{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:37:44Z","timestamp":1773113864665,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":36,"publisher":"Springer US","isbn-type":[{"value":"9781071641835","type":"print"},{"value":"9781071641842","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/978-1-0716-4184-2_15","type":"book-chapter","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T08:53:13Z","timestamp":1731315193000},"page":"281-297","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Role of Tertiary Lymphoid Structures Using a Mouse Model of Bacteria-Infected Lungs"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4442-9565","authenticated-orcid":false,"given":"Jean-Luc","family":"Teillaud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6530-4449","authenticated-orcid":false,"given":"Lucile","family":"Regard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-5888","authenticated-orcid":false,"given":"Cl\u00e9mence","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-2886","authenticated-orcid":false,"given":"Sophie","family":"Sib\u00e9ril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-9828","authenticated-orcid":false,"given":"Pierre-R\u00e9gis","family":"Burgel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"15_CR1","first-page":"686","volume":"28","author":"J Bienenstock","year":"1973","unstructured":"Bienenstock J, Johnston N, Perey DY (1973) Bronchial lymphoid tissue. I. Morphologic characteristics. Lab Invest 28:686\u2013692","journal-title":"Lab Invest"},{"key":"15_CR2","first-page":"693","volume":"28","author":"J Bienenstock","year":"1973","unstructured":"Bienenstock J, Johnston N, Perey DY (1973) Bronchial lymphoid tissue. II. Functional characteristics. Lab Invest 28:693\u2013698","journal-title":"Lab Invest"},{"key":"15_CR3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1165\/ajrcmb\/3.2.131","volume":"3","author":"R Pabst","year":"1990","unstructured":"Pabst R, Gehrke I (1990) Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans? Am J Respir Cell Mol Biol 3:131\u2013135. https:\/\/doi.org\/10.1165\/ajrcmb\/3.2.131","journal-title":"Am J Respir Cell Mol Biol"},{"key":"15_CR4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/BF02786481","volume":"19","author":"NH Ruddle","year":"1999","unstructured":"Ruddle NH (1999) Lymphoid neo-organogenesis: lympho-toxin\u2019s role in inflammation and development. Immunol Res 19:119\u2013125. https:\/\/doi.org\/10.1007\/BF02786481","journal-title":"Immunol Res"},{"key":"15_CR5","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1056\/NEJMoa032158","volume":"350","author":"JC Hogg","year":"2004","unstructured":"Hogg JC, Chu F, Utokaparch S et al (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350:2645\u20132653. https:\/\/doi.org\/10.1056\/NEJMoa032158","journal-title":"N Engl J Med"},{"key":"15_CR6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1164\/rccm.201105-0927OC","volume":"185","author":"F Perros","year":"2012","unstructured":"Perros F, Dorfm\u00fcller P, Montani D et al (2012) Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 185:311\u2013321. https:\/\/doi.org\/10.1164\/rccm.201105-0927OC","journal-title":"Am J Respir Crit Care Med"},{"key":"15_CR7","doi-asserted-by":"publisher","first-page":"5735","DOI":"10.4049\/jimmunol.176.10.5735","volume":"176","author":"J Marchal-Somm\u00e9","year":"2006","unstructured":"Marchal-Somm\u00e9 J, Uzunhan Y, Marchand-Adam S et al (2006) Cutting edge: non-proliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J Immunol 176:5735\u20135739. https:\/\/doi.org\/10.4049\/jimmunol.176.10.5735","journal-title":"J Immunol"},{"key":"15_CR8","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1164\/rccm.200308-1167C","volume":"169","author":"JG Elliot","year":"2004","unstructured":"Elliot JG, Jensen CM, Mutavdzic S et al (2004) Aggregation of lymphoid cells in the airways of nonsmokers, smokers and subjects with asthma. Am J Respir Crit Care Med 169:712\u2013718. https:\/\/doi.org\/10.1164\/rccm.200308-1167C","journal-title":"Am J Respir Crit Care Med"},{"key":"15_CR9","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1172\/JCI28756","volume":"116","author":"J Rangel-Moreno","year":"2006","unstructured":"Rangel-Moreno J, Harton L, Navarro C et al (2006) Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J Clin Invest 116:3183\u20133194. https:\/\/doi.org\/10.1172\/JCI28756","journal-title":"J Clin Invest"},{"key":"15_CR10","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.1200\/JCO.2007.15.0284","volume":"26","author":"MC Dieu-Nosjean","year":"2008","unstructured":"Dieu-Nosjean MC, Antoine M, Danel C et al (2008) Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol 26:4410\u20134417. https:\/\/doi.org\/10.1200\/JCO.2007.15.0284","journal-title":"J Clin Oncol"},{"key":"15_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.698604","volume":"12","author":"C Domblides","year":"2021","unstructured":"Domblides C, Rochefort J, Riffard C et al (2021) Tumor-associated tertiary lymphoid structures: from basic and clinical knowledge