luu CD, Agrawal R, Ghosh A, Mortellaro A, Rackoczy E, Mohan RR, Barathi VA (2018) The NLRP3 inflammasome may contribute to pathologic neovascularization in the advanced stages of diabetic retinopathy. Sci Rep 8(1):2847. https:\/\/doi.org\/10.1038\/s41598-018-21198-z","DOI":"10.1038\/s41598-018-21198-z"},{"key":"2_CR6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.exer.2014.03.005","volume":"122","author":"J Wisniewska-Kruk","year":"2014","unstructured":"Wisniewska-Kruk J, Klaassen I, Vogels IM, Magno AL, Lai CM, Van Noorden CJ, Schlingemann RO, Rakoczy EP (2014) Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy. Exp Eye Res 122:123\u2013131. https:\/\/doi.org\/10.1016\/j.exer.2014.03.005","journal-title":"Exp Eye Res"},{"issue":"8","key":"2_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160442","volume":"11","author":"N Binz","year":"2016","unstructured":"Binz N, Rakoczy EP, Ali Rahman IS, Vagaja NN, Lai CM (2016) Biomarkers for diabetic retinopathy \u2013 could endothelin 2 be part of the answer? PLoS One 11(8):e0160442. https:\/\/doi.org\/10.1371\/journal.pone.0160442","journal-title":"PLoS One"},{"issue":"5","key":"2_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065691","volume":"8","author":"TA Mendel","year":"2013","unstructured":"Mendel TA, Clabough EB, Kao DS, Demidova-Rice TN, Durham JT, Zotter BC, Seaman SA, Cronk SM, Rakoczy EP, Katz AJ, Herman IM, Peirce SM, Yates PA (2013) Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy. PLoS One 8(5):e65691. https:\/\/doi.org\/10.1371\/journal.pone.0065691","journal-title":"PLoS One"},{"key":"2_CR9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.exer.2017.09.012","volume":"165","author":"T Van Bergen","year":"2017","unstructured":"Van Bergen T, Hu TT, Etienne I, Reyns GE, Moons L, Feyen JHM (2017) Neutralization of placental growth factor as a novel treatment option in diabetic retinopathy. Exp Eye Res 165:136\u2013150. https:\/\/doi.org\/10.1016\/j.exer.2017.09.012","journal-title":"Exp Eye Res"},{"key":"2_CR10","doi-asserted-by":"publisher","unstructured":"Matthews JR, Schlaich MP, Rakoczy EP, Matthews VB, Herat LY (2022) The effect of SGLT2 inhibition on diabetic kidney disease in a model of diabetic retinopathy. Biomedicine 10(3). https:\/\/doi.org\/10.3390\/biomedicines10030522","DOI":"10.3390\/biomedicines10030522"},{"issue":"5","key":"2_CR11","doi-asserted-by":"publisher","first-page":"459","DOI":"10.5966\/sctm.2014-0108","volume":"4","author":"SM Cronk","year":"2015","unstructured":"Cronk SM, Kelly-Goss MR, Ray HC, Mendel TA, Hoehn KL, Bruce AC, Dey BK, Guendel AM, Tavakol DN, Herman IM, Peirce SM, Yates PA (2015) Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy. Stem Cells Transl Med 4(5):459\u2013467. https:\/\/doi.org\/10.5966\/sctm.2014-0108","journal-title":"Stem Cells Transl Med"},{"issue":"6","key":"2_CR12","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1167\/iovs.04-1340","volume":"46","author":"AJ Barber","year":"2005","unstructured":"Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK (2005) The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci 46(6):2210\u20132218. https:\/\/doi.org\/10.1167\/iovs.04-1340","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"2_CR13","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1167\/iovs.05-1376","volume":"47","author":"MJ Gastinger","year":"2006","unstructured":"Gastinger MJ, Singh RS, Barber AJ (2006) Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas. Invest Ophthalmol Vis Sci 47(7):3143\u20133150. https:\/\/doi.org\/10.1167\/iovs.05-1376","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"2_CR14","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.1167\/iovs.06-0251","volume":"47","author":"PE Van Eeden","year":"2006","unstructured":"Van Eeden PE, Tee LB, Lukehurst S, Lai CM, Rakoczy EP, Beazley LD, Dunlop SA (2006) Early vascular and neuronal changes in a VEGF transgenic mouse model of retinal neovascularization. Invest Ophthalmol Vis Sci 47(10):4638\u20134645. https:\/\/doi.org\/10.1167\/iovs.06-0251","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"2_CR15","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1007\/s00125-006-0274-8","volume":"49","author":"WY Shen","year":"2006","unstructured":"Shen WY, Lai CM, Graham CE, Binz N, Lai YK, Eade J, Guidolin D, Ribatti D, Dunlop SA, Rakoczy PE (2006) Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model. Diabetologia 49(7):1690\u20131701. https:\/\/doi.org\/10.1007\/s00125-006-0274-8","journal-title":"Diabetologia"},{"key":"2_CR16","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-62703-080-9_3","volume":"935","author":"AF