{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:59:34Z","timestamp":1787961574931,"version":"build-2784847793"},"publisher-location":"New York, NY","reference-count":91,"publisher":"Springer US","isbn-type":[{"value":"9781071637739","type":"print"},{"value":"9781071637746","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-1-0716-3774-6_13","type":"book-chapter","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T10:02:25Z","timestamp":1709287345000},"page":"195-218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach"],"prefix":"10.1007","author":[{"given":"Elena","family":"Rodriguez-Vieitez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona-Lisa","family":"Malarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Ioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa M.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Chiotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"key":"13_CR1","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.dadm.2015.09.001","volume":"1","author":"N Mattsson","year":"2015","unstructured":"Mattsson N, Carrillo MC, Dean RA et al (2015) Revolutionizing Alzheimer\u2019s disease and clinical trials through biomarkers. Alzheimers Dement (Amst) 1:412\u2013419. https:\/\/doi.org\/10.1016\/j.dadm.2015.09.001","journal-title":"Alzheimers Dement (Amst)"},{"key":"13_CR2","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239\u2013259. https:\/\/doi.org\/10.1007\/BF00308809","journal-title":"Acta Neuropathol"},{"key":"13_CR3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics. Science 297:353\u2013356. https:\/\/doi.org\/10.1126\/science.1072994","journal-title":"Science"},{"key":"13_CR4","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","volume":"12","author":"CR Jack","year":"2013","unstructured":"Jack CR, Knopman DS, Jagust WJ et al (2013) Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12:207\u2013216. https:\/\/doi.org\/10.1016\/S1474-4422(12)70291-0","journal-title":"Lancet Neurol"},{"key":"13_CR5","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1212\/01.wnl.0000435556.21319.e4","volume":"81","author":"CR Jack","year":"2013","unstructured":"Jack CR, Wiste HJ, Weigand SD et al (2013) Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity. Neurology 81:1732\u20131740. https:\/\/doi.org\/10.1212\/01.wnl.0000435556.21319.e4","journal-title":"Neurology"},{"key":"13_CR6","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","volume":"84","author":"R Sperling","year":"2014","unstructured":"Sperling R, Mormino E, Johnson K (2014) The evolution of preclinical Alzheimer\u2019s disease: implications for prevention trials. Neuron 84:608\u2013622. https:\/\/doi.org\/10.1016\/j.neuron.2014.10.038","journal-title":"Neuron"},{"key":"13_CR7","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka MT, Carson MJ, Khoury JE et al (2015) Neuroinflammation in Alzheimer\u2019s disease. Lancet Neurol 14:388\u2013405. https:\/\/doi.org\/10.1016\/S1474-4422(15)70016-5","journal-title":"Lancet Neurol"},{"key":"13_CR8","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","volume":"164","author":"B De Strooper","year":"2016","unstructured":"De Strooper B, Karran E (2016) The cellular phase of Alzheimer\u2019s disease. Cell 164:603\u2013615. https:\/\/doi.org\/10.1016\/j.cell.2015.12.056","journal-title":"Cell"},{"key":"13_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2012.04.021","volume":"236","author":"DR Thal","year":"2012","unstructured":"Thal DR (2012) The role of astrocytes in amyloid \u03b2-protein toxicity and clearance. Exp Neurol 236:1\u20135. https:\/\/doi.org\/10.1016\/j.expneurol.2012.04.021","journal-title":"Exp Neurol"},{"key":"13_CR10","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1002\/jnr.24075","volume":"95","author":"C Acosta","year":"2017","unstructured":"Acosta C, Anderson HD, Anderson CM (2017) Astrocyte dysfunction in Alzheimer disease: astrocytes in Alzheimer\u2019s disease. J Neurosci Res 95:2430\u20132447. https:\/\/doi.org\/10.1002\/jnr.24075","journal-title":"J Neurosci Res"},{"key":"13_CR11","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1177\/1073858414547132","volume":"21","author":"A Verkhratsky","year":"2015","unstructured":"Verkhratsky A, Marutle A, Rodr\u00edguez-Arellano JJ, Nordberg A (2015) Glial asthenia and functional paralysis: a new perspective on neurodegeneration and Alzheimer\u2019s disease. Neuroscientist 