{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:10:16Z","timestamp":1789542616198,"version":"build-2803163510"},"publisher-location":"New York, NY","reference-count":13,"publisher":"Springer US","isbn-type":[{"value":"9781071634080","type":"print"},{"value":"9781071634097","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-1-0716-3409-7_10","type":"book-chapter","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T16:03:24Z","timestamp":1691597004000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optic Nerve Crush Injury in Rodents to Study Retinal Ganglion Cell Neuroprotection and Regeneration"],"prefix":"10.1007","author":[{"given":"Zubair","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"10_CR1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0165-3806(84)90027-0","volume":"318","author":"D Allcutt","year":"1984","unstructured":"Allcutt D, Berry M, Sievers J (1984) A quantitative comparison of the reactions of retinal ganglion cells to optic nerve crush in neonatal and adult mice. Brain Res 318:219\u2013230","journal-title":"Brain Res"},{"key":"10_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.54","volume":"2","author":"Z Ahmed","year":"2011","unstructured":"Ahmed Z, Kalinski H, Berry M et al (2011) Ocular neuroprotection by siRNA targeting caspase-2. Cell Death and Dis 2:e173","journal-title":"Cell Death and Dis"},{"key":"10_CR3","doi-asserted-by":"publisher","first-page":"aebq2611","DOI":"10.1126\/sciadv.abq2611","volume":"8","author":"MJ Taylor","year":"2022","unstructured":"Taylor MJ, Thompson AM, Almutiri S et al (2022) Inhibition of Chk2 promotes neuroprotection, axon regeneration and functional recovery after CNS injury. Sci Adv 8:aebq2611","journal-title":"Sci Adv"},{"key":"10_CR4","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1167\/iovs.18-26449","volume":"60","author":"A Thompson","year":"2019","unstructured":"Thompson A, Berry M, Logan A et al (2019) Activation of the Smad1\/BMP4 pathway promotes retinal ganglion cell survival and axon regeneration independent of mTOR. Invest Ophthalmol Vis Sci 60:1748\u20131759","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10_CR5","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1093\/brain\/awu037","volume":"137","author":"V Vigneswara","year":"2014","unstructured":"Vigneswara V, Akpan N, Berry M et al (2014) Combined suppression of caspase-2 and caspase-6 protects retinal ganglion cells from apoptosis and promotes regeneration through CNTF-mediated JAK\/STAT signalling pathway. Brain 137:1656\u20131675","journal-title":"Brain"},{"key":"10_CR6","doi-asserted-by":"publisher","first-page":"5309","DOI":"10.1126\/science.1161566","volume":"322","author":"KK Park","year":"2008","unstructured":"Park KK, Liu K, Hu Y et al (2008) Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway. Science 322:5309","journal-title":"Science"},{"key":"10_CR7","doi-asserted-by":"publisher","first-page":"5614","DOI":"10.1038\/s41467-020-19436-y","volume":"11","author":"V Petrova","year":"2020","unstructured":"Petrova V, Pearson CS, Ching J et al (2020) Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS. Nature Comms 11:5614","journal-title":"Nature Comms"},{"key":"10_CR8","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.1167\/iovs.08-3267","volume":"50","author":"FM Nadal-Nicol\u00e1s","year":"2009","unstructured":"Nadal-Nicol\u00e1s FM, Jim\u00e9nez-L\u00f3pez M, Sobrado-Calvo P et al (2009) Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas. Invest Ophthalmol Vis Sci 50:3860\u20133868","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10_CR9","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1002\/cne.23521","volume":"522","author":"AR Rodriguez","year":"2014","unstructured":"Rodriguez AR, de Sevilla M\u00fcller LP, Brecha NC (2014) The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina. J Comp Neurol 522:1411\u20131443","journal-title":"J Comp Neurol"},{"key":"10_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110612","volume":"10","author":"B Mead","year":"2014","unstructured":"Mead B, Thompson A, Scheven BA et al (2014) Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts. PLoS One 10:e110612","journal-title":"PLoS One"},{"key":"10_CR11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.exer.2016.08.006","volume":"151","author":"B Mead","year":"2017","unstructured":"Mead B, Tomarev S (2017) Evaluating retinal ganglion cell loss and dysfunction. Exp Eye Res 151:96\u2013106","journal-title":"Exp Eye Res"},{"key":"10_CR12","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1167\/iovs.10-6311","volume":"52","author":"ML Gabrielle","year":"2011","unstructured":"Gabrielle ML, Ishikawa H, Schuman JS et al (2011) Optic nerve crush mice followed longitudinally with spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 52:2250\u20132254","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10_CR13","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1167\/iovs.16-19955","volume":"57","author":"J Yi","year":"2016","unstructured":"Yi J, Puyan Z, Feng L et al (2016) Optical detection of early damage in retinal ganglion cells in a mouse model of partial optic nerve crush injury. Invest Ophthalmol Vis Sci 57:5665\u20135671","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Methods in Molecular Biology","Retinal Ganglion Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3409-7_10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T16:05:36Z","timestamp":1691597136000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3409-7_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9781071634080","9781071634097"],"references-count":13,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3409-7_10","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"10 August 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}