{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:07:37Z","timestamp":1793243257755,"version":"4.5.0"},"publisher-location":"New York, NY","reference-count":48,"publisher":"Springer US","isbn-type":[{"value":"9781071636930","type":"print"},{"value":"9781071636947","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-1-0716-3694-7_2","type":"book-chapter","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T06:02:20Z","timestamp":1707112940000},"page":"15-25","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Diethylnitrosamine Induction of Hepatocarcinogenesis in Mice"],"prefix":"10.1007","author":[{"given":"Jules","family":"Sotty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bablon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Henry","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Soussan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"2_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin 71:209\u2013249","journal-title":"CA A Cancer J Clin"},{"key":"2_CR2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fonc.2020.00171","volume":"10","author":"P Dasgupta","year":"2020","unstructured":"Dasgupta P, Henshaw C, Youlden DR et al (2020) Global trends in incidence rates of primary adult liver cancers: a systematic review and meta-analysis. Front Oncol 10:171","journal-title":"Front Oncol"},{"key":"2_CR3","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1053\/j.gastro.2004.09.014","volume":"127","author":"G Fattovich","year":"2004","unstructured":"Fattovich G, Stroffolini T, Zagni I et al (2004) Hepatocellular carcinoma in cirrhosis: Incidence and risk factors. Gastroenterology 127:S35\u2013S50","journal-title":"Gastroenterology"},{"key":"2_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.cgh.2015.07.019","volume":"14","author":"S Mittal","year":"2016","unstructured":"Mittal S, El-Serag HB, Sada YH et al (2016) Hepatocellular carcinoma in the absence of cirrhosis in US veterans is associated with non-alcoholic fatty liver disease. Clin Gastroenterol Hepatol 14:124\u2013131.e1","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2_CR5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41467-019-14050-z","volume":"11","author":"B Losic","year":"2020","unstructured":"Losic B, Craig AJ, Villacorta-Martin C et al (2020) Intratumoral heterogeneity and clonal evolution in liver cancer. Nat Commun 11:291","journal-title":"Nat Commun"},{"key":"2_CR6","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1053\/j.gastro.2017.06.007","volume":"153","author":"D Sia","year":"2017","unstructured":"Sia D, Jiao Y, Martinez-Quetglas I et al (2017) Identification of an immune-specific class of hepatocellular carcinoma, based on molecular features. Gastroenterology 153:812\u2013826","journal-title":"Gastroenterology"},{"key":"2_CR7","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","volume":"184","author":"Y Sun","year":"2021","unstructured":"Sun Y, Wu L, Zhong Y et al (2021) Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma. Cell 184:404\u2013421.e16","journal-title":"Cell"},{"key":"2_CR8","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1136\/gutjnl-2019-318912","volume":"68","author":"Q Zhang","year":"2019","unstructured":"Zhang Q, Lou Y, Yang J et al (2019) Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas. Gut 68:2019\u20132031","journal-title":"Gut"},{"key":"2_CR9","first-page":"1499","volume":"48","author":"JS Yoo","year":"1988","unstructured":"Yoo JS, Guengerich FP, Yang CS (1988) Metabolism of N-nitrosodialkylamines by human liver microsomes. Cancer Res 48:1499\u20131504","journal-title":"Cancer Res"},{"key":"2_CR10","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1021\/acs.joc.0c02774","volume":"86","author":"JC Beard","year":"2021","unstructured":"Beard JC, Swager TM (2021) An organic chemist\u2019s guide to N -nitrosamines: their structure, reactivity, and role as contaminants. J Org Chem 86:2037\u20132057","journal-title":"J Org Chem"},{"key":"2_CR11","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0165-1218(91)90123-4","volume":"259","author":"AR Tricker","year":"1991","unstructured":"Tricker AR, Preussmann R (1991) Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutation Res\/Genet Toxicol 259:277\u2013289","journal-title":"Mutation Res\/Genet