21:552\u2013568. https:\/\/doi.org\/10.1177\/1073858414547132","journal-title":"Neuroscientist"},{"key":"13_CR12","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1038\/nn.4142","volume":"18","author":"W-S Chung","year":"2015","unstructured":"Chung W-S, Welsh CA, Barres BA, Stevens B (2015) Do glia drive synaptic and cognitive impairment in disease? Nat Neurosci 18:1539\u20131545. https:\/\/doi.org\/10.1038\/nn.4142","journal-title":"Nat Neurosci"},{"key":"13_CR13","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S1474-4422(11)70156-9","volume":"10","author":"ME Murray","year":"2011","unstructured":"Murray ME, Graff-Radford NR, Ross OA et al (2011) Neuropathologically defined subtypes of Alzheimer\u2019s disease with distinct clinical characteristics: a retrospective study. Lancet Neurol 10:785\u2013796. https:\/\/doi.org\/10.1016\/S1474-4422(11)70156-9","journal-title":"Lancet Neurol"},{"key":"13_CR14","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.4.1.011013","volume":"4","author":"T Jones","year":"2017","unstructured":"Jones T, Townsend D (2017) History and future technical innovation in positron emission tomography. J Med Imaging 4:011013. https:\/\/doi.org\/10.1117\/1.JMI.4.1.011013","journal-title":"J Med Imaging"},{"key":"13_CR15","volume-title":"Experimental design and practical data analysis in positron emission tomography","author":"F Turkheimer","year":"2014","unstructured":"Turkheimer F, Dunn J (2014) Experimental design and practical data analysis in positron emission tomography. Published independently, London, London"},{"key":"13_CR16","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.tips.2009.05.005","volume":"30","author":"VW Pike","year":"2009","unstructured":"Pike VW (2009) PET radiotracers: crossing the blood\u2013brain barrier and surviving metabolism. Trends Pharmacol Sci 30:431\u2013440. https:\/\/doi.org\/10.1016\/j.tips.2009.05.005","journal-title":"Trends Pharmacol Sci"},{"key":"13_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimer\u2019s Dement 7:263\u2013269. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.005","journal-title":"Alzheimer\u2019s Dement"},{"key":"13_CR18","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","volume":"13","author":"B Dubois","year":"2014","unstructured":"Dubois B, Feldman HH, Jacova C et al (2014) Advancing research diagnostic criteria for Alzheimer\u2019s disease: the IWG-2 criteria. Lancet Neurol 13:614\u2013629. https:\/\/doi.org\/10.1016\/S1474-4422(14)70090-0","journal-title":"Lancet Neurol"},{"key":"13_CR19","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/s41380-018-0342-8","volume":"24","author":"A Leuzy","year":"2019","unstructured":"Leuzy A, Chiotis K, Lemoine L et al (2019) Tau PET imaging in neurodegenerative tauopathies-still a challenge. Mol Psychiatry 24:1112\u20131134. https:\/\/doi.org\/10.1038\/s41380-018-0342-8","journal-title":"Mol Psychiatry"},{"key":"13_CR20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1021\/acschemneuro.6b00056","volume":"7","author":"DS Albrecht","year":"2016","unstructured":"Albrecht DS, Granziera C, Hooker JM, Loggia ML (2016) In vivo imaging of human neuroinflammation. ACS Chem Neurosci 7:470\u2013483. https:\/\/doi.org\/10.1021\/acschemneuro.6b00056","journal-title":"ACS Chem Neurosci"},{"key":"13_CR21","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1007\/s00259-019-04462-w","volume":"46","author":"D Boche","year":"2019","unstructured":"Boche D, Gerhard A, Rodriguez-Vieitez E, Faculty MINC (2019) Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer\u2019s disease. Eur J Nucl Med Mol Imaging 46:2831\u20132847. https:\/\/doi.org\/10.1007\/s00259-019-04462-w","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"13_CR22","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.3390\/cells12111469","volume":"12","author":"IC Fontana","year":"2023","unstructured":"Fontana IC, Scarpa M, Malarte M-L et al (2023) Astrocyte signature in Alzheimer\u2019s disease continuum through a multi-PET tracer imaging perspective. Cell 12:1469. https:\/\/doi.org\/10.3390\/cells12111469","journal-title":"Cell"},{"key":"13_CR23","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","volume":"81","author":"JE Burda","year":"2014","unstructured":"Burda JE, Sofroniew MV (2014) Reactive gliosis and the multicellular response to CNS damage and disease. Neuron 81:229\u2013248. https:\/\/doi.org\/10.1016\/j.neuron.2013.12.034","journal-title":"Neuron"},{"key":"13_CR24","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/jnc.15565","volume":"164","author":"A