Alex","year":"2013","unstructured":"Alex AF, Heiduschka P, Eter N (2013) Retinal fundus imaging in mouse models of retinal diseases. Methods Mol Biol 935:41\u201367. https:\/\/doi.org\/10.1007\/978-1-62703-080-9_3","journal-title":"Methods Mol Biol"},{"issue":"5","key":"2_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128418","volume":"10","author":"JP Wigg","year":"2015","unstructured":"Wigg JP, Zhang H, Yang D (2015) A quantitative and standardized method for the evaluation of choroidal neovascularization using MICRON III fluorescein angiograms in rats. PLoS One 10(5):e0128418. https:\/\/doi.org\/10.1371\/journal.pone.0128418","journal-title":"PLoS One"},{"key":"2_CR18","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/978-1-4939-8669-9_18","volume":"1834","author":"GA Ochakovski","year":"2019","unstructured":"Ochakovski GA, Fischer MD (2019) Phenotyping of mouse models with OCT. Methods Mol Biol 1834:285\u2013291. https:\/\/doi.org\/10.1007\/978-1-4939-8669-9_18","journal-title":"Methods Mol Biol"},{"issue":"5","key":"2_CR19","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1167\/iovs.18-26441","volume":"60","author":"CA Smith","year":"2019","unstructured":"Smith CA, Hooper ML, Chauhan BC (2019) Optical coherence tomography angiography in mice: quantitative analysis after experimental models of retinal damage. Invest Ophthalmol Vis Sci 60(5):1556\u20131565. https:\/\/doi.org\/10.1167\/iovs.18-26441","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.104055","volume":"132","author":"E Duggan","year":"2020","unstructured":"Duggan E, Smith CA, Hooper ML, Chauhan BC (2020) Colocalization of optical coherence tomography angiography with histology in the mouse retina. Microvasc Res 132:104055. https:\/\/doi.org\/10.1016\/j.mvr.2020.104055","journal-title":"Microvasc Res"},{"issue":"3","key":"2_CR21","first-page":"89","volume":"5","author":"W Liu","year":"2017","unstructured":"Liu W, Luisi J, Liu H, Motamedi M, Zhang W (2017) OCT-angiography for non-invasive monitoring of neuronal and vascular structure in mouse retina: implication for characterization of retinal neurovascular coupling. EC Ophthalmol 5(3):89\u201398","journal-title":"EC Ophthalmol"},{"issue":"3","key":"2_CR22","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/BF02512526","volume":"32","author":"H Fujii","year":"1994","unstructured":"Fujii H (1994) Visualisation of retinal blood flow by laser speckle flow-graphy. Med Biol Eng Comput 32(3):302\u2013304. https:\/\/doi.org\/10.1007\/BF02512526","journal-title":"Med Biol Eng Comput"},{"key":"2_CR23","doi-asserted-by":"publisher","unstructured":"Kobayashi T, Shiba T, Okamoto K, Usui T, Hori Y (2022) Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects. Graefes Arch Clin Exp Ophthalmol. https:\/\/doi.org\/10.1007\/s00417-022-05631-8","DOI":"10.1007\/s00417-022-05631-8"},{"issue":"1","key":"2_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/09273948.2018.1429637","volume":"28","author":"R Agrawal","year":"2020","unstructured":"Agrawal R, Tun SBB, Balne PK, Zhu HY, Khandelwal N, Barathi VA (2020) Fluorescein labeled leukocytes for in vivo imaging of retinal vascular inflammation and infiltrating leukocytes in laser-induced choroidal neovascularization model. Ocul Immunol Inflamm 28(1):7\u201313. https:\/\/doi.org\/10.1080\/09273948.2018.1429637","journal-title":"Ocul Immunol Inflamm"},{"key":"2_CR25","doi-asserted-by":"publisher","unstructured":"Agrawal R, Balne PK, Tun SBB, Sia Wey Y, Khandelwal N, Barathi VA (2017) Fluorescent dye labeling of erythrocytes and leukocytes for studying the flow dynamics in mouse retinal circulation. J Vis Exp 125. https:\/\/doi.org\/10.3791\/55495","DOI":"10.3791\/55495"},{"issue":"1","key":"2_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-014-9473-7","volume":"130","author":"DL McCulloch","year":"2015","unstructured":"McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M (2015) ISCEV standard for full-field clinical electroretinography (2015 update). Doc Ophthalmol 130(1):1\u201312. https:\/\/doi.org\/10.1007\/s10633-014-9473-7","journal-title":"Doc Ophthalmol"}],"container-title":["Methods in Molecular Biology","Diabetic Retinopathy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3255-0_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T11:03:05Z","timestamp":1686913385000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3255-0_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9781071632543","9781071632550"],"references-count":26,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3255-0_2","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"17 June 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}