to therapeutic manipulation. Front Immunol 12:698604. https:\/\/doi.org\/10.3389\/fimmu.2021.698604","journal-title":"Front Immunol"},{"key":"15_CR12","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/s41586-019-1922-8","volume":"577","author":"BA Helmink","year":"2020","unstructured":"Helmink BA, Reddy SM, Gao J et al (2020) B cells and tertiary lymphoid structures promote immunotherapy response. Nature 577:549\u2013555. https:\/\/doi.org\/10.1038\/s41586-019-1922-8","journal-title":"Nature"},{"key":"15_CR13","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41586-019-1906-8","volume":"577","author":"F Petitprez","year":"2020","unstructured":"Petitprez F, de Reyni\u00e8s A, Keung EZ et al (2020) B cells are associated with survival and immunotherapy response in sarcoma. Nature 577:556\u2013560. https:\/\/doi.org\/10.1038\/s41586-019-1906-8","journal-title":"Nature"},{"key":"15_CR14","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/s41586-019-1914-8","volume":"577","author":"R Cabrita","year":"2020","unstructured":"Cabrita R, Lauss M, Sanna A et al (2020) Tertiary lymphoid structures improve immunotherapy and survival in melanoma. Nature 577:561\u2013565. https:\/\/doi.org\/10.1038\/s41586-019-1914-8","journal-title":"Nature"},{"issue":"4","key":"15_CR15","doi-asserted-by":"publisher","first-page":"pii: 1601873","DOI":"10.1183\/13993003.01873-2016","volume":"49","author":"J Frija-Masson","year":"2017","unstructured":"Frija-Masson J, Martin C, Regard L et al (2017) Bacteria-driven peribronchial lymphoid neogenesis in bronchiectasis and cystic fibrosis. Eur Respir J 49(4):pii: 1601873. https:\/\/doi.org\/10.1183\/13993003.01873-2016","journal-title":"Eur Respir J"},{"key":"15_CR16","unstructured":"Vaincre la Mucoviscidose (2023) French CF Registry \u2013 2022 annual data report, Paris, p 27. http:\/\/www.registredelamuco.org"},{"key":"15_CR17","unstructured":"CFF (2023) Cystic Fibrosis Foundation Patient Registry \u2013 2022 annual data report, Bethesda, MD, p 8. https:\/\/www.cff.org\/"},{"issue":"10","key":"15_CR18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI167957","volume":"133","author":"DP Nichols","year":"2023","unstructured":"Nichols DP, Morgan SJ, Skalland M et al (2023) Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist. J Clin Invest 133(10):e167957. https:\/\/doi.org\/10.1172\/JCI167957","journal-title":"J Clin Invest"},{"key":"15_CR19","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/mi.2010.52","volume":"3","author":"SY Foo","year":"2010","unstructured":"Foo SY, Phipps S (2010) Regulation of inducible BALT formation and contribution to immunity and pathology. Mucosal Immunol 3:537\u2013544. https:\/\/doi.org\/10.1038\/mi.2010.52","journal-title":"Mucosal Immunol"},{"issue":"10","key":"15_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048655","volume":"7","author":"TR Crother","year":"2012","unstructured":"Crother TR, Ma J, Jupelli M et al (2012) Plasmacytoid dendritic cells play a role for effective innate immune responses during chlamydia pneumoniae infection in mice. PLoS One 7(10):e48655. https:\/\/doi.org\/10.1371\/journal.pone.0048655","journal-title":"PLoS One"},{"key":"15_CR21","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/ni.3290","volume":"16","author":"S Finkin","year":"2015","unstructured":"Finkin S, Yuan D, Stein I et al (2015) Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol 16:1235\u20131244. https:\/\/doi.org\/10.1038\/ni.3290","journal-title":"Nat Immunol"},{"key":"15_CR22","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.immuni.2015.08.006","volume":"43","author":"NS Joshi","year":"2015","unstructured":"Joshi NS, Akama-Garren EH, Lu Y et al (2015) Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses. Immunity 43:579\u2013590. https:\/\/doi.org\/10.1016\/j.immuni.2015.08.006","journal-title":"Immunity"},{"key":"15_CR23","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1038\/s42003-022-04356-y","volume":"5","author":"P Devi-Marulkar","year":"2022","unstructured":"Devi-Marulkar P, Fastenackels S, Karapentiantz P et al (2022) Regulatory T cells infiltrate the tumor-induced tertiary lymphoid structures and are associated with poor clinical outcomes in NSCLC. Commun Biol 5:1416. https:\/\/doi.org\/10.1038\/s42003-022-04356-y","journal-title":"Commun Biol"},{"key":"15_CR24","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1183\/09031936.00134910","volume":"38","author":"C Martin","year":"2011","unstructured":"Martin C, Thevenot G, Danel S et al (2011) Pseudomonas aeruginosa induces vascular endothelial growth factor synthesis in airway epithelium in vitro and in vivo. Eur Respir J 38:939\u2013946. https:\/\/doi.org\/10.1183\/09031936.00134910","journal-title":"Eur Respir J"},{"key":"15_CR25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.healun.2014.09.019","volume":"34","author":"F Ius","year":"2015","unstructured":"Ius F, Sommer W, Tudorache I et al (2015) Preemptive treatment with therapeutic plasma exchange and rituximab for early donor-specific antibodies after lung transplantation. J