Kumar","year":"2023","unstructured":"Kumar A, Fontana IC, Nordberg A (2023) Reactive astrogliosis: a friend or foe in the pathogenesis of Alzheimer\u2019s disease. J Neurochem 164:309\u2013324. https:\/\/doi.org\/10.1111\/jnc.15565","journal-title":"J Neurochem"},{"key":"13_CR25","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.nurt.2010.07.003","volume":"7","author":"ME Hamby","year":"2010","unstructured":"Hamby ME, Sofroniew MV (2010) Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics 7:494\u2013506. https:\/\/doi.org\/10.1016\/j.nurt.2010.07.003","journal-title":"Neurotherapeutics"},{"key":"13_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1136\/jnnp-2015-311336","volume":"87","author":"J Stefaniak","year":"2015","unstructured":"Stefaniak J, O\u2019Brien J (2015) Imaging of neuroinflammation in dementia: a review. J Neurol Neurosurg Psychiatry 87:21. https:\/\/doi.org\/10.1136\/jnnp-2015-311336","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"13_CR27","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/j.1365-2990.2008.01006.x","volume":"35","author":"M Cosenza-Nashat","year":"2009","unstructured":"Cosenza-Nashat M, Zhao M-L, Suh H-S et al (2009) Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol 35:306\u2013328. https:\/\/doi.org\/10.1111\/j.1365-2990.2008.01006.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"13_CR28","doi-asserted-by":"publisher","first-page":"10809","DOI":"10.1523\/JNEUROSCI.1487-12.2012","volume":"32","author":"S Lavisse","year":"2012","unstructured":"Lavisse S, Guillermier M, H\u00e9rard A-S et al (2012) Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging. J Neurosci 32:10809\u201310818. https:\/\/doi.org\/10.1523\/JNEUROSCI.1487-12.2012","journal-title":"J Neurosci"},{"key":"13_CR29","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1042\/BST20150058","volume":"43","author":"FE Turkheimer","year":"2015","unstructured":"Turkheimer FE, Rizzo G, Bloomfield PS et al (2015) The methodology of TSPO imaging with positron emission tomography. Biochem Soc Trans 43:586\u2013592. https:\/\/doi.org\/10.1042\/BST20150058","journal-title":"Biochem Soc Trans"},{"key":"13_CR30","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","volume":"24","author":"C Escartin","year":"2021","unstructured":"Escartin C, Galea E, Lakatos A et al (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci 24:312\u2013325. https:\/\/doi.org\/10.1038\/s41593-020-00783-4","journal-title":"Nat Neurosci"},{"key":"13_CR31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.molmed.2018.11.006","volume":"25","author":"SF Carter","year":"2019","unstructured":"Carter SF, Herholz K, Rosa-Neto P et al (2019) Astrocyte biomarkers in Alzheimer\u2019s disease. Trends Mol Med 25:77\u201395. https:\/\/doi.org\/10.1016\/j.molmed.2018.11.006","journal-title":"Trends Mol Med"},{"key":"13_CR32","doi-asserted-by":"publisher","first-page":"e2944","DOI":"10.1212\/WNL.0000000000012109","volume":"96","author":"B Bellaver","year":"2021","unstructured":"Bellaver B, Ferrari-Souza JP, Uglione Da Ros L et al (2021) Astrocyte biomarkers in Alzheimer disease: a systematic review and meta-analysis. Neurology 96:e2944\u2013e2955. https:\/\/doi.org\/10.1212\/WNL.0000000000012109","journal-title":"Neurology"},{"key":"13_CR33","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/978-3-030-53176-8_15","volume-title":"PET and SPECT of neurobiological systems","author":"E Rodriguez-Vieitez","year":"2021","unstructured":"Rodriguez-Vieitez E (2021) Chapter 20: PET imaging of monoamine oxidase B. In: PET and SPECT of neurobiological systems, 2nd edn. Springer Nature, pp 521\u2013545","edition":"2"},{"key":"13_CR34","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.2967\/jnumed.121.263254","volume":"63","author":"VL Villemagne","year":"2022","unstructured":"Villemagne VL, Harada R, Dor\u00e9 V et al (2022) First-in-humans evaluation of 18F-SMBT-1, a novel 18F-labeled monoamine oxidase-B PET tracer for imaging reactive Astrogliosis. J Nucl Med 63:1551\u20131559. https:\/\/doi.org\/10.2967\/jnumed.121.263254","journal-title":"J Nucl Med"},{"key":"13_CR35","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.2967\/jnumed.121.263255","volume":"63","author":"VL Villemagne","year":"2022","unstructured":"Villemagne VL, Harada R, Dor\u00e9 V et al (2022) Assessing reactive Astrogliosis with 18 F-SMBT-1 across the Alzheimer disease Spectrum. J Nucl Med 63:1560\u20131569. https:\/\/doi.org\/10.2967\/jnumed.121.263255","journal-title":"J