{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:36:04Z","timestamp":1766050564263,"version":"3.40.3"},"publisher-location":"New York, NY","reference-count":22,"publisher":"Springer US","isbn-type":[{"type":"print","value":"9781071637852"},{"type":"electronic","value":"9781071637869"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/978-1-0716-3786-9_19","type":"book-chapter","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T16:03:05Z","timestamp":1710950585000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Detection of Pre-Existing Antibodies to Polyethylene Glycol and PEGylated Liposomes in Human Serum"],"prefix":"10.1007","author":[{"given":"Barry W.","family":"Neun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina A.","family":"Dobrovolskaia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"issue":"5","key":"19_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1897","volume":"15","author":"AK Andrianov","year":"2023","unstructured":"Andrianov AK (2023) Noncovalent PEGylation of protein and peptide therapeutics. Wiley Interdiscip Rev Nanomed Nanobiotechnol 15(5):e1897","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"1","key":"19_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s40199-023-00455-1","volume":"31","author":"C Chapa Gonz\u00e1lez","year":"2023","unstructured":"Chapa Gonz\u00e1lez C, Mart\u00ednez Sar\u00e1oz JV, Roacho P\u00e9rez JA, Olivas Armend\u00e1riz I (2023) Lipid nanoparticles for gene therapy in ocular diseases. Daru 31(1):75\u201382","journal-title":"Daru"},{"key":"19_CR3","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jconrel.2022.09.031","volume":"351","author":"M Ibrahim","year":"2022","unstructured":"Ibrahim M, Ramadan E, Elsadek NE, Emam SE, Shimizu T, Ando H, Ishima Y, Elgarhy OH, Sarhan HA, Hussein AK, Ishida T (2022) Polyethylene glycol (PEG): the nature, immunogenicity, and role in the hypersensitivity of PEGylated products. J Control Release 351:215\u2013230","journal-title":"J Control Release"},{"key":"19_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114079","volume":"180","author":"D Shi","year":"2022","unstructured":"Shi D, Beasock D, Fessler A, Szebeni J, Ljubimova JY, Afonin KA, Dobrovolskaia MA (2022) To PEGylate or not to PEGylate: immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives. Adv Drug Deliv Rev 180:114079","journal-title":"Adv Drug Deliv Rev"},{"key":"19_CR5","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jconrel.2023.01.012","volume":"354","author":"M Ibrahim","year":"2023","unstructured":"Ibrahim M, Shimizu T, Ando H, Ishima Y, Elgarhy OH, Sarhan HA, Hussein AK, Ishida T (2023) Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice. J Control Release 354:260\u2013267","journal-title":"J Control Release"},{"issue":"8","key":"19_CR6","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/cpdd.1225","volume":"12","author":"N Okada","year":"2023","unstructured":"Okada N, Taro S, Ando H, Nakamura S, Goda M, Abe M, Kitahara T, Ishida T, Ishizawa K (2023) Clinical impact of antipolyethylene glycol (PEG) antibody in hematological patients administered PEGylated-granulocyte colony-stimulating factor. Clin Pharmacol Drug Dev 12(8):826\u2013831","journal-title":"Clin Pharmacol Drug Dev"},{"key":"19_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jconrel.2023.06.027","volume":"360","author":"H Takata","year":"2023","unstructured":"Takata H, Shimizu T, Yamade R, Elsadek NE, Emam SE, Ando H, Ishima Y, Ishida T (2023) Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route. J Control Release 360:285\u2013292","journal-title":"J Control Release"},{"issue":"9","key":"19_CR8","doi-asserted-by":"publisher","first-page":"14022","DOI":"10.1021\/acsnano.1c05922","volume":"15","author":"BM Chen","year":"2021","unstructured":"Chen BM, Cheng TL, Roffler SR (2021) Polyethylene glycol immunogenicity: theoretical, clinical, and practical aspects of anti-polyethylene glycol antibodies. ACS Nano 15(9):14022\u201314048","journal-title":"ACS Nano"},{"key":"19_CR9","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jconrel.2019.06.007","volume":"306","author":"Y Bavli","year":"2019","unstructured":"Bavli Y, Winkler I, Chen BM, Roffler S, Cohen R, Szebeni J, Barenholz Y (2019) Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs. J Control Release 306:138\u2013148","journal-title":"J Control Release"},{"issue":"7","key":"19_CR10","doi-asserted-by":"publisher","first-page":"7808","DOI":"10.1021\/acsnano.9b07218","volume":"14","author":"E Chen","year":"2020","unstructured":"Chen E, Chen BM, Su YC, Chang YC, Cheng TL, Barenholz Y, Roffler SR (2020) Premature drug release from polyethylene glycol (PEG)-coated liposomal doxorubicin via formation of the membrane attack complex. ACS Nano 14(7):7808\u20137822","journal-title":"ACS Nano"},{"issue":"6","key":"19_CR11","doi-asserted-by":"publisher","first-page":"5757","DOI":"10.1021\/acsnano.2c12193","volume":"17","author":"WA Chen","year":"2023","unstructured":"Chen WA, Chang DY, Chen BM, Lin YC, Barenholz Y, Roffler SR (2023) Antibodies against poly(ethylene glycol) activate innate immune cells and induce hypersensitivity reactions to PEGylated nanomedicines. ACS Nano 17(6):5757\u20135772","journal-title":"ACS Nano"},{"issue":"1","key":"19_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12929-019-0589-7","volume":"27","author":"CC