Toxicol"},{"key":"2_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0163-7258(96)00062-9","volume":"71","author":"L Verna","year":"1996","unstructured":"Verna L (1996) N-Nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Therap 71:57\u201381","journal-title":"Pharmacol Therap"},{"key":"2_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41421-017-0007-9","volume":"4","author":"D Li","year":"2018","unstructured":"Li D, Hu M, Liu Y et al (2018) CD24\u2013p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages. Cell Discov 4:6","journal-title":"Cell Discov"},{"key":"2_CR14","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.3390\/ijms23094559","volume":"23","author":"Y Li","year":"2022","unstructured":"Li Y, Hecht SS (2022) Metabolic activation and DNA interactions of carcinogenic N-nitrosamines to which humans are commonly exposed. IJMS 23:4559","journal-title":"IJMS"},{"key":"2_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1289\/ehp.856241","volume":"62","author":"B Singer","year":"1985","unstructured":"Singer B (1985) In vivo formation and persistence of modified nucleosides resulting from alkylating agents. Environ Health Persp 62:41\u201348","journal-title":"Environ Health Persp"},{"key":"2_CR16","doi-asserted-by":"publisher","first-page":"101042831769592","DOI":"10.1177\/1010428317695923","volume":"39","author":"NP Santos","year":"2017","unstructured":"Santos NP, Cola\u00e7o AA, Oliveira PA (2017) Animal models as a tool in hepatocellular carcinoma research: a review. Tumour Biol 39:1010428317695923","journal-title":"Tumour Biol"},{"key":"2_CR17","doi-asserted-by":"publisher","first-page":"5461","DOI":"10.3390\/ijms21155461","volume":"21","author":"A Memon","year":"2020","unstructured":"Memon A, Pyao Y, Jung Y et al (2020) A modified protocol of diethylnitrosamine administration in mice to model hepatocellular carcinoma. IJMS 21:5461","journal-title":"IJMS"},{"key":"2_CR18","first-page":"1574","volume":"135","author":"EB Unterberger","year":"2014","unstructured":"Unterberger EB, Eichner J, Wrzodek C et al (2014) Ha-ras and \u03b2-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors. 135:1574\u20131585","journal-title":"Ha-ras and \u03b2-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors."},{"key":"2_CR19","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1053\/j.gastro.2018.11.019","volume":"156","author":"S Liang","year":"2019","unstructured":"Liang S, Ma H-Y, Zhong Z et al (2019) NADPH oxidase 1 in liver macrophages promotes inflammation and tumor development in mice. Gastroenterology 156:1156\u20131172.e6","journal-title":"Gastroenterology"},{"key":"2_CR20","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.cell.2005.04.014","volume":"121","author":"S Maeda","year":"2005","unstructured":"Maeda S, Kamata H, Luo J-L et al (2005) IKK\u03b2 couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121:977\u2013990","journal-title":"Cell"},{"key":"2_CR21","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1126\/science.1140485","volume":"317","author":"WE Naugler","year":"2007","unstructured":"Naugler WE, Sakurai T, Kim S et al (2007) Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317:121\u2013124","journal-title":"Science"},{"key":"2_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ccr.2008.06.016","volume":"14","author":"T Sakurai","year":"2008","unstructured":"Sakurai T, He G, Matsuzawa A et al (2008) Hepatocyte necrosis induced by oxidative stress and IL-1\u03b1 release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14:156\u2013165","journal-title":"Cancer Cell"},{"key":"2_CR23","doi-asserted-by":"publisher","first-page":"6818","DOI":"10.1038\/ncomms7818","volume":"6","author":"CL Wilson","year":"2015","unstructured":"Wilson CL, Jurk D, Fullard N et al (2015) NF\u03baB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun 6:6818","journal-title":"Nat Commun"},{"key":"2_CR24","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1136\/gutjnl-2011-301116","volume":"61","author":"C Schneider","year":"2012","unstructured":"Schneider C, Teufel A, Yevsa T et al (2012) Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer. Gut 61:1733\u20131743","journal-title":"Gut"},{"key":"2_CR25","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1053\/j.gastro.2019.01.247","volume":"156","author":"JC