Nucl Med"},{"key":"13_CR36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jns.2007.01.057","volume":"255","author":"A Johansson","year":"2007","unstructured":"Johansson A, Engler H, Blomquist G et al (2007) Evidence for astrocytosis in ALS demonstrated by [11C](l)-deprenyl-D2 PET. J Neurol Sci 255:17\u201322. https:\/\/doi.org\/10.1016\/j.jns.2007.01.057","journal-title":"J Neurol Sci"},{"key":"13_CR37","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.pharmthera.2017.03.009","volume":"178","author":"J-X Li","year":"2017","unstructured":"Li J-X (2017) Imidazoline I 2 receptors: an update. Pharmacol Ther 178:48\u201356. https:\/\/doi.org\/10.1016\/j.pharmthera.2017.03.009","journal-title":"Pharmacol Ther"},{"key":"13_CR38","doi-asserted-by":"publisher","first-page":"9787","DOI":"10.3390\/ijms24129787","volume":"24","author":"CA Parker","year":"2023","unstructured":"Parker CA, Nutt DJ, Tyacke RJ (2023) Imidazoline-I2 PET Tracers in Neuroimaging. IJMS 24:9787. https:\/\/doi.org\/10.3390\/ijms24129787","journal-title":"IJMS"},{"key":"13_CR39","doi-asserted-by":"publisher","first-page":"5833","DOI":"10.1038\/s41380-021-01101-5","volume":"26","author":"A Kumar","year":"2021","unstructured":"Kumar A, Koistinen NA, Malarte M-L et al (2021) Astroglial tracer BU99008 detects multiple binding sites in Alzheimer\u2019s disease brain. Mol Psychiatry 26:5833\u20135847. https:\/\/doi.org\/10.1038\/s41380-021-01101-5","journal-title":"Mol Psychiatry"},{"key":"13_CR40","doi-asserted-by":"publisher","first-page":"5848","DOI":"10.1038\/s41380-021-01193-z","volume":"26","author":"V Calsolaro","year":"2021","unstructured":"Calsolaro V, Matthews PM, Donat CK et al (2021) Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load. Mol Psychiatry 26:5848\u20135855. https:\/\/doi.org\/10.1038\/s41380-021-01193-z","journal-title":"Mol Psychiatry"},{"key":"13_CR41","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/brain\/awad037","volume":"146","author":"M-H Nam","year":"2023","unstructured":"Nam M-H, Ko HY, Kim D et al (2023) Visualizing reactive astrocyte-neuron interaction in Alzheimer\u2019s disease using 11C-acetate and 18F-FDG. Brain 146:2957\u20132974. https:\/\/doi.org\/10.1093\/brain\/awad037","journal-title":"Brain"},{"key":"13_CR42","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1097\/MNM.0000000000001460","volume":"42","author":"MT Duong","year":"2021","unstructured":"Duong MT, Chen YJ, Doot RK et al (2021) Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology. Nucl Med Commun 42:1261\u20131269. https:\/\/doi.org\/10.1097\/MNM.0000000000001460","journal-title":"Nucl Med Commun"},{"key":"13_CR43","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.3099392","volume":"235","author":"JS Fowler","year":"1987","unstructured":"Fowler JS, MacGregor RR, Wolf AP et al (1987) Mapping human brain monoamine oxidase a and B with 11 C-labeled suicide Inactivators and PET. Science 235:481\u2013485. https:\/\/doi.org\/10.1126\/science.3099392","journal-title":"Science"},{"key":"13_CR44","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s11307-005-0016-1","volume":"7","author":"JS Fowler","year":"2005","unstructured":"Fowler JS, Logan J, Volkow ND, Wang G-J (2005) Translational neuroimaging: positron emission tomography studies of monoamine oxidase. Mol Imaging Biol 7:377\u2013387. https:\/\/doi.org\/10.1007\/s11307-005-0016-1","journal-title":"Mol Imaging Biol"},{"key":"13_CR45","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/978-3-7091-9324-2_33","volume-title":"Amine oxidases: function and dysfunction","author":"J Ekblom","year":"1994","unstructured":"Ekblom J, Jossan SS, Oreland L et al (1994) Reactive gliosis and monoamine oxidase B. In: Tipton KF, Youdim MBH, Barwell CJ et al (eds) Amine oxidases: function and dysfunction. Springer Vienna, Vienna, pp 253\u2013258"},{"key":"13_CR46","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/glia.440080208","volume":"8","author":"J Ekblom","year":"1993","unstructured":"Ekblom J, Jossan SS, Bergstr\u00fcm M et al (1993) Monoamine oxidase-B in astrocytes. Glia 8:122\u2013132. https:\/\/doi.org\/10.1002\/glia.440080208","journal-title":"Glia"},{"key":"13_CR47","doi-asserted-by":"publisher","first-page":"6385","DOI":"10.1073\/pnas.79.20.6385","volume":"79","author":"P Levitt","year":"1982","unstructured":"Levitt P, Pintar JE, Breakefield XO (1982) Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. Proc Natl Acad Sci U S A 