{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:33:51Z","timestamp":1783838031072,"version":"3.55.0"},"publisher-location":"New York, NY","reference-count":15,"publisher":"Springer US","isbn-type":[{"value":"9781071635407","type":"print"},{"value":"9781071635414","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-1-0716-3541-4_31","type":"book-chapter","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:27:05Z","timestamp":1701390425000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantitation of Urine Nicotine, Cotinine, and 3-OH-Cotinine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS\/MS)"],"prefix":"10.1007","author":[{"given":"Wenbo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun Susan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Noguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"31_CR1","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1001\/jama.291.10.1238","volume":"291","author":"AH Mokdad","year":"2004","unstructured":"Mokdad AH, Marks JS, Stroup DF et al (2004) Actual causes of death in the United States, 2000. JAMA 291:1238\u20131245","journal-title":"JAMA"},{"key":"31_CR2","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1253\/circj.CJ-19-0323","volume":"83","author":"T Kondo","year":"2019","unstructured":"Kondo T, Nakano Y, Adachi S et al (2019) Effects of tobacco smoking on cardiovascular disease. Circ J 83:1980\u20131985","journal-title":"Circ J"},{"key":"31_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev.pharmtox.48.113006.094742","volume":"49","author":"NL Benowitz","year":"2009","unstructured":"Benowitz NL (2009) Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annu Rev Pharmacol Toxicol 49:57\u201371","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"31_CR4","first-page":"296","volume":"268","author":"NL Benowitz","year":"1994","unstructured":"Benowitz NL, Jacob P 3rd, Fong I et al (1994) Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp Ther 268:296\u2013303","journal-title":"J Pharmacol Exp Ther"},{"key":"31_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2021.122736","volume":"1179","author":"N Mallock","year":"2021","unstructured":"Mallock N, Rabenstein A, Peter L et al (2021) Rapid sensitive, and reliable quantitation of nicotine and its main metabolites cotinine and trans-3\u2032-hydroxycotinine by LC-MS\/MS: method development and validation for human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 1179:122736","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"31_CR6","doi-asserted-by":"publisher","first-page":"5565","DOI":"10.1021\/acsomega.0c00384","volume":"5","author":"TD Nguyen","year":"2020","unstructured":"Nguyen TD, Riordan-Short S, Dang TT et al (2020) Quantitation of select terpenes\/terpenoids and nicotine using gas chromatography-mass spectrometry with high-temperature headspace sampling. ACS Omega 5:5565\u20135573","journal-title":"ACS Omega"},{"key":"31_CR7","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1158\/1055-9965.EPI-06-0265","volume":"15","author":"I Stepanov","year":"2006","unstructured":"Stepanov I, Feuer R, Jensen J et al (2006) Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails. Cancer Epidemiol Biomark Prev 15:2378\u20132383","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"31_CR8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jchromb.2013.03.032","volume":"928","author":"I Shu","year":"2013","unstructured":"Shu I, Wang P (2013) Simultaneous serum nicotine, cotinine, and trans-3\u2032-hydroxycotinine quantitation with minimal sample volume for tobacco exposure status of solid organ transplant patients. J Chromatogr B Analyt Technol Biomed Life Sci 928:139\u2013145","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"31_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/978-1-60761-459-3_38","volume":"603","author":"B Yue","year":"2010","unstructured":"Yue B, Kushnir MM, Urry FM et al (2010) Quantitation of nicotine, its metabolites, and other related alkaloids in urine, serum, and plasma using LC-MS-MS. Method Mol Biol 603:389\u2013398","journal-title":"Method Mol Biol"},{"key":"31_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jaoac\/85.1.1","volume":"85","author":"MB Clarke","year":"2002","unstructured":"Clarke MB (2002) Quantitation of nicotine in tobacco products by capillary electrophoresis. J AOAC Int 85:1\u20137","journal-title":"J AOAC Int"},{"key":"31_CR11","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1093\/clinchem\/48.9.1460","volume":"48","author":"TP Moyer","year":"2002","unstructured":"Moyer TP, Charlson JR, Enger RJ et al (2002) Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles. Clin Chem 48:1460\u20131471","journal-title":"Clin Chem"},{"key":"31_CR12","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.jchromb.2009.12.018","volume":"878","author":"EI Miller","year":"2010","unstructured":"Miller EI, Norris HRK, Rollins DE et al (2010) A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 878:725\u2013737","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"31_CR13","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1309\/LQ8U3UL956ET324X","volume":"126","author":"AN Hoofnagle","year":"2006","unstructured":"Hoofnagle AN, Laha TJ, Rainey PM et al (2006) Specific detection of anabasine, nicotine, and nicotine metabolites in urine by liquid chromatography-tandem mass spectrometry. Am J Clin Pathol 126:880\u2013887","journal-title":"Am J Clin Pathol"},{"key":"31_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101816","volume":"9","author":"JE McGuffey","year":"2014","unstructured":"McGuffey JE, Wei B, Bernert JT et al (2014) Validation of a LC-MS\/MS method for quantifying urinary nicotine, six nicotine metabolites and the minor tobacco alkaloids-anatabine and anabasine- in smokers\u2019 urine. PLoS One 9:e101816","journal-title":"PLoS One"},{"key":"31_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1093\/jat\/bkaa177","volume":"46","author":"J Oh","year":"2022","unstructured":"Oh J, Park MS, Chun MR et al (2022) A simple and high-throughput LC-MS-MS method for simultaneous measurement of nicotine, cotinine, 3-OH cotine, nornicotine and anabasine in urine and its application in the general Korean population. J Anal Toxicol 46:25\u201336","journal-title":"J Anal Toxicol"}],"container-title":["Methods in Molecular Biology","Clinical Applications of Mass Spectrometry in Drug Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3541-4_31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:33:08Z","timestamp":1701390788000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3541-4_31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"ISBN":["9781071635407","9781071635414"],"references-count":15,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3541-4_31","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,1]]},"assertion":[{"value":"1 December 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}