Mossanen","year":"2019","unstructured":"Mossanen JC, Kohlhepp M, Wehr A et al (2019) CXCR6 inhibits hepatocarcinogenesis by promoting natural killer T- and CD4+ T-cell\u2013dependent control of senescence. Gastroenterology 156:1877\u20131889.e4","journal-title":"Gastroenterology"},{"key":"2_CR26","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.jhep.2018.06.009","volume":"69","author":"F Connor","year":"2018","unstructured":"Connor F, Rayner TF, Aitken SJ et al (2018) Mutational landscape of a chemically-induced mouse model of liver cancer. J Hepatol 69:840\u2013850","journal-title":"J Hepatol"},{"key":"2_CR27","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jhep.2010.06.027","volume":"54","author":"J Cany","year":"2011","unstructured":"Cany J, Barteau B, Tran L et al (2011) AFP-specific immunotherapy impairs growth of autochthonous hepatocellular carcinoma in mice. J Hepatol 54:115\u2013121","journal-title":"J Hepatol"},{"key":"2_CR28","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1289\/ehp.8350149","volume":"50","author":"S Goldfarb","year":"1983","unstructured":"Goldfarb S, Pugh TD, Koen H et al (1983) Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy. Environ Health Perspect 50:149\u2013161","journal-title":"Environ Health Perspect"},{"key":"2_CR29","first-page":"7029","volume":"34","author":"RMG Costa","year":"2014","unstructured":"Costa RMG, Paula-Santos N, Faustino Rocha A et al (2014) The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions. Anticancer Res 34:7029\u20137038","journal-title":"Anticancer Res"},{"key":"2_CR30","first-page":"4","volume":"51","author":"G-H Lee","year":"1991","unstructured":"Lee G-H, Nomura K, Kanda H et al (1991) Strain specific sensitivity to diethylnitrosamine-induced carcinogenesis is maintained in hepatocytes of C3H\/HeN^C57BL\/6N. Chimeric Mice 51:4","journal-title":"Chimeric Mice"},{"key":"2_CR31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/iep.12082","volume":"95","author":"NP Santos","year":"2014","unstructured":"Santos NP, Oliveira PA, Arantes-Rodrigues R et al (2014) Cytokeratin 7\/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: implications for histogenesis. Int J Exp Pathol 95:191\u2013198","journal-title":"Int J Exp Pathol"},{"key":"2_CR32","doi-asserted-by":"publisher","first-page":"5S","DOI":"10.1177\/0192623310386499","volume":"38","author":"B Thoolen","year":"2010","unstructured":"Thoolen B, Maronpot RR, Harada T et al (2010) Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol Pathol 38:5S\u201381S","journal-title":"Toxicol Pathol"},{"key":"2_CR33","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/1476-4598-9-219","volume":"9","author":"F Heindryckx","year":"2010","unstructured":"Heindryckx F, Mertens K, Charette N et al (2010) Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma. Mol Cancer 9:219","journal-title":"Mol Cancer"},{"key":"2_CR34","doi-asserted-by":"publisher","first-page":"E9879","DOI":"10.1073\/pnas.1811029115","volume":"115","author":"M Dow","year":"2018","unstructured":"Dow M, Pyke RM, Tsui BY et al (2018) Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci USA 115:E9879","journal-title":"Proc Natl Acad Sci USA"},{"key":"2_CR35","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.mrfmmm.2007.08.015","volume":"638","author":"A Buchmann","year":"2008","unstructured":"Buchmann A, Karcier Z, Schmid B et al (2008) Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis. Mutation Res\/Fund Mol Mech Mutagenesis 638:66\u201374","journal-title":"Mutation Res\/Fund Mol Mech Mutagenesis"},{"key":"2_CR36","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/ng1481","volume":"36","author":"J-S Lee","year":"2004","unstructured":"Lee J-S, Chu I-S, Mikaelyan A et al (2004) Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet 36:1306\u20131311","journal-title":"Nat Genet"},{"key":"2_CR37","doi-asserted-by":"publisher","first-page":"18809","DOI":"10.1038\/s41598-021-98203-5","volume":"11","author":"A Deust","year":"2021","unstructured":"Deust A, Chobert M-N, Demontant V et al (2021) Macrophage autophagy protects against hepatocellular carcinogenesis in mice. Sci Rep 11:18809","journal-title":"Sci Rep"},{"key":"2_CR38","doi-asserted-by":"publisher","first-page":"e0146279","DOI":"10.1371\/journal.pone.0146279","volume":"11","author":"Y