79:6385\u20136389. https:\/\/doi.org\/10.1073\/pnas.79.20.6385","journal-title":"Proc Natl Acad Sci U S A"},{"key":"13_CR48","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-3-7091-9324-2_31","volume-title":"Amine oxidases: function and dysfunction","author":"SS Jossan","year":"1994","unstructured":"Jossan SS, Ekblom J, Aquilonius S-M, Oreland L (1994) Monoamine oxidase-B in motor cortex and spinal cord in amyotrophic lateral sclerosis studied by quantitative autoradiography. In: Tipton KF, Youdim MBH, Barwell CJ et al (eds) Amine oxidases: function and dysfunction. Springer Vienna, Vienna, pp 243\u2013248"},{"key":"13_CR49","doi-asserted-by":"publisher","first-page":"45496","DOI":"10.1038\/srep45496","volume":"7","author":"L Lemoine","year":"2017","unstructured":"Lemoine L, Saint-Aubert L, Nennesmo I et al (2017) Cortical laminar tau deposits and activated astrocytes in Alzheimer\u2019s disease visualised by 3H-THK5117 and 3H-deprenyl autoradiography. Sci Rep 7:45496. https:\/\/doi.org\/10.1038\/srep45496","journal-title":"Sci Rep"},{"key":"13_CR50","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1186\/1742-2094-10-90","volume":"10","author":"A Marutle","year":"2013","unstructured":"Marutle A, Gillberg P-G, Bergfors A et al (2013) 3H-Deprenyl and 3H-PIB autoradiography show different laminar distributions of astroglia and fibrillar \u03b2-amyloid in Alzheimer brain. J Neuroinflammation 10:861. https:\/\/doi.org\/10.1186\/1742-2094-10-90","journal-title":"J Neuroinflammation"},{"key":"13_CR51","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0306-4522(94)90311-5","volume":"62","author":"J Saura","year":"1994","unstructured":"Saura J, Luque JM, Cesura AM et al (1994) Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience 62:15\u201330. https:\/\/doi.org\/10.1016\/0306-4522(94)90311-5","journal-title":"Neuroscience"},{"key":"13_CR52","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.neuint.2010.10.013","volume":"58","author":"B Guly\u00e1s","year":"2011","unstructured":"Guly\u00e1s B, Pavlova E, K\u00e1sa P et al (2011) Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-l-deprenyl using whole hemisphere autoradiography. Neurochem Int 58:60\u201368. https:\/\/doi.org\/10.1016\/j.neuint.2010.10.013","journal-title":"Neurochem Int"},{"key":"13_CR53","first-page":"1255","volume":"36","author":"JS Fowler","year":"1995","unstructured":"Fowler JS, Wang GJ, Logan J et al (1995) Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping. J Nucl Med 36:1255\u20131262","journal-title":"J Nucl Med"},{"key":"13_CR54","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1111\/j.1471-4159.1988.tb01121.x","volume":"51","author":"JS Fowler","year":"1988","unstructured":"Fowler JS, Wolf AP, MacGregor RR et al (1988) Mechanistic positron emission tomography studies: demonstration of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]L-deprenyl in living baboon brain. J Neurochem 51:1524\u20131534. https:\/\/doi.org\/10.1111\/j.1471-4159.1988.tb01121.x","journal-title":"J Neurochem"},{"key":"13_CR55","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2967\/jnumed.110.087031","volume":"53","author":"SF Carter","year":"2012","unstructured":"Carter SF, Sch\u00f6ll M, Almkvist O et al (2012) Evidence for Astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-Deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18 F-FDG. J Nucl Med 53:37\u201346. https:\/\/doi.org\/10.2967\/jnumed.110.087031","journal-title":"J Nucl Med"},{"key":"13_CR56","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13024-023-00647-y","volume":"18","author":"K Chiotis","year":"2023","unstructured":"Chiotis K, Johansson C, Rodriguez-Vieitez E et al (2023) Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer\u2019s disease with multi-modal PET and plasma GFAP. Mol Neurodegener 18:60. https:\/\/doi.org\/10.1186\/s13024-023-00647-y","journal-title":"Mol Neurodegener"},{"key":"13_CR57","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1093\/brain\/awv404","volume":"139","author":"E Rodriguez-Vieitez","year":"2016","unstructured":"Rodriguez-Vieitez E, Saint-Aubert L, Carter SF et al (2016) Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer\u2019s disease. Brain 139:922\u2013936. https:\/\/doi.org\/10.1093\/brain\/awv404","journal-title":"Brain"},{"key":"13_CR58","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00259-002-1008-x","volume":"30","author":"H Engler","year":"2003","unstructured":"Engler H, Lundberg P, Ekbom