Heart Lung Transplant 34:50\u201358. https:\/\/doi.org\/10.1016\/j.healun.2014.09.019","journal-title":"J Heart Lung Transplant"},{"key":"15_CR26","doi-asserted-by":"publisher","first-page":"2000768","DOI":"10.1183\/13993003.00768-2020","volume":"57","author":"L Regard","year":"2021","unstructured":"Regard L, Martin C, Teillaud JL et al (2021) Effective control of Staphylococcus aureus lung infection despite tertiary lymphoid structure disorganisation. Eur Respir J 57:2000768. https:\/\/doi.org\/10.1183\/13993003.00768-2020","journal-title":"Eur Respir J"},{"key":"15_CR27","doi-asserted-by":"publisher","DOI":"10.17226\/12910","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals","year":"2011","unstructured":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals (2011) Guide for the care and use of laboratory animals, 8th edn. National Academies Press (US), Washington, DC. https:\/\/doi.org\/10.17226\/12910","edition":"8"},{"key":"15_CR28","first-page":"33","volume":"L276","author":"The European Parliament and the Council of the European Union","year":"2010","unstructured":"The European Parliament and the Council of the European Union (2010) Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Off J Eur Union L276:33\u201379","journal-title":"Off J Eur Union"},{"key":"15_CR29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1258\/0023677021911740","volume":"36","author":"W Nicklas","year":"2002","unstructured":"Nicklas W, Baneux P, Boot R et al (2002) Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim 36:20\u201342. https:\/\/doi.org\/10.1258\/0023677021911740","journal-title":"Lab Anim"},{"key":"15_CR30","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1258\/002367702320162405","volume":"36","author":"AM van Heeckeren","year":"2002","unstructured":"van Heeckeren AM, Schluchter MD (2002) Murine models of chronic Pseudomonas aeruginosa lung infection. Lab Anim 36:291\u2013312. https:\/\/doi.org\/10.1258\/002367702320162405","journal-title":"Lab Anim"},{"key":"15_CR31","doi-asserted-by":"publisher","DOI":"10.3791\/50318","volume":"73","author":"S Das","year":"2013","unstructured":"Das S, MacDonald K, Chang HY, Mitzner W (2013) A simple method of mouse lung intubation. J Vis Exp 73:e50318. https:\/\/doi.org\/10.3791\/50318","journal-title":"J Vis Exp"},{"key":"15_CR32","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1164\/rccm.200809-1522ST","volume":"181","author":"CC Hsia","year":"2010","unstructured":"Hsia CC, Hyde DM, Ochs M, Weibel ER, ATS\/ERS Joint Task Force on Quantitative Assessment of Lung Structure (2010) An official research policy statement of the American Thoracic Society\/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 181:394\u2013418. https:\/\/doi.org\/10.1164\/rccm.200809-1522ST","journal-title":"Am J Respir Crit Care Med"},{"key":"15_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-62703-664-1_1","volume":"1085","author":"EL Palavecino","year":"2014","unstructured":"Palavecino EL (2014) Clinical, epidemiologic, and laboratory aspects of methicillin-resistant Staphylococcus aureus infections. Methods Mol Biol 1085:1\u201324. https:\/\/doi.org\/10.1007\/978-1-62703-664-1_1","journal-title":"Methods Mol Biol"},{"key":"15_CR34","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.ijmm.2010.08.003","volume":"300","author":"C Goerke","year":"2010","unstructured":"Goerke C, Wolz C (2010) Adaptation of Staphylococcus aureus to the cystic fibrosis lung. Int J Med Microbiol 300:520\u2013525. https:\/\/doi.org\/10.1016\/j.ijmm.2010.08.003","journal-title":"Int J Med Microbiol"},{"key":"15_CR35","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nm1748","volume":"14","author":"V Teichgr\u00e4ber","year":"2008","unstructured":"Teichgr\u00e4ber V, Ulrich M, Endlich N et al (2008) Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med 14:382\u2013391. https:\/\/doi.org\/10.1038\/nm1748","journal-title":"Nat Med"},{"key":"15_CR36","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1128\/iai.63.5.1718-1724.1995","volume":"63","author":"C Morissette","year":"1995","unstructured":"Morissette C, Skamene E, Gervais F (1995) Endobronchial inflammation following Pseudomonas aeruginosa infection in resistant and susceptible strains of mice. Infect Immun 63:1718\u20131724. https:\/\/doi.org\/10.1128\/iai.63.5.1718-1724.1995","journal-title":"Infect Immun"}],"container-title":["Methods in Molecular Biology","Tertiary Lymphoid Structures"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-1-0716-4184-2_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T09:02:58Z","timestamp":1731315778000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-1-0716-4184-2_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"ISBN":["9781071641835","9781071641842"],"references-count":36,"URL":"https:\/\/doi.org\/10.1007\/978-1-0716-4184-2_15","relation":{},"ISSN":["1064-3745","1940-6029"],"issn-type":[{"value":"1064-3745","type":"print"},{"value":"1940-6029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"12 November 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}