{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:22:47Z","timestamp":1774689767642,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":20,"publisher":"Springer US","isbn-type":[{"value":"9781071634325","type":"print"},{"value":"9781071634332","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-1-0716-3433-2_5","type":"book-chapter","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T07:02:20Z","timestamp":1691996540000},"page":"45-60","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Organoids Models of Pancreatic Duct Adenocarcinoma"],"prefix":"10.1007","author":[{"given":"Chunhua","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daolin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"5_CR1","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/s41575-021-00486-6","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Zeh HJ, Kang R et al (2021) Cell death in pancreatic cancer: from pathogenesis to therapy. Nat Rev Gastroenterol Hepatol 18:804\u2013823","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"5_CR2","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.trecan.2021.04.005","volume":"7","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G et al (2021) Targeting ferroptosis in pancreatic cancer: a double-edged sword. Trends Cancer 7:891\u2013901","journal-title":"Trends Cancer"},{"key":"5_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.773909","volume":"12","author":"J Liu","year":"2021","unstructured":"Liu J, Kang R, Tang D (2021) The art of war: ferroptosis and pancreatic cancer. Front Pharmacol 12:773909","journal-title":"Front Pharmacol"},{"key":"5_CR4","doi-asserted-by":"publisher","first-page":"6339","DOI":"10.1038\/s41467-020-20154-8","volume":"11","author":"E Dai","year":"2020","unstructured":"Dai E, Han L, Liu J et al (2020) Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173\/STING-dependent DNA sensor pathway. Nat Commun 11:6339","journal-title":"Nat Commun"},{"key":"5_CR5","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1080\/15548627.2020.1714209","volume":"16","author":"E Dai","year":"2020","unstructured":"Dai E, Han L, Liu J et al (2020) Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein. Autophagy 16:2069\u20132083","journal-title":"Autophagy"},{"key":"5_CR6","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1080\/15548627.2020.1739447","volume":"17","author":"C Li","year":"2021","unstructured":"Li C, Zhang Y, Liu J et al (2021) Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. Autophagy 17:948\u2013960","journal-title":"Autophagy"},{"key":"5_CR7","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1080\/15548627.2022.2111635","volume":"19","author":"J Liu","year":"2023","unstructured":"Liu J, Liu Y, Wang Y et al (2023) TMEM164 is a new determinant of autophagy-dependent ferroptosis. Autophagy 19:945\u2013956","journal-title":"Autophagy"},{"key":"5_CR8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41417-020-0182-y","volume":"28","author":"Y Liu","year":"2021","unstructured":"Liu Y, Wang Y, Liu J et al (2021) Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death. Cancer Gene Ther 28:55\u201363","journal-title":"Cancer Gene Ther"},{"key":"5_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.698679","volume":"9","author":"C Li","year":"2021","unstructured":"Li C, Liu J, Hou W et al (2021) STING1 promotes ferroptosis through MFN1\/2-dependent mitochondrial fusion. Front Cell Dev Biol 9:698679","journal-title":"Front Cell Dev Biol"},{"key":"5_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108767","volume":"34","author":"X Song","year":"2021","unstructured":"Song X, Liu J, Kuang F et al (2021) PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis. Cell Rep 34:108767","journal-title":"Cell Rep"},{"key":"5_CR11","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1158\/0008-5472.CAN-16-1979","volume":"77","author":"S Zhu","year":"2017","unstructured":"Zhu S, Zhang Q, Sun X et al (2017) HSPA5 regulates ferroptotic cell death in cancer cells. Cancer Res 77:2064\u20132077","journal-title":"Cancer Res"},{"key":"5_CR12","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1038\/nm.3973","volume":"21","author":"L Huang","year":"2015","unstructured":"Huang L, Holtzinger A, Jagan I et al (2015) Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nat Med 21:1364\u20131371","journal-title":"Nat Med"},{"key":"5_CR13","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/nm.3992","volume":"21","author":"HC Zhang","year":"2015","unstructured":"Zhang HC, Kuo CJ (2015) Personalizing pancreatic cancer organoids with hPSCs. Nat Med 21:1249\u20131251","journal-title":"Nat Med"},{"key":"5_CR14","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1038\/s41596-020-00490-1","volume":"16","author":"BFL Lai","year":"2021","unstructured":"Lai BFL, Lu RXZ, Davenport Huyer L et al (2021) A well plate-based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nat Protoc 16:2158\u20132189","journal-title":"Nat Protoc"},{"key":"5_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nrgastro.2015.1","volume":"12","author":"G Patman","year":"2015","unstructured":"Patman G (2015) Pancreatic cancer: from normal to metastases--a whole gamut of pancreatic organoids. Nat Rev Gastroenterol Hepatol 12:61","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"5_CR16","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.trecan.2016.03.004","volume":"2","author":"LA Baker","year":"2016","unstructured":"Baker LA, Tiriac H, Clevers H et al (2016) Modeling pancreatic cancer with organoids. Trends Cancer 2:176\u2013190","journal-title":"Trends Cancer"},{"key":"5_CR17","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202215707","volume":"14","author":"S Sandhya","year":"2022","unstructured":"Sandhya S, Hogenson TL, Fernandez-Zapico ME (2022) Patient-derived organoids, creating a new window of opportunities for pancreatic cancer patients. EMBO Mol Med 14:e15707","journal-title":"EMBO Mol Med"},{"key":"5_CR18","doi-asserted-by":"crossref","unstructured":"Jeong YJ, Knutsdottir H, Shojaeian F et al (2023) Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion. J Clin Invest 133:e162054","DOI":"10.1172\/JCI162054"},{"key":"5_CR19","first-page":"e137809","volume":"5","author":"Z Dantes","year":"2020","unstructured":"Dantes Z, Yen HY, Pfarr N et al (2020) Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology. JCI. Insight 5:e137809","journal-title":"Insight"},{"key":"5_CR20","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1038\/s41467-022-29857-6","volume":"13","author":"X Shi","year":"2022","unstructured":"Shi X, Li Y, Yuan Q et al (2022) Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity. Nat Commun 13:2169","journal-title":"Nat Commun"}],"container-title":["Methods in Molecular Biology","Ferroptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3433-2_5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T07:02:44Z","timestamp":1691996564000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3433-2_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9781071634325","9781071634332"],"references-count":20,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3433-2_5","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"15 August 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}