K et al (2003) Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease. Eur J Nucl Med Mol Imaging 30:85\u201395. https:\/\/doi.org\/10.1007\/s00259-002-1008-x","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"13_CR59","first-page":"201","volume":"5","author":"H Engler","year":"2012","unstructured":"Engler H, Nennesmo I, Kumlien E et al (2012) Imaging astrocytosis with PET in Creutzfeldt-Jakob disease: case report with histopathological findings. Int J Clin Exp Med 5:201\u2013207","journal-title":"Int J Clin Exp Med"},{"key":"13_CR60","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1007\/s00259-014-2859-7","volume":"41","author":"IH Choo","year":"2014","unstructured":"Choo IH, Carter SF, Sch\u00f6ll ML, Nordberg A (2014) Astrocytosis measured by 11C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer\u2019s patients. Eur J Nucl Med Mol Imaging 41:2120\u20132126. https:\/\/doi.org\/10.1007\/s00259-014-2859-7","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"13_CR61","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.2967\/jnumed.115.168732","volume":"57","author":"E Rodriguez-Vieitez","year":"2016","unstructured":"Rodriguez-Vieitez E, Carter SF, Chiotis K et al (2016) Comparison of early-phase 11 C-deuterium-l-Deprenyl and 11 C-Pittsburgh compound B PET for assessing brain perfusion in Alzheimer disease. J Nucl Med 57:1071\u20131077. https:\/\/doi.org\/10.2967\/jnumed.115.168732","journal-title":"J Nucl Med"},{"key":"13_CR62","doi-asserted-by":"publisher","first-page":"16404","DOI":"10.1038\/srep16404","volume":"5","author":"M Sch\u00f6ll","year":"2015","unstructured":"Sch\u00f6ll M, Carter SF, Westman E et al (2015) Early astrocytosis in autosomal dominant Alzheimer\u2019s disease measured in vivo by multi-tracer positron emission tomography. Sci Rep 5:16404. https:\/\/doi.org\/10.1038\/srep16404","journal-title":"Sci Rep"},{"key":"13_CR63","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s00259-018-4217-7","volume":"46","author":"SF Carter","year":"2019","unstructured":"Carter SF, Chiotis K, Nordberg A, Rodriguez-Vieitez E (2019) Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer\u2019s disease. Eur J Nucl Med Mol Imaging 46:348\u2013356. https:\/\/doi.org\/10.1007\/s00259-018-4217-7","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"13_CR64","doi-asserted-by":"publisher","first-page":"e2026","DOI":"10.1212\/WNL.0000000000009405","volume":"94","author":"E Vilaplana","year":"2020","unstructured":"Vilaplana E, Rodriguez-Vieitez E, Ferreira D et al (2020) Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease. Neurology 94:e2026\u2013e2036. https:\/\/doi.org\/10.1212\/WNL.0000000000009405","journal-title":"Neurology"},{"key":"13_CR65","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1007\/s00259-015-3047-0","volume":"42","author":"E Rodriguez-Vieitez","year":"2015","unstructured":"Rodriguez-Vieitez E, Ni R, Guly\u00e1s B et al (2015) Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study. Eur J Nucl Med Mol Imaging 42:1119\u20131132. https:\/\/doi.org\/10.1007\/s00259-015-3047-0","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"13_CR66","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1093\/brain\/awv405","volume":"139","author":"JM Schott","year":"2016","unstructured":"Schott JM, Fox NC (2016) Inflammatory changes in very early Alzheimer\u2019s disease: friend, foe, or don\u2019t know? Brain 139:647\u2013650. https:\/\/doi.org\/10.1093\/brain\/awv405","journal-title":"Brain"},{"key":"13_CR67","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","volume":"78","author":"AL Benedet","year":"2021","unstructured":"Benedet AL, Mil\u00e0-Alom\u00e0 M, Vrillon A et al (2021) Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the Alzheimer disease continuum. JAMA Neurol 78:1471. https:\/\/doi.org\/10.1001\/jamaneurol.2021.3671","journal-title":"JAMA Neurol"},{"key":"13_CR68","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1093\/brain\/awac399","volume":"146","author":"C Johansson","year":"2023","unstructured":"Johansson C, Thordardottir S, Laffita-Mesa J et al (2023) Plasma biomarker profiles in autosomal dominant Alzheimer\u2019s disease. Brain 146:1132\u20131140. https:\/\/doi.org\/10.1093\/brain\/awac399","journal-title":"Brain"},{"key":"13_CR69","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3233\/JAD-220908","volume":"92","author":"P Chatterjee","year":"2023","unstructured":"Chatterjee P, Dor\u00e9 V, Pedrini S et al (2023) Plasma glial