Lee","year":"2020","unstructured":"Lee CC, Su YC, Ko TP, Lin LL, Yang CY, Chang SS, Roffler SR, Wang AH (2020) Structural basis of polyethylene glycol recognition by antibody. J Biomed Sci 27(1):12","journal-title":"J Biomed Sci"},{"key":"19_CR13","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.jconrel.2023.01.021","volume":"354","author":"YC Lin","year":"2023","unstructured":"Lin YC, Chen BM, Tran TTM, Chang TC, Al-Qaisi TS, Roffler SR (2023) Accelerated clearance by antibodies against methoxy PEG depends on pegylation architecture. J Control Release 354:354\u2013367","journal-title":"J Control Release"},{"issue":"1","key":"19_CR14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s42004-022-00709-0","volume":"5","author":"MT Nguyen","year":"2022","unstructured":"Nguyen MT, Shih YC, Lin MH, Roffler SR, Hsiao CY, Cheng TL, Lin WW, Lin EC, Jong YJ, Chang CY, Su YC (2022) Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group. Commun Chem 5(1):88","journal-title":"Commun Chem"},{"issue":"2","key":"19_CR15","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s11357-021-00495-y","volume":"44","author":"L D\u00e9zsi","year":"2022","unstructured":"D\u00e9zsi L, M\u00e9sz\u00e1ros T, Kozma G, H-Velkei M, Ol\u00e1h CZ, Szab\u00f3 M, Patk\u00f3 Z, F\u00fcl\u00f6p T, Hennies M, Szebeni M, Barta BA, Merkely B, Radovits T, Szebeni J (2022) A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor. GeroScience 44(2):597\u2013618","journal-title":"GeroScience"},{"key":"19_CR16","doi-asserted-by":"publisher","unstructured":"Kozma GT, M\u00e9sz\u00e1ros T, Ber\u00e9nyi P, Facsk\u00f3 R, Patk\u00f3 Z, Ol\u00e1h CZ, Nagy A, F\u00fcl\u00f6p TG, Glatter KA, Radovits T, Merkely B, Szebeni J (2023) Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: evidence for immunogenicity of PEG. Vaccine. https:\/\/doi.org\/10.1016\/j.vaccine.2023.06.009","DOI":"10.1016\/j.vaccine.2023.06.009"},{"issue":"14","key":"19_CR17","doi-asserted-by":"publisher","first-page":"13147","DOI":"10.1021\/acsnano.2c11904","volume":"17","author":"J Szebeni","year":"2023","unstructured":"Szebeni J, Kiss B, Boz\u00f3 T, Turjeman K, Levi-Kalisman Y, Barenholz Y, Kellermayer M (2023) Insights into the structure of comirnaty covid-19 vaccine: a theory on soft, partially bilayer-covered nanoparticles with hydrogen bond-stabilized mRNA-lipid complexes. ACS Nano 17(14):13147\u201313157","journal-title":"ACS Nano"},{"issue":"4","key":"19_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41565-022-01071-x","volume":"17","author":"J Szebeni","year":"2022","unstructured":"Szebeni J, Storm G, Ljubimova JY, Castells M, Phillips EJ, Turjeman K, Barenholz Y, Crommelin DJA, Dobrovolskaia MA (2022) Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines. Nat Nanotechnol 17(4):337\u2013346","journal-title":"Nat Nanotechnol"},{"issue":"6","key":"19_CR19","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3390\/vaccines11061020","volume":"11","author":"XR Lim","year":"2023","unstructured":"Lim XR, Chan GYL, Tan JWL, Ng CYL, Chua CG, Tan GB, Chan SSW, Ong KH, Tan YZ, Tan SHZ, Teo CML, Lee SSM, Thong BYH, Leung BPL (2023) Anaphylatoxin complement 5a in Pfizer BNT162b2-induced immediate-type vaccine hypersensitivity reactions. Vaccines (Basel) 11(6):1020","journal-title":"Vaccines (Basel)"},{"issue":"28","key":"19_CR20","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1016\/j.vaccine.2023.05.029","volume":"41","author":"ZH Zhou","year":"2023","unstructured":"Zhou ZH, Cortese MM, Fang JL, Wood R, Hummell DS, Risma KA, Norton AE, KuKuruga M, Kirshner S, Rabin RL, Agarabi C, Staat MA, Halasa N, Ware RE, Stahl A, McMahon M, Browning P, Maniatis P, Bolcen S, Edwards KM, Su JR, Dharmarajan S, Forshee R, Broder KR, Anderson S, Kozlowski S (2023) Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination. Vaccine 41(28):4183\u20134189","journal-title":"Vaccine"},{"key":"19_CR21","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.toxrep.2020.12.022","volume":"8","author":"JL Fang","year":"2021","unstructured":"Fang JL, Beland FA, Tang Y, Roffler SR (2021) Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma. Toxicol Rep 8:148\u2013154","journal-title":"Toxicol Rep"},{"issue":"7","key":"19_CR22","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.3390\/molecules23071700","volume":"23","author":"BW Neun","year":"2018","unstructured":"Neun BW, Barenholz Y, Szebeni J, Dobrovolskaia MA (2018) Understanding the role of anti-PEG antibodies in the complement activation by doxil in vitro. Molecules 23(7):1700","journal-title":"Molecules"}],"container-title":["Methods in Molecular Biology","Characterization of Nanoparticles Intended for Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-3786-9_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T16:04:11Z","timestamp":1710950651000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-3786-9_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9781071637852","9781071637869"],"references-count":22,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-3786-9_19","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"type":"print","value":"1064-3745"},{"type":"electronic","value":"1940-6029"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"21 March 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}