{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:45:54Z","timestamp":1790390754198,"version":"4.1.0"},"publisher-location":"New York, NY","reference-count":12,"publisher":"Springer US","isbn-type":[{"value":"9781071635407","type":"print"},{"value":"9781071635414","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-1-0716-3541-4_41","type":"book-chapter","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:27:05Z","timestamp":1701390425000},"page":"443-452","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantification of Thiopurine Metabolites in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS\/MS)"],"prefix":"10.1007","author":[{"given":"Lie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine R.","family":"Crews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro R.","family":"Molinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"issue":"4900","key":"41_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1126\/science.2649979","volume":"244","author":"GB Elion","year":"1989","unstructured":"Elion GB (1989) The purine path to chemotherapy. Science 244(4900):41\u201347","journal-title":"Science"},{"issue":"4","key":"41_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/BF02220605","volume":"43","author":"L Lennard","year":"1992","unstructured":"Lennard L (1992) The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 43(4):329\u2013339","journal-title":"Eur J Clin Pharmacol"},{"issue":"9","key":"41_CR3","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/FPC.0b013e328334338f","volume":"20","author":"G Zaza","year":"2010","unstructured":"Zaza G, Cheok M, Krynetskaia N, Thorn C, Stocco G, Hebert JM, McLeod H, Weinshilboum RM, Relling MV, Evans WE, Klein TE, Altman RB (2010) Thiopurine pathway. Pharmacogenet Genomics 20(9):573\u2013574","journal-title":"Pharmacogenet Genomics"},{"issue":"2","key":"41_CR4","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/00007691-200404000-00018","volume":"26","author":"WE Evans","year":"2004","unstructured":"Evans WE (2004) Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy. Ther Drug Monit 26(2):186\u2013191","journal-title":"Ther Drug Monit"},{"issue":"5","key":"41_CR5","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1002\/cpt.1304","volume":"105","author":"MV Relling","year":"2019","unstructured":"Relling MV, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui CH, Stein CM, Moyer AM, Evans WE, Klein TE, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ (2019) Clinical Pharmacogenetics Implementation Consortium guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 update. Clin Pharmacol Ther 105(5):1095\u20131105","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"41_CR6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/cpt.463","volume":"101","author":"C Liu","year":"2017","unstructured":"Liu C, Yang W, Pei D, Cheng C, Smith C, Landier W, Hageman L, Chen Y, Yang JJ, Crews KR, Kornegay N, Karol SE, Wong FL, Jeha S, Sandlund JT, Ribeiro RC, Rubnitz JE, Metzger ML, Pui CH, Evans WE, Bhatia S, Relling MV (2017) Genomewide approach validates thiopurine methyltransferase activity is a monogenic pharmacogenomic trait. Clin Pharmacol Ther 101(3):373\u2013381","journal-title":"Clin Pharmacol Ther"},{"issue":"25","key":"41_CR7","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.3748\/wjg.v16.i25.3187","volume":"16","author":"XW Dong","year":"2010","unstructured":"Dong XW, Zheng Q, Zhu MM, Tong JL, Ran ZH (2010) Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease. World J Gastroenterol 16(25):3187\u20133195","journal-title":"World J Gastroenterol"},{"issue":"5","key":"41_CR8","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/gut.48.5.591","volume":"48","author":"WJ Sandborn","year":"2001","unstructured":"Sandborn WJ (2001) Rational dosing of azathioprine and 6-mercaptopurine. Gut 48(5):591\u2013592","journal-title":"Gut"},{"issue":"9544","key":"41_CR9","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0140-6736(06)69558-5","volume":"368","author":"A Vora","year":"2006","unstructured":"Vora A, Mitchell CD, Lennard L, Eden TO, Kinsey SE, Lilleyman J, Richards SM, Medical Research Council; National Cancer Research Network Childhood Leukaemia Working Party (2006) Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet 368(9544):1339\u20131348","journal-title":"Lancet"},{"issue":"3","key":"41_CR10","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/MPH.0000000000000733","volume":"39","author":"MS Ebbesen","year":"2017","unstructured":"Ebbesen MS, Nygaard U, Rosth\u00f8j S, S\u00f8rensen D, Nersting J, Vettenranta K, Wesenberg F, Kristinsson J, Harila-Saari A, Schmiegelow K (2017) Hepatotoxicity during maintenance therapy and prognosis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol 39(3):161\u2013166","journal-title":"J Pediatr Hematol Oncol"},{"issue":"11","key":"41_CR11","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1373\/clinchem.2005.050831","volume":"51","author":"T Dervieux","year":"2005","unstructured":"Dervieux T, Meyer G, Barham R, Matsutani M, Barry M, Boulieu R, Neri B, Seidman E (2005) Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine\/6-mercaptopurine therapy. Clin Chem 51(11):2074\u20132084","journal-title":"Clin Chem"},{"issue":"12","key":"41_CR12","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1093\/clinchem\/44.12.2511","volume":"44","author":"T Dervieux","year":"1998","unstructured":"Dervieux T, Boulieu R (1998) Identification of 6-methylmercaptopurine derivative formed during acid hydrolysis of thiopurine nucleotides in erythrocytes, using liquid chromatography-mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance assay. Clin Chem 44(12):2511\u20132515","journal-title":"Clin Chem"}],"container-title":["Methods in Molecular Biology","Clinical Applications of Mass Spectrometry in Drug Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3541-4_41","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:33:42Z","timestamp":1701390822000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3541-4_41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"ISBN":["9781071635407","9781071635414"],"references-count":12,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3541-4_41","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,1]]},"assertion":[{"value":"1 December 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}