fibrillary acidic protein is associated with 18F-SMBT-1 PET: two putative astrocyte reactivity biomarkers for Alzheimer\u2019s disease. JAD 92:615\u2013628. https:\/\/doi.org\/10.3233\/JAD-220908","journal-title":"JAD"},{"key":"13_CR70","first-page":"663","volume":"25","author":"PD Acton","year":"1998","unstructured":"Acton PD, Friston KJ (1998) Statistical parametric mapping in functional neuroimaging: beyond PET and fMRI activation studies. Eur J Nucl Med 25:663\u2013667","journal-title":"Eur J Nucl Med"},{"key":"13_CR71","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/jcbfm.1995.45","volume":"15","author":"KJ Friston","year":"1995","unstructured":"Friston KJ (1995) Commentary and opinion: II. Statistical parametric mapping: ontology and current issues. J Cereb Blood Flow Metab 15:361\u2013370. https:\/\/doi.org\/10.1038\/jcbfm.1995.45","journal-title":"J Cereb Blood Flow Metab"},{"key":"13_CR72","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1006\/nimg.1997.0265","volume":"5","author":"SJ Kiebel","year":"1997","unstructured":"Kiebel SJ, Ashburner J, Poline J-B, Friston KJ (1997) MRI and PET Coregistration\u2014a cross validation of statistical parametric mapping and automated image registration. NeuroImage 5:271\u2013279. https:\/\/doi.org\/10.1006\/nimg.1997.0265","journal-title":"NeuroImage"},{"key":"13_CR73","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.neuroimage.2006.09.011","volume":"34","author":"R Casanova","year":"2007","unstructured":"Casanova R, Srikanth R, Baer A et al (2007) Biological parametric mapping: a statistical toolbox for multimodality brain image analysis. NeuroImage 34:137\u2013143. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.09.011","journal-title":"NeuroImage"},{"key":"13_CR74","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3233\/JAD-141965","volume":"47","author":"K Farid","year":"2015","unstructured":"Farid K, Carter SF, Rodriguez-Vieitez E et al (2015) Case report of complex amyotrophic lateral sclerosis with cognitive impairment and cortical amyloid deposition. JAD 47:661\u2013667. https:\/\/doi.org\/10.3233\/JAD-141965","journal-title":"JAD"},{"key":"13_CR75","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/jcbfm.1985.87","volume":"5","author":"CS Patlak","year":"1985","unstructured":"Patlak CS, Blasberg RG (1985) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 5:584\u2013590. https:\/\/doi.org\/10.1038\/jcbfm.1985.87","journal-title":"J Cereb Blood Flow Metab"},{"key":"13_CR76","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/j.1600-0404.1998.tb07300.x","volume":"98","author":"M Bergstr\u00f6m","year":"1998","unstructured":"Bergstr\u00f6m M, Kumlien E, Lilja A et al (1998) Temporal lobe epilepsy visualized with PET with 11C-L-deuterium-deprenyl \u2013 analysis of kinetic data. Acta Neurol Scand 98:224\u2013231. https:\/\/doi.org\/10.1111\/j.1600-0404.1998.tb07300.x","journal-title":"Acta Neurol Scand"},{"key":"13_CR77","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","volume":"256","author":"RC Petersen","year":"2004","unstructured":"Petersen RC (2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256:183\u2013194. https:\/\/doi.org\/10.1111\/j.1365-2796.2004.01388.x","journal-title":"J Intern Med"},{"key":"13_CR78","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M et al (1984) Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s disease. Neurology 34:939\u2013939. https:\/\/doi.org\/10.1212\/WNL.34.7.939","journal-title":"Neurology"},{"key":"13_CR79","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s00259-012-2237-2","volume":"40","author":"A Nordberg","year":"2013","unstructured":"Nordberg A, Carter SF, Rinne J et al (2013) A European multicentre PET study of fibrillar amyloid in Alzheimer\u2019s disease. Eur J Nucl Med Mol Imaging 40:104\u2013114. https:\/\/doi.org\/10.1007\/s00259-012-2237-2","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"13_CR80","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/ana.20009","volume":"55","author":"WE Klunk","year":"2004","unstructured":"Klunk WE, Engler H, Nordberg A et al (2004) Imaging brain amyloid in Alzheimer\u2019s disease with Pittsburgh Compound-B: imaging amyloid in AD with PIB. Ann Neurol 55:306\u2013319. https:\/\/doi.org\/10.1002\/ana.20009","journal-title":"Ann Neurol"},{"key":"13_CR81","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1021\/jm030026b","volume":"46","author":"CA Mathis","year":"2003","unstructured":"Mathis CA, Wang