Shibata","year":"2016","unstructured":"Shibata Y, Hara T, Nagano J et al (2016) The role of indoleamine 2,3-dioxygenase in diethylnitrosamine-induced liver carcinogenesis. PLoS One 11:e0146279","journal-title":"PLoS One"},{"key":"2_CR39","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jhep.2013.06.010","volume":"59","author":"T Kapanadze","year":"2013","unstructured":"Kapanadze T, Gamrekelashvili J, Ma C et al (2013) Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma. J Hepatol 59:1007\u20131013","journal-title":"J Hepatol"},{"key":"2_CR40","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.intimp.2014.07.007","volume":"22","author":"S Song","year":"2014","unstructured":"Song S, Yuan P, Li P et al (2014) Dynamic analysis of tumor-associated immune cells in DEN-induced rat hepatocellular carcinoma. Int Immunopharmacol 22:392\u2013399","journal-title":"Int Immunopharmacol"},{"key":"2_CR41","doi-asserted-by":"publisher","first-page":"e1601479","DOI":"10.1080\/2162402X.2019.1601479","volume":"8","author":"C Yin","year":"2019","unstructured":"Yin C, Han Q, Xu D et al (2019) SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC. OncoImmunology 8:e1601479","journal-title":"OncoImmunology"},{"key":"2_CR42","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1158\/1940-6207.CAPR-20-0200","volume":"13","author":"AS Chung","year":"2020","unstructured":"Chung AS, Mettlen M, Ganguly D et al (2020) Immune checkpoint inhibition is safe and effective for liver cancer prevention in a mouse model of hepatocellular carcinoma. Cancer Prev Res (Phila) 13:911\u2013922","journal-title":"Cancer Prev Res (Phila)"},{"key":"2_CR43","doi-asserted-by":"publisher","first-page":"5725","DOI":"10.1038\/s41467-021-25967-9","volume":"12","author":"C Liu","year":"2021","unstructured":"Liu C, Yang Y, Chen C et al (2021) Environmental eustress modulates \u03b2-ARs\/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice. Nat Commun 12:5725","journal-title":"Nat Commun"},{"key":"2_CR44","first-page":"5044","volume":"49","author":"CJ Kemp","year":"1989","unstructured":"Kemp CJ, Drinkwater NR (1989) Genetic variation in liver tumor susceptibility, plasma testosterone levels, and androgen receptor binding in six inbred strains of mice. Cancer Res 49:5044\u20135047","journal-title":"Cancer Res"},{"key":"2_CR45","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.3390\/cancers13102355","volume":"13","author":"MH O\u2019Brien","year":"2021","unstructured":"O\u2019Brien MH, Pitot HC, Chung S-H et al (2021) Estrogen receptor-\u03b1 suppresses liver carcinogenesis and establishes sex-specific gene expression. Cancers 13:2355","journal-title":"Cancers"},{"key":"2_CR46","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1002\/hep.22194","volume":"47","author":"NC Teoh","year":"2008","unstructured":"Teoh NC, Dan YY, Swisshelm K et al (2008) Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. Hepatology 47:2078\u20132088","journal-title":"Hepatology"},{"key":"2_CR47","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1038\/cdd.2016.81","volume":"23","author":"S Shalini","year":"2016","unstructured":"Shalini S, Nikolic A, Wilson CH et al (2016) Caspase-2 deficiency accelerates chemically induced liver cancer in mice. Cell Death Differ 23:1727\u20131736","journal-title":"Cell Death Differ"},{"key":"2_CR48","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0304-3835(75)97372-3","volume":"1","author":"BA Diwan","year":"1975","unstructured":"Diwan BA, Meier H (1975) Carcinogenic effects of a single dose of diethylnitrosamine in three unrelated strains of mice: Genetic dependence of the induced tumor types and incidence. Cancer Letters 1:249\u2013253","journal-title":"Cancer Letters"}],"container-title":["Methods in Molecular Biology","Liver Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3694-7_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T08:10:17Z","timestamp":1707120617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3694-7_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9781071636930","9781071636947"],"references-count":48,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3694-7_2","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"6 February 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}