Y, Holt DP et al (2003) Synthesis and evaluation of 11C-labeled 6-substituted 2-Arylbenzothiazoles as amyloid imaging agents. J Med Chem 46:2740\u20132754. https:\/\/doi.org\/10.1021\/jm030026b","journal-title":"J Med Chem"},{"key":"13_CR82","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","volume":"26","author":"J Ashburner","year":"2005","unstructured":"Ashburner J, Friston KJ (2005) Unified segmentation. NeuroImage 26:839\u2013851. https:\/\/doi.org\/10.1016\/j.neuroimage.2005.02.018","journal-title":"NeuroImage"},{"key":"13_CR83","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/hbm.10123","volume":"19","author":"A Hammers","year":"2003","unstructured":"Hammers A, Allom R, Koepp MJ et al (2003) Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp 19:224\u2013247. https:\/\/doi.org\/10.1002\/hbm.10123","journal-title":"Hum Brain Mapp"},{"key":"13_CR84","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1212\/WNL.46.2.406","volume":"46","author":"CF Lippa","year":"1996","unstructured":"Lippa CF, Saunders AM, Smith TW et al (1996) Familial and sporadic Alzheimer\u2019s disease: neuropathology cannot exclude a final common pathway. Neurology 46:406\u2013412. https:\/\/doi.org\/10.1212\/WNL.46.2.406","journal-title":"Neurology"},{"key":"13_CR85","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/00004728-199507000-00006","volume":"19","author":"S Minoshima","year":"1995","unstructured":"Minoshima S, Frey KA, Foster NL, Kuhl DE (1995) Preserved pontine glucose metabolism in Alzheimer disease: a reference region for functional brain image (PET) analysis. J Comput Assist Tomogr 19:541\u2013547. https:\/\/doi.org\/10.1097\/00004728-199507000-00006","journal-title":"J Comput Assist Tomogr"},{"issue":"1","key":"13_CR86","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate\u2014a practical and powerful approach to multiple testing. J R Stat Soc Ser B (Methodological) 57(1):289\u2013300","journal-title":"J R Stat Soc Ser B (Methodological)"},{"key":"13_CR87","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1006\/nimg.2001.0764","volume":"13","author":"FE Turkheimer","year":"2001","unstructured":"Turkheimer FE, Smith CB, Schmidt K (2001) Estimation of the number of \u201ctrue\u201d null hypotheses in multivariate analysis of neuroimaging data. NeuroImage 13:920\u2013930. https:\/\/doi.org\/10.1006\/nimg.2001.0764","journal-title":"NeuroImage"},{"key":"13_CR88","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s12021-018-9384-y","volume":"17","author":"FJ L\u00f3pez-Gonz\u00e1lez","year":"2019","unstructured":"L\u00f3pez-Gonz\u00e1lez FJ, Paredes-Pacheco J, Thurnhofer-Hemsi K et al (2019) QModeling: a multiplatform, easy-to-use and open-source toolbox for PET kinetic analysis. Neuroinformatics 17:103\u2013114. https:\/\/doi.org\/10.1007\/s12021-018-9384-y","journal-title":"Neuroinformatics"},{"key":"13_CR89","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1016\/j.neuroimage.2012.01.099","volume":"60","author":"P Edison","year":"2012","unstructured":"Edison P, Hinz R, Ramlackhansingh A et al (2012) Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans? NeuroImage 60:1716\u20131723. https:\/\/doi.org\/10.1016\/j.neuroimage.2012.01.099","journal-title":"NeuroImage"},{"key":"13_CR90","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1586\/ern.10.136","volume":"10","author":"K Herholz","year":"2010","unstructured":"Herholz K (2010) Cerebral glucose metabolism in preclinical and prodromal Alzheimer\u2019s disease. Expert Rev Neurother 10:1667\u20131673. https:\/\/doi.org\/10.1586\/ern.10.136","journal-title":"Expert Rev Neurother"},{"key":"13_CR91","first-page":"1959","volume":"46","author":"BJ Lopresti","year":"2005","unstructured":"Lopresti BJ, Klunk WE, Mathis CA et al (2005) Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis. J Nucl Med 46:1959\u20131972","journal-title":"J Nucl Med"}],"container-title":["Methods in Molecular Biology","Biomarkers for Alzheimer\u2019s Disease Drug Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3774-6_13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T18:13:50Z","timestamp":1715019230000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3774-6_13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9781071637739","9781071637746"],"references-count":91,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3774-6_13","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"2 March 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}